Aliases for CXCL3 Gene
External Ids for CXCL3 Gene
Previous HGNC Symbols for CXCL3 Gene
Previous GeneCards Identifiers for CXCL3 Gene
This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]
GeneCards Summary for CXCL3 Gene
CXCL3 (C-X-C Motif Chemokine Ligand 3) is a Protein Coding gene. Diseases associated with CXCL3 include Melanoma and Colorectal Cancer. Among its related pathways are Insulin receptor recycling and Rheumatoid arthritis. Gene Ontology (GO) annotations related to this gene include chemokine activity and CXCR chemokine receptor binding. An important paralog of this gene is CXCL2.
UniProtKB/Swiss-Prot Summary for CXCL3 Gene
Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.