Aliases for CXCL3 Gene
External Ids for CXCL3 Gene
Previous HGNC Symbols for CXCL3 Gene
Previous GeneCards Identifiers for CXCL3 Gene
This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]
GeneCards Summary for CXCL3 Gene
CXCL3 (C-X-C Motif Chemokine Ligand 3) is a Protein Coding gene. Among its related pathways are Akt Signaling and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include chemokine activity and CXCR chemokine receptor binding. An important paralog of this gene is CXCL2.
UniProtKB/Swiss-Prot for CXCL3 Gene
Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.