The protein encoded by this gene is a mucosal chemokine that attracts immature dendritic cells and blood monocytes to the lungs. The encoded protein also promotes tumorigenesis through an angiogenic activity. Finally, this protein exhibits strong antimicrobial activity against E. coli, S. aureus, Salmonella, P. aeruginosa, and C. albicans. Two transcript variants, one protein-c... See more...

Aliases for CXCL17 Gene

Aliases for CXCL17 Gene

  • C-X-C Motif Chemokine Ligand 17 2 3 5
  • Dendritic Cell And Monocyte Chemokine-Like Protein 3 4
  • Chemokine (C-X-C Motif) Ligand 17 2 3
  • VEGF Coregulated Chemokine 1 3 4
  • C-X-C Motif Chemokine 17 3 4
  • 6-Cys CXCL17 3 4
  • VCC1 3 4
  • DMC 3 4
  • VEGF Co-Regulated Chemokine 1 3
  • UNQ473 3
  • Dcip1 3
  • VCC-1 3

External Ids for CXCL17 Gene

Previous GeneCards Identifiers for CXCL17 Gene

  • GC19M047625
  • GC19M042932
  • GC19M039362

Summaries for CXCL17 Gene

Entrez Gene Summary for CXCL17 Gene

  • The protein encoded by this gene is a mucosal chemokine that attracts immature dendritic cells and blood monocytes to the lungs. The encoded protein also promotes tumorigenesis through an angiogenic activity. Finally, this protein exhibits strong antimicrobial activity against E. coli, S. aureus, Salmonella, P. aeruginosa, and C. albicans. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for CXCL17 Gene

CXCL17 (C-X-C Motif Chemokine Ligand 17) is a Protein Coding gene. Diseases associated with CXCL17 include Cholera and Photokeratitis. Among its related pathways are Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions and PEDF Induced Signaling.

UniProtKB/Swiss-Prot Summary for CXCL17 Gene

  • Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells (PubMed:16455961, PubMed:23115081). Plays a role in angiogenesis and possibly in the development of tumors (PubMed:16989774, PubMed:23115081). Acts as an anti-inflammatory in the stomach (PubMed:23115081). May play a role in the innate defense against infections (PubMed:17307946). Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions (PubMed:25411203).
  • [4-Cys CXCL17]: seems exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17.

Additional gene information for CXCL17 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CXCL17 Gene

Genomics for CXCL17 Gene

GeneHancer (GH) Regulatory Elements for CXCL17 Gene

Promoters and enhancers for CXCL17 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J042440 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 508.9 +0.0 31 5.3 FOXK2 CTCF POLR2G NCOR1 ZIC2 KDM6A TCF7 FOXA1 KLF4 MYC CXCL17 ZNF574 LIPE-AS1 CNFN PSG8 ENSG00000268355 CD177 piR-47851-002
GH19J042528 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 9.3 -85.6 -85625 2.8 CTCF POLR2G ZNF10 REST ZBTB25 RAD21 SKI TRIM22 POLR2A TEAD1 CEACAM1 CXCL17 LOC105372407 piR-59655-006 LIPE-AS1
GH19J042449 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 8 -10.3 -10317 9.4 EP300 CTCF TCF12 SP1 NCOR1 ZNF639 ZNF10 KDM6A TCF7 AFF1 LIPE LIPE-AS1 CNFN CXCL17 PSG8 ENSG00000268355 CD177 CEACAM1 piR-57614
GH19J042496 Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 8.4 -55.2 -55248 4.1 TCF12 POLR2G NCOR1 EP300 KDM6A TCF7 ZBTB25 TGIF2 SKI TRIM22 CXCL17 ZNF526 CD177 MEGF8 piR-50443-202 lnc-CEACAM8-3 LIPE-AS1
GH19J042480 Enhancer 1.1 ENCODE dbSUPER 7.7 -38.2 -38178 1.4 TCF12 POLR2G NCOR1 KDM6A TCF7 FOXA1 HES1 TGIF2 SKI TEAD1 CXCL17 PSG8 ENSG00000268355 ENSG00000269374 lnc-CEACAM1-2 RNU4-60P LIPE-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CXCL17 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CXCL17

Top Transcription factor binding sites by QIAGEN in the CXCL17 gene promoter:
  • AREB6
  • c-Myb
  • COUP
  • COUP-TF
  • COUP-TF1
  • FOXD1
  • ITF-2
  • RORalpha1
  • Sox9
  • Tal-1beta

Genomic Locations for CXCL17 Gene

Genomic Locations for CXCL17 Gene
chr19:42,428,278-42,442,984
(GRCh38/hg38)
Size:
14,707 bases
Orientation:
Minus strand
chr19:42,932,440-42,947,200
(GRCh37/hg19)
Size:
14,761 bases
Orientation:
Minus strand

Genomic View for CXCL17 Gene

Genes around CXCL17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCL17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCL17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL17 Gene

Proteins for CXCL17 Gene

  • Protein details for CXCL17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXB2-CXL17_HUMAN
    Recommended name:
    C-X-C motif chemokine 17
    Protein Accession:
    Q6UXB2
    Secondary Accessions:
    • A8KAC0

    Protein attributes for CXCL17 Gene

    Size:
    119 amino acids
    Molecular mass:
    13819 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CXCL17 Gene

Post-translational modifications for CXCL17 Gene

  • Likely to undergo an endoproteolytic process to form a four-cysteine-containing mature peptide with a canonical CXC chemokine scaffold after secretion.

Other Protein References for CXCL17 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CXCL17 Gene

Domains & Families for CXCL17 Gene

Gene Families for CXCL17 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for CXCL17 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CXCL17 Gene

GenScript: Design optimal peptide antigens:
  • Dendritic cell and monocyte chemokine-like protein (VCC1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6UXB2

UniProtKB/Swiss-Prot:

CXL17_HUMAN :
  • Belongs to the intercrine alpha (chemokine CxC) family.
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL17: view

Function for CXCL17 Gene

Molecular function for CXCL17 Gene

UniProtKB/Swiss-Prot Function:
Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells (PubMed:16455961, PubMed:23115081). Plays a role in angiogenesis and possibly in the development of tumors (PubMed:16989774, PubMed:23115081). Acts as an anti-inflammatory in the stomach (PubMed:23115081). May play a role in the innate defense against infections (PubMed:17307946). Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions (PubMed:25411203).
UniProtKB/Swiss-Prot Function:
[4-Cys CXCL17]: seems exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17.
UniProtKB/Swiss-Prot Induction:
Found to be up-regulated in duodenal mucosa during acute cholera.

Gene Ontology (GO) - Molecular Function for CXCL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 28381538
genes like me logo Genes that share ontologies with CXCL17: view
genes like me logo Genes that share phenotypes with CXCL17: view

Animal Models for CXCL17 Gene

MGI Knock Outs for CXCL17:
  • Cxcl17 Cxcl17<tm1b(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for CXCL17

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXCL17

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CXCL17 Gene

Localization for CXCL17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL17 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXCL17 gene
Compartment Confidence
extracellular 5
plasma membrane 1
cytoskeleton 1
nucleus 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CXCL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IMP 23115081
genes like me logo Genes that share ontologies with CXCL17: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CXCL17 Gene

Pathways & Interactions for CXCL17 Gene

genes like me logo Genes that share pathways with CXCL17: view

Pathways by source for CXCL17 Gene

Gene Ontology (GO) - Biological Process for CXCL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IMP 23115081
GO:0001525 angiogenesis IEA --
GO:0006935 chemotaxis IEA --
GO:0007275 multicellular organism development IEA --
GO:0010575 positive regulation of vascular endothelial growth factor production IMP 23115081
genes like me logo Genes that share ontologies with CXCL17: view

No data available for SIGNOR curated interactions for CXCL17 Gene

Drugs & Compounds for CXCL17 Gene

No Compound Related Data Available

Transcripts for CXCL17 Gene

mRNA/cDNA for CXCL17 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXCL17

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL17 Gene

No ASD Table

Relevant External Links for CXCL17 Gene

GeneLoc Exon Structure for
CXCL17

Expression for CXCL17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CXCL17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXCL17 Gene

This gene is overexpressed in Stomach (x16.0), Minor Salivary Gland (x11.6), Esophagus - Mucosa (x9.8), and Lung (x5.5).

Protein differential expression in normal tissues from HIPED for CXCL17 Gene

This gene is overexpressed in Lung (45.7) and Pancreas (23.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CXCL17 Gene



Protein tissue co-expression partners for CXCL17 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CXCL17

SOURCE GeneReport for Unigene cluster for CXCL17 Gene:

Hs.445586

mRNA Expression by UniProt/SwissProt for CXCL17 Gene:

Q6UXB2-CXL17_HUMAN
Tissue specificity: Detected in trachea, stomach, lung and skeletal muscle. Detected in intestine and in normal and asthmatic lung (at protein level). Breast tumors showed 3- to 24-fold up-regulation.

Evidence on tissue expression from TISSUES for CXCL17 Gene

  • Lung(4.5)
  • Heart(4)
  • Stomach(2.3)
genes like me logo Genes that share expression patterns with CXCL17: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCL17 Gene

Orthologs for CXCL17 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CXCL17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXCL17 31 30
  • 98.6 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CXCL17 31 30
  • 84.42 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CXCL17 31
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cxcl17 17 31 30
  • 80.33 (n)
rat
(Rattus norvegicus)
Mammalia Cxcl17 30
  • 78 (n)
Species where no ortholog for CXCL17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL17 Gene

ENSEMBL:
Gene Tree for CXCL17 (if available)
TreeFam:
Gene Tree for CXCL17 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CXCL17: view image

Paralogs for CXCL17 Gene

No data available for Paralogs for CXCL17 Gene

Variants for CXCL17 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CXCL17 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
719830 Benign: not provided 42,442,779(-) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for CXCL17 Gene

Structural Variations from Database of Genomic Variants (DGV) for CXCL17 Gene

Variant ID Type Subtype PubMed ID
esv2422471 CNV deletion 17116639
nsv526186 CNV gain 19592680

Variation tolerance for CXCL17 Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXCL17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXCL17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL17 Gene

Disorders for CXCL17 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CXCL17 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cholera
  • cholera - vibrio cholerae
photokeratitis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CXCL17

genes like me logo Genes that share disorders with CXCL17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL17 Gene

Publications for CXCL17 Gene

  1. VCC-1, a novel chemokine, promotes tumor growth. (PMID: 16989774) Weinstein EJ … Mazzarella R (Biochemical and biophysical research communications 2006) 3 4 23 54
  2. Cutting edge: GPR35/CXCR8 is the receptor of the mucosal chemokine CXCL17. (PMID: 25411203) Maravillas-Montero JL … Zlotnik A (Journal of immunology (Baltimore, Md. : 1950) 2015) 3 4 54
  3. CXCL17, an orphan chemokine, acts as a novel angiogenic and anti-inflammatory factor. (PMID: 23115081) Lee WY … Luo CW (American journal of physiology. Endocrinology and metabolism 2013) 3 4 54
  4. The chemokine and chemokine receptor superfamilies and their molecular evolution. (PMID: 17201934) Zlotnik A … Nomiyama H (Genome biology 2006) 2 3 54
  5. Cutting edge: novel human dendritic cell- and monocyte-attracting chemokine-like protein identified by fold recognition methods. (PMID: 16455961) Pisabarro MT … Schmidt KN (Journal of immunology (Baltimore, Md. : 1950) 2006) 3 4 54

Products for CXCL17 Gene

  • Signalway ELISA kits for CXCL17
  • Signalway Proteins for CXCL17

Sources for CXCL17 Gene