Aliases for CXCL17 Gene
External Ids for CXCL17 Gene
Previous GeneCards Identifiers for CXCL17 Gene
The protein encoded by this gene is a mucosal chemokine that attracts immature dendritic cells and blood monocytes to the lungs. The encoded protein also promotes tumorigenesis through an angiogenic activity. Finally, this protein exhibits strong antimicrobial activity against E. coli, S. aureus, Salmonella, P. aeruginosa, and C. albicans. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]
GeneCards Summary for CXCL17 Gene
CXCL17 (C-X-C Motif Chemokine Ligand 17) is a Protein Coding gene. Diseases associated with CXCL17 include Cholera. Among its related pathways are PEDF Induced Signaling and Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions.
UniProtKB/Swiss-Prot Summary for CXCL17 Gene
Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells (PubMed:16455961, PubMed:23115081). Plays a role in angiogenesis and possibly in the development of tumors (PubMed:16989774, PubMed:23115081). Acts as an anti-inflammatory in the stomach (PubMed:23115081). May play a role in the innate defense against infections (PubMed:17307946). Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions (PubMed:25411203).
4-Cys CXCL17: seems exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17.