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Aliases for CXCL16 Gene

Aliases for CXCL16 Gene

  • C-X-C Motif Chemokine Ligand 16 2 3 5
  • Scavenger Receptor For Phosphatidylserine And Oxidized Low Density Lipoprotein 3 4
  • Chemokine (C-X-C Motif) Ligand 16 2 3
  • Transmembrane Chemokine CXCL16 3 4
  • Small-Inducible Cytokine B16 3 4
  • CXC Chemokine Ligand 16 2 3
  • SR-PSOX 3 4
  • SRPSOX 3 4
  • C-X-C Motif Chemokine 16 3
  • CXCLG16 3
  • SCYB16 4

External Ids for CXCL16 Gene

Previous GeneCards Identifiers for CXCL16 Gene

  • GC17M005063
  • GC17M004982
  • GC17M004587
  • GC17M004843
  • GC17M004583
  • GC17M004637
  • GC17M004527

Summaries for CXCL16 Gene

GeneCards Summary for CXCL16 Gene

CXCL16 (C-X-C Motif Chemokine Ligand 16) is a Protein Coding gene. Diseases associated with CXCL16 include Xanthogranulomatous Cholecystitis. Among its related pathways are Akt Signaling and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include chemokine activity and low-density lipoprotein particle receptor activity.

UniProtKB/Swiss-Prot for CXCL16 Gene

  • Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.

Additional gene information for CXCL16 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL16 Gene

Genomics for CXCL16 Gene

GeneHancer (GH) Regulatory Elements for CXCL16 Gene

Promoters and enhancers for CXCL16 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J004738 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 670 +0.7 691 2.2 ATF1 SIN3A ZNF2 YY1 GLIS2 ZNF213 ZHX2 MXD4 REST ZNF184 CXCL16 ZMYND15 LOC102724009 DERL2 ENSG00000261898 GC17M004737
GH17J004730 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 18.5 +8.6 8621 2 HDGF FOXA2 PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 MED11 ENSG00000261898 CXCL16 LOC101928000 GC17M004714
GH17J004709 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 14.7 +28.6 28609 4.1 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ARRB2 PELP1 ZMYND15 C17orf107 CXCL16 ZNF232 RPAIN LOC100130950 ANKFY1 MINK1
GH17J004769 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE 16.2 -31.4 -31369 3.1 FOXA2 ARID4B DMAP1 ZNF48 YY1 SLC30A9 FOS PAF1 RXRA SP5 TM4SF5 CXCL16 ZNF232 INCA1 ZMYND15 VMO1 ENSG00000262165 ARRB2 SPAG7 MINK1
GH17J004832 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.7 -94.7 -94688 4.2 HDGF PKNOX1 FOXA2 SIN3A ZNF2 YY1 ZNF207 ZNF143 KLF13 SP3 MINK1 CHRNE DERL2 ZZEF1 LOC105371506 LOC102724009 LOC100130950 CXCL16 ZMYND15 NUP88
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CXCL16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CXCL16 gene promoter:

Genomic Locations for CXCL16 Gene

Genomic Locations for CXCL16 Gene
6,403 bases
Minus strand

Genomic View for CXCL16 Gene

Genes around CXCL16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCL16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCL16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL16 Gene

Proteins for CXCL16 Gene

  • Protein details for CXCL16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-X-C motif chemokine 16
    Protein Accession:
    Secondary Accessions:
    • A0N0N4
    • A8K7U9
    • B2RCB0
    • Q8TC80
    • Q96K63
    • Q9BXD6
    • Q9H2F6

    Protein attributes for CXCL16 Gene

    254 amino acids
    Molecular mass:
    27579 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG34365.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH17588.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH44930.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=ABK41925.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55078.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAF84803.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG37507.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CXCL16 Gene

Post-translational modifications for CXCL16 Gene

Other Protein References for CXCL16 Gene

Antibody Products

No data available for DME Specific Peptides for CXCL16 Gene

Domains & Families for CXCL16 Gene

Gene Families for CXCL16 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for CXCL16 Gene


Suggested Antigen Peptide Sequences for CXCL16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intercrine alpha (chemokine CxC) family.
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL16: view

Function for CXCL16 Gene

Molecular function for CXCL16 Gene

UniProtKB/Swiss-Prot Function:
Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.

Phenotypes From GWAS Catalog for CXCL16 Gene

Gene Ontology (GO) - Molecular Function for CXCL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005041 low-density lipoprotein particle receptor activity ISS --
GO:0005044 scavenger receptor activity IEA,TAS 11060282
GO:0005125 cytokine activity IEA --
GO:0008009 chemokine activity IEA,ISS --
genes like me logo Genes that share ontologies with CXCL16: view
genes like me logo Genes that share phenotypes with CXCL16: view

Animal Models for CXCL16 Gene

MGI Knock Outs for CXCL16:

Animal Model Products

  • Taconic Biosciences Mouse Models for CXCL16

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CXCL16 Gene

Localization for CXCL16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL16 Gene

Cell membrane; Single-pass type I membrane protein. Secreted. Note=Also exists as a soluble form.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXCL16 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CXCL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 18373975
GO:0005886 plasma membrane IEA --
GO:0016020 membrane TAS 11060282
GO:0016021 integral component of membrane NAS 11290797
genes like me logo Genes that share ontologies with CXCL16: view

Pathways & Interactions for CXCL16 Gene

genes like me logo Genes that share pathways with CXCL16: view

Interacting Proteins for CXCL16 Gene

Gene Ontology (GO) - Biological Process for CXCL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis NAS,IEA 11060282
GO:0006935 chemotaxis IEA,NAS 11290797
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0010469 regulation of signaling receptor activity IEA --
GO:0010818 T cell chemotaxis IBA --
genes like me logo Genes that share ontologies with CXCL16: view

No data available for SIGNOR curated interactions for CXCL16 Gene

Drugs & Compounds for CXCL16 Gene

(2) Drugs for CXCL16 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0

(125) Additional Compounds for CXCL16 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1-Myristoyl-2-myristoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:0)
  • Phosphatidylserine(28:0)
  • PS(28:0)
  • pSer(14:0/14:0)
  • 1-Myristoyl-2-myristoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:1)
  • Phosphatidylserine(14:0/14:1n5)
  • Phosphatidylserine(14:0/14:1W5)
  • Phosphatidylserine(28:1)
  • 1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:0)
  • Phosphatidylserine(30:0)
  • PS(30:0)
  • pSer(14:0/16:0)
  • 1-Myristoyl-2-palmitoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:1)
  • Phosphatidylserine(14:0/16:1n7)
  • Phosphatidylserine(14:0/16:1W7)
  • Phosphatidylserine(30:1)
  • 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/18:0)
  • Phosphatidylserine(32:0)
  • PS(32:0)
  • pSer(14:0/18:0)
genes like me logo Genes that share compounds with CXCL16: view

Transcripts for CXCL16 Gene

mRNA/cDNA for CXCL16 Gene

Unigene Clusters for CXCL16 Gene

Chemokine (C-X-C motif) ligand 16:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL16 Gene

No ASD Table

Relevant External Links for CXCL16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CXCL16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXCL16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXCL16 Gene

This gene is overexpressed in Whole Blood (x8.6) and Testis (x7.4).

Protein differential expression in normal tissues from HIPED for CXCL16 Gene

This gene is overexpressed in Bone (54.6) and Islet of Langerhans (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CXCL16 Gene

Protein tissue co-expression partners for CXCL16 Gene

NURSA nuclear receptor signaling pathways regulating expression of CXCL16 Gene:


SOURCE GeneReport for Unigene cluster for CXCL16 Gene:


mRNA Expression by UniProt/SwissProt for CXCL16 Gene:

Tissue specificity: Expressed in T-cell areas. Expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. Weak expression in heart and liver and no expression in brain and bone marrow.

Evidence on tissue expression from TISSUES for CXCL16 Gene

  • Lung(4.5)
  • Spleen(4.5)
  • Nervous system(3.7)
  • Lymph node(2.3)
  • Blood(2.2)
  • Intestine(2.1)
  • Heart(2)
  • Liver(2)
genes like me logo Genes that share expression patterns with CXCL16: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCL16 Gene

Orthologs for CXCL16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CXCL16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CXCL16 34 33
  • 98.78 (n)
(Canis familiaris)
Mammalia CXCL16 34 33
  • 73.65 (n)
(Mus musculus)
Mammalia Cxcl16 16 34 33
  • 68.33 (n)
(Rattus norvegicus)
Mammalia Cxcl16 33
  • 68.19 (n)
(Bos Taurus)
Mammalia CXCL16 34 33
  • 66.67 (n)
(Ornithorhynchus anatinus)
Mammalia CXCL16 34
  • 26 (a)
Species where no ortholog for CXCL16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL16 Gene

Gene Tree for CXCL16 (if available)
Gene Tree for CXCL16 (if available)
Evolutionary constrained regions (ECRs) for CXCL16: view image

Paralogs for CXCL16 Gene

No data available for Paralogs for CXCL16 Gene

Variants for CXCL16 Gene

Sequence variations from dbSNP and Humsavar for CXCL16 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000094385 -- 4,738,000(-) C/T intron_variant
rs1000529707 -- 4,737,224(-) T/G intron_variant
rs1000693154 -- 4,739,775(-) G/A/C 5_prime_UTR_variant
rs1001903939 -- 4,733,481(-) G/C downstream_transcript_variant
rs1002086062 -- 4,740,818(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CXCL16 Gene

Variant ID Type Subtype PubMed ID
dgv525e199 CNV deletion 23128226
esv3168235 CNV deletion 24192839
esv3554041 CNV deletion 23714750
nsv1952 CNV insertion 18451855
nsv574273 CNV gain 21841781
nsv833346 CNV loss 17160897

Variation tolerance for CXCL16 Gene

Residual Variation Intolerance Score: 80.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.64; 72.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXCL16 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL16 Gene

Disorders for CXCL16 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CXCL16 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
xanthogranulomatous cholecystitis
  • cx
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CXCL16

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CXCL16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL16 Gene

Publications for CXCL16 Gene

  1. A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. (PMID: 11017100) Matloubian M … Cyster JG (Nature immunology 2000) 2 3 4 22 58
  2. Molecular cloning of a novel scavenger receptor for oxidized low density lipoprotein, SR-PSOX, on macrophages. (PMID: 11060282) Shimaoka T … Yonehara S (The Journal of biological chemistry 2000) 2 3 4 58
  3. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 44 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. Chemokine CXC Ligand 16 serum concentration but not A181V genotype is associated with atherosclerotic stroke. (PMID: 20621591) Wang KD … Kang XX (Clinica chimica acta; international journal of clinical chemistry 2010) 3 44 58

Products for CXCL16 Gene

Sources for CXCL16 Gene

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