This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotacti... See more...

Aliases for CXCL14 Gene

Aliases for CXCL14 Gene

  • C-X-C Motif Chemokine Ligand 14 2 3 5
  • Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 14 (BRAK) 2 3
  • Chemokine (C-X-C Motif) Ligand 14 2 3
  • Small-Inducible Cytokine B14 3 4
  • C-X-C Motif Chemokine 14 3 4
  • Breast And Kidney 2 3
  • Chemokine BRAK 3 4
  • SCYB14 3 4
  • MIP2G 3 4
  • NJAC 3 4
  • CXC Chemokine In Breast And Kidney 3
  • Tumor-Suppressing Chemokine 3
  • MIP-2 Gamma 3
  • Bolekine 3
  • MIP-2g 3
  • MIP-2G 4
  • BMAC 3
  • BRAK 3
  • KEC 3
  • KS1 3

External Ids for CXCL14 Gene

Previous HGNC Symbols for CXCL14 Gene

  • SCYB14

Previous GeneCards Identifiers for CXCL14 Gene

  • GC05M134742
  • GC05M134937
  • GC05M134982
  • GC05M134934
  • GC05M130094

Summaries for CXCL14 Gene

Entrez Gene Summary for CXCL14 Gene

  • This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. [provided by RefSeq, Sep 2014]

GeneCards Summary for CXCL14 Gene

CXCL14 (C-X-C Motif Chemokine Ligand 14) is a Protein Coding gene. Diseases associated with CXCL14 include Cervical Squamous Cell Carcinoma and Squamous Cell Carcinoma, Head And Neck. Among its related pathways are CCR5 Pathway in Macrophages and ERK Signaling. Gene Ontology (GO) annotations related to this gene include chemokine activity.

UniProtKB/Swiss-Prot Summary for CXCL14 Gene

  • Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays.

Additional gene information for CXCL14 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CXCL14 Gene

Genomics for CXCL14 Gene

GeneHancer (GH) Regulatory Elements for CXCL14 Gene

Promoters and enhancers for CXCL14 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CXCL14 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CXCL14

Top Transcription factor binding sites by QIAGEN in the CXCL14 gene promoter:
  • AML1a
  • CP2
  • FOXL1
  • HNF-4alpha1
  • HNF-4alpha2
  • NF-kappaB
  • NF-kappaB1
  • POU2F1
  • POU2F1a
  • RP58

Genomic Locations for CXCL14 Gene

Genomic Locations for CXCL14 Gene
chr5:135,570,679-135,579,279
(GRCh38/hg38)
Size:
8,601 bases
Orientation:
Minus strand
chr5:134,906,369-134,914,969
(GRCh37/hg19)
Size:
8,601 bases
Orientation:
Minus strand

Genomic View for CXCL14 Gene

Genes around CXCL14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCL14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCL14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL14 Gene

Proteins for CXCL14 Gene

  • Protein details for CXCL14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95715-CXL14_HUMAN
    Recommended name:
    C-X-C motif chemokine 14
    Protein Accession:
    O95715
    Secondary Accessions:
    • B3KQU8
    • Q6UW97
    • Q86U69
    • Q9BTR1
    • Q9NS21

    Protein attributes for CXCL14 Gene

    Size:
    111 amino acids
    Molecular mass:
    13078 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD38944.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CXCL14 Gene

neXtProt entry for CXCL14 Gene

Post-translational modifications for CXCL14 Gene

Other Protein References for CXCL14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CXCL14 Gene

Domains & Families for CXCL14 Gene

Gene Families for CXCL14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for CXCL14 Gene

Suggested Antigen Peptide Sequences for CXCL14 Gene

GenScript: Design optimal peptide antigens:
  • Small-inducible cytokine B14 (CXL14_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95715

UniProtKB/Swiss-Prot:

CXL14_HUMAN :
  • The destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
  • Belongs to the intercrine alpha (chemokine CxC) family.
Domain:
  • The destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL14: view

Function for CXCL14 Gene

Molecular function for CXCL14 Gene

UniProtKB/Swiss-Prot Function:
Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays.
UniProtKB/Swiss-Prot Induction:
Up-regulated in peripheral blood lymphocytes in response to bacterial lipopolysaccharides (LPS).

Phenotypes From GWAS Catalog for CXCL14 Gene

Gene Ontology (GO) - Molecular Function for CXCL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008009 chemokine activity IEA,TAS --
genes like me logo Genes that share ontologies with CXCL14: view
genes like me logo Genes that share phenotypes with CXCL14: view

Animal Models for CXCL14 Gene

MGI Knock Outs for CXCL14:

Animal Model Products

  • Taconic Biosciences Mouse Models for CXCL14

CRISPR Products

miRNA for CXCL14 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CXCL14 Gene

Localization for CXCL14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL14 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXCL14 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
plasma membrane 3
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CXCL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with CXCL14: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CXCL14 Gene

Pathways & Interactions for CXCL14 Gene

PathCards logo

SuperPathways for CXCL14 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.47
.46
2 ERK Signaling
.61
.61
.51
3 CCR5 Pathway in Macrophages
.33
4 Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions
5 Akt Signaling
.60
.60
genes like me logo Genes that share pathways with CXCL14: view

Pathways by source for CXCL14 Gene

17 Qiagen pathways for CXCL14 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Chemokine Signaling
  • Endothelin-1 Signaling Pathway

Gene Ontology (GO) - Biological Process for CXCL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis TAS 10049774
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 10049774
GO:0007267 cell-cell signaling TAS 10049774
GO:0045662 negative regulation of myoblast differentiation IEA --
genes like me logo Genes that share ontologies with CXCL14: view

No data available for SIGNOR curated interactions for CXCL14 Gene

Drugs & Compounds for CXCL14 Gene

No Compound Related Data Available

Transcripts for CXCL14 Gene

mRNA/cDNA for CXCL14 Gene

1 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL14 Gene

No ASD Table

Relevant External Links for CXCL14 Gene

GeneLoc Exon Structure for
CXCL14

Expression for CXCL14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CXCL14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXCL14 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x8.9) and Skin - Not Sun Exposed (Suprapubic) (x7.8).

Protein differential expression in normal tissues from HIPED for CXCL14 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CXCL14 Gene



Protein tissue co-expression partners for CXCL14 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CXCL14

SOURCE GeneReport for Unigene cluster for CXCL14 Gene:

Hs.483444

mRNA Expression by UniProt/SwissProt for CXCL14 Gene:

O95715-CXL14_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highly expressed in normal tissue without inflammatory stimuli and infrequently expressed in cancer cell lines. Weakly expressed in monocyte-derived dendritic cells. Not detected in lung or unstimulated peripheral blood lymphocytes.

Evidence on tissue expression from TISSUES for CXCL14 Gene

  • Pancreas(4.1)
  • Nervous system(4)
  • Kidney(3.8)
  • Eye(3.7)
  • Skin(3)
  • Intestine(2.6)
  • Lung(2.6)
  • Lymph node(2.6)
  • Spleen(2.5)
  • Stomach(2.3)
  • Heart(2.1)
  • Liver(2.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with CXCL14: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCL14 Gene

Orthologs for CXCL14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCL14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXCL14 31 30
  • 100 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CXCL14 31 30
  • 97.53 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CXCL14 31 30
  • 94.28 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cxcl14 17 31 30
  • 93.98 (n)
rat
(Rattus norvegicus)
Mammalia Cxcl14 30
  • 92.37 (n)
oppossum
(Monodelphis domestica)
Mammalia CXCL14 31
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CXCL14 31
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves CXCL14 30
  • 67.5 (n)
JSC 31
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CXCL14 31
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cxcl14 30
  • 67.47 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24598 30
zebrafish
(Danio rerio)
Actinopterygii cxcl14 31 30
  • 65.06 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2735 30
Species where no ortholog for CXCL14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXCL14 Gene

ENSEMBL:
Gene Tree for CXCL14 (if available)
TreeFam:
Gene Tree for CXCL14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CXCL14: view image

Paralogs for CXCL14 Gene

(2) SIMAP similar genes for CXCL14 Gene using alignment to 1 proteins:

  • CXL14_HUMAN
genes like me logo Genes that share paralogs with CXCL14: view

No data available for Paralogs for CXCL14 Gene

Variants for CXCL14 Gene

Additional dbSNP identifiers (rs#s) for CXCL14 Gene

Variation tolerance for CXCL14 Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXCL14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXCL14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for CXCL14 Gene

Disorders for CXCL14 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CXCL14 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
cervical squamous cell carcinoma
  • squamous cell carcinoma of cervix
squamous cell carcinoma, head and neck
  • hnscc
adult malignant schwannoma
  • adult mpnst
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CXCL14

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CXCL14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL14 Gene

Publications for CXCL14 Gene

  1. Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cells. (PMID: 10049774) Hromas R … Hou YH (Biochemical and biophysical research communications 1999) 2 3 4 23 54
  2. Structural determinants involved in the regulation of CXCL14/BRAK expression by the 26 S proteasome. (PMID: 16987528) Peterson FC … Schwarze SR (Journal of molecular biology 2006) 3 4 23 54
  3. In vivo expression of the novel CXC chemokine BRAK in normal and cancerous human tissue. (PMID: 10854217) Frederick MJ … Clayman GL (The American journal of pathology 2000) 3 4 23 54
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  5. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L … Crovella S (Vaccine 2010) 3 41 54

Products for CXCL14 Gene

Sources for CXCL14 Gene