Aliases for CXCL14 Gene
External Ids for CXCL14 Gene
Previous HGNC Symbols for CXCL14 Gene
Previous GeneCards Identifiers for CXCL14 Gene
This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. [provided by RefSeq, Sep 2014]
GeneCards Summary for CXCL14 Gene
CXCL14 (C-X-C Motif Chemokine Ligand 14) is a Protein Coding gene. Diseases associated with CXCL14 include Cervical Squamous Cell Carcinoma and Squamous Cell Carcinoma, Head And Neck. Among its related pathways are CCR5 Pathway in Macrophages and ERK Signaling. Gene Ontology (GO) annotations related to this gene include chemokine activity.
UniProtKB/Swiss-Prot Summary for CXCL14 Gene
Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays.