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Aliases for CXCL14 Gene

Aliases for CXCL14 Gene

  • C-X-C Motif Chemokine Ligand 14 2 3 5
  • Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 14 (BRAK) 2 3
  • Chemokine (C-X-C Motif) Ligand 14 2 3
  • Small-Inducible Cytokine B14 3 4
  • Breast And Kidney 2 3
  • Chemokine BRAK 3 4
  • SCYB14 3 4
  • MIP2G 3 4
  • NJAC 3 4
  • CXC Chemokine In Breast And Kidney 3
  • Tumor-Suppressing Chemokine 3
  • C-X-C Motif Chemokine 14 3
  • MIP-2 Gamma 3
  • Bolekine 3
  • MIP-2g 3
  • MIP-2G 4
  • BMAC 3
  • BRAK 3
  • KEC 3
  • KS1 3

External Ids for CXCL14 Gene

Previous HGNC Symbols for CXCL14 Gene

  • SCYB14

Previous GeneCards Identifiers for CXCL14 Gene

  • GC05M134742
  • GC05M134937
  • GC05M134982
  • GC05M134934
  • GC05M130094

Summaries for CXCL14 Gene

Entrez Gene Summary for CXCL14 Gene

  • This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. [provided by RefSeq, Sep 2014]

GeneCards Summary for CXCL14 Gene

CXCL14 (C-X-C Motif Chemokine Ligand 14) is a Protein Coding gene. Diseases associated with CXCL14 include Pelvic Lipomatosis and Otomycosis. Among its related pathways are Akt Signaling and ERK Signaling. Gene Ontology (GO) annotations related to this gene include chemokine activity.

UniProtKB/Swiss-Prot for CXCL14 Gene

  • Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays.

Additional gene information for CXCL14 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL14 Gene

Genomics for CXCL14 Gene

GeneHancer (GH) Regulatory Elements for CXCL14 Gene

Promoters and enhancers for CXCL14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J135578 Promoter/Enhancer 0.9 EPDnew Ensembl 655.5 +0.4 354 1.6 HDAC2 EZH2 CXCL14 SLC25A48 PIR44584 ENSG00000250167
GH05J135455 Enhancer 1.5 FANTOM5 Ensembl ENCODE 10.3 +122.6 122632 2.1 PKNOX1 ATF1 ZNF2 IRF4 ZNF48 YY1 TCF12 ZNF766 CBX5 ZNF143 TIFAB DDX46 ENSG00000250167 CXCL14 JADE2 H2AFY ENSG00000249639 NEUROG1
GH05J135488 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.1 +89.4 89434 2.2 FOXA2 SIN3A ZNF48 GLIS2 ZNF213 KLF7 SP3 SP5 NFYC NFIL3 NEUROG1 ENSG00000250167 CXCL14 TIFAB ENSG00000249639 JADE2 ENSG00000270021
GH05J135482 Enhancer 1.2 ENCODE dbSUPER 11 +96.9 96910 0.6 HDGF FOXA2 MLX ARID4B DMAP1 GLI4 ZNF48 ETS1 GATA2 ZNF416 SMAD5 DDX46 ENSG00000250167 NEUROG1 CXCL14 TGFBI C5orf66 ENSG00000254239 TIFAB
GH05J135481 Enhancer 0.8 ENCODE 11 +97.8 97771 0.1 HDAC1 ARNT TCF12 GATA2 ETV6 CREM ZBTB11 NCOA1 ZEB2 MEF2D ENSG00000250167 CXCL14 TIFAB NEUROG1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CXCL14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CXCL14 gene promoter:
  • NF-kappaB
  • NF-kappaB1
  • POU2F1a
  • POU2F1
  • CP2
  • FOXL1
  • HNF-4alpha2
  • HNF-4alpha1
  • AML1a
  • RP58

Genomic Locations for CXCL14 Gene

Genomic Locations for CXCL14 Gene
chr5:135,570,679-135,579,279
(GRCh38/hg38)
Size:
8,601 bases
Orientation:
Minus strand
chr5:134,906,369-134,914,969
(GRCh37/hg19)
Size:
8,601 bases
Orientation:
Minus strand

Genomic View for CXCL14 Gene

Genes around CXCL14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCL14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCL14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL14 Gene

Proteins for CXCL14 Gene

  • Protein details for CXCL14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95715-CXL14_HUMAN
    Recommended name:
    C-X-C motif chemokine 14
    Protein Accession:
    O95715
    Secondary Accessions:
    • B3KQU8
    • Q6UW97
    • Q86U69
    • Q9BTR1
    • Q9NS21

    Protein attributes for CXCL14 Gene

    Size:
    111 amino acids
    Molecular mass:
    13078 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD38944.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CXCL14 Gene

neXtProt entry for CXCL14 Gene

Post-translational modifications for CXCL14 Gene

Other Protein References for CXCL14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CXCL14 Gene

Domains & Families for CXCL14 Gene

Gene Families for CXCL14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for CXCL14 Gene

Suggested Antigen Peptide Sequences for CXCL14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95715

UniProtKB/Swiss-Prot:

CXL14_HUMAN :
  • The destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
  • Belongs to the intercrine alpha (chemokine CxC) family.
Domain:
  • The destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL14: view

Function for CXCL14 Gene

Molecular function for CXCL14 Gene

UniProtKB/Swiss-Prot Function:
Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays.
UniProtKB/Swiss-Prot Induction:
Up-regulated in peripheral blood lymphocytes in response to bacterial lipopolysaccharides (LPS).

Phenotypes From GWAS Catalog for CXCL14 Gene

Gene Ontology (GO) - Molecular Function for CXCL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008009 chemokine activity IEA,TAS --
genes like me logo Genes that share ontologies with CXCL14: view
genes like me logo Genes that share phenotypes with CXCL14: view

Animal Models for CXCL14 Gene

MGI Knock Outs for CXCL14:

Animal Model Products

  • Taconic Biosciences Mouse Models for CXCL14

miRNA for CXCL14 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CXCL14 Gene

Localization for CXCL14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL14 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXCL14 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
plasma membrane 2
nucleus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CXCL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with CXCL14: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CXCL14 Gene

Pathways & Interactions for CXCL14 Gene

genes like me logo Genes that share pathways with CXCL14: view

Gene Ontology (GO) - Biological Process for CXCL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis TAS 10049774
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 10049774
GO:0007267 cell-cell signaling TAS 10049774
GO:0010469 regulation of signaling receptor activity IEA --
genes like me logo Genes that share ontologies with CXCL14: view

No data available for SIGNOR curated interactions for CXCL14 Gene

Drugs & Compounds for CXCL14 Gene

No Compound Related Data Available

Transcripts for CXCL14 Gene

mRNA/cDNA for CXCL14 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(300) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CXCL14 Gene

Chemokine (C-X-C motif) ligand 14:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL14 Gene

No ASD Table

Relevant External Links for CXCL14 Gene

GeneLoc Exon Structure for
CXCL14
ECgene alternative splicing isoforms for
CXCL14

Expression for CXCL14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXCL14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXCL14 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x8.9) and Skin - Not Sun Exposed (Suprapubic) (x7.8).

Protein differential expression in normal tissues from HIPED for CXCL14 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CXCL14 Gene



Protein tissue co-expression partners for CXCL14 Gene

NURSA nuclear receptor signaling pathways regulating expression of CXCL14 Gene:

CXCL14

SOURCE GeneReport for Unigene cluster for CXCL14 Gene:

Hs.483444

mRNA Expression by UniProt/SwissProt for CXCL14 Gene:

O95715-CXL14_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highly expressed in normal tissue without inflammatory stimuli and infrequently expressed in cancer cell lines. Weakly expressed in monocyte-derived dendritic cells. Not detected in lung or unstimulated peripheral blood lymphocytes.

Evidence on tissue expression from TISSUES for CXCL14 Gene

  • Pancreas(4.1)
  • Nervous system(4)
  • Kidney(3.8)
  • Eye(3.7)
  • Skin(3)
  • Intestine(2.6)
  • Lung(2.6)
  • Lymph node(2.6)
  • Spleen(2.5)
  • Stomach(2.3)
  • Heart(2.1)
  • Liver(2.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with CXCL14: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCL14 Gene

Orthologs for CXCL14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCL14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXCL14 34 33
  • 100 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CXCL14 34 33
  • 97.53 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CXCL14 34 33
  • 94.28 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cxcl14 16 34 33
  • 93.98 (n)
rat
(Rattus norvegicus)
Mammalia Cxcl14 33
  • 92.37 (n)
oppossum
(Monodelphis domestica)
Mammalia CXCL14 34
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CXCL14 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves CXCL14 33
  • 67.5 (n)
JSC 34
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CXCL14 34
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cxcl14 33
  • 67.47 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24598 33
zebrafish
(Danio rerio)
Actinopterygii cxcl14 34 33
  • 65.06 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2735 33
Species where no ortholog for CXCL14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXCL14 Gene

ENSEMBL:
Gene Tree for CXCL14 (if available)
TreeFam:
Gene Tree for CXCL14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CXCL14: view image

Paralogs for CXCL14 Gene

(2) SIMAP similar genes for CXCL14 Gene using alignment to 1 proteins:

  • CXL14_HUMAN
genes like me logo Genes that share paralogs with CXCL14: view

No data available for Paralogs for CXCL14 Gene

Variants for CXCL14 Gene

Sequence variations from dbSNP and Humsavar for CXCL14 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000341601 -- 135,579,223(-) T/G 5_prime_UTR_variant
rs1000883172 -- 135,572,860(-) A/C intron_variant
rs1001006665 -- 135,579,128(-) G/T 5_prime_UTR_variant
rs1001383465 -- 135,572,465(-) G/A intron_variant
rs1001770811 -- 135,572,141(-) G/A intron_variant

Variation tolerance for CXCL14 Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXCL14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXCL14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CXCL14 Gene

Disorders for CXCL14 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CXCL14 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
pelvic lipomatosis
  • excess of mature unencapsulated fatty tissue in the pelvis
otomycosis
  • singapore ear
squamous cell carcinoma, head and neck
  • hnscc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CXCL14

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CXCL14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL14 Gene

Publications for CXCL14 Gene

  1. Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cells. (PMID: 10049774) Hromas R … Hou YH (Biochemical and biophysical research communications 1999) 2 3 4 22 58
  2. Structural determinants involved in the regulation of CXCL14/BRAK expression by the 26 S proteasome. (PMID: 16987528) Peterson FC … Schwarze SR (Journal of molecular biology 2006) 3 4 22 58
  3. In vivo expression of the novel CXC chemokine BRAK in normal and cancerous human tissue. (PMID: 10854217) Frederick MJ … Clayman GL (The American journal of pathology 2000) 3 4 22 58
  4. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L … Crovella S (Vaccine 2010) 3 44 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for CXCL14 Gene

Sources for CXCL14 Gene

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