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Aliases for CXCL13 Gene

Aliases for CXCL13 Gene

  • C-X-C Motif Chemokine Ligand 13 2 3 5
  • Small Inducible Cytokine B Subfamily (Cys-X-Cys Motif), Member 13 (B-Cell Chemoattractant) 2 3
  • B Cell-Attracting Chemokine 1 3 4
  • B Lymphocyte Chemoattractant 3 4
  • Small-Inducible Cytokine B13 3 4
  • B-Cell Chemoattractant 2 3
  • CXC Chemokine BLC 3 4
  • SCYB13 3 4
  • BCA-1 3 4
  • BCA1 3 4
  • BLC 3 4
  • B-Cell-Homing Chemokine (Ligand For Burkitts Lymphoma Receptor-1) 3
  • Chemokine (C-X-C Motif) Ligand 13 (B-Cell Chemoattractant) 3
  • Chemokine (C-X-C Motif) Ligand 13 2
  • B-Cell-Attracting Chemokine 1 3
  • B-Lymphocyte Chemoattractant 3
  • C-X-C Motif Chemokine 13 3
  • ANGIE2 3
  • ANGIE 3
  • BLR1L 3
  • Angie 4

External Ids for CXCL13 Gene

Previous HGNC Symbols for CXCL13 Gene

  • SCYB13

Previous GeneCards Identifiers for CXCL13 Gene

  • GC04P078343
  • GC04P078623
  • GC04P078825
  • GC04P078891
  • GC04P078866
  • GC04P078790
  • GC04P074184

Summaries for CXCL13 Gene

Entrez Gene Summary for CXCL13 Gene

  • B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. [provided by RefSeq, Oct 2014]

GeneCards Summary for CXCL13 Gene

CXCL13 (C-X-C Motif Chemokine Ligand 13) is a Protein Coding gene. Diseases associated with CXCL13 include Angioimmunoblastic T-Cell Lymphoma and Burkitt Lymphoma. Among its related pathways are Akt Signaling and CXCR3-mediated signaling events. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and chemokine activity.

UniProtKB/Swiss-Prot for CXCL13 Gene

  • Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5.

Gene Wiki entry for CXCL13 Gene

Additional gene information for CXCL13 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL13 Gene

Genomics for CXCL13 Gene

GeneHancer (GH) Regulatory Elements for CXCL13 Gene

Promoters and enhancers for CXCL13 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J077605 Promoter 0.8 EPDnew 650.2 +94.0 94048 0.1 ZNF316 MAFF MAFG EMSY MAFK CXCL13 GC04P077623 LOC105377296
GH04J077539 Enhancer 0.8 ENCODE 12.1 +27.1 27147 0.9 FOXA2 NFIB KLF17 FEZF1 RAD21 RFX5 ZEB1 FOS RXRA USF2 CXCL13 CNOT6L GC04P077551
GH04J077538 Enhancer 0.7 ENCODE 12.2 +26.6 26579 0.2 KLF1 FOXA2 JUN KLF17 FEZF1 ZEB1 CTBP1 ZNF26 PRDM10 FOSL2 CXCL13 GC04P077551
GH04J078244 Enhancer 0.3 ENCODE 4.4 +733.2 733173 1.3 PRDM6 CXCL13 GC04M078185 SERBP1P5 FRAS1
GH04J077369 Enhancer 0.2 FANTOM5 2.3 -142.0 -142028 0 CXCL13 LOC100421142 GC04M077367 CCNG2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CXCL13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CXCL13 gene promoter:
  • Evi-1
  • Nkx2-2
  • Pax-4a
  • POU2F1
  • POU2F1a
  • PPAR-gamma1
  • PPAR-gamma2
  • IRF-7A
  • ISGF-3
  • RORalpha1

Genomic Locations for CXCL13 Gene

Genomic Locations for CXCL13 Gene
100,082 bases
Plus strand
100,082 bases
Plus strand

Genomic View for CXCL13 Gene

Genes around CXCL13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCL13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCL13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL13 Gene

Proteins for CXCL13 Gene

  • Protein details for CXCL13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-X-C motif chemokine 13
    Protein Accession:

    Protein attributes for CXCL13 Gene

    109 amino acids
    Molecular mass:
    12664 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CXCL13 Gene

neXtProt entry for CXCL13 Gene

Post-translational modifications for CXCL13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CXCL13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CXCL13 Gene

Domains & Families for CXCL13 Gene

Gene Families for CXCL13 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CXCL13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intercrine alpha (chemokine CxC) family.
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL13: view

Function for CXCL13 Gene

Molecular function for CXCL13 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5.

Phenotypes From GWAS Catalog for CXCL13 Gene

Gene Ontology (GO) - Molecular Function for CXCL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0008009 chemokine activity IDA 11554781
GO:0008201 heparin binding IDA 11708770
GO:0017134 fibroblast growth factor binding IDA 11708770
GO:0031724 CXCR5 chemokine receptor binding IDA 9463416
genes like me logo Genes that share ontologies with CXCL13: view
genes like me logo Genes that share phenotypes with CXCL13: view

Animal Models for CXCL13 Gene

MGI Knock Outs for CXCL13:

Animal Model Products

miRNA for CXCL13 Gene

miRTarBase miRNAs that target CXCL13

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CXCL13 Gene

Localization for CXCL13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL13 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXCL13 gene
Compartment Confidence
extracellular 5
cytoskeleton 2
plasma membrane 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CXCL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IDA --
GO:0005615 extracellular space IBA --
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with CXCL13: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CXCL13 Gene

Pathways & Interactions for CXCL13 Gene

genes like me logo Genes that share pathways with CXCL13: view

Gene Ontology (GO) - Biological Process for CXCL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002467 germinal center formation NAS 16543475
GO:0002518 lymphocyte chemotaxis across high endothelial venule ISS --
GO:0002544 chronic inflammatory response NAS 15284119
GO:0002690 positive regulation of leukocyte chemotaxis IBA --
GO:0002920 regulation of humoral immune response NAS 16531331
genes like me logo Genes that share ontologies with CXCL13: view

No data available for SIGNOR curated interactions for CXCL13 Gene

Drugs & Compounds for CXCL13 Gene

(1) Drugs for CXCL13 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0

(2) Additional Compounds for CXCL13 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CXCL13: view

Transcripts for CXCL13 Gene

mRNA/cDNA for CXCL13 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(99) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CXCL13 Gene

Chemokine (C-X-C motif) ligand 13:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL13 Gene

No ASD Table

Relevant External Links for CXCL13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CXCL13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXCL13 Gene

mRNA differential expression in normal tissues according to GTEx for CXCL13 Gene

This gene is overexpressed in Spleen (x38.1) and Small Intestine - Terminal Ileum (x6.1).

Protein differential expression in normal tissues from HIPED for CXCL13 Gene

This gene is overexpressed in Stomach (29.4), Lung (13.9), Testis (10.9), and Esophagus (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CXCL13 Gene

Protein tissue co-expression partners for CXCL13 Gene

NURSA nuclear receptor signaling pathways regulating expression of CXCL13 Gene:


SOURCE GeneReport for Unigene cluster for CXCL13 Gene:


mRNA Expression by UniProt/SwissProt for CXCL13 Gene:

Tissue specificity: Highest levels in liver, followed by spleen, lymph node, appendix and stomach. Low levels in salivary gland, mammary gland and fetal spleen.

Evidence on tissue expression from TISSUES for CXCL13 Gene

  • Blood(4.5)
  • Muscle(4.2)
  • Lymph node(3.7)
  • Spleen(3.5)
  • Intestine(2.6)
  • Bone marrow(2.3)
  • Stomach(2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with CXCL13: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCL13 Gene

Orthologs for CXCL13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CXCL13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CXCL13 34 33
  • 99.69 (n)
(Canis familiaris)
Mammalia CXCL13 34 33
  • 75.62 (n)
(Bos Taurus)
Mammalia CXCL13 34 33
  • 72.59 (n)
(Rattus norvegicus)
Mammalia Cxcl13 33
  • 67.04 (n)
(Mus musculus)
Mammalia Cxcl13 16 34 33
  • 64.04 (n)
Species where no ortholog for CXCL13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL13 Gene

Gene Tree for CXCL13 (if available)
Gene Tree for CXCL13 (if available)
Evolutionary constrained regions (ECRs) for CXCL13: view image

Paralogs for CXCL13 Gene

(5) SIMAP similar genes for CXCL13 Gene using alignment to 3 proteins:

  • L8E878_HUMAN
  • Q53X90_HUMAN
genes like me logo Genes that share paralogs with CXCL13: view

No data available for Paralogs for CXCL13 Gene

Variants for CXCL13 Gene

Sequence variations from dbSNP and Humsavar for CXCL13 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000016046 -- 77,553,975(+) A/C genic_upstream_transcript_variant, intron_variant
rs1000056936 -- 77,563,367(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000065124 -- 77,521,235(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000066223 -- 77,518,261(+) C/G/T genic_upstream_transcript_variant, intron_variant
rs1000115685 -- 77,607,250(+) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CXCL13 Gene

Variant ID Type Subtype PubMed ID
esv2669104 CNV deletion 23128226
esv29506 CNV loss 19812545
esv3601076 CNV loss 21293372
esv3601077 CNV loss 21293372
nsv1010104 CNV loss 25217958
nsv1119999 CNV deletion 24896259
nsv1134095 CNV deletion 24896259
nsv4395 CNV insertion 18451855
nsv7363 OTHER inversion 18451855
nsv829975 CNV gain 17160897

Variation tolerance for CXCL13 Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXCL13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL13 Gene

Disorders for CXCL13 Gene

MalaCards: The human disease database

(10) MalaCards diseases for CXCL13 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CXCL13

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CXCL13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL13 Gene

Publications for CXCL13 Gene

  1. A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. (PMID: 9486651) Gunn MD … Williams LT (Nature 1998) 2 3 4 22 58
  2. B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. (PMID: 9463416) Legler DF … Moser B (The Journal of experimental medicine 1998) 2 3 4 22 58
  3. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L … Crovella S (Vaccine 2010) 3 44 58
  4. Evaluation of the presence of B-cell attractant chemokines in chronic rhinosinusitis. (PMID: 20109310) Patadia M … Schleimer R (American journal of rhinology & allergy 2010) 3 22 58
  5. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 44 58

Products for CXCL13 Gene

Sources for CXCL13 Gene

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