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This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth a... See more...
Aliases for CXCL12 Gene
Aliases for CXCL12 Gene
External Ids for CXCL12 Gene
- HGNC: 10672
- NCBI Entrez Gene: 6387
- Ensembl: ENSG00000107562
- OMIM®: 600835
- UniProtKB/Swiss-Prot: P48061
Previous HGNC Symbols for CXCL12 Gene
- SDF1A
- SDF1B
- SDF1
Previous GeneCards Identifiers for CXCL12 Gene
- GC10M044154
- GC10M044334
- GC10M044640
- GC10M044149
- GC10M044185
- GC10M044865
- GC10M041391
- GC10M044370
Summaries for CXCL12 Gene
-
This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
GeneCards Summary for CXCL12 Gene
CXCL12 (C-X-C Motif Chemokine Ligand 12) is a Protein Coding gene. Diseases associated with CXCL12 include Human Immunodeficiency Virus Type 1 and Whim Syndrome. Among its related pathways are ERK Signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and chemokine activity.
UniProtKB/Swiss-Prot Summary for CXCL12 Gene
-
Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (PubMed:29301984). Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells (By similarity).
Additional gene information for CXCL12 Gene
- HGNC (10672)
- NCBI Entrez Gene (6387)
- Ensembl (ENSG00000107562)
- OMIM® (600835)
- UniProtKB/Swiss-Prot (P48061)
- Open Targets Platform(ENSG00000107562)
- Monarch Initiative
- Search for CXCL12 at DataMed
- Search for CXCL12 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CXCL12 Gene
Genomics for CXCL12 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CXCL12 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CXCL12 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CXCL12
- Top Transcription factor binding sites by QIAGEN in the CXCL12 gene promoter:
-
- CREB
- deltaCREB
- STAT1
- STAT5A
Genomic Locations for CXCL12 Gene
Latest Assembly
- chr10:44,292,088-44,386,493
- (GRCh38/hg38)
- Size:
- 94,406 bases
- Orientation:
- Minus strand
Previous Assembly
- chr10:44,865,613-44,880,545
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 14,933 bases
- Orientation:
- Minus strand
- chr10:44,793,038-44,881,941
- (GRCh37/hg19 by Ensembl)
- Size:
- 88,904 bases
- Orientation:
- Minus strand
Genomic View for CXCL12 Gene
Genes around CXCL12 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q11.21 by HGNC
- 10q11.21 by Entrez Gene
- 10q11.21 by Ensembl
CXCL12 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CXCL12 Gene
Proteins for CXCL12 Gene
-
Protein details for CXCL12 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P48061-SDF1_HUMAN
- Recommended name:
- Stromal cell-derived factor 1
- Protein Accession:
- P48061
- B2R4G0
- E7EVL0
- H7BYN8
- Q2L985
- Q2L986
- Q2L988
- Q5IT36
- Q6ICW0
- Q9H554
Protein attributes for CXCL12 Gene
- Size:
- 93 amino acids
- Molecular mass:
- 10666 Da
- Quaternary structure:
-
- Monomer or homodimer; in equilibrium. Dimer formation is induced by non acidic pH and the presence of multivalent anions, and by binding to CXCR4 or heparin. Monomeric form is required for full chemotactic activity and resistance to ischemia/reperfusion injury, whereas the dimeric form acts as a partial agonist of CXCR4, stimulating Ca2+ mobilization but with no chemotactic activity and instead acts as a selective antagonist that blocks chemotaxis induced by the monomeric form. Interacts with the N-terminus of ACKR3. Interacts with integrin subunit ITGB3 (via the allosteric site (site 2)) (PubMed:29301984).
- (Microbial infection) Interacts with molluscum contagiosum virus protein MC148.
Three dimensional structures from OCA and Proteopedia for CXCL12 Gene
Protein Expression for CXCL12 Gene
Post-translational modifications for CXCL12 Gene
- Processed forms SDF-1-beta(3-72) and SDF-1-alpha(3-67) are produced after secretion by proteolytic cleavage of isoforms Beta and Alpha, respectively. The N-terminal processing is probably achieved by DPP4. Isoform Alpha is first cleaved at the C-terminus to yield a SDF-1-alpha(1-67) intermediate before being processed at the N-terminus. The C-terminal processing of isoform Alpha is reduced by binding to heparin and, probably, cell surface proteoglycans.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CXCL12 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences SDF1 / CXCL12 Antibody (LS-B943) and SDF1 / CXCL12 Antibody (LS-B2437)
- G Biosciences Immunotag™ SDF 1 Antibody
- NSJ Bioreagents CXCL12 Antibody
- BioLegend CXCL12 (SDF-1beta) Antibody
- GeneTex Anti-SDF1 alpha antibody and Anti-SDF1 antibody [N1C3]
- Novus Biologicals Antibodies for CXCL12
-
Abcam antibodies for CXCL12
- Invitrogen Antibodies for CXCL12 (AFLGC-CXCL12)
- antibodies-online: Show 67 available CXCL12 Antibodies ranked by validation data
- Compare Top CXCL12 Antibodies
-
Recommended
- 111 WB Antibodies (anti-human)
- 24 IHC (p) Antibodies (anti-human)
- 14 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 8 IHC Antibodies (anti-human)
- 55 WB Antibodies (anti-mouse)
- 12 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 7 IHC Antibodies (anti-mouse)
- 5 IHC (p) Antibodies (anti-mouse)
- 23 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 5 IHC (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
-
Custom Antibody ServicesProSci Antibodies for CXCL12
- chemokine (C-X-C motif) ligand 12 [7591]
- chemokine (C-X-C motif) ligand 12 [31-056]
- chemokine (C-X-C motif) ligand 12 [XP-5269]
- chemokine (C-X-C motif) ligand 12 [XP-5269Bt]
- chemokine (C-X-C motif) ligand 12 [XP-5270]
- chemokine (C-X-C motif) ligand 12 [XP-5270Bt]
- chemokine (C-X-C motif) ligand 12 [XP-5271]
- chemokine (C-X-C motif) ligand 12 [XP-5271Bt]
-
Santa Cruz Biotechnology (SCBT) Antibodies for CXCL12
- Sino Biological Antibodies for CXCL12
Protein products for research
-
Chemotactics
- CXCL12 (SDF-1a) (CXCL12-100ug)
- CXCL12 (SDF-1a) (CXCL12-50ug)
- CXCL12 (SDF-1a) (CXCL12-20ug)
- Biotininylated CXCL12 (SDF-1a) (B-CXCL12-100ug)
- CXCL12 (SDF-1a) (CXCL12-5ug)
- Biotininylated CXCL12 (SDF-1a) (B-CXCL12-50ug)
- CXCL12 (SDF-1a) (CXCL12-1mg)
- Biotininylated CXCL12 (SDF-1a) (B-CXCL12-2ug)
- Biotininylated CXCL12 (SDF-1a) (B-CXCL12-10ug)
-
BioLegend
- Recombinant Human CXCL12 (SDF-1alpha) (carrier-free) (581202)
- Recombinant Human CXCL12 (SDF-1alpha) (carrier-free) (581208)
- Recombinant Human CXCL12 (SDF-1alpha) (carrier-free) (581204)
- Recombinant Human CXCL12 (SDF-1alpha) (carrier-free) (581206)
- Recombinant Human CXCL12 (SDF-1beta) (carrier-free) (587708)
- Recombinant Human CXCL12 (SDF-1beta) (carrier-free) (587706)
- Recombinant Human CXCL12 (SDF-1beta) (carrier-free) (587704)
- Recombinant Human CXCL12 (SDF-1beta) (carrier-free) (587702)
- Search Origene for MassSpec and Protein Over-expression Lysates for CXCL12
- Origene Custom Protein Services for CXCL12
- Sino Biological Recombinant Proteins for CXCL12
- Sino Biological Cell Lysates for CXCL12
- ProSpec Recombinant Proteins for CXCL12
-
ProSci Proteins for CXCL12
- C-X-C motif chemokine ligand 12 [91-104]
- C-X-C motif chemokine ligand 12 [91-105]
- chemokine (C-X-C motif) ligand 12 [40-236]
- chemokine (C-X-C motif) ligand 12 [40-347]
- chemokine (C-X-C motif) ligand 12 [40-348]
- chemokine (C-X-C motif) ligand 12 [40-377]
- chemokine (C-X-C motif) ligand 12 [40-378]
- chemokine (C-X-C motif) ligand 12 [40-414]
- chemokine (C-X-C motif) ligand 12 [40-415]
- chemokine (C-X-C motif) ligand 12 [91-583]
- chemokine (C-X-C motif) ligand 12 [40-754]
- chemokine (C-X-C motif) ligand 12 [40-755]
-
Abcam proteins for CXCL12
Assay products for research
- RayBiotech Human SDF-1 alpha ELISA and Human SDF-1 beta ELISA
- Novus Biologicals ELISA Kits for CXCL12
- antibodies-online: Show 119 available CXCL12 Elisa Kits ranked by validation data
- Compare Top CXCL12 Elisa Kits
-
Quality Products:
- ABIN6730881
- ABIN625084
- ABIN414920
- ABIN1117243
- ABIN365325
- ABIN3032987
- ABIN1572316
- ABIN3198419
- ABIN1380026
- ABIN5523101
- ABIN625176
- ABIN415535
- ABIN1117244
- ABIN365473
- ABIN1000226
- ABIN3032840
- ABIN1572317
- ABIN1117247
- ABIN5523102
- ABIN5526840
- ABIN1117248
- ABIN365568
- ABIN416336
- ABIN1572318
- ABIN4948043
- ABIN5523107
- ABIN4993683
- ABIN5670728
- ABIN5671026
- ABIN627343
- ABIN1566965
- ABIN6214355
No data available for DME Specific Peptides for CXCL12 Gene
Domains & Families for CXCL12 Gene
Gene Families for CXCL12 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for CXCL12 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CXCL12 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ76575, highly similar to Homo sapiens chemokine (C-X-C motif) ligand 12 (stromalcell-derived factor 1) (CXCL12), mRNA (Q6ICW0_HUMAN)
- Pre-B cell growth-stimulating factor (SDF1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P48061- Family:
-
- Belongs to the intercrine alpha (chemokine CxC) family.
Function for CXCL12 Gene
Molecular function for CXCL12 Gene
- UniProtKB/Swiss-Prot Function:
- Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (PubMed:29301984). Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells (By similarity).
LifeMap Function Summary for CXCL12 Gene
During embryonic development, CXCL12 as signaling molecule is secreted from the following cells
- Bone
- Pancreas
- Gut Tube
- Brain
It affects the following cells:
- Lateral Plate Mesoderm
- Limb
- Somite
- Pancreas
- Gut Tube
- Placenta
CXCL12 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
- Brain
Phenotypes From GWAS Catalog for CXCL12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | TAS | 10358157 |
| GO:0005125 | cytokine activity | IEA | -- |
| GO:0005178 | integrin binding | IDA | 29301984 |
| GO:0005515 | protein binding | IPI | 28381538 |
| GO:0008009 | chemokine activity | IMP,TAS | 12782716 |
Phenotypes for CXCL12 Gene
- MGI mutant phenotypes for CXCL12:
- inferred from 11 alleles
- GenomeRNAi human phenotypes for CXCL12:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Strongly decreased CFP-tsO45G cell surface transport
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Decreased free cholesterol
- Negative genetic interaction between BLM-/- and BLM+/+
- Increased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Increased free cholesterol
- Increased LDL uptake
Animal Models for CXCL12 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CXCL12 - Starting at $85 >
- * CXCL12 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CXCL12
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CXCL12
-
Santa Cruz Biotechnology (SCBT) CRISPR for CXCL12
miRNA for CXCL12 Gene
- miRTarBase miRNAs that target CXCL12
-
- hsa-miR-23a-3p (MIRT001776)
- mmu-miR-140-5p (MIRT004253)
- hsa-miR-31-5p (MIRT004980)
- mmu-miR-27b-3p (MIRT006457)
- hsa-miR-886-3p (MIRT006598)
- hsa-miR-126-5p (MIRT007380)
- hsa-miR-126-3p (MIRT007381)
- mmu-miR-17-5p (MIRT009864)
- mmu-miR-340-5p (MIRT010237)
- mmu-miR-15a-5p (MIRT011537)
- mmu-miR-34b-5p (MIRT012708)
- mmu-miR-149-5p (MIRT014500)
- mmu-miR-9-5p (MIRT015175)
- mmu-miR-124-3p (MIRT015733)
- hsa-miR-146a-5p (MIRT438058)
- hsa-miR-7152-3p (MIRT610958)
- hsa-miR-6891-3p (MIRT610959)
- hsa-miR-6072 (MIRT610960)
- hsa-miR-6765-3p (MIRT610961)
- hsa-miR-1228-3p (MIRT610962)
- hsa-miR-362-3p (MIRT610963)
- hsa-miR-329-3p (MIRT610964)
- hsa-miR-8485 (MIRT610965)
- mmu-miR-210-3p (MIRT731513)
- hsa-miR-221-3p (MIRT731986)
- hsa-miR-454-3p (MIRT734466)
- hsa-miR-137 (MIRT734562)
- hsa-miR-1-5p (MIRT734701)
- hsa-miR-1-3p (MIRT734702)
- hsa-miR-448 (MIRT734772)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CXCL12
- Browse OriGene Inhibitory RNA Products For CXCL12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXCL12
Clone products for research
- Applied Biological Materials (abm): Clones for CXCL12 - Starting at $45 >
- * CXCL12 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG227145
- MG227229
- MG227231
- MR227145
- MR227145L3
- MR227145L4
- MR227229
- MR227229L3
- MR227229L4
- MR227231
- MR227231L3
- MR227231L4
- RC207891
- RC207891L1
- RC207891L2
- RC207891L3
- RC207891L4
- RC211693
- RC211693L1
- RC211693L2
- RC211693L3
- RC211693L4
- RC223855
- RC223855L3
- RC223855L4
- RC229575
- RC229575L3
- RC229575L4
- RC235621
- RG207891
- RG211693
- RG223855
- RG229575
- RR200480
- RR200480L3
- RR200480L4
- RR200481
- RR200481L3
- RR200481L4
- RR200482
- RR200482L3
- RR200482L4
- MR227145L3V
- MR227145L4V
- MR227229L3V
- MR227229L4V
- MR227231L3V
- MR227231L4V
- RC207891L1V
- RC207891L2V
- RC207891L3V
- RC207891L4V
- RC211693L1V
- RC211693L2V
- RC211693L3V
- RC211693L4V
- RC223855L3V
- RC223855L4V
- RC229575L3V
- RC229575L4V
- RR200480L3V
- RR200480L4V
- RR200481L3V
- RR200481L4V
- RR200482L3V
- RR200482L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CXCL12
- Addgene plasmids for CXCL12
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CXCL12
Cell Lines for research
-
Horizon Cell Lines for CXCL12
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CXCL12 Gene
Localization for CXCL12 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CXCL12 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 4 |
| nucleus | 4 |
| cytoskeleton | 3 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CXCL12 Gene
Pathways & Interactions for CXCL12 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
| 2 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
|
IL-6 Pathway
.61
NFAT Signaling and Lymphocyte Interactions
.57
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
|
| 3 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
| 4 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
| 5 | Nanog in Mammalian ESC Pluripotency |
GSK3 Signaling
.61
Nanog in Mammalian ESC Pluripotency
.61
|
14-3-3 Induced Intracellular Signaling
.59
eNOS Signaling
.48
|
Pathways by source for CXCL12 Gene
6 BioSystems pathways for CXCL12 Gene
10 Reactome pathways for CXCL12 Gene
11 KEGG pathways for CXCL12 Gene
4 GeneGo (Thomson Reuters) pathways for CXCL12 Gene
- Apoptosis and survival Lymphotoxin-beta receptor signaling
- Cell adhesion Integrin inside-out signaling
- Chemotaxis CXCR4 signaling pathway
- Cytoskeleton remodeling Reverse signaling by ephrin B
2 R&D Systems pathways for CXCL12 Gene
70 Qiagen pathways for CXCL12 Gene
- 14-3-3 Induced Intracellular Signaling
- Actin-Based Motility by Rho Family GTPases
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Activation of PKC through GPCR
1 Cell Signaling Technology pathway for CXCL12 Gene
Interacting Proteins for CXCL12 Gene
Selected Interacting proteins:
P48061-SDF1_HUMAN
ENSP00000379140
for CXCL12 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CXCL12
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001666 | response to hypoxia | IEA | -- |
| GO:0001764 | neuron migration | IEA | -- |
| GO:0001938 | positive regulation of endothelial cell proliferation | IEA | -- |
| GO:0006874 | cellular calcium ion homeostasis | TAS | 10772939 |
| GO:0006935 | chemotaxis | TAS | 12782716 |
Drugs & Compounds for CXCL12 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| rituximab | Approved | Pharma | Therapeutic Antibodies | 2101 | ||
| Cyclophosphamide | Approved, Investigational | Pharma | Nitrogen mustard alkylating agent and prodrug. | 3824 | ||
| Dexamethasone | Approved, Investigational, Vet_approved | Pharma | Anti-inflammatory glucocorticoid | 3084 | ||
| Tinzaparin | Approved | Pharma | Target, binder | 443 | ||
| alemtuzumab | Approved, Investigational | Pharma | Therapeutic Antibodies | 353 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug products for research
-
Chemotactics
- CXCL12 (SDF-1a) (CXCL12-100ug)
- CXCL12 (SDF-1a) (CXCL12-50ug)
- CXCL12 (SDF-1a) (CXCL12-20ug)
- Biotininylated CXCL12 (SDF-1a) (B-CXCL12-100ug)
- CXCL12 (SDF-1a) (CXCL12-5ug)
- Biotininylated CXCL12 (SDF-1a) (B-CXCL12-50ug)
- CXCL12 (SDF-1a) (CXCL12-1mg)
- Biotininylated CXCL12 (SDF-1a) (B-CXCL12-2ug)
- Biotininylated CXCL12 (SDF-1a) (B-CXCL12-10ug)
-
BioLegend
- Recombinant Human CXCL12 (SDF-1alpha) (carrier-free) (581202)
- Recombinant Human CXCL12 (SDF-1alpha) (carrier-free) (581208)
- Recombinant Human CXCL12 (SDF-1alpha) (carrier-free) (581204)
- Recombinant Human CXCL12 (SDF-1alpha) (carrier-free) (581206)
- Recombinant Human CXCL12 (SDF-1beta) (carrier-free) (587708)
- Recombinant Human CXCL12 (SDF-1beta) (carrier-free) (587706)
- Recombinant Human CXCL12 (SDF-1beta) (carrier-free) (587704)
- Recombinant Human CXCL12 (SDF-1beta) (carrier-free) (587702)
Transcripts for CXCL12 Gene
mRNA/cDNA for CXCL12 Gene
- 5 REFSEQ mRNAs :
- 24 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000343575 1857 nts (view in UCSC)
- ENST00000374426 470 nts (view in UCSC)
- ENST00000374429 3532 nts (view in UCSC)
- ENST00000395793 665 nts (view in UCSC)
- ENST00000395794 1052 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CXCL12 - Starting at $85 >
- * CXCL12 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CXCL12
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CXCL12
-
Santa Cruz Biotechnology (SCBT) CRISPR for CXCL12
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CXCL12
- Browse OriGene Inhibitory RNA Products For CXCL12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXCL12
Clone products for research
- Applied Biological Materials (abm): Clones for CXCL12 - Starting at $45 >
- * CXCL12 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG227145
- MG227229
- MG227231
- MR227145
- MR227145L3
- MR227145L4
- MR227229
- MR227229L3
- MR227229L4
- MR227231
- MR227231L3
- MR227231L4
- RC207891
- RC207891L1
- RC207891L2
- RC207891L3
- RC207891L4
- RC211693
- RC211693L1
- RC211693L2
- RC211693L3
- RC211693L4
- RC223855
- RC223855L3
- RC223855L4
- RC229575
- RC229575L3
- RC229575L4
- RC235621
- RG207891
- RG211693
- RG223855
- RG229575
- RR200480
- RR200480L3
- RR200480L4
- RR200481
- RR200481L3
- RR200481L4
- RR200482
- RR200482L3
- RR200482L4
- MR227145L3V
- MR227145L4V
- MR227229L3V
- MR227229L4V
- MR227231L3V
- MR227231L4V
- RC207891L1V
- RC207891L2V
- RC207891L3V
- RC207891L4V
- RC211693L1V
- RC211693L2V
- RC211693L3V
- RC211693L4V
- RC223855L3V
- RC223855L4V
- RC229575L3V
- RC229575L4V
- RR200480L3V
- RR200480L4V
- RR200481L3V
- RR200481L4V
- RR200482L3V
- RR200482L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CXCL12
- Addgene plasmids for CXCL12
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CXCL12
Relevant External Links for CXCL12 Gene
- GeneLoc Exon Structure for
- CXCL12
Expression for CXCL12 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Meningeal Cells Anterior Meninges
- Bone (Muscoskeletal System)
- Mesenchymal Stem Cells
This gene is overexpressed in Urine (29.5) and Bone marrow mesenchymal stem cell (17.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CXCL12 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CXCL12
SOURCE GeneReport for Unigene cluster for CXCL12 Gene:
Hs.522891mRNA Expression by UniProt/SwissProt for CXCL12 Gene:
P48061-SDF1_HUMAN
Tissue specificity:
Isoform Alpha and isoform Beta are ubiquitously expressed, with highest levels detected in liver, pancreas and spleen. Isoform Gamma is mainly expressed in heart, with weak expression detected in several other tissues. Isoform Delta, isoform Epsilon and isoform Theta have highest expression levels in pancreas, with lower levels detected in heart, kidney, liver and spleen.
Evidence on tissue expression from TISSUES for CXCL12 Gene
- Nervous system(4.8)
- Heart(4.8)
- Liver(4.7)
- Spleen(3.8)
- Lymph node(3.7)
- Bone marrow(3.6)
- Muscle(3.5)
- Kidney(3.5)
- Bone(3.4)
- Intestine(3.4)
- Skin(3.3)
- Blood(3.3)
- Stomach(3.2)
- Lung(3.1)
- Pancreas(3)
- Gall bladder(2.8)
- Adrenal gland(2.7)
- Eye(2.7)
- Thyroid gland(2.6)
Primer products for research
-
OriGene qPCR primer pairs for CXCL12
-
OriGene qPCR primer pairs and template standards for CXCL12
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCL12 Gene
Orthologs for CXCL12 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CXCL12 31 |
|
OneToOne | |
| LOC741624 30 |
|
||||
| Dog (Canis familiaris) |
Mammalia | CXCL12 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CXCL12 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Cxcl12 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cxcl12 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | CXCL12 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CXCL12 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CXCL12 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CXCL12 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cxcl12 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68770 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | cxcl12b 31 |
|
OneToMany | |
| cxcl12a 31 |
|
OneToMany |
- Species where no ortholog for CXCL12 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CXCL12 Gene
- ENSEMBL:
- Gene Tree for CXCL12 (if available)
- TreeFam:
- Gene Tree for CXCL12 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CXCL12: view image
Paralogs for CXCL12 Gene
(10) SIMAP similar genes for CXCL12 Gene using alignment to 2 proteins:
- SDF1_HUMAN
- H7BYN8_HUMAN
No data available for Paralogs for CXCL12 Gene
Variants for CXCL12 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CXCL12 Gene
| SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs387906400 | Protective: Human immunodeficiency virus type 1, susceptibility to | 44,378,102(-) |
C/T NM_199168.4(CXCL12):c.*531G>A |
THREE_PRIME_UTR_VARIANT,INTRON | |
| rs749856360 | Uncertain Significance: not provided | 44,378,631(-) |
G/A NM_000609.7(CXCL12):c.266+6C>T |
THREE_PRIME_UTR_VARIANT,INTRON |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1038511 | CNV | loss | 25217958 |
| nsv1054649 | CNV | gain | 25217958 |
| nsv1068306 | CNV | deletion | 25765185 |
| nsv483001 | CNV | loss | 15286789 |
| nsv550699 | CNV | gain | 21841781 |
| nsv550700 | CNV | gain | 21841781 |
| nsv825357 | CNV | gain | 20364138 |
Residual Variation Intolerance Score:
64.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.53;
11.56% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CXCL12 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL12 Gene
Disorders for CXCL12 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| human immunodeficiency virus type 1 |
|
|
| whim syndrome |
|
|
| ischemia |
|
|
| molluscum contagiosum |
|
|
| bursitis |
|
|
Search CXCL12 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CXCL12
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL12 Gene
Publications for CXCL12 Gene
- Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene. (PMID: 7490086) Shirozu M … Honjo T (Genomics 1995) 2 3 4 23
- HIV infection and host genetic mutation among injecting drug-users of northeastern states of India. (PMID: 20411675) Sarkar K … Chakraborti S (Journal of health, population, and nutrition 2010) 3 23 41
- Chemokine polymorphisms and lymphoma: a pooled analysis. (PMID: 20038229) Bracci PM … Wiencke JK (Leukemia & lymphoma 2010) 3 23 41
- CXCL12 rs1801157 polymorphism in patients with breast cancer, Hodgkin's lymphoma, and non-Hodgkin's lymphoma. (PMID: 19927352) de Oliveira KB … Watanabe MA (Journal of clinical laboratory analysis 2009) 3 23 41
- CCR2, MCP-1, SDF-1a & DC-SIGN gene polymorphisms in HIV-1 infected patients with & without tuberculosis. (PMID: 19942750) Alagarasu K … Narayanan PR (The Indian journal of medical research 2009) 3 23 41
ExternalLinks
Products for CXCL12 Gene
- View all 27 R&D Systems CXCL12 (CXCL12/SDF-1) Products
- View all 3 R&D Systems CXCL12 (CXCL12/SDF-1 alpha) Products
- View all 4 R&D Systems CXCL12 (CXCL12/SDF-1 beta) Products
- View all R&D Systems CXCL12 (CXCL12/SDF-1 gamma) Products
- View all 4 R&D Systems CXCL12 (CXCL12/SDF-1) Proteins and Enzymes
- View all R&D Systems CXCL12 (CXCL12/SDF-1 alpha) Proteins and Enzymes
- View all 2 R&D Systems CXCL12 (CXCL12/SDF-1 beta) Proteins and Enzymes
- View all R&D Systems CXCL12 (CXCL12/SDF-1 gamma) Proteins and Enzymes
- View all 18 R&D Systems CXCL12 (CXCL12/SDF-1) Primary Antibodies
- View all 2 R&D Systems CXCL12 (CXCL12/SDF-1 beta) Primary Antibodies
- View all 2 R&D Systems CXCL12 (CXCL12/SDF-1) ELISAs
- View all R&D Systems CXCL12 (CXCL12/SDF-1 alpha) ELISAs
- View all R&D Systems CXCL12 (CXCL12/SDF-1 alpha) Simple Plex Assays
- View all 3 R&D Systems CXCL12 (CXCL12/SDF-1) Proteome Profiler Antibody Arrays
- Learn more about R&D Systems custom CXCL12 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for CXCL12
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CXCL12
- Origene Custom Protein Services for CXCL12
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CXCL12
- Browse OriGene Inhibitory RNA Products For CXCL12
- OriGene qPCR primer pairs for CXCL12
- OriGene qPCR primer pairs and template standards for CXCL12
- OriGene CRISPR knockouts for CXCL12
- MG227145
- MG227229
- MG227231
- MR227145
- MR227145L3
- MR227145L4
- MR227229
- MR227229L3
- MR227229L4
- MR227231
- MR227231L3
- MR227231L4
- RC207891
- RC207891L1
- RC207891L2
- RC207891L3
- RC207891L4
- RC211693
- RC211693L1
- RC211693L2
- RC211693L3
- RC211693L4
- RC223855
- RC223855L3
- RC223855L4
- RC229575
- RC229575L3
- RC229575L4
- RC235621
- RG207891
- RG211693
- RG223855
- RG229575
- RR200480
- RR200480L3
- RR200480L4
- RR200481
- RR200481L3
- RR200481L4
- RR200482
- RR200482L3
- RR200482L4
- MR227145L3V
- MR227145L4V
- MR227229L3V
- MR227229L4V
- MR227231L3V
- MR227231L4V
- RC207891L1V
- RC207891L2V
- RC207891L3V
- RC207891L4V
- RC211693L1V
- RC211693L2V
- RC211693L3V
- RC211693L4V
- RC223855L3V
- RC223855L4V
- RC229575L3V
- RC229575L4V
- RR200480L3V
- RR200480L4V
- RR200481L3V
- RR200481L4V
- RR200482L3V
- RR200482L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CXCL12
- Sino Biological Human cDNA Clone for CXCL12
- Sino Biological Recombinant Proteins for CXCL12
- Sino Biological Cell Lysates for CXCL12
- Sino Biological Antibodies for CXCL12
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CXCL12
- Novus Biologicals proteins and lysates for CXCL12
- Novus Biologicals ELISA Kits for CXCL12
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CXCL12
- Abcam proteins for CXCL12
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for CXCL12 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CXCL12 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CXCL12 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CXCL12 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CXCL12
- Addgene plasmids for CXCL12
- antibodies-online: Show 67 available CXCL12 Antibodies ranked by validation data
- Compare Top CXCL12 Antibodies
- Recommended
- 111 WB Antibodies (anti-human)
- 24 IHC (p) Antibodies (anti-human)
- 14 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 8 IHC Antibodies (anti-human)
- 55 WB Antibodies (anti-mouse)
- 12 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 7 IHC Antibodies (anti-mouse)
- 5 IHC (p) Antibodies (anti-mouse)
- 23 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 5 IHC (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- antibodies-online: Show 119 available CXCL12 Elisa Kits ranked by validation data
- Compare Top CXCL12 Elisa Kits
- Quality Products:
- ABIN6730881
- ABIN625084
- ABIN414920
- ABIN1117243
- ABIN365325
- ABIN3032987
- ABIN1572316
- ABIN3198419
- ABIN1380026
- ABIN5523101
- ABIN625176
- ABIN415535
- ABIN1117244
- ABIN365473
- ABIN1000226
- ABIN3032840
- ABIN1572317
- ABIN1117247
- ABIN5523102
- ABIN5526840
- ABIN1117248
- ABIN365568
- ABIN416336
- ABIN1572318
- ABIN4948043
- ABIN5523107
- ABIN4993683
- ABIN5670728
- ABIN5671026
- ABIN627343
- ABIN1566965
- ABIN6214355
- antibodies-online: Show 138 available CXCL12 Proteins ranked by validation data
- Compare Top CXCL12 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CXCL12
- Search Santa Cruz Biotechnology (SCBT) for CXCL12 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CXCL12
- Custom Antibody ServicesProSci Antibodies for CXCL12
- chemokine (C-X-C motif) ligand 12 [7591]
- chemokine (C-X-C motif) ligand 12 [31-056]
- chemokine (C-X-C motif) ligand 12 [XP-5269]
- chemokine (C-X-C motif) ligand 12 [XP-5269Bt]
- chemokine (C-X-C motif) ligand 12 [XP-5270]
- chemokine (C-X-C motif) ligand 12 [XP-5270Bt]
- chemokine (C-X-C motif) ligand 12 [XP-5271]
- chemokine (C-X-C motif) ligand 12 [XP-5271Bt]
- ProSci Proteins for CXCL12
- C-X-C motif chemokine ligand 12 [91-104]
- C-X-C motif chemokine ligand 12 [91-105]
- chemokine (C-X-C motif) ligand 12 [40-236]
- chemokine (C-X-C motif) ligand 12 [40-347]
- chemokine (C-X-C motif) ligand 12 [40-348]
- chemokine (C-X-C motif) ligand 12 [40-377]
- chemokine (C-X-C motif) ligand 12 [40-378]
- chemokine (C-X-C motif) ligand 12 [40-414]
- chemokine (C-X-C motif) ligand 12 [40-415]
- chemokine (C-X-C motif) ligand 12 [91-583]
- chemokine (C-X-C motif) ligand 12 [40-754]
- chemokine (C-X-C motif) ligand 12 [40-755]
- Horizon Cell Lines for CXCL12
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CXCL12
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CXCL12
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CXCL12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXCL12
Sources for CXCL12 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB