Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects ... See more...

Aliases for CXCL11 Gene

Aliases for CXCL11 Gene

  • C-X-C Motif Chemokine Ligand 11 2 3 5
  • Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 11 2 3
  • Interferon-Inducible T-Cell Alpha Chemoattractant 3 4
  • Interferon Gamma-Inducible Protein 9 3 4
  • Chemokine (C-X-C Motif) Ligand 11 2 3
  • C-X-C Motif Chemokine 11 3 4
  • Beta-R1 3 4
  • SCYB11 3 4
  • SCYB9B 3 4
  • I-TAC 3 4
  • H174 3 4
  • IP-9 3 4
  • Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 9B 3
  • Small Inducible Cytokine B11 3
  • Small-Inducible Cytokine B11 4
  • B-R1 3
  • ITAC 4
  • IP9 3

External Ids for CXCL11 Gene

Previous HGNC Symbols for CXCL11 Gene

  • SCYB9B
  • SCYB11

Previous GeneCards Identifiers for CXCL11 Gene

  • GC04M076850
  • GC04M077145
  • GC04M077347
  • GC04M077413
  • GC04M077312
  • GC04M076954
  • GC04M072707

Summaries for CXCL11 Gene

Entrez Gene Summary for CXCL11 Gene

  • Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

GeneCards Summary for CXCL11 Gene

CXCL11 (C-X-C Motif Chemokine Ligand 11) is a Protein Coding gene. Diseases associated with CXCL11 include Nasal Cavity Cancer and Nasal Cavity Adenocarcinoma. Among its related pathways are Signaling by GPCR and CCR5 Pathway in Macrophages. Gene Ontology (GO) annotations related to this gene include heparin binding and CXCR3 chemokine receptor binding. An important paralog of this gene is CXCL9.

UniProtKB/Swiss-Prot Summary for CXCL11 Gene

  • Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.

Gene Wiki entry for CXCL11 Gene

Additional gene information for CXCL11 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CXCL11 Gene

Genomics for CXCL11 Gene

GeneHancer (GH) Regulatory Elements for CXCL11 Gene

Promoters and enhancers for CXCL11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J076037 Promoter/Enhancer 0.9 EPDnew Ensembl 500.4 +5.3 5315 2.6 FOS YY1 NFE2 JUN CTCF ESRRA IKZF1 POLR2A PRDM1 RUNX3 RPL36P8 lnc-CXCL10-1 CXCL11 ART3 NAAA NUP54 CXCL9 SDAD1 CXCL10
GH04J076042 Enhancer 0.7 FANTOM5 Ensembl 524.1 -0.8 -844 0.5 FOS POLR2H ATF2 JUNB ZBTB33 JUN NFIC CXCL11 lnc-FAM47E-1 piR-33422-320 piR-39099-185 piR-58297-349 CXCL9 ART3 CXCL10 NAAA
GH04J076059 Enhancer 1.3 FANTOM5 Ensembl ENCODE 18.6 -19.2 -19186 4.8 NCOR1 FOXA1 JUND RELA HES1 MEF2C RCOR1 REST TRIM22 TEAD1 ART3 CXCL10 CXCL9 NAAA CXCL11 NUP54 SDAD1 LOC101928809 KR153194-147 piR-58297-350
GH04J075843 Enhancer 1 FANTOM5 Ensembl ENCODE 19.2 +196.5 196537 2.6 TCF12 NR2F2 FOXA2 CEBPB USF1 CEBPG SRF FOSL2 ATF3 SMAD4 CXCL10 CXCL9 CXCL11 NAAA piR-37097-076 RF00004-088 RNU2-16P
GH04J076027 Enhancer 0.8 FANTOM5 ENCODE 18.7 +13.1 13087 0.9 NFIC IRF1 PBX2 STAT1 NFIB MEIS2 NFIA ZNF175 FOXA1 SOX6 ART3 CXCL9 CXCL10 CXCL11 SDAD1 NAAA lnc-CXCL10-1 RPL36P8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CXCL11 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CXCL11

Top Transcription factor binding sites by QIAGEN in the CXCL11 gene promoter:
  • AML1a
  • STAT3

Genomic Locations for CXCL11 Gene

Genomic Locations for CXCL11 Gene
chr4:76,033,682-76,041,415
(GRCh38/hg38)
Size:
7,734 bases
Orientation:
Minus strand
chr4:76,954,835-76,962,568
(GRCh37/hg19)
Size:
7,734 bases
Orientation:
Minus strand

Genomic View for CXCL11 Gene

Genes around CXCL11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCL11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCL11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL11 Gene

Proteins for CXCL11 Gene

  • Protein details for CXCL11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14625-CXL11_HUMAN
    Recommended name:
    C-X-C motif chemokine 11
    Protein Accession:
    O14625
    Secondary Accessions:
    • Q53YA3
    • Q92840

    Protein attributes for CXCL11 Gene

    Size:
    94 amino acids
    Molecular mass:
    10365 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB17374.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CXCL11 Gene

neXtProt entry for CXCL11 Gene

Post-translational modifications for CXCL11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CXCL11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CXCL11 Gene

Domains & Families for CXCL11 Gene

Gene Families for CXCL11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CXCL11 Gene

GenScript: Design optimal peptide antigens:
  • Small-inducible cytokine B11 (CXL11_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14625

UniProtKB/Swiss-Prot:

CXL11_HUMAN :
  • Belongs to the intercrine alpha (chemokine CxC) family.
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL11: view

Function for CXCL11 Gene

Molecular function for CXCL11 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma and IFNB1/IFN-beta. Induction by IFNG/IFN-gamma is enhanced by TNF in monocytes, dermal fibroblasts and endothelial cells, and by IL1/interleukin-1 in astrocytes.

Phenotypes From GWAS Catalog for CXCL11 Gene

Gene Ontology (GO) - Molecular Function for CXCL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18275857
GO:0008009 chemokine activity IDA,TAS 12782716
GO:0008201 heparin binding IMP 18645041
GO:0048248 CXCR3 chemokine receptor binding IDA 12782716
genes like me logo Genes that share ontologies with CXCL11: view
genes like me logo Genes that share phenotypes with CXCL11: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CXCL11

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXCL11

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXCL11 Gene

Localization for CXCL11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL11 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXCL11 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CXCL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with CXCL11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CXCL11 Gene

Pathways & Interactions for CXCL11 Gene

PathCards logo

SuperPathways for CXCL11 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.47
.46
2 Peptide ligand-binding receptors
3 Toll-like Receptor Signaling Pathway
4 Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions
5 ERK Signaling
.61
.61
.51
genes like me logo Genes that share pathways with CXCL11: view

Pathways by source for CXCL11 Gene

1 GeneGo (Thomson Reuters) pathway for CXCL11 Gene
  • Immune response TLR signaling pathways
17 Qiagen pathways for CXCL11 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Chemokine Signaling
  • Endothelin-1 Signaling Pathway

Gene Ontology (GO) - Biological Process for CXCL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IDA,TAS 12782716
GO:0006952 defense response IEA --
GO:0006954 inflammatory response IBA,TAS 21873635
GO:0006955 immune response IBA 21873635
GO:0007165 signal transduction TAS 10233762
genes like me logo Genes that share ontologies with CXCL11: view

No data available for SIGNOR curated interactions for CXCL11 Gene

Drugs & Compounds for CXCL11 Gene

(8) Drugs for CXCL11 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7884

(3) Additional Compounds for CXCL11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CXCL11: view

Transcripts for CXCL11 Gene

mRNA/cDNA for CXCL11 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXCL11

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2:

Relevant External Links for CXCL11 Gene

GeneLoc Exon Structure for
CXCL11

Expression for CXCL11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CXCL11 Gene

mRNA differential expression in normal tissues according to GTEx for CXCL11 Gene

This gene is overexpressed in Brain - Substantia nigra (x18.6) and Pancreas (x4.8).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CXCL11

SOURCE GeneReport for Unigene cluster for CXCL11 Gene:

Hs.632592

mRNA Expression by UniProt/SwissProt for CXCL11 Gene:

O14625-CXL11_HUMAN
Tissue specificity: High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders.

Evidence on tissue expression from TISSUES for CXCL11 Gene

  • Blood(4.5)
  • Bone marrow(4.4)
  • Liver(4.4)
  • Skin(4.4)
  • Nervous system(4.4)
  • Lung(2.5)
  • Lymph node(2.3)
  • Spleen(2.2)
  • Kidney(2.1)
  • Heart(2)
  • Intestine(2)
genes like me logo Genes that share expression patterns with CXCL11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCL11 Gene

Orthologs for CXCL11 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CXCL11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXCL11 31 30
  • 100 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CXCL11 31 30
  • 87.1 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CXCL11 30
  • 86.88 (n)
rat
(Rattus norvegicus)
Mammalia Cxcl11 30
  • 74.11 (n)
mouse
(Mus musculus)
Mammalia Cxcl11 31
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CXCL11 31
  • 44 (a)
OneToOne
Species where no ortholog for CXCL11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL11 Gene

ENSEMBL:
Gene Tree for CXCL11 (if available)
TreeFam:
Gene Tree for CXCL11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CXCL11: view image

Paralogs for CXCL11 Gene

Paralogs for CXCL11 Gene

(5) SIMAP similar genes for CXCL11 Gene using alignment to 2 proteins:

  • CXL11_HUMAN
  • L8E879_HUMAN
genes like me logo Genes that share paralogs with CXCL11: view

Variants for CXCL11 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CXCL11 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs4859596 - p.Asn55Ser

Additional dbSNP identifiers (rs#s) for CXCL11 Gene

Structural Variations from Database of Genomic Variants (DGV) for CXCL11 Gene

Variant ID Type Subtype PubMed ID
esv27112 CNV gain 19812545
nsv7363 OTHER inversion 18451855

Variation tolerance for CXCL11 Gene

Residual Variation Intolerance Score: 53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXCL11 Gene

Human Gene Mutation Database (HGMD)
CXCL11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXCL11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL11 Gene

Disorders for CXCL11 Gene

MalaCards: The human disease database

(18) MalaCards diseases for CXCL11 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
nasal cavity cancer
  • malignant neoplasm of nasal cavities
nasal cavity adenocarcinoma
  • adenocarcinoma of nasal cavity
endotheliitis
ethmoid sinus adenocarcinoma
  • adenocarcinoma of ethmoid sinus
ethmoid sinus cancer
  • malignant neoplasm of ethmoidal sinus
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CXCL11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CXCL11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL11 Gene

Publications for CXCL11 Gene

  1. Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation. (PMID: 18645041) Loos T … Proost P (Blood 2008) 3 4 23 54
  2. NMR structure of CXCR3 binding chemokine CXCL11 (ITAC). (PMID: 15273303) Booth V … Sykes BD (Protein science : a publication of the Protein Society 2004) 3 4 23 54
  3. Genomic organization, sequence and transcriptional regulation of the human CXCL 11(1) gene. (PMID: 10395932) Tensen CP … Willemze R (Biochimica et biophysica acta 1999) 3 4 23 54
  4. Structure and expression of the human small cytokine B subfamily member 11 (SCYB11/formerly SCYB9B, alias I-TAC) gene cloned from IFN-gamma-treated human monocytes (THP-1). (PMID: 10386863) Laich A … Werner-Felmayer G (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1999) 3 4 23 54
  5. Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3). (PMID: 10233762) Tensen CP … Willemze R (The Journal of investigative dermatology 1999) 3 4 23 54

Products for CXCL11 Gene

Sources for CXCL11 Gene