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This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. This gene may also be a key regulator of the 'cytokine storm' immune response to SARS-CoV-2 in... See more...
Aliases for CXCL10 Gene
Aliases for CXCL10 Gene
External Ids for CXCL10 Gene
- HGNC: 10637
- NCBI Entrez Gene: 3627
- Ensembl: ENSG00000169245
- OMIM®: 147310
- UniProtKB/Swiss-Prot: P02778
Previous HGNC Symbols for CXCL10 Gene
- INP10
- SCYB10
Previous GeneCards Identifiers for CXCL10 Gene
- GC04M076838
- GC04M077132
- GC04M077335
- GC04M077400
- GC04M077299
- GC04M076942
- GC04M072694
Summaries for CXCL10 Gene
-
This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. This gene may also be a key regulator of the 'cytokine storm' immune response to SARS-CoV-2 infection. [provided by RefSeq, Sep 2020]
GeneCards Summary for CXCL10 Gene
CXCL10 (C-X-C Motif Chemokine Ligand 10) is a Protein Coding gene. Diseases associated with CXCL10 include Hepatitis C and Viral Encephalitis. Among its related pathways are Signaling by GPCR and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and chemokine activity. An important paralog of this gene is CXCL9.
UniProtKB/Swiss-Prot Summary for CXCL10 Gene
-
Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (PubMed:7540647, PubMed:11157474, PubMed:22652417). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization (PubMed:12750173, PubMed:19151743). In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (PubMed:12750173, PubMed:12663757). Activation of the CXCL10/CXCR3 axis plays also an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity).
Additional gene information for CXCL10 Gene
- HGNC (10637)
- NCBI Entrez Gene (3627)
- Ensembl (ENSG00000169245)
- OMIM® (147310)
- UniProtKB/Swiss-Prot (P02778)
- Open Targets Platform(ENSG00000169245)
- Monarch Initiative
- Alliance of Genome Resources
- Search for CXCL10 at DataMed
- Search for CXCL10 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CXCL10 Gene
Genomics for CXCL10 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CXCL10 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH04J076023 | Promoter | 0.5 | EPDnew | 250.7 | 0.0 | -20 | 0.1 | L3MBTL2 MGA | CXCL10 ART3 HSALNG0035292 RPL36P8 lnc-CXCL10-1 CXCL11 | |
| GH04J076024 | Promoter | 0.5 | Ensembl | 250.7 | -0.2 | -204 | 0.2 | L3MBTL2 MGA | CXCL10 ART3 HSALNG0035292 RPL36P8 lnc-CXCL10-1 CXCL11 | |
| GH04J076022 | Enhancer | 0.3 | Ensembl | 250.7 | +1.2 | 1196 | 0.2 | HMBOX1 | CXCL10 ART3 HSALNG0035292 | |
| GH04J076059 | Enhancer | 1.3 | FANTOM5 Ensembl ENCODE | 32.9 | -37.2 | -37203 | 4.6 | BCLAF1 NCOR1 CEBPA NFIC YY1 BCL11A FOXA1 TRIM22 HES1 HOMEZ | ART3 CXCL10 CXCL9 NAAA CXCL11 NUP54 SDAD1 SDAD1-AS1 KR153194-146 piR-58297-350 | |
| GH04J076042 | Enhancer | 0.6 | FANTOM5 Ensembl | 58 | -18.8 | -18762 | 0.5 | ZBTB33 ATF2 JUNB FOS | CXCL11 lnc-FAM47E-1 piR-39099-185 piR-33422-320 piR-58297-349 CXCL9 ART3 CXCL10 NAAA HSALNG0035292 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CXCL10 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CXCL10
- Top Transcription factor binding sites by QIAGEN in the CXCL10 gene promoter:
-
- AML1a
- STAT3
Genomic Locations for CXCL10 Gene
Latest Assembly
- chr4:76,021,118-76,023,497
- (GRCh38/hg38)
- Size:
- 2,380 bases
- Orientation:
- Minus strand
Previous Assembly
- chr4:76,942,271-76,944,650
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 2,380 bases
- Orientation:
- Minus strand
Genomic View for CXCL10 Gene
Genes around CXCL10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q21.1 by HGNC
- 4q21.1 by Entrez Gene
- 4q21.1 by Ensembl
CXCL10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CXCL10 Gene
Proteins for CXCL10 Gene
-
Protein details for CXCL10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P02778-CXL10_HUMAN
- Recommended name:
- C-X-C motif chemokine 10
- Protein Accession:
- P02778
- Q96QJ5
Protein attributes for CXCL10 Gene
- Size:
- 98 amino acids
- Molecular mass:
- 10881 Da
- Quaternary structure:
-
- Monomer, dimer, and tetramer (PubMed:12737818). Interacts with CXCR3 (via N-terminus) (PubMed:19151743).
Protein Expression for CXCL10 Gene
Post-translational modifications for CXCL10 Gene
- Several proteases can mediate post-secretion cleavages. DPP4 cleaves CXCL10 on its N-terminal 2 amino acids leading to an antagonist form of CXCL10. This dominant negative form is capable of binding CXCR3 but does not induce signaling. MMP9 cleaves 9 amino acids instead.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CXCL10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences CXCL10 / IP-10 Antibody
- G Biosciences Immunotag™ CXCL10 Antibody
- NSJ Bioreagents IP10 Antibody
-
Custom Antibody ServicesOriGene Antibodies for CXCL10
- Novus Biologicals Antibodies for CXCL10
-
Abcam antibodies for CXCL10
- Invitrogen Antibodies for CXCL10 (AFLGC-CXCL10)
-
Custom Antibody ServicesProSci Antibodies for CXCL10
- chemokine (C-X-C motif) ligand 10 [38-252]
- chemokine (C-X-C motif) ligand 10 [38-255]
- chemokine (C-X-C motif) ligand 10 [38-267]
- chemokine (C-X-C motif) ligand 10 [XP-5203]
- chemokine (C-X-C motif) ligand 10 [XP-5203Bt]
- chemokine (C-X-C motif) ligand 10 [XP-5204]
- chemokine (C-X-C motif) ligand 10 [XP-5204Bt]
- chemokine (C-X-C motif) ligand 10 [XW-7299]
-
Santa Cruz Biotechnology (SCBT) Antibodies for CXCL10
- Sino Biological Antibodies for CXCL10
Protein products for research
- RayBiotech Recombinant Human CXCL10 (IP10)
- Search Origene for MassSpec and Protein Over-expression Lysates for CXCL10
- Origene Custom Protein Services for CXCL10
- Sino Biological Recombinant Proteins for CXCL10
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for CXCL10
-
Abcam proteins for CXCL10
Assay products for research
- RayBiotech Human IP-10 ELISA
- Novus Biologicals ELISA Kits for CXCL10
-
Abcam assays for CXCL10
- Sino Biological Assays for CXCL10
No data available for DME Specific Peptides for CXCL10 Gene
Domains & Families for CXCL10 Gene
Gene Families for CXCL10 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for CXCL10 Gene
Suggested Antigen Peptide Sequences for CXCL10 Gene
- GenScript: Design optimal peptide antigens:
-
- Small-inducible cytokine B10 (CXL10_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P02778- Family:
-
- Belongs to the intercrine alpha (chemokine CxC) family.
Function for CXCL10 Gene
Molecular function for CXCL10 Gene
- UniProtKB/Swiss-Prot Function:
- Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (PubMed:7540647, PubMed:11157474, PubMed:22652417). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization (PubMed:12750173, PubMed:19151743). In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (PubMed:12750173, PubMed:12663757). Activation of the CXCL10/CXCR3 axis plays also an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity).
- UniProtKB/Swiss-Prot Induction:
- By IFNG/IFN-gamma. A diverse population of cell types rapidly increases transcription of mRNA encoding this protein. This suggests that gamma-induced protein may be a key mediator of the IFNG/IFN-gamma response.
Phenotypes From GWAS Catalog for CXCL10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | TAS | 10201891 |
| GO:0005125 | cytokine activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 18275857 |
| GO:0008009 | chemokine activity | TAS,IDA | 12782716 |
| GO:0008201 | heparin binding | IMP | 18645041 |
Phenotypes for CXCL10 Gene
- MGI mutant phenotypes for CXCL10:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CXCL10:
Animal Models for CXCL10 Gene
- MGI Knock Outs for CXCL10:
-
- Cxcl10 Cxcl10<tm1Adl>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CXCL10 - Starting at $85 >
- * CXCL10 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CXCL10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CXCL10
-
Santa Cruz Biotechnology (SCBT) CRISPR for CXCL10
miRNA for CXCL10 Gene
- miRTarBase miRNAs that target CXCL10
-
- hsa-miR-21-5p (MIRT438112)
- hsa-miR-6864-3p (MIRT540499)
- hsa-miR-3672 (MIRT540500)
- hsa-miR-6888-3p (MIRT540501)
- hsa-miR-550a-3p (MIRT540502)
- hsa-miR-200c-5p (MIRT540503)
- hsa-miR-196a-3p (MIRT540504)
- hsa-miR-661 (MIRT540505)
- hsa-miR-873-3p (MIRT540506)
- hsa-miR-4522 (MIRT540507)
- hsa-miR-302a-5p (MIRT540508)
- hsa-miR-3120-5p (MIRT540509)
- hsa-miR-6860 (MIRT540510)
- hsa-miR-612 (MIRT540511)
- hsa-miR-5189-5p (MIRT540512)
- hsa-miR-3187-5p (MIRT540513)
- hsa-miR-1285-3p (MIRT540514)
- hsa-miR-939-3p (MIRT540515)
- hsa-miR-6849-3p (MIRT540516)
- hsa-miR-3065-5p (MIRT540517)
- hsa-miR-520h (MIRT540518)
- hsa-miR-520g-3p (MIRT540519)
- hsa-miR-3664-5p (MIRT540520)
- hsa-miR-548ah-5p (MIRT540521)
- hsa-miR-3609 (MIRT540522)
- hsa-miR-1231 (MIRT659955)
- hsa-miR-632 (MIRT659956)
- hsa-miR-4288 (MIRT659957)
- hsa-miR-767-5p (MIRT659958)
- hsa-miR-1226-3p (MIRT659959)
- hsa-miR-15a-5p (MIRT731341)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CXCL10
- Browse OriGene Inhibitory RNA Products For CXCL10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXCL10
Clone products for research
- Applied Biological Materials (abm): Clones for CXCL10 - Starting at $45 >
- * CXCL10 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CXCL10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CXCL10
Cell Lines for research
-
Horizon Cell Lines for CXCL10
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CXCL10 Gene
Localization for CXCL10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CXCL10 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 4 |
| cytoskeleton | 3 |
| nucleus | 3 |
| cytosol | 3 |
| lysosome | 3 |
| mitochondrion | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| golgi apparatus | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IDA,TAS | -- |
| GO:0005615 | extracellular space | IBA | 21873635 |
| GO:0009897 | external side of plasma membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CXCL10 Gene
Pathways & Interactions for CXCL10 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
|
IL-6 Pathway
.61
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
|
| 2 | Toll-like Receptor Signaling Pathway |
.34
|
|
| 3 | Peptide ligand-binding receptors | ||
| 4 | Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions | ||
| 5 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
|
Molecular Mechanisms of Cancer
.51
|
Pathways by source for CXCL10 Gene
6 BioSystems pathways for CXCL10 Gene
12 Reactome pathways for CXCL10 Gene
12 KEGG pathways for CXCL10 Gene
1 GeneGo (Thomson Reuters) pathway for CXCL10 Gene
- Immune response TLR signaling pathways
1 R&D Systems pathway for CXCL10 Gene
17 Qiagen pathways for CXCL10 Gene
- Akt Signaling
- all-trans-Retinoic Acid Signaling in Brain
- Antioxidant Action of Vitamin-C
- Chemokine Signaling
- Endothelin-1 Signaling Pathway
1 Cell Signaling Technology pathway for CXCL10 Gene
Interacting Proteins for CXCL10 Gene
Selected Interacting proteins:
P02778-CXL10_HUMAN
ENSP00000305651
for CXCL10 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CXCL10
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002690 | positive regulation of leukocyte chemotaxis | IEA | -- |
| GO:0006935 | chemotaxis | TAS,IDA | 12782716 |
| GO:0006952 | defense response | IEA | -- |
| GO:0006954 | inflammatory response | TAS,IBA | 21873635 |
| GO:0006955 | immune response | IEA | -- |
Drugs & Compounds for CXCL10 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for CXCL10 Gene
mRNA/cDNA for CXCL10 Gene
- 1 REFSEQ mRNAs :
- 5 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000306602 1175 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CXCL10 - Starting at $85 >
- * CXCL10 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CXCL10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CXCL10
-
Santa Cruz Biotechnology (SCBT) CRISPR for CXCL10
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CXCL10
- Browse OriGene Inhibitory RNA Products For CXCL10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXCL10
Clone products for research
- Applied Biological Materials (abm): Clones for CXCL10 - Starting at $45 >
- * CXCL10 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CXCL10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CXCL10
Relevant External Links for CXCL10 Gene
- GeneLoc Exon Structure for
- CXCL10
Expression for CXCL10 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Adipose (Muscoskeletal System)
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
-
Testis (Reproductive System)
- Sertoli cells Seminiferous Tubules
-
Peripheral Nervous System (Nervous System)
- Schwann Precursor Cells Peripheral Nerve Domain
-
Brain (Nervous System)
- Adult Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Adult Endothelial Cells Blood Brain Barrier
-
Pancreas (Endocrine System)
- Duct Cells Pancreatic Ducts
-
Epithelial Cells
- Duct Cells Pancreatic Ducts
- Thymus (Hematopoietic System)
- Epiblast (Early Embryonic Tissues)
-
Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for CXCL10 Gene
This gene is overexpressed in Brain - Substantia nigra (x10.4), Cervix - Ectocervix (x4.4), and Lung (x4.0).
This gene is overexpressed in Ovary (60.4) and Placenta (8.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CXCL10 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CXCL10
SOURCE GeneReport for Unigene cluster for CXCL10 Gene:
Hs.632586mRNA Expression by UniProt/SwissProt for CXCL10 Gene:
P02778-CXL10_HUMAN
Tissue specificity:
Mainly secreted by monocytes, endothelial cells as well as fibroblasts. Expressed by epithelial cells in thymus (PubMed:11157474). Microglial cells produce CXCL10 in response to viral stimulation (PubMed:12663757).
Evidence on tissue expression from TISSUES for CXCL10 Gene
- Skin(4.5)
- Lymph node(3.6)
- Spleen(3.3)
- Intestine(3.3)
- Blood(3.2)
- Lung(3.1)
- Liver(3.1)
- Nervous system(2.9)
- Heart(2.8)
- Kidney(2.6)
- Bone marrow(2.5)
- Muscle(2.5)
- Stomach(2.4)
- Thyroid gland(2.1)
- Bone(2.1)
- Urine(2.1)
- Eye(2)
- Pancreas(2)
Primer products for research
-
OriGene qPCR primer pairs for CXCL10
-
OriGene qPCR primer pairs and template standards for CXCL10
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCL10 Gene
Orthologs for CXCL10 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CXCL10 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CXCL10 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CXCL10 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Cxcl10 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cxcl10 29 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | CXCL10 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 30 |
|
OneToMany |
- Species where no ortholog for CXCL10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for CXCL10 Gene
- ENSEMBL:
- Gene Tree for CXCL10 (if available)
- TreeFam:
- Gene Tree for CXCL10 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CXCL10: view image
- Alliance of Genome Resources:
- Additional Orthologs for CXCL10
Paralogs for CXCL10 Gene
Paralogs for CXCL10 Gene
(12) SIMAP similar genes for CXCL10 Gene using alignment to 1 proteins:
- CXL10_HUMAN
Variants for CXCL10 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CXCL10 Gene
| SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs11548618 | Benign: not provided | 76,022,794(-) |
G/A NM_001565.4(CXCL10):c.85C>T (p.Arg29Cys) |
MISSENSE_VARIANT,INTRON | |
| rs139813823 | Benign: not provided | 76,022,401(-) |
G/T NM_001565.4(CXCL10):c.243C>A (p.Ala81=) |
SYNONYMOUS_VARIANT,INTRON |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
77.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.66;
14.09% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CXCL10 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL10 Gene
Disorders for CXCL10 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hepatitis c |
|
|
| viral encephalitis |
|
|
| avian influenza |
|
|
| endotheliitis |
|
|
| paracoccidioidomycosis |
|
|
Search CXCL10 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CXCL10
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL10 Gene
Publications for CXCL10 Gene
- Genetic association between a chemokine gene CXCL-10 (IP-10, interferon gamma inducible protein 10) and susceptibility to tuberculosis. (PMID: 19523460) Tang NL … Chan CY (Clinica chimica acta; international journal of clinical chemistry 2009) 3 22 40
- Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation. (PMID: 18645041) Loos T … Proost P (Blood 2008) 3 4 22
- CXCL10 production from cytomegalovirus-stimulated microglia is regulated by both human and viral interleukin-10. (PMID: 12663757) Cheeran MC … Lokensgard JR (Journal of virology 2003) 3 4 22
- The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions. (PMID: 12173928) Booth V … Sykes BD (Biochemistry 2002) 3 4 22
- Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8. (PMID: 8423327) Proost P … Van Damme J (Journal of immunology (Baltimore, Md. : 1950) 1993) 3 4 22
ExternalLinks
Products for CXCL10 Gene
- View all 45 R&D Systems CXCL10 (CXCL10/IP-10/CRG-2) Products
- View all R&D Systems CXCL10 (CXCL10/IP-10/CRG-2) Proteins and Enzymes
- View all 27 R&D Systems CXCL10 (CXCL10/IP-10/CRG-2) Primary Antibodies
- View all 4 R&D Systems CXCL10 (CXCL10/IP-10/CRG-2) ELISAs
- View all R&D Systems CXCL10 (CXCL10/IP-10/CRG-2) Simple Plex Assays
- View all 8 R&D Systems CXCL10 (CXCL10/IP-10/CRG-2) Luminex Assays
- View all 3 R&D Systems CXCL10 (CXCL10/IP-10/CRG-2) Proteome Profiler Antibody Arrays
- View all R&D Systems CXCL10 (CXCL10/IP-10/CRG-2) ELISpot and FluoroSpot Kits
- Learn more about R&D Systems custom CXCL10 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for CXCL10
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- Search Origene for MassSpec and Protein Over-expression Lysates for CXCL10
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for CXCL10
- Browse OriGene Inhibitory RNA Products For CXCL10
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- OriGene CRISPR knockouts for CXCL10
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CXCL10
- Sino Biological Human cDNA Clone for CXCL10
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- VectorBuilder Custom and pre-made DNA vectors for CXCL10 (ie. gene expression, shRNA knockdown, CRISPR)
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- VectorBuilder CRISPR vectors for CXCL10 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CXCL10 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CXCL10
- antibodies-online: Show 100 available CXCL10 Antibodies ranked by validation data
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- antibodies-online: Show 149 available CXCL10 Elisa Kits ranked by validation data
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- antibodies-online: Show 95 available CXCL10 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for CXCL10
- Search Santa Cruz Biotechnology (SCBT) for CXCL10 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CXCL10
- Custom Antibody ServicesProSci Antibodies for CXCL10
- chemokine (C-X-C motif) ligand 10 [38-252]
- chemokine (C-X-C motif) ligand 10 [38-255]
- chemokine (C-X-C motif) ligand 10 [38-267]
- chemokine (C-X-C motif) ligand 10 [XP-5203]
- chemokine (C-X-C motif) ligand 10 [XP-5203Bt]
- chemokine (C-X-C motif) ligand 10 [XP-5204]
- chemokine (C-X-C motif) ligand 10 [XP-5204Bt]
- chemokine (C-X-C motif) ligand 10 [XW-7299]
- Horizon Cell Lines for CXCL10
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CXCL10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CXCL10
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CXCL10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXCL10
Sources for CXCL10 Gene
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- (7) GeneLoc
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