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This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014]
CXCL10 (C-X-C Motif Chemokine Ligand 10) is a Protein Coding gene. Diseases associated with CXCL10 include Endotheliitis and Neurosyphilis. Among its related pathways are CCR5 Pathway in Macrophages and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and chemokine activity. An important paralog of this gene is CXCL9.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH04J076023 | Promoter | 0.6 | EPDnew | 750.6 | +0.0 | 19 | 0.1 | RELA L3MBTL2 MGA | CXCL10 ART3 | |
GH04J076024 | Promoter | 0.6 | Ensembl | 750.6 | -0.2 | -165 | 0.2 | RELA L3MBTL2 MGA | CXCL10 ART3 lnc-CXCL10-1 RPL36P8 | |
GH04J076022 | Enhancer | 0.2 | Ensembl | 750.6 | +1.2 | 1235 | 0.2 | CXCL10 ART3 | ||
GH04J076059 | Enhancer | 1.3 | FANTOM5 Ensembl ENCODE | 32.9 | -37.1 | -37065 | 4.8 | ZBTB40 ATF1 CREB1 JUND CC2D1A NFYC ETV6 RELA DACH1 TEAD4 | ART3 CXCL10 CXCL9 NAAA CXCL11 NUP54 SDAD1 LOC101928809 KR153194-148 piR-58297-350 | |
GH04J076042 | Enhancer | 0.7 | FANTOM5 Ensembl | 58 | -18.7 | -18723 | 0.5 | JUNB JUN FOS ATF2 ZBTB33 | CXCL11 lnc-FAM47E-1 piR-39099-185 piR-33422-320 piR-58297-349 CXCL9 ART3 CXCL10 NAAA |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | TAS | 10201891 |
GO:0005125 | cytokine activity | IEA | -- |
GO:0005515 | protein binding | IPI | 18275857 |
GO:0008009 | chemokine activity | TAS,IDA | 12782716 |
GO:0008201 | heparin binding | IMP | 18645041 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS,IDA | -- |
GO:0005615 | extracellular space | IBA | 21873635 |
GO:0009897 | external side of plasma membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
|
IL-6 Pathway
.61
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
|
2 | Toll-like Receptor Signaling Pathway |
.34
|
|
3 | Peptide ligand-binding receptors | ||
4 | RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | ||
5 | Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006935 | chemotaxis | TAS,IDA | 12782716 |
GO:0006952 | defense response | IEA | -- |
GO:0006954 | inflammatory response | IBA,TAS | 21873635 |
GO:0006955 | immune response | IBA | 21873635 |
GO:0007165 | signal transduction | TAS | 10201891 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | CXCL10 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | CXCL10 33 32 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | CXCL10 33 32 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Cxcl10 17 33 32 |
|
||
rat (Rattus norvegicus) |
Mammalia | Cxcl10 32 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | CXCL10 33 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 33 |
|
OneToMany |
SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000929937 | -- | 76,023,629(-) | A/C | upstream_transcript_variant | |
rs10014837 | -- | 76,020,665(-) | G/A | downstream_transcript_variant | |
rs1002751668 | -- | 76,021,479(-) | C/A | 3_prime_UTR_variant | |
rs1003151410 | -- | 76,021,171(-) | T/C | 3_prime_UTR_variant | |
rs1003678109 | -- | 76,024,771(-) | G/A | upstream_transcript_variant |
Disorder | Aliases | PubMed IDs |
---|---|---|
endotheliitis |
|
|
neurosyphilis |
|
|
paracoccidioidomycosis |
|
|
severe acute respiratory syndrome |
|
|
sydenham chorea |
|
|