CXCL10 Gene (Protein Coding)

C-X-C Motif Chemokine Ligand 10

GC04M076021
GIFtS:
45
This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014] See more...

Aliases for CXCL10 Gene

Aliases for CXCL10 Gene

  • C-X-C Motif Chemokine Ligand 10 2 3 5
  • Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 10 2 3
  • 10 KDa Interferon Gamma-Induced Protein 3 4
  • Chemokine (C-X-C Motif) Ligand 10 2 3
  • Small-Inducible Cytokine B10 3 4
  • C-X-C Motif Chemokine 10 3 4
  • SCYB10 3 4
  • INP10 3 4
  • IP-10 3 4
  • Protein 10 From Interferon (Gamma)-Induced Cell Line 3
  • Interferon-Inducible Cytokine IP-10 3
  • Gamma IP10 3
  • Gamma-IP10 4
  • GIP-10 3
  • IFI10 3
  • Crg-2 3
  • Mob-1 3
  • C7 3

External Ids for CXCL10 Gene

Previous HGNC Symbols for CXCL10 Gene

  • INP10
  • SCYB10

Previous GeneCards Identifiers for CXCL10 Gene

  • GC04M076838
  • GC04M077132
  • GC04M077335
  • GC04M077400
  • GC04M077299
  • GC04M076942
  • GC04M072694

Summaries for CXCL10 Gene

Entrez Gene Summary for CXCL10 Gene

  • This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014]

GeneCards Summary for CXCL10 Gene

CXCL10 (C-X-C Motif Chemokine Ligand 10) is a Protein Coding gene. Diseases associated with CXCL10 include Endotheliitis and Neurosyphilis. Among its related pathways are CCR5 Pathway in Macrophages and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and chemokine activity. An important paralog of this gene is CXCL9.

UniProtKB/Swiss-Prot Summary for CXCL10 Gene

  • Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (PubMed:7540647, PubMed:11157474, PubMed:22652417). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization (PubMed:12750173, PubMed:19151743). In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (PubMed:12750173, PubMed:12663757). Activation of the CXCL10/CXCR3 axis plays also an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity).

Gene Wiki entry for CXCL10 Gene

Additional gene information for CXCL10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CXCL10 Gene

Genomics for CXCL10 Gene

GeneHancer (GH) Regulatory Elements for CXCL10 Gene

Promoters and enhancers for CXCL10 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH04J076023 Promoter 0.6 EPDnew 750.6 +0.0 19 0.1 RELA L3MBTL2 MGA CXCL10 ART3
GH04J076024 Promoter 0.6 Ensembl 750.6 -0.2 -165 0.2 RELA L3MBTL2 MGA CXCL10 ART3 lnc-CXCL10-1 RPL36P8
GH04J076022 Enhancer 0.2 Ensembl 750.6 +1.2 1235 0.2 CXCL10 ART3
GH04J076059 Enhancer 1.3 FANTOM5 Ensembl ENCODE 32.9 -37.1 -37065 4.8 ZBTB40 ATF1 CREB1 JUND CC2D1A NFYC ETV6 RELA DACH1 TEAD4 ART3 CXCL10 CXCL9 NAAA CXCL11 NUP54 SDAD1 LOC101928809 KR153194-148 piR-58297-350
GH04J076042 Enhancer 0.7 FANTOM5 Ensembl 58 -18.7 -18723 0.5 JUNB JUN FOS ATF2 ZBTB33 CXCL11 lnc-FAM47E-1 piR-39099-185 piR-33422-320 piR-58297-349 CXCL9 ART3 CXCL10 NAAA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CXCL10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CXCL10 gene promoter:
  • AML1a
  • STAT3

Genomic Locations for CXCL10 Gene

Genomic Locations for CXCL10 Gene
chr4:76,021,116-76,023,536
(GRCh38/hg38)
Size:
2,421 bases
Orientation:
Minus strand
chr4:76,942,269-76,944,689
(GRCh37/hg19)
Size:
2,421 bases
Orientation:
Minus strand

Genomic View for CXCL10 Gene

Genes around CXCL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCL10 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CXCL10 Gene

Proteins for CXCL10 Gene

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  • Protein details for CXCL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02778-CXL10_HUMAN
    Recommended name:
    C-X-C motif chemokine 10
    Protein Accession:
    P02778
    Secondary Accessions:
    • Q96QJ5

    Protein attributes for CXCL10 Gene

    Size:
    98 amino acids
    Molecular mass:
    10881 Da
    Quaternary structure:
    • Monomer, dimer, and tetramer (PubMed:12737818). Interacts with CXCR3 (via N-terminus) (PubMed:19151743).

    Three dimensional structures from OCA and Proteopedia for CXCL10 Gene

neXtProt entry for CXCL10 Gene

Protein Expression for CXCL10 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CXCL10 Gene

  • Several proteases can mediate post-secretion cleavages. DPP4 cleaves CXCL10 on its N-terminal 2 amino acids leading to an antagonist form of CXCL10. This dominant negative form is capable of binding CXCR3 but does not induce signaling. MMP9 cleaves 9 amino acids instead.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CXCL10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CXCL10
  • Santa Cruz Biotechnology (SCBT) Antibodies for CXCL10

Protein Products

  • Abcam proteins for CXCL10

No data available for DME Specific Peptides for CXCL10 Gene

Domains & Families for CXCL10 Gene

Gene Families for CXCL10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for CXCL10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CXCL10 Gene

GenScript: Design optimal peptide antigens:
  • Small-inducible cytokine B10 (CXL10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P02778

UniProtKB/Swiss-Prot:

CXL10_HUMAN :
  • Belongs to the intercrine alpha (chemokine CxC) family.
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL10: view

Function for CXCL10 Gene

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  2. CRISPR
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Molecular function for CXCL10 Gene

UniProtKB/Swiss-Prot Function:
Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (PubMed:7540647, PubMed:11157474, PubMed:22652417). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization (PubMed:12750173, PubMed:19151743). In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (PubMed:12750173, PubMed:12663757). Activation of the CXCL10/CXCR3 axis plays also an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity).
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma. A diverse population of cell types rapidly increases transcription of mRNA encoding this protein. This suggests that gamma-induced protein may be a key mediator of the IFNG/IFN-gamma response.

Phenotypes From GWAS Catalog for CXCL10 Gene

Gene Ontology (GO) - Molecular Function for CXCL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS 10201891
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 18275857
GO:0008009 chemokine activity TAS,IDA 12782716
GO:0008201 heparin binding IMP 18645041
genes like me logo Genes that share ontologies with CXCL10: view
genes like me logo Genes that share phenotypes with CXCL10: view

Animal Models for CXCL10 Gene

MGI Knock Outs for CXCL10:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CXCL10 Gene

Localization for CXCL10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXCL10 gene
Compartment Confidence
extracellular 5
plasma membrane 3
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CXCL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IDA --
GO:0005615 extracellular space IBA 21873635
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with CXCL10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CXCL10 Gene

Pathways & Interactions for CXCL10 Gene

genes like me logo Genes that share pathways with CXCL10: view

Pathways by source for CXCL10 Gene

1 GeneGo (Thomson Reuters) pathway for CXCL10 Gene
17 Qiagen pathways for CXCL10 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Chemokine Signaling
  • Endothelin-1 Signaling Pathway
1 Cell Signaling Technology pathway for CXCL10 Gene

Gene Ontology (GO) - Biological Process for CXCL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis TAS,IDA 12782716
GO:0006952 defense response IEA --
GO:0006954 inflammatory response IBA,TAS 21873635
GO:0006955 immune response IBA 21873635
GO:0007165 signal transduction TAS 10201891
genes like me logo Genes that share ontologies with CXCL10: view

No data available for SIGNOR curated interactions for CXCL10 Gene

Drugs & Compounds for CXCL10 Gene

Products:

  1. Drug

(38) Drugs for CXCL10 Gene - From: DrugBank, PharmGKB, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clove oil Approved Nutra Target 0
Peginterferon alfa-2a Approved, Investigational Pharma 588
Peginterferon alfa-2b Approved Pharma 320
N-Methylleucine Experimental Pharma Target 0
Eldelumab Investigational Pharma Target 0

(24) Additional Compounds for CXCL10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CXCL10: view

Transcripts for CXCL10 Gene

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mRNA/cDNA for CXCL10 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(90) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL10 Gene

No ASD Table

Relevant External Links for CXCL10 Gene

GeneLoc Exon Structure for
CXCL10
ECgene alternative splicing isoforms for
CXCL10

Expression for CXCL10 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXCL10 Gene

mRNA expression in normal human tissues for CXCL10 Gene
mRNA expression by GTEx for CXCL10 GenemRNA expression by BioGPS for CXCL10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXCL10 Gene

This gene is overexpressed in Brain - Substantia nigra (x10.4), Cervix - Ectocervix (x4.4), and Lung (x4.0).

Protein differential expression in normal tissues from HIPED for CXCL10 Gene

This gene is overexpressed in Ovary (60.4) and Placenta (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CXCL10 Gene



Protein tissue co-expression partners for CXCL10 Gene

NURSA nuclear receptor signaling pathways regulating expression of CXCL10 Gene:

CXCL10

SOURCE GeneReport for Unigene cluster for CXCL10 Gene:

Hs.632586

mRNA Expression by UniProt/SwissProt for CXCL10 Gene:

P02778-CXL10_HUMAN
Tissue specificity: Mainly secreted by monocytes, endothelial cells as well as fibroblasts. Expressed by epithelial cells in thymus (PubMed:11157474). Microglial cells produce CXCL10 in response to viral stimulation (PubMed:12663757).

Evidence on tissue expression from TISSUES for CXCL10 Gene

  • Skin(4.5)
  • Blood(3.3)
  • Lymph node(3.3)
  • Lung(3.1)
  • Spleen(3.1)
  • Intestine(3)
  • Liver(2.7)
  • Nervous system(2.6)
  • Heart(2.3)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with CXCL10: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCL10 Gene

Orthologs for CXCL10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CXCL10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CXCL10 33 32
  • 98.96 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia CXCL10 33 32
  • 86.05 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia CXCL10 33 32
  • 85.07 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Cxcl10 17 33 32
  • 74.49 (n)
rat
(Rattus norvegicus)
 Mammalia Cxcl10 32
  • 74.15 (n)
oppossum
(Monodelphis domestica)
 Mammalia CXCL10 33
  • 44 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 33
  • 36 (a)
 OneToMany
Species where no ortholog for CXCL10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL10 Gene

ENSEMBL:
Gene Tree for CXCL10 (if available)
TreeFam:
Gene Tree for CXCL10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CXCL10: view image

Paralogs for CXCL10 Gene

Paralogs for CXCL10 Gene

(12) SIMAP similar genes for CXCL10 Gene using alignment to 1 proteins:

  • CXL10_HUMAN
genes like me logo Genes that share paralogs with CXCL10: view

Variants for CXCL10 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for CXCL10 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000929937 -- 76,023,629(-) A/C upstream_transcript_variant
rs10014837 -- 76,020,665(-) G/A downstream_transcript_variant
rs1002751668 -- 76,021,479(-) C/A 3_prime_UTR_variant
rs1003151410 -- 76,021,171(-) T/C 3_prime_UTR_variant
rs1003678109 -- 76,024,771(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CXCL10 Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER inversion 18451855

Variation tolerance for CXCL10 Gene

Residual Variation Intolerance Score: 77.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXCL10 Gene

Human Gene Mutation Database (HGMD)
CXCL10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXCL10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL10 Gene

Disorders for CXCL10 Gene

MalaCards: The human disease database

(68) MalaCards diseases for CXCL10 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
endotheliitis
neurosyphilis
paracoccidioidomycosis
  • mucocutaneous-lymphangitic paracoccidioidomycosis
severe acute respiratory syndrome
  • sars
sydenham chorea
  • saint vitus dance
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CXCL10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CXCL10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL10 Gene

Publications for CXCL10 Gene

  1. Genetic association between a chemokine gene CXCL-10 (IP-10, interferon gamma inducible protein 10) and susceptibility to tuberculosis. (PMID: 19523460) Tang NL … Chan CY (Clinica chimica acta; international journal of clinical chemistry 2009) 3 23 43 56
  2. Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation. (PMID: 18645041) Loos T … Proost P (Blood 2008) 3 4 23 56
  3. CXCL10 production from cytomegalovirus-stimulated microglia is regulated by both human and viral interleukin-10. (PMID: 12663757) Cheeran MC … Lokensgard JR (Journal of virology 2003) 3 4 23 56
  4. The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions. (PMID: 12173928) Booth V … Sykes BD (Biochemistry 2002) 3 4 23 56
  5. Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. (PMID: 3925348) Luster AD … Ravetch JV (Nature 1985) 2 3 4 56

ExternalLinks

View latest publications for CXCL10 gene in Mastermind

Products for CXCL10 Gene

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