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This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014]
CXCL10 (C-X-C Motif Chemokine Ligand 10) is a Protein Coding gene. Diseases associated with CXCL10 include Hepatitis C and Endotheliitis. Among its related pathways are Signaling by GPCR and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and chemokine activity. An important paralog of this gene is CXCL9.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH04J076024 | Promoter | 0.6 | Ensembl | 600.7 | -0.2 | -204 | 0.2 | RELA MGA L3MBTL2 | CXCL10 RPL36P8 ART3 lnc-CXCL10-1 CXCL11 | |
GH04J076023 | Promoter | 0.6 | EPDnew | 600.7 | 0.0 | -20 | 0.1 | RELA MGA L3MBTL2 | CXCL10 RPL36P8 ART3 lnc-CXCL10-1 CXCL11 | |
GH04J076022 | Enhancer | 0.3 | Ensembl | 600.7 | +1.2 | 1196 | 0.2 | HMBOX1 | CXCL10 ART3 | |
GH04J076059 | Enhancer | 1.3 | FANTOM5 Ensembl ENCODE | 32.9 | -37.1 | -37104 | 4.8 | GATAD2A ZNF512 LEF1 JUND GABPA RELA PKNOX1 RXRB NR2C1 IKZF2 | ART3 CXCL10 CXCL9 NAAA CXCL11 NUP54 SDAD1 SDAD1-AS1 KR153194-147 piR-58297-350 | |
GH04J076042 | Enhancer | 0.6 | FANTOM5 Ensembl | 58 | -18.8 | -18762 | 0.5 | JUNB ATF2 JUN FOS ZBTB33 | CXCL11 piR-33422-320 lnc-FAM47E-1 piR-39099-185 piR-58297-349 CXCL9 ART3 CXCL10 NAAA NUP54 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | TAS | 10201891 |
GO:0005125 | cytokine activity | IEA | -- |
GO:0005515 | protein binding | IPI | 18275857 |
GO:0008009 | chemokine activity | TAS,IDA | 12782716 |
GO:0008201 | heparin binding | IMP | 18645041 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IDA,TAS | -- |
GO:0005615 | extracellular space | IBA | 21873635 |
GO:0005623 | cell | IEA | -- |
GO:0009897 | external side of plasma membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
|
IL-6 Pathway
.61
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
|
2 | Toll-like Receptor Signaling Pathway |
.34
|
|
3 | Peptide ligand-binding receptors | ||
4 | Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions | ||
5 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
|
Molecular Mechanisms of Cancer
.51
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002690 | positive regulation of leukocyte chemotaxis | IEA | -- |
GO:0006935 | chemotaxis | TAS,IDA | 12782716 |
GO:0006952 | defense response | IEA | -- |
GO:0006954 | inflammatory response | TAS,IBA | 21873635 |
GO:0006955 | immune response | IBA | 21873635 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CXCL10 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CXCL10 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CXCL10 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cxcl10 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cxcl10 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | CXCL10 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
hepatitis c |
|
|
endotheliitis |
|
|
viral encephalitis |
|
|
avian influenza |
|
|
paracoccidioidomycosis |
|