Aliases for CXCL10 Gene
Aliases for CXCL10 Gene
- C-X-C Motif Chemokine Ligand 10 2 3 5
- Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 10 2 3
- 10 KDa Interferon Gamma-Induced Protein 3 4
- Chemokine (C-X-C Motif) Ligand 10 2 3
- Small-Inducible Cytokine B10 3 4
- SCYB10 3 4
- INP10 3 4
- IP-10 3 4
- Protein 10 From Interferon (Gamma)-Induced Cell Line 3
- Interferon-Inducible Cytokine IP-10 3
External Ids for CXCL10 Gene
- HGNC: 10637
- Entrez Gene: 3627
- Ensembl: ENSG00000169245
- OMIM: 147310
- UniProtKB: P02778
Previous HGNC Symbols for CXCL10 Gene
- INP10
- SCYB10
Previous GeneCards Identifiers for CXCL10 Gene
- GC04M076838
- GC04M077132
- GC04M077335
- GC04M077400
- GC04M077299
- GC04M076942
- GC04M072694
Summaries for CXCL10 Gene
-
This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014]
GeneCards Summary for CXCL10 Gene
CXCL10 (C-X-C Motif Chemokine Ligand 10) is a Protein Coding gene. Diseases associated with CXCL10 include Endotheliitis and Neurosyphilis. Among its related pathways are Akt Signaling and CXCR3-mediated signaling events. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and chemokine activity. An important paralog of this gene is CXCL9.
UniProtKB/Swiss-Prot for CXCL10 Gene
-
Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.
Additional gene information for CXCL10 Gene
- Monarch Initiative
- Search for CXCL10 at DataMed
- Search for CXCL10 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL10 Gene
Genomics for CXCL10 Gene
GeneHancer (GH) Regulatory Elements for CXCL10 Gene
Promoters and enhancers for CXCL10 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH04J076023 | Promoter/Enhancer | 1 | EPDnew Ensembl | 650.7 | -0.2 | -165 | 0.6 | L3MBTL2 ATF2 MGA RELA | CXCL10 GC04M075923 ART3 | |
| GH04J076059 | Enhancer | 0.9 | FANTOM5 ENCODE | 32.8 | -36.4 | -36439 | 1.2 | SP1 ZGPAT ZNF512 CREB1 HNF4A ZNF384 ZBTB40 SPI1 NR2C2 | ART3 CXCL10 CXCL9 NAAA CXCL11 SDAD1 LOC101928809 GC04P076101 | |
| GH04J076042 | Enhancer | 0.5 | FANTOM5 | 58 | -18.9 | -18898 | 0.2 | JUN JUNB FOS ATF2 | CXCL11 CXCL9 CXCL10 NAAA ART3 GC04P076101 | |
| GH04J076027 | Enhancer | 1.1 | FANTOM5 Ensembl ENCODE | 20 | -4.9 | -4898 | 1.1 | MEIS2 NFIC STAT1 NFIA NFIB SOX6 YY1 | ART3 CXCL9 CXCL10 CXCL11 SDAD1 NAAA GC04M075923 RPL36P8 | |
| GH04J076089 | Enhancer | 1.4 | FANTOM5 Ensembl ENCODE | 12.5 | -66.8 | -66795 | 2.1 | PKNOX1 SMAD1 ATF1 ARNT BRCA1 TCF12 ZNF766 GATA2 FOS ATF7 | NUP54 CXCL10 CXCL9 SDAD1 ART3 NAAA CXCL11 GC04P076101 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CXCL10 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CXCL10 gene promoter:
-
- STAT3
- AML1a
Regulatory Element Products
Genomic Locations for CXCL10 Gene
Genomic Locations for CXCL10 Gene
- chr4:76,021,116-76,023,536
- (GRCh38/hg38)
- Size:
- 2,421 bases
- Orientation:
- Minus strand
- chr4:76,942,269-76,944,689
- (GRCh37/hg19)
- Size:
- 2,421 bases
- Orientation:
- Minus strand
Genomic View for CXCL10 Gene
Genes around CXCL10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q21.1 by Entrez Gene
- 4q21.1 by HGNC
- 4q21.1 by Ensembl
CXCL10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CXCL10 Gene
Proteins for CXCL10 Gene
-
Protein details for CXCL10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P02778-CXL10_HUMAN
- Recommended name:
- C-X-C motif chemokine 10
- Protein Accession:
- P02778
- Q96QJ5
Protein attributes for CXCL10 Gene
- Size:
- 98 amino acids
- Molecular mass:
- 10881 Da
- Quaternary structure:
- No Data Available
Protein Expression for CXCL10 Gene
Post-translational modifications for CXCL10 Gene
- CXCL10(1-73) is produced by proteolytic cleavage after secretion from keratinocytes.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CXCL10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CXCL10 (CXCL10/IP-10/CRG-2)
-
Custom Antibody ServicesOriGene Antibodies for CXCL10
- Novus Biologicals Antibodies for CXCL10
- Invitrogen Antibodies for CXCL10
- GeneTex CXCL10 Antibody for CXCL10
-
Santa Cruz Biotechnology (SCBT) Antibodies for CXCL10
- Sino Biological Antibodies for CXCL10
Protein Products
- R&D Systems Proteins and Enzymes for CXCL10 (CXCL10/IP-10/CRG-2)
- Search Origene for MassSpec and Protein Over-expression Lysates for CXCL10
- Origene Custom Protein Services for CXCL10
- Sino Biological Recombinant Proteins for CXCL10
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for CXCL10
- GeneTex Proteins for CXCL10
Assay Products
- R&D Systems ELISAs, ELISpot and FluoroSpot Kits, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for CXCL10 (CXCL10/IP-10/CRG-2)
- Novus Biologicals ELISA Kits for CXCL10
No data available for DME Specific Peptides for CXCL10 Gene
Domains & Families for CXCL10 Gene
Gene Families for CXCL10 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for CXCL10 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CXCL10 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P02778- Family:
-
- Belongs to the intercrine alpha (chemokine CxC) family.
Function for CXCL10 Gene
Molecular function for CXCL10 Gene
- UniProtKB/Swiss-Prot Function:
- Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.
- UniProtKB/Swiss-Prot Induction:
- By IFNG/IFN-gamma. A diverse population of cell types rapidly increases transcription of mRNA encoding this protein. This suggests that gamma-induced protein may be a key mediator of the IFNG/IFN-gamma response.
Phenotypes From GWAS Catalog for CXCL10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | TAS | 10201891 |
| GO:0005125 | cytokine activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 18275857 |
| GO:0008009 | chemokine activity | TAS,IDA | 12782716 |
| GO:0008201 | heparin binding | IMP | 18645041 |
Phenotypes for CXCL10 Gene
- MGI mutant phenotypes for CXCL10:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CXCL10:
Animal Models for CXCL10 Gene
- MGI Knock Outs for CXCL10:
-
- Cxcl10 Cxcl10<tm1Adl>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CXCL10
-
CRISPR Products
-
OriGene CRISPR knockouts for CXCL10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CXCL10
- genomics-online: gRNA clones - Search results for 128 available CXCL10 gene related products
- Overview of 128 available CXCL10 gene related products
- Applied Biological Materials CRISPR for CXCL10
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CXCL10
- GenScript: Design CRISPR guide RNA sequences for CXCL10
miRNA for CXCL10 Gene
- miRTarBase miRNAs that target CXCL10
-
- hsa-mir-21-5p (MIRT438112)
- hsa-mir-6864-3p (MIRT540499)
- hsa-mir-3672 (MIRT540500)
- hsa-mir-6888-3p (MIRT540501)
- hsa-mir-550a-3p (MIRT540502)
- hsa-mir-200c-5p (MIRT540503)
- hsa-mir-196a-3p (MIRT540504)
- hsa-mir-661 (MIRT540505)
- hsa-mir-873-3p (MIRT540506)
- hsa-mir-4522 (MIRT540507)
- hsa-mir-302a-5p (MIRT540508)
- hsa-mir-3120-5p (MIRT540509)
- hsa-mir-6860 (MIRT540510)
- hsa-mir-612 (MIRT540511)
- hsa-mir-5189-5p (MIRT540512)
- hsa-mir-3187-5p (MIRT540513)
- hsa-mir-1285-3p (MIRT540514)
- hsa-mir-939-3p (MIRT540515)
- hsa-mir-6849-3p (MIRT540516)
- hsa-mir-3065-5p (MIRT540517)
- hsa-mir-520h (MIRT540518)
- hsa-mir-520g-3p (MIRT540519)
- hsa-mir-3664-5p (MIRT540520)
- hsa-mir-548ah-5p (MIRT540521)
- hsa-mir-3609 (MIRT540522)
- hsa-mir-1231 (MIRT659955)
- hsa-mir-632 (MIRT659956)
- hsa-mir-4288 (MIRT659957)
- hsa-mir-767-5p (MIRT659958)
- hsa-mir-1226-3p (MIRT659959)
- hsa-mir-15a-5p (MIRT731341)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CXCL10
- Browse OriGene Inhibitory RNA Products For CXCL10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXCL10
- genomics-online: shRNA clones - Search results for 128 available CXCL10 gene related products
- Overview of 128 available CXCL10 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CXCL10
- VectorBuilder custom plasmid, inducible vectors for CXCL10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CXCL10
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CXCL10
- Applied Biological Materials Clones for CXCL10
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CXCL10
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CXCL10 Gene
Localization for CXCL10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CXCL10 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 3 |
| cytoskeleton | 2 |
| nucleus | 2 |
| cytosol | 2 |
| lysosome | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IDA,TAS | -- |
| GO:0005615 | extracellular space | IBA | -- |
| GO:0009897 | external side of plasma membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CXCL10 Gene
Pathways & Interactions for CXCL10 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
.61
.47
|
|
| 2 | Peptide ligand-binding receptors | ||
| 3 | RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | ||
| 4 | Toll-like Receptor Signaling Pathway | ||
| 5 | ERK Signaling |
.61
|
|
Pathways by source for CXCL10 Gene
6 BioSystems pathways for CXCL10 Gene
12 Reactome pathways for CXCL10 Gene
8 KEGG pathways for CXCL10 Gene
1 GeneGo (Thomson Reuters) pathway for CXCL10 Gene
2 R&D Systems pathways for CXCL10 Gene
17 Qiagen pathways for CXCL10 Gene
1 Cell Signaling Technology pathway for CXCL10 Gene
Interacting Proteins for CXCL10 Gene
Selected Interacting proteins:
P02778-CXL10_HUMAN
ENSP00000305651
for CXCL10 Gene via
IID
MINT
UniProtKB
STRING
GPS-Prot Interaction Network for CXCL10
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002690 | positive regulation of leukocyte chemotaxis | IBA | -- |
| GO:0006935 | chemotaxis | TAS,IDA | 12782716 |
| GO:0006952 | defense response | IEA | -- |
| GO:0006954 | inflammatory response | IBA,TAS | -- |
| GO:0006955 | immune response | IBA | -- |
No data available for SIGNOR curated interactions for CXCL10 Gene
Drugs & Compounds for CXCL10 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for CXCL10 Gene
mRNA/cDNA for CXCL10 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (90) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000306602 1176 bps (uc003hjl.5)
Unigene Clusters for CXCL10 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CXCL10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CXCL10
- genomics-online: gRNA clones - Search results for 128 available CXCL10 gene related products
- Overview of 128 available CXCL10 gene related products
- Applied Biological Materials CRISPR for CXCL10
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CXCL10
- GenScript: Design CRISPR guide RNA sequences for CXCL10
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CXCL10
- Browse OriGene Inhibitory RNA Products For CXCL10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXCL10
- genomics-online: shRNA clones - Search results for 128 available CXCL10 gene related products
- Overview of 128 available CXCL10 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CXCL10
- VectorBuilder custom plasmid, inducible vectors for CXCL10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CXCL10
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CXCL10
- Applied Biological Materials Clones for CXCL10
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for CXCL10 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Adipose (Muscoskeletal System)
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
-
Testis (Reproductive System)
- Sertoli cells Seminiferous Tubules
-
Peripheral Nervous System (Nervous System)
- Schwann Precursor Cells Peripheral Nerve Domain
-
Brain (Nervous System)
- Adult Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Adult Endothelial Cells Blood Brain Barrier
-
Pancreas (Endocrine System)
- Duct Cells Pancreatic Ducts
-
Epithelial Cells
- Duct Cells Pancreatic Ducts
- Thymus (Hematopoietic System)
- Epiblast (Early Embryonic Tissues)
-
Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for CXCL10 Gene
This gene is overexpressed in Brain - Substantia nigra (x10.4), Cervix - Ectocervix (x4.4), and Lung (x4.0).
This gene is overexpressed in Ovary (60.4) and Placenta (8.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CXCL10 Gene
NURSA nuclear receptor signaling pathways regulating expression of CXCL10 Gene:
CXCL10SOURCE GeneReport for Unigene cluster for CXCL10 Gene:
Hs.632586Evidence on tissue expression from TISSUES for CXCL10 Gene
- Skin(4.5)
- Blood(3.3)
- Lymph node(3.3)
- Lung(3.1)
- Spleen(3.1)
- Intestine(3)
- Liver(2.7)
- Nervous system(2.6)
- Heart(2.3)
- Kidney(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for CXCL10
-
OriGene qPCR primer pairs for CXCL10
- genomics-online: primer clones - Search results for 128 available CXCL10 gene related products
- Overview of 128 available CXCL10 gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCL10 Gene
Orthologs for CXCL10 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CXCL10 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CXCL10 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CXCL10 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Cxcl10 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cxcl10 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CXCL10 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany |
- Species where no ortholog for CXCL10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for CXCL10 Gene
- ENSEMBL:
- Gene Tree for CXCL10 (if available)
- TreeFam:
- Gene Tree for CXCL10 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CXCL10: view image
Paralogs for CXCL10 Gene
Variants for CXCL10 Gene
| SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000929937 | -- | 76,023,629(-) | A/C | upstream_transcript_variant | |
| rs10014837 | -- | 76,020,665(-) | G/A | downstream_transcript_variant | |
| rs1002751668 | -- | 76,021,479(-) | C/A | 3_prime_UTR_variant | |
| rs1003151410 | -- | 76,021,171(-) | T/C | 3_prime_UTR_variant | |
| rs1003678109 | -- | 76,024,771(-) | G/A | upstream_transcript_variant |
Residual Variation Intolerance Score:
77.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.66;
14.09% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CXCL10 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL10 Gene
Disorders for CXCL10 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| endotheliitis |
|
|
| neurosyphilis |
|
|
| paracoccidioidomycosis |
|
|
| severe acute respiratory syndrome |
|
|
| avian influenza |
|
|
Search CXCL10 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CXCL10
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL10 Gene
Publications for CXCL10 Gene
- Genetic association between a chemokine gene CXCL-10 (IP-10, interferon gamma inducible protein 10) and susceptibility to tuberculosis. (PMID: 19523460) Tang NL … Chan CY (Clinica chimica acta; international journal of clinical chemistry 2009) 3 22 44 58
- Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation. (PMID: 18645041) Loos T … Proost P (Blood 2008) 3 4 22 58
- The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions. (PMID: 12173928) Booth V … Sykes BD (Biochemistry 2002) 3 4 22 58
- Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. (PMID: 3925348) Luster AD … Ravetch JV (Nature 1985) 2 3 4 58
- CXCL10 production by human monocytes in response to Leishmania braziliensis infection. (PMID: 19901067) Vargas-Inchaustegui DA … Soong L (Infection and immunity 2010) 3 22 58
Products for CXCL10 Gene
- R&D Systems Antibodies for CXCL10 (CXCL10/IP-10/CRG-2)
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- Custom Antibody ServicesOriGene Antibodies for CXCL10
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- Search Origene for MassSpec and Protein Over-expression Lysates for CXCL10
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- OriGene qPCR primer pairs and template standards for CXCL10
- OriGene qPCR primer pairs for CXCL10
- OriGene CRISPR knockouts for CXCL10
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- GenScript: Design CRISPR guide RNA sequences for CXCL10
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- Gene Mutant Library, Variants up to 10^11
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CXCL10
- Novus Biologicals proteins and lysates for CXCL10
- Novus Biologicals ELISA Kits for CXCL10
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- ProSpec Recombinant Proteins for CXCL10
- VectorBuilder custom plasmid, inducible vectors for CXCL10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CXCL10
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 341 available CXCL10 Antibodies ranked by validation data
- Compare Top CXCL10 Antibodies
- antibodies-online: Search results for 122 available CXCL10 Elisa Kits ranked by validation data
- Compare Top CXCL10 Elisa Kits
- antibodies-online: Search results for 92 available CXCL10 Proteins ranked by validation data
- Compare Top CXCL10 Proteins
- GeneTex CXCL10 Antibody for CXCL10
- GeneTex Proteins for CXCL10
- Santa Cruz Biotechnology (SCBT) Antibodies for CXCL10
- Search Santa Cruz Biotechnology (SCBT) for CXCL10 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CXCL10
- Horizon Cell Lines for CXCL10
- genomics-online: cdna clones - Search results for 128 available CXCL10 gene related products
- Overview of 128 available CXCL10 gene related products
- orf clones - Search results for 128 available CXCL10 gene related products
- Overview of 128 available CXCL10 gene related products
- genomics-online: gRNA clones - Search results for 128 available CXCL10 gene related products
- Overview of 128 available CXCL10 gene related products
- genomics-online: primer clones - Search results for 128 available CXCL10 gene related products
- Overview of 128 available CXCL10 gene related products
- genomics-online: shRNA clones - Search results for 128 available CXCL10 gene related products
- Overview of 128 available CXCL10 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CXCL10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CXCL10
- GeneCopoeia miRNA 3'UTR Target clone products for CXCL10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXCL10
Sources for CXCL10 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt