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Aliases for CXCL1 Gene

Aliases for CXCL1 Gene

  • C-X-C Motif Chemokine Ligand 1 2 3 5
  • Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha) 2 3
  • GRO1 Oncogene (Melanoma Growth Stimulating Activity, Alpha) 2 3
  • Melanoma Growth Stimulating Activity, Alpha 2 3
  • Neutrophil-Activating Protein 3 3 4
  • Fibroblast Secretory Protein 2 3
  • C-X-C Motif Chemokine 1 3 4
  • GRO-Alpha(1-73) 3 4
  • NAP-3 3 4
  • SCYB1 3 4
  • GROa 3 4
  • GRO1 3 4
  • MGSA 3 4
  • GRO1 Oncogene (Melanoma Growth-Stimulating Activity) 3
  • Melanoma Growth Stimulatory Activity Alpha 3
  • Melanoma Growth Stimulatory Activity 4
  • Growth-Regulated Alpha Protein 3
  • MGSA Alpha 3
  • MGSA-A 3
  • FSP 3
  • GRO 4

External Ids for CXCL1 Gene

Previous HGNC Symbols for CXCL1 Gene

  • MGSA
  • GRO1
  • FSP

Previous GeneCards Identifiers for CXCL1 Gene

  • GC04P074724
  • GC04P074974
  • GC04P075135
  • GC04P075201
  • GC04P075100
  • GC04P070546

Summaries for CXCL1 Gene

Entrez Gene Summary for CXCL1 Gene

  • This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014]

GeneCards Summary for CXCL1 Gene

CXCL1 (C-X-C Motif Chemokine Ligand 1) is a Protein Coding gene. Diseases associated with CXCL1 include Kaposi Sarcoma and Melanoma. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include receptor binding and chemokine activity. An important paralog of this gene is CXCL2.

UniProtKB/Swiss-Prot for CXCL1 Gene

  • Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.

Gene Wiki entry for CXCL1 Gene

Additional gene information for CXCL1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL1 Gene

Genomics for CXCL1 Gene

GeneHancer (GH) Regulatory Elements for CXCL1 Gene

Promoters and enhancers for CXCL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I073867 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +0.1 87 3.2 PKNOX1 RB1 RAD21 ZNF335 GLIS2 SCRT2 SP3 CEBPB REST ZEB2 CXCL1 PF4V1 PF4 HNRNPA1P55
GH04I073702 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 2 -164.7 -164694 3.8 PKNOX1 ATF1 ARNT FEZF1 YY1 TCF12 POLR2B ZNF766 E2F8 FOS CXCL8 CXCL2 CXCL3 ANKRD17 HMGA1P2 PF4V1 LOC105377272 CXCL5 MTHFD2L CXCL1
GH04I073730 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 1.8 -136.0 -135982 5.2 HDAC1 ATF1 PKNOX1 SMAD1 BMI1 BATF KLF5 IRF4 ZBTB40 ZNF766 CXCL8 CXCL2 CXCL3 PF4V1 MTHFD2L ANKRD17 CXCL1 LOC105377272
GH04I074107 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 1.8 +243.5 243522 10.3 SIN3A BMI1 RFX5 YY1 SCRT2 FOS ZNF680 CEBPB REST NR2F2 MTHFD2L CXCL2 EREG CXCL8 CXCL3 CXCL1 AREG LOC105377277
GH04I073915 Enhancer 1.1 FANTOM5 Ensembl ENCODE 2.4 +47.9 47904 2.9 ZNF449 CEBPB EP300 ZIC2 SP1 ZFHX2 JUND ATF4 FOS FOSL2 CXCL3 CXCL8 EREG PF4 CXCL2 CXCL1 MTHFD2L HNRNPA1P55
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CXCL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CXCL1 gene promoter:

Genomic Locations for CXCL1 Gene

Genomic Locations for CXCL1 Gene
chr4:73,869,392-73,871,302
(GRCh38/hg38)
Size:
1,911 bases
Orientation:
Plus strand
chr4:74,735,109-74,736,959
(GRCh37/hg19)

Genomic View for CXCL1 Gene

Genes around CXCL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL1 Gene

Proteins for CXCL1 Gene

  • Protein details for CXCL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09341-GROA_HUMAN
    Recommended name:
    Growth-regulated alpha protein
    Protein Accession:
    P09341
    Secondary Accessions:
    • Q9UCR7

    Protein attributes for CXCL1 Gene

    Size:
    107 amino acids
    Molecular mass:
    11301 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CXCL1 Gene

neXtProt entry for CXCL1 Gene

Post-translational modifications for CXCL1 Gene

  • N-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.

Other Protein References for CXCL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CXCL1 (CXCL1/GRO alpha/KC/CINC-1)

No data available for DME Specific Peptides for CXCL1 Gene

Domains & Families for CXCL1 Gene

Gene Families for CXCL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CXCL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P09341

UniProtKB/Swiss-Prot:

GROA_HUMAN :
  • Belongs to the intercrine alpha (chemokine CxC) family.
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL1: view

Function for CXCL1 Gene

Molecular function for CXCL1 Gene

UniProtKB/Swiss-Prot Function:
Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.

Phenotypes From GWAS Catalog for CXCL1 Gene

Gene Ontology (GO) - Molecular Function for CXCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 9079638
GO:0005125 cytokine activity IEA --
GO:0008009 chemokine activity IBA,TAS --
GO:0008047 enzyme activator activity TAS 9079638
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with CXCL1: view
genes like me logo Genes that share phenotypes with CXCL1: view

Animal Model Products

CRISPR Products

miRNA for CXCL1 Gene

miRTarBase miRNAs that target CXCL1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXCL1 Gene

Localization for CXCL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXCL1 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
nucleus 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CXCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS,IBA --
GO:0035580 specific granule lumen TAS --
GO:1904724 tertiary granule lumen TAS --
genes like me logo Genes that share ontologies with CXCL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CXCL1 Gene

Pathways & Interactions for CXCL1 Gene

genes like me logo Genes that share pathways with CXCL1: view

SIGNOR curated interactions for CXCL1 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for CXCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis TAS 10820279
GO:0006952 defense response IEA --
GO:0006954 inflammatory response IBA,TAS --
GO:0006955 immune response IBA --
GO:0007165 signal transduction TAS 9725262
genes like me logo Genes that share ontologies with CXCL1: view

Drugs & Compounds for CXCL1 Gene

(22) Drugs for CXCL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(24) Additional Compounds for CXCL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CXCL1: view

Transcripts for CXCL1 Gene

mRNA/cDNA for CXCL1 Gene

Unigene Clusters for CXCL1 Gene

Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL1 Gene

No ASD Table

Relevant External Links for CXCL1 Gene

GeneLoc Exon Structure for
CXCL1
ECgene alternative splicing isoforms for
CXCL1

Expression for CXCL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXCL1 Gene

mRNA differential expression in normal tissues according to GTEx for CXCL1 Gene

This gene is overexpressed in Spleen (x12.2).

Protein differential expression in normal tissues from HIPED for CXCL1 Gene

This gene is overexpressed in Amniocyte (60.6) and Islet of Langerhans (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CXCL1 Gene



Protein tissue co-expression partners for CXCL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CXCL1 Gene:

CXCL1

SOURCE GeneReport for Unigene cluster for CXCL1 Gene:

Hs.789

Evidence on tissue expression from TISSUES for CXCL1 Gene

  • Blood(4.6)
  • Skin(4.5)
  • Lung(3.1)
  • Spleen(3.1)
  • Intestine(3)
  • Nervous system(2.9)
  • Heart(2.6)
  • Bone marrow(2.5)
  • Liver(2.5)
  • Kidney(2.3)
  • Muscle(2.3)
  • Lymph node(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with CXCL1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCL1 Gene

Orthologs for CXCL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXCL1 33 34
  • 98.75 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 81 (a)
ManyToMany
CXCL3 34
  • 78 (a)
ManyToMany
GRO1 34
  • 50 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cxcl1 34
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 58 (a)
ManyToMany
-- 34
  • 53 (a)
ManyToMany
-- 34
  • 52 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 41 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 40 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 38 (a)
OneToMany
Species where no ortholog for CXCL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL1 Gene

ENSEMBL:
Gene Tree for CXCL1 (if available)
TreeFam:
Gene Tree for CXCL1 (if available)

Paralogs for CXCL1 Gene

Paralogs for CXCL1 Gene

(13) SIMAP similar genes for CXCL1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CXCL1 Gene

genes like me logo Genes that share paralogs with CXCL1: view

Variants for CXCL1 Gene

Sequence variations from dbSNP and Humsavar for CXCL1 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1001317244 -- 73,871,314(+) C/A downstream_transcript_variant
rs1001588641 -- 73,869,158(+) G/A/T upstream_transcript_variant
rs1001871719 -- 73,870,381(+) T/C intron_variant
rs1002558056 -- 73,871,398(+) G/A downstream_transcript_variant
rs1002606331 -- 73,867,893(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CXCL1 Gene

Variant ID Type Subtype PubMed ID
nsv525980 CNV gain 19592680
nsv1001725 CNV gain 25217958

Variation tolerance for CXCL1 Gene

Residual Variation Intolerance Score: 59.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXCL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXCL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL1 Gene

Disorders for CXCL1 Gene

MalaCards: The human disease database

(19) MalaCards diseases for CXCL1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
kaposi sarcoma
  • kaposi sarcoma, susceptibility to
melanoma
  • malignant melanoma
rheumatoid arthritis
  • ra
helicobacter pylori infection
  • helicobacter pylori infection, susceptibility to
gastritis
  • acute gastric mucosal erosion
- elite association - COSMIC cancer census association via MalaCards
Search CXCL1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CXCL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CXCL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL1 Gene

Publications for CXCL1 Gene

  1. Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population. (PMID: 15843053) Tamura Y … Hohjoh H (Neuroscience letters 2005) 3 22 44 58
  2. Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms. (PMID: 10095777) Wuyts A … Van Damme J (European journal of biochemistry 1999) 3 4 22 58
  3. Identification of three related human GRO genes encoding cytokine functions. (PMID: 2217207) Haskill S … Sager R (Proceedings of the National Academy of Sciences of the United States of America 1990) 2 3 22 58
  4. Lipopolysaccharide-stimulated human monocytes secrete, apart from neutrophil-activating peptide 1/interleukin 8, a second neutrophil-activating protein. NH2-terminal amino acid sequence identity with melanoma growth stimulatory activity. (PMID: 2182761) Schröder JM … Christophers E (The Journal of experimental medicine 1990) 3 4 22 58
  5. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 44 58

Products for CXCL1 Gene

Sources for CXCL1 Gene

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