Aliases for CWC15 Gene

Aliases for CWC15 Gene

  • CWC15 Spliceosome Associated Protein Homolog 2 3 5
  • C11orf5 2 3 4
  • Spliceosome-Associated Protein CWC15 Homolog 3 4
  • CWC15 Spliceosome-Associated Protein 2 3
  • HSPC148 2 3
  • AD002 2 3
  • Cwf15 2 3
  • CWC15 Spliceosome-Associated Protein Homolog (S. Cerevisiae) 2
  • CWC15 Homolog (S. Cerevisiae) 2
  • CWC15 5
  • ORF5 3

External Ids for CWC15 Gene

Previous GeneCards Identifiers for CWC15 Gene

  • GC11M094337
  • GC11M094695
  • GC11M090760

Summaries for CWC15 Gene

GeneCards Summary for CWC15 Gene

CWC15 (CWC15 Spliceosome Associated Protein Homolog) is a Protein Coding gene. Diseases associated with CWC15 include Actinobacillosis and Microphthalmia, Syndromic 10. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot Summary for CWC15 Gene

  • Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:28076346). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.

Gene Wiki entry for CWC15 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CWC15 Gene

Genomics for CWC15 Gene

GeneHancer (GH) Regulatory Elements Pubs


GeneHancers around CWC15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CWC15

Top Transcription factor binding sites by QIAGEN in the CWC15 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • En-1
  • Nkx2-2
  • RREB-1
  • Sp1

Genomic Locations for CWC15 Gene

Latest Assembly
chr11:94,962,620-94,973,586
(GRCh38/hg38)
Size:
10,967 bases
Orientation:
Minus strand

Previous Assembly
chr11:94,695,785-94,706,720
(GRCh37/hg19 by Entrez Gene)
Size:
10,936 bases
Orientation:
Minus strand

chr11:94,695,787-94,706,776
(GRCh37/hg19 by Ensembl)
Size:
10,990 bases
Orientation:
Minus strand

Genomic View for CWC15 Gene

Genes around CWC15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CWC15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CWC15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CWC15 Gene

Proteins for CWC15 Gene

  • Protein details for CWC15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P013-CWC15_HUMAN
    Recommended name:
    Spliceosome-associated protein CWC15 homolog
    Protein Accession:
    Q9P013
    Secondary Accessions:
    • B2RC17
    • Q05BV9
    • Q05DM1
    • Q9UI29

    Protein attributes for CWC15 Gene

    Size:
    229 amino acids
    Molecular mass:
    26624 Da
    Quaternary structure:
    • Identified in the spliceosome C complex (PubMed:28502770, PubMed:28076346). Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8 (PubMed:20176811). Interacts directly with CTNNBL1 in the complex (PubMed:20176811).

    Three dimensional structures from OCA and Proteopedia for CWC15 Gene

neXtProt entry for CWC15 Gene

Post-translational modifications for CWC15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CWC15 Gene

No data available for DME Specific Peptides for CWC15 Gene

Domains & Families for CWC15 Gene

Gene Families for CWC15 Gene

Protein Domains for CWC15 Gene

InterPro:

Suggested Antigen Peptide Sequences for CWC15 Gene

GenScript: Design optimal peptide antigens:
  • Protein CWC15 homolog (CWC15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9P013

UniProtKB/Swiss-Prot:

CWC15_HUMAN :
  • Belongs to the CWC15 family.
Family:
  • Belongs to the CWC15 family.
genes like me logo Genes that share domains with CWC15: view

Function for CWC15 Gene

Molecular function for CWC15 Gene

UniProtKB/Swiss-Prot Function:
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:28076346). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.

Phenotypes From GWAS Catalog for CWC15 Gene

Gene Ontology (GO) - Molecular Function for CWC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA,ISS --
GO:0005515 protein binding IPI 20176811
genes like me logo Genes that share ontologies with CWC15: view
genes like me logo Genes that share phenotypes with CWC15: view

miRNA for CWC15 Gene

miRTarBase miRNAs that target CWC15

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CWC15

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CWC15 Gene

Localization for CWC15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CWC15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CWC15 gene
Compartment Confidence
nucleus 5
mitochondrion 4
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CWC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 20176811
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IDA 20176811
GO:0005739 mitochondrion IDA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with CWC15: view

Pathways & Interactions for CWC15 Gene

genes like me logo Genes that share pathways with CWC15: view

Pathways by source for CWC15 Gene

Gene Ontology (GO) - Biological Process for CWC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0045292 mRNA cis splicing, via spliceosome IBA 21873635
genes like me logo Genes that share ontologies with CWC15: view

No data available for SIGNOR curated interactions for CWC15 Gene

Drugs & Compounds for CWC15 Gene

No Compound Related Data Available

Transcripts for CWC15 Gene

mRNA/cDNA for CWC15 Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CWC15

Alternative Splicing Database (ASD) splice patterns (SP) for CWC15 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2: - - -
SP3: - -
SP4: -
SP5:

Relevant External Links for CWC15 Gene

GeneLoc Exon Structure for
CWC15

Expression for CWC15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CWC15 Gene

Protein differential expression in normal tissues from HIPED for CWC15 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.8), Breast (9.7), NK cells (6.6), and Lymph node (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CWC15 Gene



Protein tissue co-expression partners for CWC15 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CWC15

SOURCE GeneReport for Unigene cluster for CWC15 Gene:

Hs.503597

Evidence on tissue expression from TISSUES for CWC15 Gene

  • Kidney(4.3)
  • Blood(4.3)
  • Nervous system(4.2)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with CWC15: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CWC15 Gene

Orthologs for CWC15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CWC15 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CWC15 29
  • 99.71 (n)
Dog
(Canis familiaris)
Mammalia -- 30
  • 99 (a)
OneToMany
-- 30
  • 96 (a)
OneToMany
CWC15 29
  • 91.7 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 96 (a)
OneToMany
-- 30
  • 79 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 93 (a)
OneToMany
-- 30
  • 86 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia CWC15 29 30
  • 91.99 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Cwc15 29 16 30
  • 90.54 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cwc15 29
  • 90.54 (n)
Chicken
(Gallus gallus)
Aves CWC15 29 30
  • 82.97 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CWC15 30
  • 89 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cwc15 29
  • 76.95 (n)
Str.6431 29
Zebrafish
(Danio rerio)
Actinopterygii CWC15 30
  • 79 (a)
OneToOne
zgc:86607 29
  • 74.3 (n)
wufj68d08 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4317 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010594 29
  • 58.22 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta c12.1 29 30
  • 56.43 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea CELE_T10C6.5 29
  • 61.04 (n)
T10C6.5 30
  • 59 (a)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons EMB2769 29
  • 54.39 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7824 29
Soybean
(Glycine max)
eudicotyledons Gma.2337 29
Rice
(Oryza sativa)
Liliopsida Os06g0106100 29
  • 55.01 (n)
Barley
(Hordeum vulgare)
Liliopsida Hv.6306 29
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3383 30
  • 61 (a)
OneToOne
Species where no ortholog for CWC15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CWC15 Gene

ENSEMBL:
Gene Tree for CWC15 (if available)
TreeFam:
Gene Tree for CWC15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CWC15: view image
Alliance of Genome Resources:
Additional Orthologs for CWC15

Paralogs for CWC15 Gene

No data available for Paralogs for CWC15 Gene

Variants for CWC15 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CWC15 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CWC15 Gene

Variant ID Type Subtype PubMed ID
nsv446 CNV deletion 18451855

Variation tolerance for CWC15 Gene

Gene Damage Index Score: 0.10; 2.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CWC15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CWC15
Leiden Open Variation Database (LOVD)
CWC15

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CWC15 Gene

Disorders for CWC15 Gene

MalaCards: The human disease database

(9) MalaCards diseases for CWC15 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards
Search CWC15 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CWC15

genes like me logo Genes that share disorders with CWC15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CWC15 Gene

Publications for CWC15 Gene

  1. Characterization of five novel human genes in the 11q13-q22 region. (PMID: 10873569) O'Brien KP … Dumanski JP (Biochemical and biophysical research communications 2000) 2 3 4
  2. Cryo-EM structure of a human spliceosome activated for step 2 of splicing. (PMID: 28076346) Bertram K … Lührmann R (Nature 2017) 3 4
  3. Molecular architecture of the human Prp19/CDC5L complex. (PMID: 20176811) Grote M … Lührmann R (Molecular and cellular biology 2010) 3 4
  4. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney RJ … Gill M (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 40
  5. Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs. (PMID: 11884590) Ohi MD … Gould KL (Molecular and cellular biology 2002) 2 3

Products for CWC15 Gene

Sources for CWC15 Gene