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Aliases for CWC15 Gene

Aliases for CWC15 Gene

  • CWC15 Spliceosome Associated Protein Homolog 2 3 5
  • CWC15 Spliceosome-Associated Protein 2 3
  • C11orf5 3 4
  • CWC15 Spliceosome-Associated Protein Homolog (S. Cerevisiae) 2
  • Spliceosome-Associated Protein CWC15 Homolog 3
  • CWC15 Homolog (S. Cerevisiae) 2
  • HSPC148 3
  • AD002 3
  • Cwf15 3
  • ORF5 3

External Ids for CWC15 Gene

Previous GeneCards Identifiers for CWC15 Gene

  • GC11M094337
  • GC11M094695
  • GC11M090760

Summaries for CWC15 Gene

GeneCards Summary for CWC15 Gene

CWC15 (CWC15 Spliceosome Associated Protein Homolog) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for CWC15 Gene

  • Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.

Gene Wiki entry for CWC15 Gene

Additional gene information for CWC15 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CWC15 Gene

Genomics for CWC15 Gene

GeneHancer (GH) Regulatory Elements for CWC15 Gene

Promoters and enhancers for CWC15 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I094972 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 568.6 +0.3 262 2.1 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 E2F8 ZNF143 CWC15 KDM4D ANKRD49 MRE11 FAM76B GC11P094966
GH11I095066 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.6 -94.5 -94500 3.7 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SRSF8 GC11M095066 GC11P095067 ENDOD1 LOC101929295 KDM4E CWC15 KDM4D MTMR2 GC11P095083
GH11I094948 Enhancer 1 Ensembl ENCODE 20.3 +25.0 25022 1 BCOR MEIS2 ZBTB6 TEAD4 ZMYM3 FOSL1 ZNF664 ADNP ZSCAN5C SMARCA5 CWC15 ENSG00000256469 KDM4D LOC105369438 KDM4E GC11P094966
GH11I095106 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.3 -134.3 -134328 3.9 PKNOX1 ATF1 ARNT FEZF1 ZNF2 NCOA2 TCF12 POLR2B GATA2 FOS LOC101929295 CWC15 KDM4D ENDOD1 GC11M095076 GC11P095138
GH11I095095 Enhancer 1.1 Ensembl ENCODE dbSUPER 10 -122.6 -122632 1.7 PKNOX1 PAX8 BATF NFATC1 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 NR2F1 LOC101929295 ENDOD1 CWC15 KDM4D KDM4E GC11P095093 GC11M095076
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CWC15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CWC15 gene promoter:

Genomic Locations for CWC15 Gene

Genomic Locations for CWC15 Gene
10,991 bases
Minus strand

Genomic View for CWC15 Gene

Genes around CWC15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CWC15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CWC15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CWC15 Gene

Proteins for CWC15 Gene

  • Protein details for CWC15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Spliceosome-associated protein CWC15 homolog
    Protein Accession:
    Secondary Accessions:
    • B2RC17
    • Q05BV9
    • Q05DM1
    • Q9UI29

    Protein attributes for CWC15 Gene

    229 amino acids
    Molecular mass:
    26624 Da
    Quaternary structure:
    • Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly with CTNNBL1 in the complex.

    Three dimensional structures from OCA and Proteopedia for CWC15 Gene

neXtProt entry for CWC15 Gene

Post-translational modifications for CWC15 Gene

No Post-translational modifications

Other Protein References for CWC15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CWC15 Gene

Domains & Families for CWC15 Gene

Gene Families for CWC15 Gene

Protein Domains for CWC15 Gene


Suggested Antigen Peptide Sequences for CWC15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CWC15 family.
  • Belongs to the CWC15 family.
genes like me logo Genes that share domains with CWC15: view

Function for CWC15 Gene

Molecular function for CWC15 Gene

UniProtKB/Swiss-Prot Function:
Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.

Phenotypes From GWAS Catalog for CWC15 Gene

Gene Ontology (GO) - Molecular Function for CWC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding ISS --
GO:0005515 protein binding IPI 20176811
genes like me logo Genes that share ontologies with CWC15: view
genes like me logo Genes that share phenotypes with CWC15: view

Animal Model Products

miRNA for CWC15 Gene

miRTarBase miRNAs that target CWC15

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CWC15 Gene

Localization for CWC15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CWC15 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CWC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 20176811
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IEA,IDA 20176811
GO:0005739 mitochondrion IDA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with CWC15: view

No data available for Subcellular locations from COMPARTMENTS for CWC15 Gene

Pathways & Interactions for CWC15 Gene

genes like me logo Genes that share pathways with CWC15: view

Pathways by source for CWC15 Gene

Interacting Proteins for CWC15 Gene

Gene Ontology (GO) - Biological Process for CWC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with CWC15: view

No data available for SIGNOR curated interactions for CWC15 Gene

Drugs & Compounds for CWC15 Gene

No Compound Related Data Available

Transcripts for CWC15 Gene

Unigene Clusters for CWC15 Gene

CWC15 spliceosome-associated protein homolog (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CWC15 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7
SP2: - - -
SP3: - -
SP4: -

Relevant External Links for CWC15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CWC15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CWC15 Gene

Protein differential expression in normal tissues from HIPED for CWC15 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.8), Breast (9.7), NK cells (6.6), and Lymph node (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CWC15 Gene

Protein tissue co-expression partners for CWC15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CWC15 Gene:


SOURCE GeneReport for Unigene cluster for CWC15 Gene:

genes like me logo Genes that share expression patterns with CWC15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CWC15 Gene

Orthologs for CWC15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CWC15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CWC15 33
  • 99.71 (n)
(Canis familiaris)
Mammalia -- 34
  • 99 (a)
-- 34
  • 96 (a)
CWC15 33
  • 91.7 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 96 (a)
-- 34
  • 79 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 93 (a)
-- 34
  • 86 (a)
(Bos Taurus)
Mammalia CWC15 33 34
  • 91.99 (n)
(Mus musculus)
Mammalia Cwc15 33 16 34
  • 90.54 (n)
(Rattus norvegicus)
Mammalia Cwc15 33
  • 90.54 (n)
(Gallus gallus)
Aves CWC15 33 34
  • 82.97 (n)
(Anolis carolinensis)
Reptilia CWC15 34
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cwc15 33
  • 76.95 (n)
Str.6431 33
(Danio rerio)
Actinopterygii CWC15 34
  • 79 (a)
zgc:86607 33
  • 74.3 (n)
wufj68d08 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4317 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010594 33
  • 58.22 (n)
fruit fly
(Drosophila melanogaster)
Insecta c12.1 33 34
  • 56.43 (n)
(Caenorhabditis elegans)
Secernentea CELE_T10C6.5 33
  • 61.04 (n)
T10C6.5 34
  • 59 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons EMB2769 33
  • 54.39 (n)
(Glycine max)
eudicotyledons Gma.2337 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7824 33
(Oryza sativa)
Liliopsida Os06g0106100 33
  • 55.01 (n)
(Hordeum vulgare)
Liliopsida Hv.6306 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3383 34
  • 61 (a)
Species where no ortholog for CWC15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CWC15 Gene

Gene Tree for CWC15 (if available)
Gene Tree for CWC15 (if available)

Paralogs for CWC15 Gene

No data available for Paralogs for CWC15 Gene

Variants for CWC15 Gene

Sequence variations from dbSNP and Humsavar for CWC15 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000201931 -- 94,972,040(-) A/G intron_variant
rs1000547672 -- 94,965,258(-) G/A intron_variant
rs1001156033 -- 94,966,812(-) T/C intron_variant
rs1001522139 -- 94,967,174(-) C/T intron_variant
rs1001842168 -- 94,970,671(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CWC15 Gene

Variant ID Type Subtype PubMed ID
nsv446 CNV deletion 18451855

Variation tolerance for CWC15 Gene

Gene Damage Index Score: 0.10; 2.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CWC15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CWC15 Gene

Disorders for CWC15 Gene

Additional Disease Information for CWC15

No disorders were found for CWC15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CWC15 Gene

Publications for CWC15 Gene

  1. Characterization of five novel human genes in the 11q13-q22 region. (PMID: 10873569) O'Brien KP … Dumanski JP (Biochemical and biophysical research communications 2000) 2 3 4 58
  2. Molecular architecture of the human Prp19/CDC5L complex. (PMID: 20176811) Grote M … Lührmann R (Molecular and cellular biology 2010) 3 4 58
  3. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney RJ … Gill M (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 44 58
  4. Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs. (PMID: 11884590) Ohi MD … Gould KL (Molecular and cellular biology 2002) 2 3 58
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4 58

Products for CWC15 Gene

Sources for CWC15 Gene

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