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Aliases for CUZD1 Gene

Aliases for CUZD1 Gene

  • CUB And Zona Pellucida Like Domains 1 2 3 5
  • CUB And ZP Domain-Containing Protein 1 3 4
  • Transmembrane Protein UO-44 3 4
  • CUB And Zona Pellucida-Like Domain-Containing Protein 1 3
  • CUB And Zona Pellucida-Like Domains 1 2
  • Estrogen Regulated Gene 1 3
  • ITMAP1 3
  • ERG-1 3
  • UO-44 3
  • ERG1 3

External Ids for CUZD1 Gene

Previous GeneCards Identifiers for CUZD1 Gene

  • GC10M124132
  • GC10M124582
  • GC10M118209

Summaries for CUZD1 Gene

GeneCards Summary for CUZD1 Gene

CUZD1 (CUB And Zona Pellucida Like Domains 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CUZD1 Gene

  • CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes. May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic acinar cells.

Gene Wiki entry for CUZD1 Gene

Additional gene information for CUZD1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUZD1 Gene

Genomics for CUZD1 Gene

GeneHancer (GH) Regulatory Elements for CUZD1 Gene

Promoters and enhancers for CUZD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J122875 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.3 -27.2 -27210 5.7 HDGF ARID4B SIN3A YY1 POLR2B ZNF207 ZNF143 SP3 JUNB MXD4 LOC399815 FAM24B-CUZD1 FAM24B CUZD1 BUB3 PIR46723 GC10M122775
GH10J122849 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 650.7 -2.8 -2754 7.7 MEIS2 ZNF768 JUN INSM2 ZIC2 ZNF335 ZFHX2 ZNF316 POLR2A SCRT2 FAM24B CUZD1 C10orf88 LOC399815 ACADSB IKZF5 FAM24B-CUZD1 GC10M122775
GH10J122847 Promoter/Enhancer 1.2 EPDnew ENCODE dbSUPER 650.7 +2.3 2320 2.1 POLR2A SCRT2 CEBPB CBFA2T3 CUZD1 ACADSB FAM24B LOC399815 IKZF5 FAM24B-CUZD1 DMBT1P1 GC10M122775
GH10J122845 Promoter/Enhancer 1 EPDnew ENCODE 650.7 +4.4 4439 1.9 POLR2A GLIS1 ZNF143 BACH1 SIN3A CTBP2 ZIC2 CUZD1 ACADSB FAM24B LOC399815 C10orf88 IKZF5 FAM24B-CUZD1 DMBT1P1 GC10M122775
GH10J122860 Enhancer 1.3 Ensembl ENCODE dbSUPER 0.4 -12.4 -12388 5.1 HDAC1 PKNOX1 FOXA2 SIN3A THRB RARA ZEB1 TCF12 ZNF366 RCOR1 C10orf88 ACADSB CUZD1 LOC399815 FAM24B-CUZD1 FAM24B GC10M122775
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CUZD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CUZD1 gene promoter:
  • Nkx2-5
  • Evi-1
  • C/EBPbeta
  • Meis-1b
  • Meis-1
  • HOXA9B
  • HOXA9
  • AREB6
  • Cdc5
  • MZF-1

Genomic Locations for CUZD1 Gene

Genomic Locations for CUZD1 Gene
chr10:122,832,149-122,850,793
(GRCh38/hg38)
Size:
18,645 bases
Orientation:
Minus strand
chr10:124,591,665-124,639,146
(GRCh37/hg19)
Size:
47,482 bases
Orientation:
Minus strand

Genomic View for CUZD1 Gene

Genes around CUZD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CUZD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CUZD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUZD1 Gene

Proteins for CUZD1 Gene

  • Protein details for CUZD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UP6-CUZD1_HUMAN
    Recommended name:
    CUB and zona pellucida-like domain-containing protein 1
    Protein Accession:
    Q86UP6
    Secondary Accessions:
    • A8K080
    • B2RN93
    • D3DRE5
    • Q7Z660
    • Q7Z661
    • Q86SG1
    • Q86UP5
    • Q9HAR7

    Protein attributes for CUZD1 Gene

    Size:
    607 amino acids
    Molecular mass:
    68153 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG23215.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for CUZD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CUZD1 Gene

Post-translational modifications for CUZD1 Gene

  • Glycosylation at Asn419, posLast=394394, posLast=271271, Asn67, Asn57, and posLast=2929
  • Modification sites at PhosphoSitePlus

Other Protein References for CUZD1 Gene

No data available for DME Specific Peptides for CUZD1 Gene

Domains & Families for CUZD1 Gene

Gene Families for CUZD1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CUZD1 Gene

Suggested Antigen Peptide Sequences for CUZD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CUZD1: view

No data available for UniProtKB/Swiss-Prot for CUZD1 Gene

Function for CUZD1 Gene

Molecular function for CUZD1 Gene

UniProtKB/Swiss-Prot Function:
CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes. May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic acinar cells.
genes like me logo Genes that share phenotypes with CUZD1: view

Animal Models for CUZD1 Gene

MGI Knock Outs for CUZD1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CUZD1

miRNA for CUZD1 Gene

miRTarBase miRNAs that target CUZD1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CUZD1 Gene

Localization for CUZD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CUZD1 Gene

Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I membrane protein. Note=Associated with zymogen granule membranes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CUZD1 gene
Compartment Confidence
plasma membrane 3
extracellular 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CUZD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 15184879
GO:0030658 transport vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
GO:0042589 zymogen granule membrane ISS --
genes like me logo Genes that share ontologies with CUZD1: view

Pathways & Interactions for CUZD1 Gene

SuperPathways for CUZD1 Gene

No Data Available

Interacting Proteins for CUZD1 Gene

Gene Ontology (GO) - Biological Process for CUZD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006931 substrate-dependent cell migration, cell attachment to substrate NAS 15184879
GO:0007049 cell cycle IEA --
GO:0007155 cell adhesion IEA --
GO:0008283 cell proliferation NAS 15184879
GO:0032023 trypsinogen activation ISS --
genes like me logo Genes that share ontologies with CUZD1: view

No data available for Pathways by source and SIGNOR curated interactions for CUZD1 Gene

Drugs & Compounds for CUZD1 Gene

No Compound Related Data Available

Transcripts for CUZD1 Gene

mRNA/cDNA for CUZD1 Gene

Unigene Clusters for CUZD1 Gene

CUB and zona pellucida-like domains 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CUZD1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - -
SP2: - -
SP3: - - -
SP4: - -
SP5: - - -
SP6: - - - - - - -
SP7: - - - -
SP8: -
SP9:

Relevant External Links for CUZD1 Gene

GeneLoc Exon Structure for
CUZD1
ECgene alternative splicing isoforms for
CUZD1

Expression for CUZD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CUZD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CUZD1 Gene

This gene is overexpressed in Pancreas (x52.3).

Protein differential expression in normal tissues from HIPED for CUZD1 Gene

This gene is overexpressed in Pancreatic juice (43.3), Islet of Langerhans (15.9), and Pancreas (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CUZD1 Gene



Protein tissue co-expression partners for CUZD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CUZD1 Gene:

CUZD1

SOURCE GeneReport for Unigene cluster for CUZD1 Gene:

Hs.647182

mRNA Expression by UniProt/SwissProt for CUZD1 Gene:

Q86UP6-CUZD1_HUMAN
Tissue specificity: Detected in pancreas and epithelium of ovary. Expressed at higher levels in ovarian tumors than in normal tissue.

Evidence on tissue expression from TISSUES for CUZD1 Gene

  • Nervous system(4.1)
  • Pancreas(3.2)
genes like me logo Genes that share expression patterns with CUZD1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CUZD1 Gene

Orthologs for CUZD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CUZD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CUZD1 34 33
  • 99.62 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CUZD1 34 33
  • 82.73 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cuzd1 33
  • 77.92 (n)
mouse
(Mus musculus)
Mammalia Cuzd1 16 34 33
  • 77.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CUZD1 34
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CUZD1 34
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves CUZD1 34
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CUZD1 34
  • 33 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485179 33
  • 53.85 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC555768 33
  • 50.6 (n)
CUZD1 (3 of 5) 34
  • 28 (a)
OneToMany
CUZD1 (5 of 5) 34
  • 23 (a)
OneToMany
CUZD1 (1 of 5) 34
  • 23 (a)
OneToMany
CUZD1 (4 of 5) 34
  • 17 (a)
OneToMany
CUZD1 (2 of 5) 34
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 13 (a)
OneToOne
Species where no ortholog for CUZD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CUZD1 Gene

ENSEMBL:
Gene Tree for CUZD1 (if available)
TreeFam:
Gene Tree for CUZD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CUZD1: view image

Paralogs for CUZD1 Gene

(1) SIMAP similar genes for CUZD1 Gene using alignment to 1 proteins:

  • CUZD1_HUMAN
genes like me logo Genes that share paralogs with CUZD1: view

No data available for Paralogs for CUZD1 Gene

Variants for CUZD1 Gene

Sequence variations from dbSNP and Humsavar for CUZD1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs11365591 benign, not specified 122,836,359(-) AAAAAAAAAAAAAAAA/AAAAAAAAAAA/AAAAAAAAAAAA/AAAAAAAAAAAAA/AAAAAAAAAAAAAA/AAAAAAAAAAAAAAA/AAAAAAAAAAAAAAAAA intron_variant
rs1000391048 -- 122,839,537(-) A/C intron_variant
rs1000513793 -- 122,842,903(-) C/T intron_variant
rs1000686731 -- 122,832,855(-) C/T intron_variant
rs1001029812 -- 122,846,182(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CUZD1 Gene

Variant ID Type Subtype PubMed ID
nsv1159779 CNV deletion 26073780
nsv832010 CNV gain 17160897
nsv975804 CNV duplication 23825009

Variation tolerance for CUZD1 Gene

Residual Variation Intolerance Score: 94.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.36; 53.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CUZD1 Gene

Human Gene Mutation Database (HGMD)
CUZD1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CUZD1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CUZD1 Gene

Disorders for CUZD1 Gene

Additional Disease Information for CUZD1

No disorders were found for CUZD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CUZD1 Gene

Publications for CUZD1 Gene

  1. Silencing expression of UO-44 (CUZD1) using small interfering RNA sensitizes human ovarian cancer cells to cisplatin in vitro. (PMID: 16862170) Leong CT … Huynh H (Oncogene 2007) 3 22 58
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  3. Molecular cloning, characterization and isolation of novel spliced variants of the human ortholog of a rat estrogen-regulated membrane-associated protein, UO-44. (PMID: 15184879) Leong CT … Huynh H (Oncogene 2004) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. Cloning and uterus/oviduct-specific expression of a novel estrogen-regulated gene (ERG1) (PMID: 10542259) Chen D … Bagchi IC (The Journal of biological chemistry 1999) 2 3 58

Products for CUZD1 Gene

Sources for CUZD1 Gene

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