Aliases for CUX2 Gene
External Ids for CUX2 Gene
Previous HGNC Symbols for CUX2 Gene
Previous GeneCards Identifiers for CUX2 Gene
This gene encodes a protein which contains three CUT domains and a homeodomain; both domains are DNA-binding motifs. A similar gene, whose gene product possesses different DNA-binding activities, is located on chromosome on chromosome 7. Two pseudogenes of this gene have been identified on chromosomes 10 and 4. [provided by RefSeq, Jan 2013]
GeneCards Summary for CUX2 Gene
CUX2 (Cut Like Homeobox 2) is a Protein Coding gene. Diseases associated with CUX2 include Epileptic Encephalopathy, Early Infantile, 67 and Lennox-Gastaut Syndrome. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is CUX1.
UniProtKB/Swiss-Prot Summary for CUX2 Gene
Transcription factor involved in the control of neuronal proliferation and differentiation in the brain. Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III. Binds to DNA in a sequence-specific manner.