Aliases for CUX1 Gene
External Ids for CUX1 Gene
Previous HGNC Symbols for CUX1 Gene
Previous GeneCards Identifiers for CUX1 Gene
The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011]
GeneCards Summary for CUX1 Gene
CUX1 (Cut Like Homeobox 1) is a Protein Coding gene. Diseases associated with CUX1 include Global Developmental Delay With Or Without Impaired Intellectual Development and Autosomal Dominant Non-Syndromic Intellectual Disability. Among its related pathways are Intra-Golgi traffic and Golgi-to-ER retrograde transport. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is CUX2.
UniProtKB/Swiss-Prot Summary for CUX1 Gene
May be involved in intra-Golgi retrograde transport.
Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator.