Aliases for CUX1 Gene
- Cut Like Homeobox 1 2 3 5
- CDP 2 3 4
- CUX1 Gene Alternatively Spliced Product 2 3
- Golgi Integral Membrane Protein 6 2 3
- Homeobox Protein Cut-Like 1 3 4
- CCAAT Displacement Protein 3 4
- Homeobox Protein Cux-1 3 4
- Protein CASP 3 4
- CDP/Cux P200 3 4
- CDP/Cut 2 3
- Cux/CDP 2 3
- GOLIM6 2 3
- CUTL1 3 4
- CASP 2 3
- CDP1 2 3
- Clox 2 3
External Ids for CUX1 Gene
Previous HGNC Symbols for CUX1 Gene
Previous GeneCards Identifiers for CUX1 Gene
The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011]
GeneCards Summary for CUX1 Gene
CUX1 (Cut Like Homeobox 1) is a Protein Coding gene. Diseases associated with CUX1 include Global Developmental Delay With Or Without Impaired Intellectual Development and Autosomal Dominant Non-Syndromic Intellectual Disability. Among its related pathways are Vesicle-mediated transport and Wnt / Hedgehog / Notch. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is CUX2.
UniProtKB/Swiss-Prot Summary for CUX1 Gene
May be involved in intra-Golgi retrograde transport.
Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator.
[CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1.