Aliases for CUX1 Gene
- Cut Like Homeobox 1 2 3 5
- CUX1 Gene Alternatively Spliced Product 2 3
- Golgi Integral Membrane Protein 6 2 3
- Homeobox Protein Cut-Like 1 3 4
- CCAAT Displacement Protein 3 4
- Homeobox Protein Cux-1 3 4
- Protein CASP 3 4
- CUTL1 3 4
- CDP 3 4
- Cut (Drosophila)-Like 1 (CCAAT Displacement Protein) 2
- Cut-Like 1, CCAAT Displacement Protein (Drosophila) 2
- Putative Protein Product Of Nbla10317 3
- Cut-Like Homeobox 1 2
- Cut Homolog 3
External Ids for CUX1 Gene
Previous HGNC Symbols for CUX1 Gene
Previous GeneCards Identifiers for CUX1 Gene
The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011]
GeneCards Summary for CUX1 Gene
CUX1 (Cut Like Homeobox 1) is a Protein Coding gene. Diseases associated with CUX1 include Global Developmental Delay With Or Without Impaired Intellectual Development and Autosomal Dominant Non-Syndromic Intellectual Disability. Among its related pathways are FGFR1 mutant receptor activation and Intra-Golgi traffic. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is CUX2.
UniProtKB/Swiss-Prot Summary for CUX1 Gene
May be involved in intra-Golgi retrograde transport.
Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator.