Members of the CUT family of copper transporters are associated with copper homeostasis and are involved in the uptake, storage, delivery, and efflux of copper (Gupta et al., 1995 [PubMed 7635807]; Li et al., 2005 [PubMed 16182249]).[supplied by OMIM, Mar 2008] See more...

Aliases for CUTC Gene

Aliases for CUTC Gene

  • CutC Copper Transporter 2 3 5
  • Copper Homeostasis Protein CutC Homolog 3 4
  • CGI-32 2 3
  • CutC Copper Transporter Homolog (E. Coli) 2
  • CutC Copper Transporter Homolog 3
  • CUTC 5

External Ids for CUTC Gene

Previous GeneCards Identifiers for CUTC Gene

  • GC10P101157
  • GC10P101481
  • GC10P095119

Summaries for CUTC Gene

Entrez Gene Summary for CUTC Gene

  • Members of the CUT family of copper transporters are associated with copper homeostasis and are involved in the uptake, storage, delivery, and efflux of copper (Gupta et al., 1995 [PubMed 7635807]; Li et al., 2005 [PubMed 16182249]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CUTC Gene

CUTC (CutC Copper Transporter) is a Protein Coding gene. Diseases associated with CUTC include Trimethylaminuria and Cardiomyopathy, Familial Hypertrophic, 1. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. Gene Ontology (GO) annotations related to this gene include copper ion binding.

UniProtKB/Swiss-Prot Summary for CUTC Gene

  • May play a role in copper homeostasis. Can bind one Cu(1+) per subunit.

Gene Wiki entry for CUTC Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CUTC Gene

Genomics for CUTC Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CUTC Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CUTC on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CUTC

Top Transcription factor binding sites by QIAGEN in the CUTC gene promoter:
  • AREB6
  • GATA-2
  • Lmo2
  • STAT1
  • STAT1alpha
  • STAT1beta
  • ZID

Genomic Locations for CUTC Gene

Genomic Locations for CUTC Gene
chr10:99,702,558-99,756,134
(GRCh38/hg38)
Size:
53,577 bases
Orientation:
Plus strand
chr10:101,462,315-101,515,894
(GRCh37/hg19)
Size:
53,580 bases
Orientation:
Plus strand

Genomic View for CUTC Gene

Genes around CUTC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CUTC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CUTC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUTC Gene

Proteins for CUTC Gene

  • Protein details for CUTC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTM9-CUTC_HUMAN
    Recommended name:
    Copper homeostasis protein cutC homolog
    Protein Accession:
    Q9NTM9
    Secondary Accessions:
    • Q5TCZ8
    • Q9Y321

    Protein attributes for CUTC Gene

    Size:
    273 amino acids
    Molecular mass:
    29341 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for CUTC Gene

neXtProt entry for CUTC Gene

Post-translational modifications for CUTC Gene

  • Ubiquitination at Lys269
  • Modification sites at PhosphoSitePlus

Other Protein References for CUTC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CUTC Gene

Domains & Families for CUTC Gene

Gene Families for CUTC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for CUTC Gene

Suggested Antigen Peptide Sequences for CUTC Gene

GenScript: Design optimal peptide antigens:
  • Copper homeostasis protein cutC homolog (CUTC_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NTM9

UniProtKB/Swiss-Prot:

CUTC_HUMAN :
  • Belongs to the CutC family.
Family:
  • Belongs to the CutC family.
genes like me logo Genes that share domains with CUTC: view

Function for CUTC Gene

Molecular function for CUTC Gene

UniProtKB/Swiss-Prot Function:
May play a role in copper homeostasis. Can bind one Cu(1+) per subunit.

Phenotypes From GWAS Catalog for CUTC Gene

Gene Ontology (GO) - Molecular Function for CUTC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005507 copper ion binding IEA,NAS 16182249
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CUTC: view
genes like me logo Genes that share phenotypes with CUTC: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CUTC

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CUTC Gene

Localization for CUTC Gene

Subcellular locations from UniProtKB/Swiss-Prot for CUTC Gene

Cytoplasm. Nucleus. Note=The overexpressed protein is detected in the cytoplasm, and depending on the cell line, also in the nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CUTC gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Nucleoli (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CUTC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 16182249
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA,IDA 16182249
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CUTC: view

Pathways & Interactions for CUTC Gene

genes like me logo Genes that share pathways with CUTC: view

Pathways by source for CUTC Gene

Gene Ontology (GO) - Biological Process for CUTC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006825 copper ion transport NAS 16182249
GO:0051262 protein tetramerization IPI 19878721
GO:0055070 copper ion homeostasis IEA,NAS 16182249
genes like me logo Genes that share ontologies with CUTC: view

No data available for SIGNOR curated interactions for CUTC Gene

Drugs & Compounds for CUTC Gene

(1) Drugs for CUTC Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma 249
genes like me logo Genes that share compounds with CUTC: view

Transcripts for CUTC Gene

mRNA/cDNA for CUTC Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CUTC

Alternative Splicing Database (ASD) splice patterns (SP) for CUTC Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: - -
SP2: -
SP3: - - -
SP4: -
SP5:

Relevant External Links for CUTC Gene

GeneLoc Exon Structure for
CUTC

Expression for CUTC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CUTC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CUTC Gene

This gene is overexpressed in Muscle - Skeletal (x9.5).

Protein differential expression in normal tissues from HIPED for CUTC Gene

This gene is overexpressed in Heart (11.0), Peripheral blood mononuclear cells (7.2), and Retina (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CUTC Gene



Protein tissue co-expression partners for CUTC Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CUTC

SOURCE GeneReport for Unigene cluster for CUTC Gene:

Hs.16606

mRNA Expression by UniProt/SwissProt for CUTC Gene:

Q9NTM9-CUTC_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for CUTC Gene

  • Muscle(4.6)
  • Skin(4.4)
  • Lung(4.2)
  • Liver(2.2)
  • Intestine(2.2)
  • Heart(2)
genes like me logo Genes that share expression patterns with CUTC: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CUTC Gene

Orthologs for CUTC Gene

This gene was present in the common ancestor of animals.

Orthologs for CUTC Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CUTC 30 31
  • 99.51 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CUTC 30 31
  • 92.19 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CUTC 30 31
  • 91.7 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cutc 30
  • 88.3 (n)
Mouse
(Mus musculus)
Mammalia Cutc 30 17 31
  • 87.45 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CUTC 31
  • 79 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CUTC 30 31
  • 72.42 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CUTC 31
  • 84 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cutc 30
  • 71.85 (n)
Str.16776 30
Zebrafish
(Danio rerio)
Actinopterygii cutc 30 31
  • 67.73 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG6136 30 31
  • 50.75 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002402 30
  • 48.3 (n)
Worm
(Caenorhabditis elegans)
Secernentea cutc-1 30 31
  • 50.21 (n)
OneToOne
Species where no ortholog for CUTC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CUTC Gene

ENSEMBL:
Gene Tree for CUTC (if available)
TreeFam:
Gene Tree for CUTC (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CUTC: view image

Paralogs for CUTC Gene

No data available for Paralogs for CUTC Gene

Variants for CUTC Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CUTC Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
879339 Uncertain Significance: Leigh syndrome 99,732,299(+) C/G FIVE_PRIME_UTR_VARIANT
879340 Uncertain Significance: Leigh syndrome 99,732,314(+) A/C FIVE_PRIME_UTR_VARIANT
879698 Uncertain Significance: Leigh syndrome 99,732,635(+) G/A INTRON_VARIANT
879699 Uncertain Significance: Leigh syndrome 99,732,639(+) C/T INTRON_VARIANT
rs11595470 Uncertain Significance: Leigh syndrome 99,732,455(+) G/C INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for CUTC Gene

Variation tolerance for CUTC Gene

Residual Variation Intolerance Score: 54.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CUTC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CUTC

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CUTC Gene

Disorders for CUTC Gene

MalaCards: The human disease database

(4) MalaCards diseases for CUTC Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
trimethylaminuria
  • tmau
cardiomyopathy, familial hypertrophic, 1
  • fhc
mitochondrial complex iv deficiency
  • cytochrome c oxidase deficiency
leigh syndrome
  • ls
- elite association - COSMIC cancer census association via MalaCards
Search CUTC in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CUTC

genes like me logo Genes that share disorders with CUTC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CUTC Gene

Publications for CUTC Gene

  1. Crystal structure of human copper homeostasis protein CutC reveals a potential copper-binding site. (PMID: 19878721) Li Y … Ding J (Journal of structural biology 2010) 3 4 23
  2. Identification and characterization of a novel Cut family cDNA that encodes human copper transporter protein CutC. (PMID: 16182249) Li J … Mao Y (Biochemical and biophysical research communications 2005) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 3 4

Products for CUTC Gene

Sources for CUTC Gene