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Aliases for CUTA Gene

Aliases for CUTA Gene

  • CutA Divalent Cation Tolerance Homolog 2 3 5
  • Acetylcholinesterase-Associated Protein 2 3 4
  • Brain Acetylcholinesterase Putative Membrane Anchor 3 4
  • C6orf82 3 4
  • ACHAP 3 4
  • CutA Divalent Cation Tolerance Homolog (E. Coli) 2
  • Divalent Cation Tolerant Protein CUTA 3
  • Chromosome 6 Open Reading Frame 82 2
  • Protein CutA 3

External Ids for CUTA Gene

Previous HGNC Symbols for CUTA Gene

  • C6orf82

Previous GeneCards Identifiers for CUTA Gene

  • GC06M033493
  • GC06M033126

Summaries for CUTA Gene

GeneCards Summary for CUTA Gene

CUTA (CutA Divalent Cation Tolerance Homolog) is a Protein Coding gene. Diseases associated with CUTA include Diabetes Mellitus, Permanent Neonatal. Gene Ontology (GO) annotations related to this gene include enzyme binding.

UniProtKB/Swiss-Prot for CUTA Gene

  • May form part of a complex of membrane proteins attached to acetylcholinesterase (AChE).

Additional gene information for CUTA Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUTA Gene

Genomics for CUTA Gene

GeneHancer (GH) Regulatory Elements for CUTA Gene

Promoters and enhancers for CUTA Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J033414 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 660.6 +0.6 608 6.4 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 CUTA SYNGAP1 LEMD2 BRD2 VPS52 RXRB WDR46 DAXX RGL2 HCG25
GH06J033409 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.2 +7.3 7256 4.1 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9 PHF1 DAXX BRD2 LEMD2 RXRB VPS52 RGL2 WDR46 RING1 HCG25
GH06J033452 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.5 -35.8 -35755 2.9 HDGF SMAD1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 POLR2B SYNGAP1-AS1 ZBTB9 DAXX BRD2 VPS52 WDR46 LEMD2 RXRB RGL2 ZBTB22
GH06J033287 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.8 +128.8 128800 3.1 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 POLR2B ZNF766 WDR46 MIR6834 PFDN6 TAPBP ZBTB22 KIFC1 PHF1 RPL35AP4 CUTA SYNGAP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CUTA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CUTA gene promoter:

Genomic Locations for CUTA Gene

Genomic Locations for CUTA Gene
1,876 bases
Minus strand

Genomic View for CUTA Gene

Genes around CUTA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CUTA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CUTA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUTA Gene

Proteins for CUTA Gene

  • Protein details for CUTA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein CutA
    Protein Accession:
    Secondary Accessions:
    • A2AB26
    • A2BEL4
    • Q3B784
    • Q5JXM9
    • Q5SU05
    • Q9NYQ9

    Protein attributes for CUTA Gene

    179 amino acids
    Molecular mass:
    19116 Da
    Quaternary structure:
    • Homotrimer.
    • Sequence=AAF61220.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CUTA Gene

    Alternative splice isoforms for CUTA Gene


neXtProt entry for CUTA Gene

Post-translational modifications for CUTA Gene

No data available for DME Specific Peptides for CUTA Gene

Domains & Families for CUTA Gene

Gene Families for CUTA Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CUTA Gene

Suggested Antigen Peptide Sequences for CUTA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CutA family.
  • Belongs to the CutA family.
genes like me logo Genes that share domains with CUTA: view

Function for CUTA Gene

Molecular function for CUTA Gene

UniProtKB/Swiss-Prot Function:
May form part of a complex of membrane proteins attached to acetylcholinesterase (AChE).

Phenotypes From GWAS Catalog for CUTA Gene

Gene Ontology (GO) - Molecular Function for CUTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005507 copper ion binding IBA --
GO:0005515 protein binding IPI 20195357
GO:0019899 enzyme binding IPI 10800960
genes like me logo Genes that share ontologies with CUTA: view
genes like me logo Genes that share phenotypes with CUTA: view

Animal Model Products

CRISPR Products

miRNA for CUTA Gene

miRTarBase miRNAs that target CUTA

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CUTA

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CUTA Gene

Localization for CUTA Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CUTA gene
Compartment Confidence
extracellular 5
mitochondrion 2
plasma membrane 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CUTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 10800960
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with CUTA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CUTA Gene

Pathways & Interactions for CUTA Gene

No Data Available

Gene Ontology (GO) - Biological Process for CUTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008104 protein localization IDA 10800960
GO:0010038 response to metal ion IEA --
genes like me logo Genes that share ontologies with CUTA: view

No data available for Pathways by source and SIGNOR curated interactions for CUTA Gene

Drugs & Compounds for CUTA Gene

(1) Drugs for CUTA Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mercuribenzoic Acid Experimental Pharma Target 0
genes like me logo Genes that share compounds with CUTA: view

Transcripts for CUTA Gene

Unigene Clusters for CUTA Gene

CutA divalent cation tolerance homolog (E. coli):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CUTA

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CUTA Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: -
SP6: - -
SP7: - -

Relevant External Links for CUTA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CUTA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CUTA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CUTA Gene

Protein tissue co-expression partners for CUTA Gene

NURSA nuclear receptor signaling pathways regulating expression of CUTA Gene:


SOURCE GeneReport for Unigene cluster for CUTA Gene:


mRNA Expression by UniProt/SwissProt for CUTA Gene:

Tissue specificity: Ubiquitous. Widely expressed in brain.

Evidence on tissue expression from TISSUES for CUTA Gene

  • Liver(4.4)
  • Nervous system(3.8)
  • Stomach(2.7)
  • Kidney(2.6)
  • Muscle(2.6)
  • Heart(2.3)
  • Skin(2.3)
  • Lung(2.2)
  • Eye(2.1)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with CUTA: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CUTA Gene

Orthologs for CUTA Gene

This gene was present in the common ancestor of animals.

Orthologs for CUTA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CUTA 34 33
  • 99.44 (n)
(Bos Taurus)
Mammalia CUTA 34 33
  • 88.89 (n)
(Canis familiaris)
Mammalia CUTA 34 33
  • 88.14 (n)
(Mus musculus)
Mammalia Cuta 16 34 33
  • 87.01 (n)
(Rattus norvegicus)
Mammalia Cuta 33
  • 85.12 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 69 (a)
-- 34
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia CUTA 34
  • 36 (a)
(Gallus gallus)
Aves CUTA 34
  • 33 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cuta 33
  • 66.67 (n)
Str.8974 33
(Danio rerio)
Actinopterygii LOC100535353 33
  • 68.63 (n)
  • 61 (a)
Dr.10150 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10007 33
fruit fly
(Drosophila melanogaster)
Insecta CG11590 34
  • 32 (a)
(Caenorhabditis elegans)
Secernentea F35G12.7 34
  • 37 (a)
Species where no ortholog for CUTA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CUTA Gene

Gene Tree for CUTA (if available)
Gene Tree for CUTA (if available)
Evolutionary constrained regions (ECRs) for CUTA: view image

Paralogs for CUTA Gene

No data available for Paralogs for CUTA Gene

Variants for CUTA Gene

Sequence variations from dbSNP and Humsavar for CUTA Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1001093191 -- 33,419,095(-) G/C upstream_transcript_variant
rs1002716361 -- 33,418,485(-) G/T upstream_transcript_variant
rs1003275531 -- 33,420,175(-) T/C upstream_transcript_variant
rs1004492886 -- 33,416,085(-) G/A downstream_transcript_variant
rs1004624786 -- 33,420,018(-) TC/TCGTC upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CUTA Gene

Variant ID Type Subtype PubMed ID
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1119076 CNV deletion 24896259
nsv602832 CNV loss 21841781
nsv830635 CNV loss 17160897
nsv830637 CNV loss 17160897

Variation tolerance for CUTA Gene

Residual Variation Intolerance Score: 82.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.55; 72.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CUTA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CUTA Gene

Disorders for CUTA Gene

MalaCards: The human disease database

(1) MalaCards diseases for CUTA Gene - From: DISEASES

Disorder Aliases PubMed IDs
diabetes mellitus, permanent neonatal
  • pndm
- elite association - COSMIC cancer census association via MalaCards
Search CUTA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CUTA

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CUTA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CUTA Gene

Publications for CUTA Gene

  1. Two distinct proteins are associated with tetrameric acetylcholinesterase on the cell surface. (PMID: 10954708) Perrier AL … Krejci E (The Journal of biological chemistry 2000) 3 4 22 58
  2. Role of copper and the copper-related protein CUTA in mediating APP processing and Aβ generation. (PMID: 25557959) Hou P … Zhang YW (Neurobiology of aging 2015) 2 3 58
  3. CutA divalent cation tolerance homolog (Escherichia coli) (CUTA) regulates β-cleavage of β-amyloid precursor protein (APP) through interacting with β-site APP cleaving protein 1 (BACE1). (PMID: 22351782) Zhao Y … Zhang YW (The Journal of biological chemistry 2012) 2 3 58
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 44 58
  5. Characterization of the human CUTA isoform2 present in the stably transfected HeLa cells. (PMID: 17924204) Yang J … Yu L (Molecular biology reports 2009) 3 22 58

Products for CUTA Gene

Sources for CUTA Gene

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