Aliases for CUL9 Gene

Aliases for CUL9 Gene

  • Cullin 9 2 3 5
  • P53-Associated Parkin-Like Cytoplasmic Protein 2 3 4
  • Parkin-Like Cytoplasmic P53 Binding Protein 2 3
  • UbcH7-Associated Protein 1 3 4
  • Cullin-9 3 4
  • CUL-9 3 4
  • H7AP1 3 4
  • PARC 3 4
  • KIAA0708 4

External Ids for CUL9 Gene

Previous GeneCards Identifiers for CUL9 Gene

  • GC06P043258
  • GC06P043149
  • GC06P042866

Summaries for CUL9 Gene

GeneCards Summary for CUL9 Gene

CUL9 (Cullin 9) is a Protein Coding gene. Diseases associated with CUL9 include Three M Syndrome 1. Gene Ontology (GO) annotations related to this gene include binding and ubiquitin protein ligase binding. An important paralog of this gene is CUL7.

UniProtKB/Swiss-Prot Summary for CUL9 Gene

  • Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328).

Gene Wiki entry for CUL9 Gene

Additional gene information for CUL9 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CUL9 Gene

Genomics for CUL9 Gene

GeneHancer (GH) Regulatory Elements for CUL9 Gene

Promoters and enhancers for CUL9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CUL9 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CUL9

Top Transcription factor binding sites by QIAGEN in the CUL9 gene promoter:
  • MyoD
  • Nkx2-5
  • SRF
  • SRF (504 AA)
  • YY1

Genomic Locations for CUL9 Gene

Genomic Locations for CUL9 Gene
chr6:43,182,174-43,224,587
(GRCh38/hg38)
Size:
42,414 bases
Orientation:
Plus strand
chr6:43,149,913-43,192,325
(GRCh37/hg19)
Size:
42,413 bases
Orientation:
Plus strand

Genomic View for CUL9 Gene

Genes around CUL9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CUL9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CUL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUL9 Gene

Proteins for CUL9 Gene

  • Protein details for CUL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWT3-CUL9_HUMAN
    Recommended name:
    Cullin-9
    Protein Accession:
    Q8IWT3
    Secondary Accessions:
    • O75188
    • Q5TCY3
    • Q68CP2
    • Q68D92
    • Q8N3W9
    • Q9BU56

    Protein attributes for CUL9 Gene

    Size:
    2517 amino acids
    Molecular mass:
    281229 Da
    Quaternary structure:
    • Part of a Cul9-RING complex at least composed of CUL9 and RBX1. Interacts with CUL7: interaction with CUL7 component of the 3M complex leads to inhibition of CUL9 activity. The CUL7-CUL9 heterodimer seems to interact specifically with TP53. Forms a complex with p53/TP53 in the cytoplasm of unstressed cells. Interacts with UBCH7 and UBCH8.
    SequenceCaution:
    • Sequence=BAC85207.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAC86090.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CUL9 Gene

    Alternative splice isoforms for CUL9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CUL9 Gene

Post-translational modifications for CUL9 Gene

No data available for DME Specific Peptides for CUL9 Gene

Domains & Families for CUL9 Gene

Gene Families for CUL9 Gene

Protein Domains for CUL9 Gene

Suggested Antigen Peptide Sequences for CUL9 Gene

GenScript: Design optimal peptide antigens:
  • p53-associated parkin-like cytoplasmic protein (CUL9_HUMAN)
  • CUL9 protein (Q05C85_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IWT3

UniProtKB/Swiss-Prot:

CUL9_HUMAN :
  • The IBR domain is required for interaction with UBCH7 and UBCH8.
  • Belongs to the cullin family.
Domain:
  • The IBR domain is required for interaction with UBCH7 and UBCH8.
Family:
  • Belongs to the cullin family.
genes like me logo Genes that share domains with CUL9: view

Function for CUL9 Gene

Molecular function for CUL9 Gene

UniProtKB/Swiss-Prot Function:
Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328).

Phenotypes From GWAS Catalog for CUL9 Gene

Gene Ontology (GO) - Molecular Function for CUL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18230339
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
GO:0031625 ubiquitin protein ligase binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CUL9: view
genes like me logo Genes that share phenotypes with CUL9: view

Animal Models for CUL9 Gene

MGI Knock Outs for CUL9:

Animal Model Products

CRISPR Products

miRNA for CUL9 Gene

miRTarBase miRNAs that target CUL9

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CUL9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CUL9 Gene

Localization for CUL9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CUL9 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CUL9 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CUL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS,IDA --
GO:0031461 cullin-RING ubiquitin ligase complex IDA,IEA 24793696
genes like me logo Genes that share ontologies with CUL9: view

Pathways & Interactions for CUL9 Gene

PathCards logo

SuperPathways for CUL9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CUL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA,IMP 24793696
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0007088 regulation of mitotic nuclear division IEA,IMP 24793696
GO:0016567 protein ubiquitination IEA,TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with CUL9: view

No data available for Pathways by source and SIGNOR curated interactions for CUL9 Gene

Drugs & Compounds for CUL9 Gene

No Compound Related Data Available

Transcripts for CUL9 Gene

mRNA/cDNA for CUL9 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CUL9

Alternative Splicing Database (ASD) splice patterns (SP) for CUL9 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^
SP1: - - - - -
SP2: - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: -

ExUns: 20a · 20b ^ 21a · 21b · 21c ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34a · 34b ^ 35 ^ 36 ^ 37 ^ 38 ^
SP1: - - - - -
SP2:
SP3: - - - -
SP4: -
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

ExUns: 39 ^ 40a · 40b ^ 41a · 41b ^ 42 ^ 43 ^ 44
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:

Relevant External Links for CUL9 Gene

GeneLoc Exon Structure for
CUL9

Expression for CUL9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CUL9 Gene

Protein differential expression in normal tissues from HIPED for CUL9 Gene

This gene is overexpressed in Heart (15.1), Peripheral blood mononuclear cells (14.2), Ovary (12.2), and Breast (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CUL9 Gene



Protein tissue co-expression partners for CUL9 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CUL9

SOURCE GeneReport for Unigene cluster for CUL9 Gene:

Hs.485434

mRNA Expression by UniProt/SwissProt for CUL9 Gene:

Q8IWT3-CUL9_HUMAN
Tissue specificity: Ubiquitously expressed in all tissues with highest expression in testis brain and kidney.

Evidence on tissue expression from TISSUES for CUL9 Gene

  • Nervous system(4.5)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with CUL9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CUL9 Gene

Orthologs for CUL9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CUL9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CUL9 31 30
  • 99.47 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CUL9 31 30
  • 89.96 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CUL9 31 30
  • 87.7 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cul9 30
  • 85.57 (n)
mouse
(Mus musculus)
Mammalia Cul9 17 31 30
  • 85.4 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 75 (a)
ManyToMany
-- 31
  • 72 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 64 (a)
ManyToMany
-- 31
  • 60 (a)
ManyToMany
-- 31
  • 59 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 31
  • 35 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 57 (a)
ManyToMany
-- 31
  • 55 (a)
ManyToMany
-- 31
  • 48 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cul9 30
  • 61.02 (n)
Str.19701 30
zebrafish
(Danio rerio)
Actinopterygii cul9 30
  • 59.62 (n)
CABZ01087282.2 31
  • 53 (a)
ManyToMany
CABZ01087282.1 31
  • 50 (a)
ManyToMany
wufc02b11 30
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 33 (a)
OneToMany
Species where no ortholog for CUL9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CUL9 Gene

ENSEMBL:
Gene Tree for CUL9 (if available)
TreeFam:
Gene Tree for CUL9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CUL9: view image

Paralogs for CUL9 Gene

Paralogs for CUL9 Gene

(1) SIMAP similar genes for CUL9 Gene using alignment to 6 proteins:

  • CUL9_HUMAN
  • E9PEZ1_HUMAN
  • H0Y8H9_HUMAN
  • H0YA00_HUMAN
  • L8E9R8_HUMAN
  • Q05C85_HUMAN
genes like me logo Genes that share paralogs with CUL9: view

Variants for CUL9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CUL9 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
720947 Benign: not provided 43,204,412(+) G/A SYNONYMOUS_VARIANT
735354 Likely Benign: not provided 43,202,791(+) C/T SYNONYMOUS_VARIANT
782249 Benign: not provided 43,220,758(+) G/A SYNONYMOUS_VARIANT
782947 Likely Benign: not provided 43,187,980(+) G/A MISSENSE_VARIANT
809938 Uncertain Significance: not provided 43,187,278(+) G/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for CUL9 Gene

Structural Variations from Database of Genomic Variants (DGV) for CUL9 Gene

Variant ID Type Subtype PubMed ID
esv2671960 CNV deletion 23128226
nsv1017398 CNV gain 25217958
nsv521730 CNV loss 19592680
nsv602997 CNV loss 21841781

Variation tolerance for CUL9 Gene

Residual Variation Intolerance Score: 14.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.54; 91.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CUL9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CUL9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CUL9 Gene

Disorders for CUL9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CUL9 Gene - From: DISEASES

Disorder Aliases PubMed IDs
three m syndrome 1
  • 3m1
- elite association - COSMIC cancer census association via MalaCards
Search CUL9 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CUL9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CUL9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CUL9 Gene

Publications for CUL9 Gene

  1. The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1. (PMID: 10521492) Moynihan TP … Robinson PA (The Journal of biological chemistry 1999) 2 3 4 23 54
  2. PARC and CUL7 form atypical cullin RING ligase complexes. (PMID: 17332328) Skaar JR … DeCaprio JA (Cancer research 2007) 2 3 4 54
  3. Parc: a cytoplasmic anchor for p53. (PMID: 12526791) Nikolaev AY … Gu W (Cell 2003) 2 3 4 54
  4. CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity. (PMID: 24793696) Li Z … Xiong Y (Molecular cell 2014) 3 4 54
  5. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 41 54

Products for CUL9 Gene

Sources for CUL9 Gene