Aliases for CUL9 Gene
External Ids for CUL9 Gene
Previous GeneCards Identifiers for CUL9 Gene
GeneCards Summary for CUL9 Gene
CUL9 (Cullin 9) is a Protein Coding gene. Diseases associated with CUL9 include Three M Syndrome 1. Gene Ontology (GO) annotations related to this gene include binding and ubiquitin protein ligase binding. An important paralog of this gene is CUL7.
UniProtKB/Swiss-Prot Summary for CUL9 Gene
Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328).