Aliases for CUL5 Gene
External Ids for CUL5 Gene
Previous GeneCards Identifiers for CUL5 Gene
GeneCards Summary for CUL5 Gene
CUL5 (Cullin 5) is a Protein Coding gene. Diseases associated with CUL5 include Molluscum Contagiosum and Cockayne Syndrome B. Among its related pathways are Class I MHC mediated antigen processing and presentation and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and ubiquitin protein ligase binding. An important paralog of this gene is CUL1.
UniProtKB/Swiss-Prot Summary for CUL5 Gene
Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.