Aliases for CUL5 Gene

Aliases for CUL5 Gene

  • Cullin 5 2 3 5
  • VACM-1 2 3 4
  • Vasopressin-Activated Calcium-Mobilizing Receptor 1 3 4
  • Cullin-5 3 4
  • CUL-5 3 4
  • VACM1 3 4
  • Cullin-5 (Vasopressin-Activated Calcium-Mobilizing Receptor-1) 3
  • Vasopressin-Activated Calcium-Mobilizing Receptor-1 3
  • CUL5 5

External Ids for CUL5 Gene

Previous GeneCards Identifiers for CUL5 Gene

  • GC11P110074
  • GC11P109236
  • GC11P107913
  • GC11P107417
  • GC11P107384
  • GC11P103804

Summaries for CUL5 Gene

GeneCards Summary for CUL5 Gene

CUL5 (Cullin 5) is a Protein Coding gene. Diseases associated with CUL5 include Molluscum Contagiosum and Lung Cancer. Among its related pathways are Signaling by GPCR and Signaling by ERBB2. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and ubiquitin protein ligase binding. An important paralog of this gene is CUL1.

UniProtKB/Swiss-Prot Summary for CUL5 Gene

  • Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.

Gene Wiki entry for CUL5 Gene

Additional gene information for CUL5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CUL5 Gene

Genomics for CUL5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CUL5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J108008 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +1.3 1265 3.6 BRCA1 ARHGAP35 SP1 CREB1 GATAD2A CTCF PRDM10 ZNF629 TFE3 LEF1 CUL5 ENSG00000288012 NONHSAG009537.2 NPAT CWF19L2 ALKBH8 DDX10 POGLUT3 ATM ACAT1
GH11J107927 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 10.4 -79.7 -79732 2.8 SP1 CREB1 HNRNPL ZNF629 REST IKZF1 KDM1A ZNF692 BACH1 FOS SLC35F2 RAB39A NPAT CWF19L2 CUL5 ALKBH8 DDX10 ASS1P13 piR-42694-032
GH11J107988 Enhancer 0.8 FANTOM5 Ensembl 12.1 -20.0 -20032 2.2 ATF7 RELB ATF2 BCL11A ARNT NBN IKZF1 POLR2A MTA2 JUND CUL5 ACAT1 piR-39300-028 RAB39A
GH11J108032 Enhancer 0.4 Ensembl 12.2 +23.7 23668 0.8 ZNF580 ZNF217 KDM1A piR-51137-026 CUL5 ACAT1 NONHSAG009537.2 ENSG00000200855
GH11J107999 Enhancer 0.8 Ensembl ENCODE 0.4 -8.6 -8575 0.5 CTCF ZNF143 REST RAD21 ZNF501 TRIM22 SMC3 ZNF654 ZNF2 KLF16 ACAT1 ENSG00000255467 DDX10 CUL5 piR-39300-028 RAB39A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CUL5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CUL5

Top Transcription factor binding sites by QIAGEN in the CUL5 gene promoter:
  • AhR
  • Arnt
  • ARP-1
  • C/EBPalpha
  • CHOP-10
  • ER-alpha
  • N-Myc
  • YY1
  • Zic1
  • ZID

Genomic Locations for CUL5 Gene

Genomic Locations for CUL5 Gene
chr11:108,008,733-108,107,766
(GRCh38/hg38)
Size:
99,034 bases
Orientation:
Plus strand
chr11:107,879,408-107,978,503
(GRCh37/hg19)
Size:
99,096 bases
Orientation:
Plus strand

Genomic View for CUL5 Gene

Genes around CUL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CUL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CUL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUL5 Gene

Proteins for CUL5 Gene

  • Protein details for CUL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93034-CUL5_HUMAN
    Recommended name:
    Cullin-5
    Protein Accession:
    Q93034
    Secondary Accessions:
    • A8K960
    • O14766
    • Q9BZC6

    Protein attributes for CUL5 Gene

    Size:
    780 amino acids
    Molecular mass:
    90955 Da
    Quaternary structure:
    • Component of multiple ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes formed of CUL5, Elongin BC (ELOB and ELOC), RBX2 and a variable SOCS box domain-containing protein as substrate-specific recognition component. Component of the probable ECS(LRRC41) complex with the substrate recognition component LRRC41. Component of the probable ECS(SOCS1) complex with the substrate recognition component SOCS1. Component of the probable ECS(WSB1) complex with the substrate recognition subunit WSB1. Component of the probable ECS(SOCS3) complex with the substrate recognition component SOCS3. Component of the probable ECS(SPSB1) complex with the substrate recognition component SPSB1. Component of the probable ECS(SPSB2) complex with the substrate recognition component SPSB2. Component of the probable ECS(SPSB4) complex with the substrate recognition component SPSB4. Component of the probable ECS(RAB40C) complex with the substrate recognition subunit RAB40C. May also form complexes containing CUL5, elongin BC complex (ELOB and ELOC), RBX1 and ELOA. May also form complexes containing CUL5, Elongin BC (ELOB and ELOC), RBX1 and VHL. Interacts with RNF7/RBX2, LRRC41, SOCS3, SPSB1, SPSB2, SPSB4 and RAB40C. Interacts with ASB1, ASB2, ASB6, ASB7 and ASB12. Interacts (when neddylated) with ARIH2; leading to activate the E3 ligase activity of ARIH1 (PubMed:24076655). Interacts with NOS2 in the presence of SPSB1 or SPSB2 or SPSB4 (PubMed:21199876). Interacts with ERCC6; the interaction is induced by DNA damaging agents or inhibitors of RNA polymerase II elongation (PubMed:28292928). Interacts with ELOA (via BC-box)(PubMed:28292928).
    • (Microbial infection) Interacts (via the substrate recognition component) with HIV-1 Vif.
    • (Microbial infection) Interacts (via the substrate recognition component) with human adenovirus 5 proteins E1B-55K and E4-orf6.
    • (Microbial infection) Interacts with herpes virus 8 protein LANA1; this interaction promotes the degradation of NF-kappa-B component RELA.
    • (Microbial infection) Interacts with molluscum contagiosum virus protein MC132; this interaction promotes the degradation of NF-kappa-B component RELA.

    Three dimensional structures from OCA and Proteopedia for CUL5 Gene

neXtProt entry for CUL5 Gene

Post-translational modifications for CUL5 Gene

  • Neddylated; which enhances the ubiquitination activity of SCF and prevents binding of the inhibitor CAND1. Deneddylated via its interaction with the COP9 signalosome (CSN).
  • Ubiquitination at Lys384, Lys529, and Lys724
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CUL5 Gene

Domains & Families for CUL5 Gene

Gene Families for CUL5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CUL5 Gene

GenScript: Design optimal peptide antigens:
  • Vasopressin-activated calcium-mobilizing receptor 1 (CUL5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q93034

UniProtKB/Swiss-Prot:

CUL5_HUMAN :
  • Belongs to the cullin family.
Family:
  • Belongs to the cullin family.
genes like me logo Genes that share domains with CUL5: view

Function for CUL5 Gene

Molecular function for CUL5 Gene

UniProtKB/Swiss-Prot Function:
Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.
GENATLAS Biochemistry:
cullin 5,widely expressed,C elegans,cullin Cdc53 (CUL) family member,negative regulator of cell cycle

Phenotypes From GWAS Catalog for CUL5 Gene

Gene Ontology (GO) - Molecular Function for CUL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005262 calcium channel activity TAS 9581826
GO:0005515 protein binding IPI 12504025
GO:0031625 ubiquitin protein ligase binding IEA,IDA 17636018
GO:0038023 signaling receptor activity TAS 9581826
genes like me logo Genes that share ontologies with CUL5: view
genes like me logo Genes that share phenotypes with CUL5: view

Animal Models for CUL5 Gene

MGI Knock Outs for CUL5:
  • Cul5 Cul5<tm1.1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for CUL5

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CUL5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CUL5 Gene

Localization for CUL5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CUL5 gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 2
extracellular 2
cytoskeleton 2
endosome 2
lysosome 2
golgi apparatus 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CUL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0019005 SCF ubiquitin ligase complex IBA 21873635
GO:0031461 cullin-RING ubiquitin ligase complex IBA 21873635
GO:0031466 Cul5-RING ubiquitin ligase complex IBA,IDA 17636018
GO:0090734 site of DNA damage IDA 28292928
genes like me logo Genes that share ontologies with CUL5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CUL5 Gene

Pathways & Interactions for CUL5 Gene

genes like me logo Genes that share pathways with CUL5: view

UniProtKB/Swiss-Prot Q93034-CUL5_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for CUL5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CUL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS 8681378
GO:0006511 ubiquitin-dependent protein catabolic process IEA,IBA 21873635
GO:0016032 viral process IEA --
GO:0016567 protein ubiquitination IEA --
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA 21873635
genes like me logo Genes that share ontologies with CUL5: view

Drugs & Compounds for CUL5 Gene

(2) Drugs for CUL5 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vasopressin Approved Pharma Agonist, Full agonist, Partial agonist 0

(1) Additional Compounds for CUL5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CUL5: view

Transcripts for CUL5 Gene

mRNA/cDNA for CUL5 Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CUL5

Alternative Splicing Database (ASD) splice patterns (SP) for CUL5 Gene

No ASD Table

Relevant External Links for CUL5 Gene

GeneLoc Exon Structure for
CUL5

Expression for CUL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CUL5 Gene

mRNA differential expression in normal tissues according to GTEx for CUL5 Gene

This gene is overexpressed in Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for CUL5 Gene

This gene is overexpressed in Lymph node (8.3) and Uterus (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CUL5 Gene



Protein tissue co-expression partners for CUL5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CUL5

SOURCE GeneReport for Unigene cluster for CUL5 Gene:

Hs.440320

Evidence on tissue expression from TISSUES for CUL5 Gene

  • Nervous system(3.4)
  • Kidney(2.9)
  • Muscle(2.7)
  • Heart(2.6)
  • Blood(2.6)
  • Spleen(2.5)
  • Liver(2.4)
  • Intestine(2.4)
  • Eye(2.2)
  • Skin(2.2)
  • Bone marrow(2.2)
  • Lymph node(2.2)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with CUL5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CUL5 Gene

Orthologs for CUL5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CUL5 Gene

Organism Taxonomy Gene Similarity Type Details
Oppossum
(Monodelphis domestica)
Mammalia CUL5 31
  • 100 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CUL5 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia CUL5 30 31
  • 99.83 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CUL5 30 31
  • 96.03 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CUL5 30 31
  • 95.83 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cul5 30
  • 91.28 (n)
Mouse
(Mus musculus)
Mammalia Cul5 30 17 31
  • 90.73 (n)
OneToOne
Chicken
(Gallus gallus)
Aves CUL5 30 31
  • 87.26 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CUL5 31
  • 99 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cul5 30
  • 81.84 (n)
Str.17488 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.14500 30
Zebrafish
(Danio rerio)
Actinopterygii cul5a 31
  • 97 (a)
OneToMany
cul5b 30 31
  • 78.89 (n)
OneToMany
wufi20h12 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG1401 32
  • 67 (a)
Cul-5 30 31
  • 59.5 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002404 30
  • 60.39 (n)
Worm
(Caenorhabditis elegans)
Secernentea cul-5 30 31 32
  • 56.22 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3614 31
  • 65 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.7070 30
Species where no ortholog for CUL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CUL5 Gene

ENSEMBL:
Gene Tree for CUL5 (if available)
TreeFam:
Gene Tree for CUL5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CUL5: view image

Paralogs for CUL5 Gene

Paralogs for CUL5 Gene

(2) SIMAP similar genes for CUL5 Gene using alignment to 5 proteins:

  • CUL5_HUMAN
  • E9PP19_HUMAN
  • H0YCA0_HUMAN
  • L0L6C1_HUMAN
  • L0L6D8_HUMAN
genes like me logo Genes that share paralogs with CUL5: view

Variants for CUL5 Gene

Additional dbSNP identifiers (rs#s) for CUL5 Gene

Structural Variations from Database of Genomic Variants (DGV) for CUL5 Gene

Variant ID Type Subtype PubMed ID
dgv1274n100 CNV gain 25217958
dgv1276n100 CNV gain 25217958
dgv1278n100 CNV gain 25217958
esv2745050 CNV deletion 23290073
esv2750980 CNV gain 17911159
nsv1040345 CNV gain 25217958
nsv1127231 CNV deletion 24896259
nsv472392 CNV novel sequence insertion 20440878
nsv478868 CNV novel sequence insertion 20440878
nsv507616 OTHER sequence alteration 20534489
nsv521771 CNV gain 19592680

Variation tolerance for CUL5 Gene

Residual Variation Intolerance Score: 9.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CUL5 Gene

Human Gene Mutation Database (HGMD)
CUL5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CUL5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CUL5 Gene

Disorders for CUL5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CUL5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
molluscum contagiosum
lung cancer
  • adenocarcinoma of lung
endometrial stromal sarcoma
  • endometrial stromal sarcoma, high grade
- elite association - COSMIC cancer census association via MalaCards
Search CUL5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CUL5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CUL5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CUL5 Gene

Publications for CUL5 Gene

  1. Identification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23. (PMID: 9037604) Byrd PJ … Taylor AM (Genome research 1997) 2 3 4 23
  2. Polymorphisms of CUL5 are associated with CD4+ T cell loss in HIV-1 infected individuals. (PMID: 17257057) An P … Winkler CA (PLoS genetics 2007) 3 23 41
  3. Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation. (PMID: 15574592) Mehle A … Gabuzda D (Genes & development 2004) 3 4 23
  4. Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery. (PMID: 12186903) Harada JN … Berk AJ (Journal of virology 2002) 3 4 23
  5. Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage. (PMID: 28292928) Weems JC … Conaway RC (The Journal of biological chemistry 2017) 3 4

Products for CUL5 Gene

Sources for CUL5 Gene