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This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a ... See more...
Aliases for CUL3 Gene
External Ids for CUL3 Gene
- HGNC: 2553
- NCBI Entrez Gene: 8452
- Ensembl: ENSG00000036257
- OMIM®: 603136
- UniProtKB/Swiss-Prot: Q13618
Previous GeneCards Identifiers for CUL3 Gene
- GC02M223357
- GC02M224055
- GC02M225298
- GC02M225537
- GC02M225160
- GC02M225043
- GC02M217186
Summaries for CUL3 Gene
-
This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
GeneCards Summary for CUL3 Gene
CUL3 (Cullin 3) is a Protein Coding gene. Diseases associated with CUL3 include Pseudohypoaldosteronism, Type Iie and Pseudohypoaldosteronism, Type Iia. Among its related pathways are Misspliced GSK3beta mutants stabilize beta-catenin and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and ubiquitin-protein transferase activity. An important paralog of this gene is CUL4A.
UniProtKB/Swiss-Prot Summary for CUL3 Gene
-
Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the BCR complex depends on the BTB domain-containing protein as the substrate recognition component. BCR(KLHL42) is involved in ubiquitination of KATNA1. BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, BRMS1, MACROH2A1 and DAXX, GLI2 and GLI3. Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL; these complexes have lower ubiquitin ligase activity. BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. BCR(KLHL12) is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) (PubMed:22358839, PubMed:27716508). BCR(KLHL3) acts as a regulator of ion transport in the distal nephron; by mediating ubiquitination of WNK4 (PubMed:23387299, PubMed:23453970, PubMed:23576762). The BCR(KLHL20) E3 ubiquitin ligase complex is involved in interferon response and anterograde Golgi to endosome transport: it mediates both ubiquitination leading to degradation and 'Lys-33'-linked ubiquitination (PubMed:20389280, PubMed:21840486, PubMed:21670212, PubMed:24768539). The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB (PubMed:19995937). The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation (PubMed:23455478). The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway (PubMed:29769719). The BCR(KLHL25) ubiquitin ligase complex is involved in translational homeostasis by mediating ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) (PubMed:22578813). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in ubiquitination of cyclin E and of cyclin D1 (in vitro) thus involved in regulation of G1/S transition. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41 (PubMed:15983046). In concert with ATF2 and RBX1, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. The BCR(KCTD17) E3 ubiquitin ligase complex mediates ubiquitination and degradation of TCHP, a down-regulator of cilium assembly, thereby inducing ciliogenesis (PubMed:25270598). The BCR(KLHL24) E3 ubiquitin ligase complex mediates ubiquitination of KRT14, controls KRT14 levels during keratinocytes differentiation, and is essential for skin integrity (PubMed:27798626). The BCR(KLHL18) E3 ubiquitin ligase complex mediates the ubiquitination of AURKA leading to its activation at the centrosome which is required for initiating mitotic entry (PubMed:23213400). The BCR(KEAP1) E3 ubiquitin ligase complex acts as a key sensor of oxidative and electrophilic stress by mediating ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed:15601839, PubMed:16006525).
Additional gene information for CUL3 Gene
- HGNC (2553)
- NCBI Entrez Gene (8452)
- Ensembl (ENSG00000036257)
- OMIM® (603136)
- UniProtKB/Swiss-Prot (Q13618)
- Open Targets Platform(ENSG00000036257)
- Monarch Initiative
- Search for CUL3 at DataMed
- Search for CUL3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CUL3 Gene
Genomics for CUL3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CUL3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CUL3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CUL3
- Top Transcription factor binding sites by QIAGEN in the CUL3 gene promoter:
-
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
- Egr-1
- PPAR-gamma1
- PPAR-gamma2
- RelA
Genomic Locations for CUL3 Gene
Latest Assembly
- chr2:224,470,150-224,585,397
- (GRCh38/hg38)
- Size:
- 115,248 bases
- Orientation:
- Minus strand
Previous Assembly
- chr2:225,334,867-225,450,080
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 115,214 bases
- Orientation:
- Minus strand
- chr2:225,334,867-225,450,110
- (GRCh37/hg19 by Ensembl)
- Size:
- 115,244 bases
- Orientation:
- Minus strand
Genomic View for CUL3 Gene
Genes around CUL3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q36.2 by HGNC
- 2q36.2 by Entrez Gene
- 2q36.2 by Ensembl
CUL3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CUL3 Gene
Proteins for CUL3 Gene
-
Protein details for CUL3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13618-CUL3_HUMAN
- Recommended name:
- Cullin-3
- Protein Accession:
- Q13618
- A8K536
- B8ZZC3
- O75415
- Q569L3
- Q9UBI8
- Q9UET7
Protein attributes for CUL3 Gene
- Size:
- 768 amino acids
- Molecular mass:
- 88930 Da
- Quaternary structure:
-
- Forms neddylation-dependent homodimers. Component of multiple BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes formed of CUL3, RBX1 and a variable BTB domain-containing protein acting as both, adapter to cullin and substrate recognition subunit. The BCR complex may be active as a heterodimeric complex, in which NEDD8, covalently attached to one CUL3 molecule, binds to the C-terminus of a second CUL3 molecule. Interacts with RBX1, RNF7, CYCE and TIP120A/CAND1 (PubMed:10500095, PubMed:10230407, PubMed:12609982). Part of the BCR(SPOP) containing SPOP, and of BCR containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL. Part of the probable BCR(KLHL9-KLHL13) complex with BTB domain proteins KLHL9 and KLHL13. Part of the BCR(KLHL41) complex containing KLHL41. Component of the BCR(KLHL12) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL12 and RBX1. Component of the BCR(KLHL3) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL3 and RBX1 (Probable). Part of the BCR(ENC1) complex containing ENC1. Part of a complex consisting of BMI1/PCGF4, CUL3 and SPOP. Part of a complex consisting of BRMS1, CUL3 and SPOP. Component of the BCR(KLHL21) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL21 and RBX1. Component of the BCR(KLHL22) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL22 and RBX1. Component of the BCR(KLHL25) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL25 and RBX1. Part of a complex consisting of MACROH2A1, CUL3 and SPOP. Component of the BCR(KLHL42) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL42. Interacts with KLHL42 (via the BTB domain). Interacts with KATNA1; the interaction is enhanced by KLHL42. Component of the BCR(KBTBD8) E3 ubiquitin ligase complex, at least composed of CUL3, KBTBD8 and RBX1 (PubMed:26399832). Interacts with KCTD5, KLHL9, KLHL11, KLHL13, GAN, ZBTB16, KLHL3, KLHL15, KLHL20, KLHL36, GMCL2, BTBD1. Part of a complex that contains CUL3, RBX1 and GAN. Interacts (via BTB domain) with KLHL17; the interaction regulates surface GRIK2 expression. Interacts with KCTD7. Part of the BCR(GAN) complex containing GAN. Part of the BCR(KEAP1) complex containing KEAP1 (PubMed:15983046, PubMed:15601839). Interacts with KLHL10 (By similarity). Interacts with KAT5 and ATF2. Interacts with KCTD17 in the BCR(KCTD17) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD17 and RBX1 (PubMed:25270598). Interacts (when neddylated) with ARIH1; leading to activate the E3 ligase activity of ARIH1 (PubMed:24076655, PubMed:27565346). Interacts with COPS9 isoform 2 (PubMed:23776465). Interacts with PPP2R5B; this interaction is indirect and mediated through KLHL15-binding and leads to PPP2R5B proteasomal degradation (PubMed:23135275). Interacts with RBBP8/CtIP; this interaction is indirect and mediated through KLHL15-binding and leads to RBBP8 proteasomal degradation (PubMed:27561354). Interacts with KLHL24 in the BCR(KLHL24) E3 ubiquitin ligase complex, composed of CUL3, RBX1 and KLHL24 (PubMed:27798626). Interacts with RHOBTB2 (PubMed:29276004). Interacts with AURKA and KLHL18 (via BTB domain) (PubMed:23213400). Interacts (unneddylated form) with DCUN1D1, DCUN1D2, DCUN1D3, DCUN1D4 and DCUN1D5; these interactions promote the cullin neddylation (PubMed:24192928, PubMed:26906416, PubMed:23201271, PubMed:25349211).
- SequenceCaution:
-
- Sequence=AAC28621.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAC36682.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAA31592.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for CUL3 Gene
Protein Expression for CUL3 Gene
Post-translational modifications for CUL3 Gene
- Neddylated. Attachment of NEDD8 is required for the E3 ubiquitin-protein ligase activity of the BCR complex. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.
-
Ubiquitination at Lys6, Lys28, Lys262, Lys292, Lys349, Lys638, Lys668, and Lys700
- NX_Q13618 (NX_Q13618-1)
- Modification sites at PhosphoSitePlus
Other Protein References for CUL3 Gene
Antibodies for research
- LifeSpan BioSciences CUL3 / Cullin 3 Antibody
-
Custom Antibody ServicesOriGene Antibodies for CUL3
- Novus Biologicals Antibodies for CUL3
- Invitrogen Antibodies for CUL3 (AFLGC-CUL3)
- antibodies-online: Show 35 available Cullin 3 Antibodies ranked by validation data
- Compare Top Cullin 3 Antibodies
-
Recommended
- 79 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 IP Antibody (anti-human)
- 44 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 1 IP Antibody (anti-mouse)
- 37 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 1 IP Antibody (anti-rat)
-
Custom Antibody ServicesProSci Antibodies for CUL3
-
Santa Cruz Biotechnology (SCBT) Antibodies for CUL3
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for CUL3
- Origene Custom Protein Services for CUL3
-
Abcam proteins for CUL3
Assay products for research
No data available for DME Specific Peptides for CUL3 Gene
Domains & Families for CUL3 Gene
Gene Families for CUL3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
Protein Domains for CUL3 Gene
- InterPro:
- Blocks:
-
- Cullin
- ProtoNet:
Suggested Antigen Peptide Sequences for CUL3 Gene
- GenScript: Design optimal peptide antigens:
-
- Cullin-3 (CUL3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q13618- Family:
-
- Belongs to the cullin family.
Function for CUL3 Gene
Molecular function for CUL3 Gene
- UniProtKB/Swiss-Prot Function:
- Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the BCR complex depends on the BTB domain-containing protein as the substrate recognition component. BCR(KLHL42) is involved in ubiquitination of KATNA1. BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, BRMS1, MACROH2A1 and DAXX, GLI2 and GLI3. Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL; these complexes have lower ubiquitin ligase activity. BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. BCR(KLHL12) is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) (PubMed:22358839, PubMed:27716508). BCR(KLHL3) acts as a regulator of ion transport in the distal nephron; by mediating ubiquitination of WNK4 (PubMed:23387299, PubMed:23453970, PubMed:23576762). The BCR(KLHL20) E3 ubiquitin ligase complex is involved in interferon response and anterograde Golgi to endosome transport: it mediates both ubiquitination leading to degradation and 'Lys-33'-linked ubiquitination (PubMed:20389280, PubMed:21840486, PubMed:21670212, PubMed:24768539). The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB (PubMed:19995937). The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation (PubMed:23455478). The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway (PubMed:29769719). The BCR(KLHL25) ubiquitin ligase complex is involved in translational homeostasis by mediating ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) (PubMed:22578813). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in ubiquitination of cyclin E and of cyclin D1 (in vitro) thus involved in regulation of G1/S transition. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41 (PubMed:15983046). In concert with ATF2 and RBX1, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. The BCR(KCTD17) E3 ubiquitin ligase complex mediates ubiquitination and degradation of TCHP, a down-regulator of cilium assembly, thereby inducing ciliogenesis (PubMed:25270598). The BCR(KLHL24) E3 ubiquitin ligase complex mediates ubiquitination of KRT14, controls KRT14 levels during keratinocytes differentiation, and is essential for skin integrity (PubMed:27798626). The BCR(KLHL18) E3 ubiquitin ligase complex mediates the ubiquitination of AURKA leading to its activation at the centrosome which is required for initiating mitotic entry (PubMed:23213400). The BCR(KEAP1) E3 ubiquitin ligase complex acts as a key sensor of oxidative and electrophilic stress by mediating ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed:15601839, PubMed:16006525).
- GENATLAS Biochemistry:
- cullin 3,salicylate suppressible gene,89kDa,C elegans cullin/Cdc53 (CUL) family member,likely involved in cell proliferation control
Phenotypes From GWAS Catalog for CUL3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | contributes_to ubiquitin-protein transferase activity | IDA | 15983046 |
| GO:0005112 | Notch binding | IPI | 25401743 |
| GO:0005515 | protein binding | IPI | 12609982 |
| GO:0030332 | cyclin binding | IEA | -- |
| GO:0031208 | POZ domain binding | IDA | 14528312 |
Phenotypes for CUL3 Gene
- MGI mutant phenotypes for CUL3:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for CUL3:
-
- no effect
- Decreased vaccinia virus (VACV) infection
- Decreased viability
- Mildly decreased CFP-tsO45G cell surface transport
- Resistant to vaccinia virus (VACV-A4L) infection
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Decreased shRNA abundance (Z-score < -2)
- Effect on mitosis
- Increased shRNA abundance (Z-score > 2)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased HPV16-GFP infection
- Increased cell death HMECs cells
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Increased G1 DNA content
- Increased homologous recombination repair frequency
- Increased viability with MLN4924 (a NAE inhibitor)
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CUL3 - Starting at $85 >
- * CUL3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CUL3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CUL3
-
Santa Cruz Biotechnology (SCBT) CRISPR for CUL3
miRNA for CUL3 Gene
- miRTarBase miRNAs that target CUL3
-
- hsa-miR-192-5p (MIRT004141)
- hsa-let-7b-5p (MIRT032239)
- hsa-miR-18a-3p (MIRT040752)
- hsa-miR-10a-5p (MIRT047577)
- hsa-miR-99a-5p (MIRT048703)
- hsa-miR-218-5p (MIRT440856)
- hsa-miR-203a-3p (MIRT447614)
- hsa-miR-4477a (MIRT447615)
- hsa-miR-4635 (MIRT447616)
- hsa-miR-1266-3p (MIRT447617)
- hsa-miR-4668-3p (MIRT447618)
- hsa-miR-3613-5p (MIRT447619)
- hsa-miR-591 (MIRT447620)
- hsa-miR-6807-5p (MIRT447621)
- hsa-miR-4764-5p (MIRT447622)
- hsa-miR-3177-5p (MIRT447623)
- hsa-miR-1233-3p (MIRT447624)
- hsa-miR-1225-3p (MIRT447625)
- hsa-miR-511-3p (MIRT447626)
- hsa-miR-1265 (MIRT447627)
- hsa-miR-4536-5p (MIRT538248)
- hsa-miR-4451 (MIRT538249)
- hsa-miR-379-5p (MIRT538250)
- hsa-miR-3529-5p (MIRT538251)
- hsa-miR-4650-3p (MIRT538252)
- hsa-miR-5197-3p (MIRT538253)
- hsa-miR-3120-3p (MIRT538254)
- hsa-miR-519c-3p (MIRT538255)
- hsa-miR-519b-3p (MIRT538256)
- hsa-miR-519a-3p (MIRT538257)
- hsa-miR-520e (MIRT538258)
- hsa-miR-302d-3p (MIRT538259)
- hsa-miR-302a-3p (MIRT538260)
- hsa-miR-302b-3p (MIRT538261)
- hsa-miR-520c-3p (MIRT538262)
- hsa-miR-520d-3p (MIRT538263)
- hsa-miR-520b (MIRT538264)
- hsa-miR-373-3p (MIRT538265)
- hsa-miR-372-3p (MIRT538266)
- hsa-miR-302e (MIRT538267)
- hsa-miR-302c-3p (MIRT538268)
- hsa-miR-520a-3p (MIRT538269)
- hsa-miR-454-3p (MIRT538270)
- hsa-miR-4295 (MIRT538271)
- hsa-miR-130a-3p (MIRT538272)
- hsa-miR-130b-3p (MIRT538273)
- hsa-miR-3666 (MIRT538274)
- hsa-miR-301a-3p (MIRT538275)
- hsa-miR-301b-3p (MIRT538276)
- hsa-miR-670-5p (MIRT659246)
- hsa-miR-4524b-5p (MIRT659247)
- hsa-miR-4524a-5p (MIRT659248)
- hsa-miR-6734-3p (MIRT659249)
- hsa-miR-4705 (MIRT659250)
- hsa-miR-339-5p (MIRT659251)
- hsa-miR-646 (MIRT659252)
- hsa-miR-6838-5p (MIRT659253)
- hsa-miR-503-5p (MIRT659254)
- hsa-miR-497-5p (MIRT659255)
- hsa-miR-424-5p (MIRT659256)
- hsa-miR-195-5p (MIRT659257)
- hsa-miR-16-5p (MIRT659258)
- hsa-miR-15b-5p (MIRT659259)
- hsa-miR-15a-5p (MIRT659260)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CUL3
- Browse OriGene Inhibitory RNA Products For CUL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CUL3
Clone products for research
- Applied Biological Materials (abm): Clones for CUL3 - Starting at $45 >
- * CUL3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CUL3
- Addgene plasmids for CUL3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CUL3
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CUL3 Gene
Localization for CUL3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CUL3 Gene
- Nucleus. Golgi apparatus. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Detected along the length of the sperm flagellum and in the cytoplasm of the germ cells (PubMed:28395323). Predominantly found in the nucleus in interphase cells, found at the centrosome at late G2 or prophase, starts accumulating at the spindle poles in prometaphase and stays on the spindle poles and the mitotic spindle at metaphase (PubMed:23213400). {ECO:0000269 PubMed:23213400, ECO:0000269 PubMed:28395323}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 4 |
| golgi apparatus | 3 |
| mitochondrion | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0000922 | spindle pole | IEA,IDA | 23213400 |
| GO:0005634 | nucleus | IEA,IDA | 23213400 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 28395323 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CUL3 Gene
Pathways & Interactions for CUL3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Class I MHC mediated antigen processing and presentation | ||
| 3 | Developmental Biology |
.51
|
|
| 4 | Cytokine Signaling in Immune system | ||
| 5 | CDK-mediated phosphorylation and removal of Cdc6 | ||
Pathways by source for CUL3 Gene
3 BioSystems pathways for CUL3 Gene
2 KEGG pathways for CUL3 Gene
1 GeneTex pathway for CUL3 Gene
UniProtKB/Swiss-Prot Q13618-CUL3_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for CUL3 Gene
Selected Interacting proteins:
Q13618-CUL3_HUMAN
ENSP00000264414
for CUL3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CUL3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | 8681378 |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000209 | protein polyubiquitination | IDA | 14528312 |
| GO:0000278 | mitotic cell cycle | IEA | -- |
Transcripts for CUL3 Gene
mRNA/cDNA for CUL3 Gene
- 3 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000264414 6756 nts (view in UCSC)
- ENST00000344951 6592 nts (view in UCSC)
- ENST00000409096 2701 nts (view in UCSC)
- ENST00000409777 3147 nts (view in UCSC)
- ENST00000432260 587 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CUL3 - Starting at $85 >
- * CUL3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CUL3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CUL3
-
Santa Cruz Biotechnology (SCBT) CRISPR for CUL3
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CUL3
- Browse OriGene Inhibitory RNA Products For CUL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CUL3
Clone products for research
- Applied Biological Materials (abm): Clones for CUL3 - Starting at $45 >
- * CUL3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CUL3
- Addgene plasmids for CUL3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CUL3
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: |
| ExUns: | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | · | 21c | ^ | 22a | · | 22b | · | 22c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||
| SP3: | |||||||||||||||||||
| SP4: | |||||||||||||||||||
| SP5: | |||||||||||||||||||
| SP6: | - | ||||||||||||||||||
| SP7: | |||||||||||||||||||
| SP8: | |||||||||||||||||||
| SP9: | |||||||||||||||||||
| SP10: |
Relevant External Links for CUL3 Gene
- GeneLoc Exon Structure for
- CUL3
Expression for CUL3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- XY Germ Cells Testis Cord
-
Gonad
- XY Germ Cells Testis Cord
- Eye (Sensory Organs)
-
Esophagus (Gastrointestinal Tract)
This gene is overexpressed in Lymph node (10.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CUL3 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CUL3
SOURCE GeneReport for Unigene cluster for CUL3 Gene:
Hs.372286mRNA Expression by UniProt/SwissProt for CUL3 Gene:
Q13618-CUL3_HUMAN
Tissue specificity:
Brain, spermatozoa, and testis (at protein level). Widely expressed.
Evidence on tissue expression from TISSUES for CUL3 Gene
- Nervous system(4.8)
- Skin(4.6)
- Kidney(3)
- Muscle(2.9)
- Eye(2.9)
- Heart(2.8)
- Liver(2.8)
- Intestine(2.7)
- Blood(2.7)
- Lung(2.6)
- Lymph node(2.5)
- Spleen(2.5)
- Thyroid gland(2.4)
- Stomach(2.4)
- Adrenal gland(2.2)
- Gall bladder(2.2)
- Bone marrow(2.2)
- Pancreas(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CUL3 Gene
Germ Layers:
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- skeletal muscle
- urinary
Regions:
Head and neck:
- ear
Thorax:
- heart
- heart valve
Abdomen:
- intestine
- kidney
- large intestine
- small intestine
General:
- blood vessel
Primer products for research
-
OriGene qPCR primer pairs for CUL3
-
OriGene qPCR primer pairs and template standards for CUL3
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues for CUL3 Gene
Orthologs for CUL3 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Oppossum (Monodelphis domestica) |
Mammalia | CUL3 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CUL3 31 |
|
OneToOne | |
| Chimpanzee (Pan troglodytes) |
Mammalia | CUL3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CUL3 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Cul3 30 17 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CUL3 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cul3 30 |
|
||
| Chicken (Gallus gallus) |
Aves | CUL3 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CUL3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cul3 30 |
|
||
| Str.1179 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.5089 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | CUL3 (2 of 2) 31 |
|
OneToMany | |
| cul3a 31 |
|
OneToMany | |||
| cul3b 30 |
|
||||
| cul3 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3721 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | gft 32 |
|
|
|
| Cul-3 30 31 |
|
OneToOne | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008105 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | cul-3 30 31 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CUL3 33 |
|
|
|
| Rice (Oryza sativa) |
Liliopsida | Os04g0643000 30 |
|
||
| Barley (Hordeum vulgare) |
Liliopsida | Hv.2891 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11274 31 |
|
OneToOne |
- Species where no ortholog for CUL3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for CUL3 Gene
- ENSEMBL:
- Gene Tree for CUL3 (if available)
- TreeFam:
- Gene Tree for CUL3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CUL3: view image
Paralogs for CUL3 Gene
Variants for CUL3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CUL3 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 895162 | Uncertain Significance: Pseudohypoaldosteronism type 2E | 224,471,111(-) |
T/A NM_003590.5(CUL3):c.*3134A>T |
THREE_PRIME_UTR | |
| 895226 | Uncertain Significance: Pseudohypoaldosteronism type 2E | 224,473,330(-) |
T/C NM_003590.5(CUL3):c.*915A>G |
THREE_PRIME_UTR | |
| 895279 | Uncertain Significance: Pseudohypoaldosteronism type 2E | 224,502,988(-) |
T/G NM_003590.5(CUL3):c.1462A>C (p.Arg488=) |
SYNONYMOUS | |
| 895280 | Benign: Pseudohypoaldosteronism type 2E | 224,503,049(-) |
C/T NM_003590.5(CUL3):c.1401G>A (p.Thr467=) |
SYNONYMOUS | |
| 895281 | Uncertain Significance: Pseudohypoaldosteronism type 2E | 224,503,736(-) |
A/G NM_003590.5(CUL3):c.1293T>C (p.Tyr431=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2461086 | CNV | deletion | 19546169 |
| esv2464203 | CNV | deletion | 19546169 |
| nsv953190 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
9.32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.93;
79.70% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CUL3 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CUL3 Gene
Disorders for CUL3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pseudohypoaldosteronism, type iie |
|
|
| pseudohypoaldosteronism, type iia |
|
|
| agenesis of corpus callosum, cardiac, ocular, and genital syndrome |
|
|
| pseudohypoaldosteronism, type i, autosomal dominant |
|
|
| pseudohypoaldosteronism |
|
|
Search CUL3 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
CUL3_HUMAN- Pseudohypoaldosteronism 2E (PHA2E) [MIM:614496]: An autosomal dominant disorder characterized by severe hypertension, hyperkalemia, hyperchloremia, hyperchloremic metabolic acidosis, and correction of physiologic abnormalities by thiazide diuretics. {ECO:0000269 PubMed:22266938}. Note=The disease is caused by variants affecting the gene represented in this entry.
Additional Disease Information for CUL3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for CUL3 Gene
Publications for CUL3 Gene
- Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities. (PMID: 22266938) Boyden LM … Lifton RP (Nature 2012) 3 4 74
- The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses. (PMID: 20389280) Lee YR … Chen RH (The EMBO journal 2010) 3 4 23
- A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells. (PMID: 17543862) Sumara I … Peter M (Developmental cell 2007) 3 4 23
- The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimer. (PMID: 17192413) Wimuttisuk W … Singer JD (Molecular biology of the cell 2007) 2 3 4
- BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase. (PMID: 16524876) Kwon JE … Chung CH (The Journal of biological chemistry 2006) 3 4 23
ExternalLinks
Products for CUL3 Gene
- Custom Antibody ServicesOriGene Antibodies for CUL3
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CUL3
- Origene Custom Protein Services for CUL3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CUL3
- Browse OriGene Inhibitory RNA Products For CUL3
- OriGene qPCR primer pairs for CUL3
- OriGene qPCR primer pairs and template standards for CUL3
- OriGene CRISPR knockouts for CUL3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CUL3
- Sino Biological Human cDNA Clone for CUL3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CUL3
- Novus Biologicals proteins and lysates for CUL3
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for CUL3
- Find your target
- Browse Primary Antibodies
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- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for CUL3 (AFLGC-CUL3)
- VectorBuilder Custom and pre-made DNA vectors for CUL3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CUL3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CUL3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CUL3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CUL3
- Addgene plasmids for CUL3
- antibodies-online: Show 35 available Cullin 3 Antibodies ranked by validation data
- Compare Top Cullin 3 Antibodies
- Recommended
- 79 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 IP Antibody (anti-human)
- 44 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 1 IP Antibody (anti-mouse)
- 37 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 1 IP Antibody (anti-rat)
- antibodies-online: Search results for available Cullin 3 related products ranked by validation data
- antibodies-online: Show 6 available Cullin 3 Proteins ranked by validation data
- Compare Top Cullin 3 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CUL3
- Search Santa Cruz Biotechnology (SCBT) for CUL3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CUL3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CUL3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CUL3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CUL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CUL3
Sources for CUL3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
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- (26) HMDB
- (27) ASD
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- (29) SOURCE
- (30) HomoloGene
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- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
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