Aliases for CUL2 Gene
External Ids for CUL2 Gene
Previous GeneCards Identifiers for CUL2 Gene
GeneCards Summary for CUL2 Gene
CUL2 (Cullin 2) is a Protein Coding gene. Diseases associated with CUL2 include Hypoxia and Von Hippel-Lindau Syndrome. Among its related pathways are Cellular Senescence (REACTOME) and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is CUL1.
UniProtKB/Swiss-Prot Summary for CUL2 Gene
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).