Aliases for CUL2 Gene
External Ids for CUL2 Gene
Previous GeneCards Identifiers for CUL2 Gene
GeneCards Summary for CUL2 Gene
CUL2 (Cullin 2) is a Protein Coding gene. Diseases associated with CUL2 include Von Hippel-Lindau Syndrome and Hypoxia. Among its related pathways are HIF1Alpha Pathway and ErbB signaling pathway. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is CUL1.
UniProtKB/Swiss-Prot Summary for CUL2 Gene
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).