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CUL1 Gene(Protein Coding)

Cullin 1

GCID:
GC07P148697
GIFtS:
52
Genes Participants
UDN Logo

Aliases for CUL1 Gene

Aliases for CUL1 Gene

  • Cullin 1 2 3 5
  • CUL-1 3 4
  • Cullin-1 3

External Ids for CUL1 Gene

Previous GeneCards Identifiers for CUL1 Gene

  • GC07P146673
  • GC07P147710
  • GC07P147787
  • GC07P147833
  • GC07P148026
  • GC07P148395
  • GC07P142474

Summaries for CUL1 Gene

GeneCards Summary for CUL1 Gene

CUL1 (Cullin 1) is a Protein Coding gene. Diseases associated with CUL1 include Weaver Syndrome and Xeroderma Pigmentosum Group E. Among its related pathways are Activated TLR4 signalling and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is CUL2.

UniProtKB/Swiss-Prot for CUL1 Gene

  • Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/or SCF(FBXW11) direct ubiquitination of CEP68 (PubMed:25704143, PubMed:25503564). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at Lys-21 and Lys-22; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2.

Gene Wiki entry for CUL1 Gene

Additional gene information for CUL1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUL1 Gene

Genomics for CUL1 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for CUL1 Gene

Promoters and enhancers for CUL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH07J148697 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 673.3 +1.5 1548 4.6 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 POLR2B CUL1 ENSG00000273314 GC07M148698 GC07M148697 ZNF212 ZNF398 ZNF783 ENSG00000271664 ZNF282 ZNF767P
GH07J148729 Promoter 0.5 EPDnew 650.3 +32.0 32028 0.1 CUL1 GC07M148697 GC07M148769
GH07J149124 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19.5 +428.9 428912 3.8 CLOCK MLX DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZFP41 ZNF398 ZNF425 RN7SL521P GC07M149126 ZNF786 ZNF212 ZNF783 ENSG00000271664 ZNF282 ZNF767P
GH07J148940 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 19.1 +243.5 243487 2.8 PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B EZH2 RNY5 GC07P148942 ZNF398 ZNF783 ZNF777 ENSG00000271664 ZNF212 ZNF767P LOC155060
GH07J148986 Promoter/Enhancer 1.6 Ensembl ENCODE 19.1 +289.2 289226 2.6 PKNOX1 SMAD1 ARNT ARID4B SIN3A ZNF2 ZNF766 ZNF213 E2F8 ZNF143 RNY1 GHET1 GC07M148988 ZNF783 LOC155060 ZNF212 ZNF398 ENSG00000271664 ZNF777 ZNF767P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CUL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CUL1 gene promoter:
  • MyoD
  • FOXO1
  • FOXO1a
  • FOXO3a
  • FOXO3b
  • FOXO3

Genomic Locations for CUL1 Gene

Genomic Locations for CUL1 Gene
chr7:148,697,914-148,801,110
(GRCh38/hg38)
Size:
103,197 bases
Orientation:
Plus strand
chr7:148,395,006-148,498,202
(GRCh37/hg19)
Size:
103,197 bases
Orientation:
Plus strand

Genomic View for CUL1 Gene

Genes around CUL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CUL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CUL1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CUL1 Gene

Proteins for CUL1 Gene

Products:

  1. Antibody
  2. Protein
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  • Protein details for CUL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13616-CUL1_HUMAN
    Recommended name:
    Cullin-1
    Protein Accession:
    Q13616
    Secondary Accessions:
    • D3DWG3
    • O60719
    • Q08AL6
    • Q8IYW1

    Protein attributes for CUL1 Gene

    Size:
    776 amino acids
    Molecular mass:
    89679 Da
    Quaternary structure:
    • Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit. Component of the SCF(FBXW11) complex containing FBXW11. Component of the SCF(SKP2) complex containing SKP2, in which it interacts directly with SKP1, SKP2 and RBX1. Component of the SCF(FBXW2) complex containing FBXW2. Component of the SCF(FBXO32) complex containing FBXO32. Component of the probable SCF(FBXO7) complex containing FBXO7. Component of the SCF(FBXO10) complex containing FBXO10. Component of the SCF(FBXO11) complex containing FBXO11. Component of the SCF(FBXO25) complex containing FBXO25. Component of the SCF(FBXO33) complex containing FBXO33. Component of the probable SCF(FBXO4) complex containing FBXO4. Component of the SCF(FBXO44) complex, composed of SKP1, CUL1 and FBXO44. Component of the SCF(BTRC) complex, composed of SKP1, CUL1 and BTRC. This complex binds phosphorylated NFKBIA. Part of a SCF complex consisting of CUL1, RBX1, SKP1 and FBXO2. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Component of the SCF(FBXO17) complex, composed of SKP1, CUL1 and FBXO17. Component of the SCF(FBXO27) complex, composed of SKP1, CUL1 and FBXO27. Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF. Component of the SCF(FBXL3) complex composed of CUL1, SKP1, RBX1 and FBXL3. Component of the SCF(FBXL21) complex composed of CUL1, SKP1, RBX1 and FBXL21. Component of the SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Component of the SCF(FBXW7) composed of CUL1, SKP1, RBX1 and FBXW7. Interacts with CHEK2; mediates CHEK2 ubiquitination and regulates its function. Part of a complex with TIP120A/CAND1 and RBX1. The unneddylated form interacts with TIP120A/CAND1 and the interaction mediates the exchange of the F-box substrate-specific subunit. Can self-associate. Interacts with FBXW8. Interacts with RNF7. Interacts with CUL7; the interaction seems to be mediated by FBXW8. Interacts with TRIM21. Interacts with COPS2. Interacts with DCUN1D3. Interacts with CEP68 as part of the SCF(FBXW11) complex; the interaction is probably mediated by FBXW11 and the complex also contains CDK5RAP2 and PCNT (PubMed:25503564). Interacts (when neddylated) with ARIH1; leading to activate the E3 ligase activity of ARIH1 (PubMed:24076655, PubMed:27565346). Interacts with COPS9 isoform 2 (PubMed:23776465). Interacts with UBXN1 (PubMed:28152074). Interacts with KAT7, probably as part of an SCF complex; the interaction mediates KAT7 ubiquitination (By similarity). Interacts with NOTCH2 (PubMed:29149593).
    • (Microbial infection) Interacts with Epstein-Barr virus BPLF1.
    • (Microbial infection) Interacts with Human adenovirus early E1A protein; this interaction inhibits RBX1-CUL1-dependent elongation reaction of ubiquitin chains by the SCF(FBXW7) complex.

    Three dimensional structures from OCA and Proteopedia for CUL1 Gene

neXtProt entry for CUL1 Gene

Protein Expression for CUL1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CUL1 Gene

  • Neddylated; which enhances the ubiquitination activity of SCF and prevents binding of the inhibitor CAND1. Deneddylated via its interaction with the COP9 signalosome (CSN) complex (PubMed:10597293, PubMed:10713156, PubMed:15537541, PubMed:18805092).
  • (Microbial infection) Deneddylated by Epstein-Barr virus BPLF1 leading to a S-phase-like environment that is required for efficient replication of the viral genome (PubMed:20190741).
  • Ubiquitination at Lys769, Lys708, Lys468, Lys464, posLast=410410, and posLast=131131
  • Modification sites at PhosphoSitePlus

Other Protein References for CUL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CUL1 Gene

Domains & Families for CUL1 Gene

Gene Families for CUL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CUL1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CUL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13616

UniProtKB/Swiss-Prot:

CUL1_HUMAN :
  • Belongs to the cullin family.
Family:
  • Belongs to the cullin family.
genes like me logo Genes that share domains with CUL1: view

Function for CUL1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CUL1 Gene

UniProtKB/Swiss-Prot Function:
Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/or SCF(FBXW11) direct ubiquitination of CEP68 (PubMed:25704143, PubMed:25503564). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at Lys-21 and Lys-22; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2.

Phenotypes From GWAS Catalog for CUL1 Gene

Gene Ontology (GO) - Molecular Function for CUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 10644755
GO:0031625 ubiquitin protein ligase binding IBA,IEA --
GO:0061630 contributes_to ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with CUL1: view
genes like me logo Genes that share phenotypes with CUL1: view

Animal Models for CUL1 Gene

MGI Knock Outs for CUL1:

Animal Model Products

miRNA for CUL1 Gene

miRTarBase miRNAs that target CUL1

Clone Products

  • Addgene plasmids for CUL1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CUL1 Gene

Localization for CUL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CUL1 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0019005 SCF ubiquitin ligase complex ISS --
GO:0031461 cullin-RING ubiquitin ligase complex IEA,IDA 22405651
GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex IPI 12628165
genes like me logo Genes that share ontologies with CUL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CUL1 Gene

Pathways & Interactions for CUL1 Gene

SuperPathways for CUL1 Gene

PathCards logo More details on SuperPathways for CUL1
SuperPathway Contained pathways
1 Activated TLR4 signalling
Toll Like Receptor 9 (TLR9) Cascade
.94
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
.94
Activated TLR4 signalling
.91
Toll Like Receptor 4 (TLR4) Cascade
.91
MyD88 cascade initiated on plasma membrane
.88
Toll Like Receptor 10 (TLR10) Cascade
.88
Toll Like Receptor 5 (TLR5) Cascade
.88
MyD88 dependent cascade initiated on endosome
.86
Toll Like Receptor 7/8 (TLR7/8) Cascade
.86
MyD88-independent TLR3/TLR4 cascade
.86
Toll Like Receptor 3 (TLR3) Cascade
.86
TRIF-mediated TLR3/TLR4 signaling
.86
MyD88-Mal cascade initiated on plasma membrane
.85
Toll Like Receptor 2 (TLR2) Cascade
.85
Toll Like Receptor TLR1-TLR2 Cascade
.85
Toll Like Receptor TLR6-TLR2 Cascade
.85
Toll-Like Receptors Cascades
.82
MAP kinase activation in TLR cascade
.76
2 CDK-mediated phosphorylation and removal of Cdc6
Cyclin A-Cdk2-associated events at S phase entry
.93
Cyclin E associated events during G1/S transition
.93
APC/C-mediated degradation of cell cycle proteins
.93
Regulation of APC/C activators between G1/S and early anaphase
.93
Regulation of mitotic cell cycle
.93
SCF-beta-TrCP mediated degradation of Emi1
.91
Degradation of GLI1 by the proteasome
.89
Degradation of GLI2 by the proteasome
.89
GLI3 is processed to GLI3R by the proteasome
.89
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
.88
SCF(Skp2)-mediated degradation of p27/p21
.86
NIK-->noncanonical NF-kB signaling
.85
Dectin-1 mediated noncanonical NF-kB signaling
.84
S Phase
.78
Activation of NF-kappaB in B cells
.77
FCERI mediated NF-kB activation
.72
Degradation of beta-catenin by the destruction complex
.64
TNFR2 non-canonical NF-kB pathway
.58
3 Signaling by NOTCH1
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
.78
Constitutive Signaling by NOTCH1 PEST Domain Mutants
.78
Signaling by NOTCH1
.78
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
.78
Signaling by NOTCH1 in Cancer
.78
Signaling by NOTCH1 PEST Domain Mutants in Cancer
.78
NOTCH1 Intracellular Domain Regulates Transcription
.68
Signaling by NOTCH
.65
4 Cell cycle Role of SCF complex in cell cycle regulation
Cell cycle Regulation of G1/S transition (part 1)
.40
Cell cycle Role of SCF complex in cell cycle regulation
.40
Cell cycle ESR1 regulation of G1/S transition
.34
Immune response MIF-JAB1 signaling
.33
5 Class I MHC mediated antigen processing and presentation
Antigen processing- Ubiquitination and Proteasome degradation
.83
Class I MHC mediated antigen processing and presentation
.83
Adaptive Immune System
.45
genes like me logo Genes that share pathways with CUL1: view

UniProtKB/Swiss-Prot Q13616-CUL1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for CUL1 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for CUL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS 8681378
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
genes like me logo Genes that share ontologies with CUL1: view

Drugs & Compounds for CUL1 Gene

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(3) Drugs for CUL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CUL1: view

Transcripts for CUL1 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CUL1 Gene

(6) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(449) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CUL1 Gene

Cullin 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for CUL1

Alternative Splicing Database (ASD) splice patterns (SP) for CUL1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^
SP1: - - - - -
SP2: -
SP3:
SP4: - - - - - - - -
SP5: - - - - - - -
SP6: - - - - -
SP7: - - - -
SP8: -
SP9:
SP10: - - - - - - - - - -
SP11: - - - - - -
SP12:
SP13:
SP14:
SP15: -
SP16:
SP17:

ExUns: 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c ^ 27a · 27b ^ 28a · 28b
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - -
SP10:
SP11:
SP12: -
SP13:
SP14: -
SP15:
SP16:
SP17:

Relevant External Links for CUL1 Gene

GeneLoc Exon Structure for
CUL1
ECgene alternative splicing isoforms for
CUL1

Expression for CUL1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CUL1 Gene

mRNA expression in normal human tissues for CUL1 Gene
mRNA expression by GTEx for CUL1 GenemRNA expression by BioGPS for CUL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CUL1 Gene

This gene is overexpressed in Lymph node (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CUL1 Gene



Protein tissue co-expression partners for CUL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CUL1 Gene:

CUL1

SOURCE GeneReport for Unigene cluster for CUL1 Gene:

Hs.146806

mRNA Expression by UniProt/SwissProt for CUL1 Gene:

Q13616-CUL1_HUMAN
Tissue specificity: Expressed in lung fibroblasts.

Evidence on tissue expression from TISSUES for CUL1 Gene

  • Nervous system(4.5)
  • Liver(4.4)
  • Lung(2.4)
  • Muscle(2.3)
  • Intestine(2.2)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with CUL1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CUL1 Gene

Orthologs for CUL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CUL1 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
 Mammalia CUL1 34
  • 100 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia CUL1 34 33
  • 99.61 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia CUL1 34
  • 99 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Cul1 16 34 33
  • 91.19 (n)
rat
(Rattus norvegicus)
 Mammalia Cul1 33
  • 90.76 (n)
dog
(Canis familiaris)
 Mammalia CUL1 34 33
  • 90.42 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia CUL1 34 33
  • 89.13 (n)
 OneToOne
chicken
(Gallus gallus)
 Aves CUL1 34 33
  • 83.85 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia CUL1 34
  • 89 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia cul1 33
  • 82.86 (n)
Str.6235 33
African clawed frog
(Xenopus laevis)
 Amphibia Xl.23826 33
zebrafish
(Danio rerio)
 Actinopterygii cul1a 34
  • 97 (a)
 OneToMany
cul1b 34 33
  • 78.44 (n)
 OneToMany
wufc13a10 33
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.14110 33
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP008007 33
  • 64.47 (n)
fruit fly
(Drosophila melanogaster)
 Insecta lin19 34 35 33
  • 59.85 (n)
 OneToOne
CG11261 35
  • 25 (a)
worm
(Caenorhabditis elegans)
 Secernentea cul-1 34 35 33
  • 52.85 (n)
 OneToMany
cul-6 34 35
  • 37 (a)
 OneToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes CDC53 36 34
  • 31 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 72 (a)
 OneToOne
Cin.13631 33
bread mold
(Neurospora crassa)
 Ascomycetes NCU05204 33
  • 53.41 (n)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes cul1 33
  • 50.57 (n)
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.13631 33
Species where no ortholog for CUL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CUL1 Gene

ENSEMBL:
Gene Tree for CUL1 (if available)
TreeFam:
Gene Tree for CUL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CUL1: view image

Paralogs for CUL1 Gene

Paralogs for CUL1 Gene

(5) SIMAP similar genes for CUL1 Gene using alignment to 2 proteins:

  • CUL1_HUMAN
  • Q75MQ1_HUMAN

Pseudogenes.org Pseudogenes for CUL1 Gene

genes like me logo Genes that share paralogs with CUL1: view

Variants for CUL1 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for CUL1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000035239 -- 148,702,938(+) A/G intron_variant
rs1000099201 -- 148,742,238(+) G/A intron_variant
rs1000153860 -- 148,736,875(+) G/A intron_variant
rs1000187366 -- 148,698,144(+) T/C upstream_transcript_variant
rs1000206601 -- 148,737,102(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CUL1 Gene

Variant ID Type Subtype PubMed ID
esv21729 CNV loss 19812545
esv2386698 CNV deletion 18987734
esv2671538 CNV deletion 23128226
esv2735325 CNV deletion 23290073
esv2735326 CNV deletion 23290073
nsv1119145 CNV deletion 24896259
nsv465194 CNV gain 19166990
nsv518186 CNV loss 19592680
nsv522305 CNV loss 19592680
nsv528653 CNV loss 19592680
nsv608972 CNV gain 21841781
nsv958422 CNV deletion 24416366

Variation tolerance for CUL1 Gene

Residual Variation Intolerance Score: 9.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CUL1 Gene

Human Gene Mutation Database (HGMD)
CUL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CUL1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CUL1 Gene

Disorders for CUL1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CUL1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
weaver syndrome
  • wvs
xeroderma pigmentosum group e
  • xeroderma pigmentosum, complementation group e
parkinson disease, late-onset
  • pd
- elite association - COSMIC cancer census association via MalaCards
Search CUL1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CUL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CUL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CUL1 Gene

Publications for CUL1 Gene

  1. CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex. (PMID: 12504026) Zheng J … Zhang H (Molecular cell 2002) 3 4 22 58
  2. Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha. (PMID: 10713156) Read MA … Palombella VJ (Molecular and cellular biology 2000) 3 4 22 58
  3. Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: chip profiling implicates its role in cell cycle regulation. (PMID: 10851089) Swaroop M … Sun Y (Oncogene 2000) 3 4 22 58
  4. Covalent modification of all members of human cullin family proteins by NEDD8. (PMID: 10597293) Hori T … Tanaka K (Oncogene 1999) 3 4 22 58
  5. Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha. (PMID: 10230406) Tan P … Pan ZQ (Molecular cell 1999) 3 4 22 58

Products for CUL1 Gene

  • Addgene plasmids for CUL1

Sources for CUL1 Gene