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Aliases for CUEDC2 Gene

Aliases for CUEDC2 Gene

  • CUE Domain Containing 2 2 3 5
  • C10orf66 3 4
  • Chromosome 10 Open Reading Frame 66 2
  • CUE Domain-Containing Protein 2 3
  • BA18I14.5 3

External Ids for CUEDC2 Gene

Previous HGNC Symbols for CUEDC2 Gene

  • C10orf66

Previous GeneCards Identifiers for CUEDC2 Gene

  • GC10M103848
  • GC10M104172
  • GC10M097816
  • GC10M104184

Summaries for CUEDC2 Gene

GeneCards Summary for CUEDC2 Gene

CUEDC2 (CUE Domain Containing 2) is a Protein Coding gene. Among its related pathways are DNA Damage.

UniProtKB/Swiss-Prot for CUEDC2 Gene

  • Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.

Additional gene information for CUEDC2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUEDC2 Gene

Genomics for CUEDC2 Gene

GeneHancer (GH) Regulatory Elements for CUEDC2 Gene

Promoters and enhancers for CUEDC2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I102431 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 550.8 -1.5 -1531 5.5 HDGF FOXA2 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 POLR2B CUEDC2 HPS6 PPRC1 LDB1 PDCD11 TAF5 SUFU GBF1 PCGF6 RPARP-AS1
GH10I102427 Promoter 0.5 EPDnew 550.8 +4.7 4683 0.1 CUEDC2 PSD GC10M102382 GC10M102383
GH10I102595 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -168.0 -168005 11.2 FOXA2 MLX ARID4B DMAP1 ZNF2 YY1 ZNF766 ZNF143 FOS SP5 MFSD13A SFXN2 ACTR1A SUFU C10orf95 PSD FBXL15 CUEDC2 MIR146B ARL3
GH10I102467 Enhancer 0.9 Ensembl ENCODE 12 -36.2 -36208 2.7 HDAC1 KLF1 NFATC3 CEBPB DPF2 ELF1 ZBTB40 GABPA NFIC MTA1 GC10P102468 MFSD13A MIR146B CUEDC2 SUFU NFKB2 RNU6-43P PSD FBXL15 ELOVL3
GH10I102478 Enhancer 0.9 ENCODE 11.6 -46.6 -46561 0.9 PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF2 IRF4 POLR2B E2F8 ARID2 MFSD13A SUFU MIR146B CUEDC2 RNU6-43P NFKB2 ELOVL3 ENSG00000273262 GC10P102474 PIR54211
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CUEDC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CUEDC2 gene promoter:

Genomic Locations for CUEDC2 Gene

Genomic Locations for CUEDC2 Gene
9,422 bases
Minus strand

Genomic View for CUEDC2 Gene

Genes around CUEDC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CUEDC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CUEDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUEDC2 Gene

Proteins for CUEDC2 Gene

  • Protein details for CUEDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CUE domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • D3DR88
    • Q9BWG8

    Protein attributes for CUEDC2 Gene

    287 amino acids
    Molecular mass:
    32009 Da
    Quaternary structure:
    • Interacts with PGR. Interacts with ESR1 in the presence or absence of 17 beta-estradiol.
    • Sequence=AAH00262.1; Type=Erroneous termination; Positions=227; Note=Translated as Glu.; Evidence={ECO:0000305};

neXtProt entry for CUEDC2 Gene

Post-translational modifications for CUEDC2 Gene

  • Ubiquitination at posLast=8282, Lys186, Lys213, Lys219, posLast=230230, Lys256, Lys261, Lys272, and posLast=279279

Other Protein References for CUEDC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CUEDC2 Gene

Domains & Families for CUEDC2 Gene

Gene Families for CUEDC2 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for CUEDC2 Gene


Suggested Antigen Peptide Sequences for CUEDC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The CUE domain mediates interaction with PGR and ESR1.
  • Belongs to the CUEDC2 family.
  • The CUE domain mediates interaction with PGR and ESR1.
  • Belongs to the CUEDC2 family.
genes like me logo Genes that share domains with CUEDC2: view

Function for CUEDC2 Gene

Molecular function for CUEDC2 Gene

UniProtKB/Swiss-Prot Function:
Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.

Phenotypes From GWAS Catalog for CUEDC2 Gene

Gene Ontology (GO) - Molecular Function for CUEDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17347654
genes like me logo Genes that share ontologies with CUEDC2: view
genes like me logo Genes that share phenotypes with CUEDC2: view

Animal Model Products

miRNA for CUEDC2 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CUEDC2 Gene

Localization for CUEDC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CUEDC2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CUEDC2 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CUEDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with CUEDC2: view

Pathways & Interactions for CUEDC2 Gene

SuperPathways for CUEDC2 Gene

SuperPathway Contained pathways
1 DNA Damage
genes like me logo Genes that share pathways with CUEDC2: view

Pathways by source for CUEDC2 Gene

1 Cell Signaling Technology pathway for CUEDC2 Gene

Gene Ontology (GO) - Biological Process for CUEDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010936 negative regulation of macrophage cytokine production IMP,IEA 24882011
GO:1900016 negative regulation of cytokine production involved in inflammatory response IEA,IMP 24882011
genes like me logo Genes that share ontologies with CUEDC2: view

No data available for SIGNOR curated interactions for CUEDC2 Gene

Drugs & Compounds for CUEDC2 Gene

No Compound Related Data Available

Transcripts for CUEDC2 Gene

Unigene Clusters for CUEDC2 Gene

CUE domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CUEDC2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - -
SP2: - -
SP3: - - -
SP4: -
SP5: -
SP6: - - -
SP7: -

Relevant External Links for CUEDC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CUEDC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CUEDC2 Gene

Protein differential expression in normal tissues from HIPED for CUEDC2 Gene

This gene is overexpressed in Bone (56.0) and Fetal Brain (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CUEDC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CUEDC2 Gene:


SOURCE GeneReport for Unigene cluster for CUEDC2 Gene:


mRNA Expression by UniProt/SwissProt for CUEDC2 Gene:

Tissue specificity: Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors.

Evidence on tissue expression from TISSUES for CUEDC2 Gene

  • Eye(4.2)
  • Bone(4)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with CUEDC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CUEDC2 Gene

Orthologs for CUEDC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CUEDC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CUEDC2 33 34
  • 99.88 (n)
(Canis familiaris)
Mammalia CUEDC2 33 34
  • 93.01 (n)
(Bos Taurus)
Mammalia CUEDC2 33 34
  • 92.11 (n)
(Rattus norvegicus)
Mammalia Cuedc2 33
  • 88.64 (n)
(Mus musculus)
Mammalia Cuedc2 33 16 34
  • 88.62 (n)
(Ornithorhynchus anatinus)
Mammalia CUEDC2 34
  • 58 (a)
(Monodelphis domestica)
Mammalia CUEDC2 34
  • 55 (a)
(Gallus gallus)
Aves CUEDC2 33 34
  • 62.86 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia cuedc2 33
  • 59.41 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398317 33
(Danio rerio)
Actinopterygii cuedc2 33 34
  • 55.19 (n)
wufi42e02 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001586 33
  • 48.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9636 33 34
  • 44.36 (n)
Species where no ortholog for CUEDC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CUEDC2 Gene

Gene Tree for CUEDC2 (if available)
Gene Tree for CUEDC2 (if available)

Paralogs for CUEDC2 Gene

No data available for Paralogs for CUEDC2 Gene

Variants for CUEDC2 Gene

Sequence variations from dbSNP and Humsavar for CUEDC2 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000023936 -- 102,432,501(-) G/A intron_variant
rs1000056704 -- 102,432,142(-) C/T intron_variant
rs1000082882 -- 102,424,972(-) G/A intron_variant
rs1000102189 -- 102,429,751(-) G/A intron_variant
rs1000473105 -- 102,429,309(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CUEDC2 Gene

Variant ID Type Subtype PubMed ID
nsv1159761 CNV deletion 26073780
nsv951006 CNV deletion 24416366

Variation tolerance for CUEDC2 Gene

Residual Variation Intolerance Score: 33.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CUEDC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CUEDC2 Gene

Disorders for CUEDC2 Gene


  • Note=May predict the clinical outcome of tamoxifen therapy of breast cancer patients. Patients with tumors that highly express CUEDC2 do not respond to tamoxifen treatment as effectively as those with tumors with low expression.

Additional Disease Information for CUEDC2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CUEDC2 Gene.

No data available for MalaCards and Genatlas for CUEDC2 Gene

Publications for CUEDC2 Gene

  1. CUEDC2 interacts with heat shock protein 70 and negatively regulates its chaperone activity. (PMID: 24685480) Gong L … Chen L (Biochemical and biophysical research communications 2014) 2 3 58
  2. Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer. (PMID: 21572428) Pan X … Zhang XM (Nature medicine 2011) 3 4 58
  3. CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasome. (PMID: 17347654) Zhang PJ … Zhang XM (The EMBO journal 2007) 3 4 58
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58

Products for CUEDC2 Gene

Sources for CUEDC2 Gene

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