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Aliases for CUEDC1 Gene
External Ids for CUEDC1 Gene
- HGNC: 31350
- Entrez Gene: 404093
- Ensembl: ENSG00000180891
- UniProtKB: Q9NWM3
Previous GeneCards Identifiers for CUEDC1 Gene
- GC17M056415
- GC17M053295
- GC17M055940
- GC17M051300
Summaries for CUEDC1 Gene
GeneCards Summary for CUEDC1 Gene
CUEDC1 (CUE Domain Containing 1) is a Protein Coding gene. Diseases associated with CUEDC1 include Proximal Symphalangism and Perrault Syndrome.
Additional gene information for CUEDC1 Gene
- HGNC(31350)
- Entrez Gene(404093)
- Ensembl(ENSG00000180891)
- UniProtKB(Q9NWM3)
- Open Targets Platform(ENSG00000180891)
- Monarch Initiative
- Search for CUEDC1 at DataMed
- Search for CUEDC1 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CUEDC1 Gene
Genomics for CUEDC1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CUEDC1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CUEDC1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CUEDC1
- Top Transcription factor binding sites by QIAGEN in the CUEDC1 gene promoter:
-
- AML1a
- c-Rel
- E47
- FOXO1
- FOXO1a
- GATA-3
- HEN1
- Lmo2
- Sox9
- Tal-1
Genomic Locations for CUEDC1 Gene
Genomic Locations for CUEDC1 Gene
- chr17:57,861,243-57,955,412
- (GRCh38/hg38)
- Size:
- 94,170 bases
- Orientation:
- Minus strand
- chr17:55,938,604-56,032,684
- (GRCh37/hg19)
- Size:
- 94,081 bases
- Orientation:
- Minus strand
Genomic View for CUEDC1 Gene
Genes around CUEDC1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q22 by HGNC
- 17q22 by Entrez Gene
- 17q22 by Ensembl
CUEDC1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CUEDC1 Gene
Proteins for CUEDC1 Gene
-
Protein details for CUEDC1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NWM3-CUED1_HUMAN
- Recommended name:
- CUE domain-containing protein 1
- Protein Accession:
- Q9NWM3
- D3DTZ2
- Q9NWD0
Protein attributes for CUEDC1 Gene
- Size:
- 386 amino acids
- Molecular mass:
- 42258 Da
- Quaternary structure:
- No Data Available
Protein Expression for CUEDC1 Gene
Post-translational modifications for CUEDC1 Gene
Other Protein References for CUEDC1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for CUEDC1
-
Abcam antibodies for CUEDC1
- Invitrogen Antibodies for CUEDC1 (AFLGC-CUEDC1)
- antibodies-online: Show 3 available CUEDC1 Antibodies ranked by validation data
-
Boster Bio Antibodies for CUEDC1
-
Custom Antibody ServicesProSci Antibodies for CUEDC1
-
Santa Cruz Biotechnology (SCBT) Antibodies for CUEDC1
Protein Products
-
OriGene Purified Proteins for CUEDC1
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- ProSpec Recombinant Proteins for CUEDC1
-
Abcam proteins for CUEDC1
No data available for DME Specific Peptides for CUEDC1 Gene
Domains & Families for CUEDC1 Gene
Gene Families for CUEDC1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CUEDC1 Gene
- InterPro:
- Blocks:
-
- Ubiquitin system component Cue
- ProtoNet:
Suggested Antigen Peptide Sequences for CUEDC1 Gene
- GenScript: Design optimal peptide antigens:
-
- CUE domain-containing protein 1 (CUED1_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CUEDC1 Gene
Function for CUEDC1 Gene
Phenotypes From GWAS Catalog for CUEDC1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IEA,IPI | 24510904 |
Phenotypes for CUEDC1 Gene
Animal Model Products
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CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CUEDC1 - Select products 50% OFF >
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-
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-
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miRNA for CUEDC1 Gene
- miRTarBase miRNAs that target CUEDC1
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for CUEDC1 - Select products 50% OFF >
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-
- MG204637
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- MR204637
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- MR206064L3
- MR206064L4
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- MR216789L3
- MR216789L4
- RC208926
- RC208926L1
- RC208926L2
- RC208926L3
- RC208926L4
- RC233946
- RC237894
- RG208926
- RG233946
- RR206745
- RR206745L3
- RR206745L4
- MR204637L3V
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CUEDC1
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Cell Line Products
-
Horizon Cell Lines for CUEDC1
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CUEDC1 Gene
Localization for CUEDC1 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| cytosol | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
- Centrosome (2)
- Cytosol (2)
- Plasma membrane (2)
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CUEDC1 Gene
Pathways & Interactions for CUEDC1 Gene
Interacting Proteins for CUEDC1 Gene
Selected Interacting proteins:
Q9NWM3-CUED1_HUMAN
ENSP00000462717
for CUEDC1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CUEDC1
No data available for Pathways by source and SIGNOR curated interactions for CUEDC1 Gene
Transcripts for CUEDC1 Gene
mRNA/cDNA for CUEDC1 Gene
- 2 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000577830 3710 nts (view in UCSC)
- ENST00000584746 2870 nts (view in UCSC)
- ENST00000407144 2190 nts (view in UCSC)
- ENST00000577422 547 nts (view in UCSC)
- ENST00000582951 756 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CUEDC1 - Select products 50% OFF >
- * CUEDC1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CUEDC1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CUEDC1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CUEDC1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CUEDC1
- Browse OriGene Inhibitory RNA Products For CUEDC1
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Clone Products
- Applied Biological Materials (abm): Clones for CUEDC1 - Select products 50% OFF >
- * CUEDC1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG204637
- MG206064
- MG216789
- MR204637
- MR204637L3
- MR204637L4
- MR206064
- MR206064L3
- MR206064L4
- MR216789
- MR216789L3
- MR216789L4
- RC208926
- RC208926L1
- RC208926L2
- RC208926L3
- RC208926L4
- RC233946
- RC237894
- RG208926
- RG233946
- RR206745
- RR206745L3
- RR206745L4
- MR204637L3V
- MR204637L4V
- MR206064L3V
- MR206064L4V
- MR216789L3V
- MR216789L4V
- RC208926L1V
- RC208926L2V
- RC208926L3V
- RC208926L4V
- RR206745L3V
- RR206745L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CUEDC1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CUEDC1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: |
Relevant External Links for CUEDC1 Gene
- GeneLoc Exon Structure for
- CUEDC1
Expression for CUEDC1 Gene
This gene is overexpressed in Lung (32.7), Frontal cortex (14.0), Urinary Bladder (10.8), and Prostate (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CUEDC1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CUEDC1
SOURCE GeneReport for Unigene cluster for CUEDC1 Gene:
Hs.46679Evidence on tissue expression from TISSUES for CUEDC1 Gene
- Nervous system(3.1)
Primer Products
-
OriGene qPCR primer pairs for CUEDC1
-
OriGene qPCR primer pairs and template standards for CUEDC1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CUEDC1 Gene
Orthologs for CUEDC1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CUEDC1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CUEDC1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CUEDC1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cuedc1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Cuedc1 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CUEDC1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CUEDC1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CUEDC1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CUEDC1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cuedc1 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | cuedc1b 30 31 |
|
OneToMany | |
| cuedc1a 31 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG12024 30 31 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006084 30 |
|
- Species where no ortholog for CUEDC1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CUEDC1 Gene
- ENSEMBL:
- Gene Tree for CUEDC1 (if available)
- TreeFam:
- Gene Tree for CUEDC1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CUEDC1: view image
Paralogs for CUEDC1 Gene
(1) SIMAP similar genes for CUEDC1 Gene using alignment to 6 proteins:
- CUED1_HUMAN
- J3KRK6_HUMAN
- J3KRV3_HUMAN
- J3KT42_HUMAN
- J3QLQ8_HUMAN
- L0R845_HUMAN
No data available for Paralogs for CUEDC1 Gene
Variants for CUEDC1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CUEDC1 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs17762338 | - | p.Arg169His | |||
| rs2304942 | - | p.Pro205Ser | |||
| rs34800498 | - | p.Arg316Gln |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3305376 | CNV | mobile element insertion | 20981092 |
| esv3308644 | CNV | mobile element insertion | 20981092 |
| esv3327169 | CNV | insertion | 20981092 |
| esv3341518 | CNV | insertion | 20981092 |
| esv3450717 | CNV | insertion | 20981092 |
| esv3554598 | CNV | deletion | 23714750 |
| nsv1070836 | CNV | deletion | 25765185 |
| nsv1116227 | CNV | deletion | 24896259 |
| nsv1143859 | CNV | deletion | 24896259 |
| nsv828066 | CNV | loss | 20364138 |
| nsv833497 | CNV | loss | 17160897 |
| nsv952346 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
22.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.87;
74.09% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CUEDC1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CUEDC1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CUEDC1 Gene
Disorders for CUEDC1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| proximal symphalangism |
|
|
| perrault syndrome |
|
|
Search CUEDC1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CUEDC1
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CUEDC1 Gene
Publications for CUEDC1 Gene
- Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis. (PMID: 20802204) Baranzini SE … Pelletier D (Brain : a journal of neurology 2010) 3 41
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
- The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics. (PMID: 29467281) O'Loughlin T … Buss F (EMBO reports 2018) 3
ExternalLinks
Products for CUEDC1 Gene
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- MG204637
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- MG216789
- MR204637
- MR204637L3
- MR204637L4
- MR206064
- MR206064L3
- MR206064L4
- MR216789
- MR216789L3
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- RC208926
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- RR206745L3
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- MR204637L3V
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- antibodies-online: Show 3 available CUEDC1 Antibodies ranked by validation data
- antibodies-online: Search results for available CUEDC1 related products ranked by validation data
- antibodies-online: Search results for available CUEDC1 related products ranked by validation data
- Santa Cruz Biotechnology (SCBT) Antibodies for CUEDC1
- Search Santa Cruz Biotechnology (SCBT) for CUEDC1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CUEDC1
- Custom Antibody ServicesProSci Antibodies for CUEDC1
- Search for CUEDC1 Proteins at ProSci
- Horizon Cell Lines for CUEDC1
- Browse GeneCopoeia Cell Lines
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- Boster Bio Antibodies for CUEDC1
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Sources for CUEDC1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
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