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Aliases for CUEDC1 Gene

Aliases for CUEDC1 Gene

  • CUE Domain Containing 1 2 3 5
  • CUE Domain-Containing Protein 1 3

External Ids for CUEDC1 Gene

Previous GeneCards Identifiers for CUEDC1 Gene

  • GC17M056415
  • GC17M053295
  • GC17M055940
  • GC17M051300

Summaries for CUEDC1 Gene

GeneCards Summary for CUEDC1 Gene

CUEDC1 (CUE Domain Containing 1) is a Protein Coding gene.

Additional gene information for CUEDC1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUEDC1 Gene

Genomics for CUEDC1 Gene

GeneHancer (GH) Regulatory Elements for CUEDC1 Gene

Promoters and enhancers for CUEDC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J057944 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 657.8 +5.1 5094 11.7 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 ZBTB7B IRF4 YY1 SLC30A9 ZNF766 CUEDC1 MRPS23 SRSF1 MKS1 ENSG00000264112 LOC101927666 SUPT4H1 ENSG00000278642 ENSG00000264914 GC17M057928
GH17J057956 Enhancer 0.9 ENCODE dbSUPER 650.7 -1.2 -1172 0.2 PKNOX1 KLF1 EBF1 IRF4 PATZ1 EED PRDM10 KLF8 IKZF2 RUNX3 CUEDC1 ENSG00000278642 GC17P057973 GC17M057928
GH17J057888 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 18.9 +63.0 62972 7.9 PKNOX1 FOXA2 SIN3A YBX1 FEZF1 DMAP1 ZNF2 IRF4 YY1 SLC30A9 SRSF1 CUEDC1 ENSG00000262298 MKS1 EPX SUPT4H1 VEZF1 ENSG00000264914 GC17P057856
GH17J057897 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 18.6 +53.4 53425 8.2 HDGF PKNOX1 CLOCK FOXA2 MLX ZFP64 ARID4B NEUROD1 SIN3A DMAP1 SRSF1 ENSG00000262298 MKS1 CUEDC1 TRIM25 EPX VEZF1 ENSG00000263004 OR4D2 ENSG00000264914
GH17J057872 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 18.1 +80.3 80257 4.9 HDGF PKNOX1 MLX ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B CUEDC1 MRPS23 ENSG00000262298 TRIM25 MKS1 SRSF1 TSPOAP1 GC17P057856 ENSG00000264914
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CUEDC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CUEDC1 gene promoter:

Genomic Locations for CUEDC1 Gene

Genomic Locations for CUEDC1 Gene
chr17:57,861,243-57,955,323
(GRCh38/hg38)
Size:
94,081 bases
Orientation:
Minus strand
chr17:55,938,604-56,032,684
(GRCh37/hg19)

Genomic View for CUEDC1 Gene

Genes around CUEDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CUEDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CUEDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUEDC1 Gene

Proteins for CUEDC1 Gene

  • Protein details for CUEDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWM3-CUED1_HUMAN
    Recommended name:
    CUE domain-containing protein 1
    Protein Accession:
    Q9NWM3
    Secondary Accessions:
    • D3DTZ2
    • Q9NWD0

    Protein attributes for CUEDC1 Gene

    Size:
    386 amino acids
    Molecular mass:
    42258 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CUEDC1 Gene

    Alternative splice isoforms for CUEDC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CUEDC1 Gene

Post-translational modifications for CUEDC1 Gene

  • Ubiquitination at posLast=342342, posLast=318318, and posLast=228228
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for CUEDC1

No data available for DME Specific Peptides for CUEDC1 Gene

Domains & Families for CUEDC1 Gene

Gene Families for CUEDC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CUEDC1 Gene

Suggested Antigen Peptide Sequences for CUEDC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CUEDC1: view

No data available for UniProtKB/Swiss-Prot for CUEDC1 Gene

Function for CUEDC1 Gene

Phenotypes From GWAS Catalog for CUEDC1 Gene

genes like me logo Genes that share phenotypes with CUEDC1: view

Animal Model Products

miRNA for CUEDC1 Gene

miRTarBase miRNAs that target CUEDC1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CUEDC1 Gene

Localization for CUEDC1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CUEDC1 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 2
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (1)
  • Cytosol (1)
  • Mitochondria (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CUEDC1 Gene

Pathways & Interactions for CUEDC1 Gene

SuperPathways for CUEDC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CUEDC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CUEDC1 Gene

Drugs & Compounds for CUEDC1 Gene

No Compound Related Data Available

Transcripts for CUEDC1 Gene

Unigene Clusters for CUEDC1 Gene

CUE domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CUEDC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c
SP1: - - - -
SP2: - - - - -
SP3: - - - - - - - - -
SP4: - -
SP5: - - -
SP6: - -
SP7: -
SP8:
SP9: -
SP10:

Relevant External Links for CUEDC1 Gene

GeneLoc Exon Structure for
CUEDC1
ECgene alternative splicing isoforms for
CUEDC1

Expression for CUEDC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CUEDC1 Gene

Protein differential expression in normal tissues from HIPED for CUEDC1 Gene

This gene is overexpressed in Lung (32.7), Frontal cortex (14.0), Urinary Bladder (10.8), and Prostate (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CUEDC1 Gene



Protein tissue co-expression partners for CUEDC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CUEDC1 Gene:

CUEDC1

SOURCE GeneReport for Unigene cluster for CUEDC1 Gene:

Hs.46679

Evidence on tissue expression from TISSUES for CUEDC1 Gene

  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with CUEDC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CUEDC1 Gene

Orthologs for CUEDC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CUEDC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CUEDC1 34 33
  • 98.97 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CUEDC1 34 33
  • 88.23 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CUEDC1 34 33
  • 87.66 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cuedc1 33
  • 85.82 (n)
mouse
(Mus musculus)
Mammalia Cuedc1 16 34 33
  • 85.35 (n)
oppossum
(Monodelphis domestica)
Mammalia CUEDC1 34
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CUEDC1 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves CUEDC1 34 33
  • 77.01 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CUEDC1 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cuedc1 33
  • 67.25 (n)
zebrafish
(Danio rerio)
Actinopterygii cuedc1b 34 33
  • 68.13 (n)
OneToMany
cuedc1a 34
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG12024 34 33
  • 54.7 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006084 33
  • 53.8 (n)
Species where no ortholog for CUEDC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CUEDC1 Gene

ENSEMBL:
Gene Tree for CUEDC1 (if available)
TreeFam:
Gene Tree for CUEDC1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CUEDC1: view image

Paralogs for CUEDC1 Gene

(1) SIMAP similar genes for CUEDC1 Gene using alignment to 6 proteins:

  • CUED1_HUMAN
  • J3KRK6_HUMAN
  • J3KRV3_HUMAN
  • J3KT42_HUMAN
  • J3QLQ8_HUMAN
  • L0R845_HUMAN
genes like me logo Genes that share paralogs with CUEDC1: view

No data available for Paralogs for CUEDC1 Gene

Variants for CUEDC1 Gene

Sequence variations from dbSNP and Humsavar for CUEDC1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000046805 -- 57,901,807(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000052012 -- 57,910,894(-) CTCT/CT genic_upstream_transcript_variant, intron_variant
rs1000054667 -- 57,877,748(-) G/A intron_variant
rs1000055749 -- 57,945,580(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000067619 -- 57,938,740(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CUEDC1 Gene

Variant ID Type Subtype PubMed ID
esv3305376 CNV mobile element insertion 20981092
esv3308644 CNV mobile element insertion 20981092
esv3327169 CNV insertion 20981092
esv3341518 CNV insertion 20981092
esv3450717 CNV insertion 20981092
esv3554598 CNV deletion 23714750
nsv1070836 CNV deletion 25765185
nsv1116227 CNV deletion 24896259
nsv1143859 CNV deletion 24896259
nsv828066 CNV loss 20364138
nsv833497 CNV loss 17160897
nsv952346 CNV deletion 24416366

Variation tolerance for CUEDC1 Gene

Residual Variation Intolerance Score: 22.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.87; 74.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CUEDC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CUEDC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CUEDC1 Gene

Disorders for CUEDC1 Gene

Additional Disease Information for CUEDC1

No disorders were found for CUEDC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CUEDC1 Gene

Publications for CUEDC1 Gene

  1. Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis. (PMID: 20802204) Baranzini SE … Pelletier D (Brain : a journal of neurology 2010) 3 44 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. An Interaction Landscape of Ubiquitin Signaling. (PMID: 28190767) Zhang X … Vermeulen M (Molecular cell 2017) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for CUEDC1 Gene

Sources for CUEDC1 Gene

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