Aliases for CUEDC1 Gene

Aliases for CUEDC1 Gene

  • CUE Domain Containing 1 2 3 5
  • CUE Domain-Containing Protein 1 3 4
  • CUEDC1 5

External Ids for CUEDC1 Gene

Previous GeneCards Identifiers for CUEDC1 Gene

  • GC17M056415
  • GC17M053295
  • GC17M055940
  • GC17M051300

Summaries for CUEDC1 Gene

GeneCards Summary for CUEDC1 Gene

CUEDC1 (CUE Domain Containing 1) is a Protein Coding gene. Diseases associated with CUEDC1 include Proximal Symphalangism and Perrault Syndrome.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CUEDC1 Gene

Genomics for CUEDC1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CUEDC1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CUEDC1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CUEDC1

Top Transcription factor binding sites by QIAGEN in the CUEDC1 gene promoter:
  • AML1a
  • c-Rel
  • E47
  • FOXO1
  • FOXO1a
  • GATA-3
  • HEN1
  • Lmo2
  • Sox9
  • Tal-1

Genomic Locations for CUEDC1 Gene

Latest Assembly
94,170 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
94,170 bases
Minus strand

(GRCh37/hg19 by Ensembl)
94,081 bases
Minus strand

Genomic View for CUEDC1 Gene

Genes around CUEDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CUEDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CUEDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUEDC1 Gene

Proteins for CUEDC1 Gene

  • Protein details for CUEDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CUE domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • D3DTZ2
    • Q9NWD0

    Protein attributes for CUEDC1 Gene

    386 amino acids
    Molecular mass:
    42258 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CUEDC1 Gene

    Alternative splice isoforms for CUEDC1 Gene


neXtProt entry for CUEDC1 Gene

Post-translational modifications for CUEDC1 Gene

  • Ubiquitination at Lys228, Lys318, and Lys342
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CUEDC1 Gene

Domains & Families for CUEDC1 Gene

Gene Families for CUEDC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CUEDC1 Gene

  • Ubiquitin system component Cue

Suggested Antigen Peptide Sequences for CUEDC1 Gene

GenScript: Design optimal peptide antigens:
  • CUE domain-containing protein 1 (CUED1_HUMAN)
genes like me logo Genes that share domains with CUEDC1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CUEDC1 Gene

Function for CUEDC1 Gene

Phenotypes From GWAS Catalog for CUEDC1 Gene

Gene Ontology (GO) - Molecular Function for CUEDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 24510904
GO:0043130 ubiquitin binding IEA --
genes like me logo Genes that share ontologies with CUEDC1: view
genes like me logo Genes that share phenotypes with CUEDC1: view

miRNA for CUEDC1 Gene

miRTarBase miRNAs that target CUEDC1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CUEDC1

Clone products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CUEDC1 Gene

Localization for CUEDC1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CUEDC1 gene
Compartment Confidence
nucleus 3
cytosol 3
cytoskeleton 2
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CUEDC1 Gene

Pathways & Interactions for CUEDC1 Gene

PathCards logo

SuperPathways for CUEDC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CUEDC1 Gene


No data available for Pathways by source and SIGNOR curated interactions for CUEDC1 Gene

Drugs & Compounds for CUEDC1 Gene

No Compound Related Data Available

Transcripts for CUEDC1 Gene

mRNA/cDNA for CUEDC1 Gene

6 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CUEDC1

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for CUEDC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c
SP1: - - - -
SP2: - - - - -
SP3: - - - - - - - - -
SP4: - -
SP5: - - -
SP6: - -
SP7: -
SP9: -

Relevant External Links for CUEDC1 Gene

GeneLoc Exon Structure for

Expression for CUEDC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CUEDC1 Gene

Protein differential expression in normal tissues from HIPED for CUEDC1 Gene

This gene is overexpressed in Lung (32.7), Frontal cortex (14.0), Urinary Bladder (10.8), and Prostate (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CUEDC1 Gene

Protein tissue co-expression partners for CUEDC1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CUEDC1

SOURCE GeneReport for Unigene cluster for CUEDC1 Gene:


Evidence on tissue expression from TISSUES for CUEDC1 Gene

  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with CUEDC1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CUEDC1 Gene

Orthologs for CUEDC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CUEDC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CUEDC1 30 31
  • 98.97 (n)
(Bos Taurus)
Mammalia CUEDC1 30 31
  • 88.23 (n)
(Canis familiaris)
Mammalia CUEDC1 30 31
  • 87.66 (n)
(Rattus norvegicus)
Mammalia Cuedc1 30
  • 85.82 (n)
(Mus musculus)
Mammalia Cuedc1 30 17 31
  • 85.35 (n)
(Monodelphis domestica)
Mammalia CUEDC1 31
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia CUEDC1 31
  • 77 (a)
(Gallus gallus)
Aves CUEDC1 30 31
  • 77.01 (n)
(Anolis carolinensis)
Reptilia CUEDC1 31
  • 84 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cuedc1 30
  • 67.25 (n)
(Danio rerio)
Actinopterygii cuedc1b 30 31
  • 68.13 (n)
cuedc1a 31
  • 57 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta CG12024 30 31
  • 54.7 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006084 30
  • 53.8 (n)
Species where no ortholog for CUEDC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CUEDC1 Gene

Gene Tree for CUEDC1 (if available)
Gene Tree for CUEDC1 (if available)
Evolutionary constrained regions (ECRs) for CUEDC1: view image

Paralogs for CUEDC1 Gene

(1) SIMAP similar genes for CUEDC1 Gene using alignment to 6 proteins:

  • J3KT42_HUMAN
  • L0R845_HUMAN
genes like me logo Genes that share paralogs with CUEDC1: view

No data available for Paralogs for CUEDC1 Gene

Variants for CUEDC1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CUEDC1 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs17762338 - p.Arg169His
rs2304942 - p.Pro205Ser
rs34800498 - p.Arg316Gln

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CUEDC1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CUEDC1 Gene

Variant ID Type Subtype PubMed ID
esv3305376 CNV mobile element insertion 20981092
esv3308644 CNV mobile element insertion 20981092
esv3327169 CNV insertion 20981092
esv3341518 CNV insertion 20981092
esv3450717 CNV insertion 20981092
esv3554598 CNV deletion 23714750
nsv1070836 CNV deletion 25765185
nsv1116227 CNV deletion 24896259
nsv1143859 CNV deletion 24896259
nsv828066 CNV loss 20364138
nsv833497 CNV loss 17160897
nsv952346 CNV deletion 24416366

Variation tolerance for CUEDC1 Gene

Residual Variation Intolerance Score: 22.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.87; 74.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CUEDC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CUEDC1 Gene

Disorders for CUEDC1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CUEDC1 Gene - From: COP

Disorder Aliases PubMed IDs
proximal symphalangism
  • cushing's symphalangism
perrault syndrome
  • gonadal dysgenesis, xx type
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CUEDC1

Genetic Association Database
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CUEDC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CUEDC1 Gene

Publications for CUEDC1 Gene

  1. Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis. (PMID: 20802204) Baranzini SE … Pelletier D (Brain : a journal of neurology 2010) 3 41
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. [Prognostic Significance of CUEDC1 in Patients with Acute Myeloid Leukemia (non-M3)]. (PMID: 33067938) Zhuang WC … Xu KL (Zhongguo shi yan xue ye xue za zhi 2020) 3

Products for CUEDC1 Gene

Sources for CUEDC1 Gene