Aliases for CTXN2 Gene

Aliases for CTXN2 Gene

  • Cortexin 2 2 3 5
  • Cortexin-2 3 4
  • CTXN2 5

External Ids for CTXN2 Gene

Previous GeneCards Identifiers for CTXN2 Gene

  • GC15U900443
  • GC15P048483
  • GC15P025316

Summaries for CTXN2 Gene

GeneCards Summary for CTXN2 Gene

CTXN2 (Cortexin 2) is a Protein Coding gene. Diseases associated with CTXN2 include Simple Partial Epilepsy and Cardiomyopathy, Dilated, 1E. An important paralog of this gene is CTXN3.

Additional gene information for CTXN2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CTXN2 Gene

Genomics for CTXN2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CTXN2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J048176 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 -0.4 -385 2.7 BRCA1 ATF7 PRDM10 ZNF629 ZNF692 BACH1 LARP7 RBFOX2 POLR2A IKZF2 CTXN2 MYEF2 SLC12A1 lnc-FBN1-4 SLC24A5
GH15J048190 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 600.4 +13.3 13257 0.8 REST TFE3 PRDM1 ZNF143 RFX1 POLR2A RXRB IRF2 EZH2 SOX13 ENSG00000259235 LOC105370807 CTXN2 SLC12A1 MYEF2 DUT
GH15J048143 Enhancer 0.6 FANTOM5 Ensembl 11.6 -33.5 -33521 2 PRDM1 JUND MTA2 SLC12A1 CTXN2 SLC24A5 lnc-SLC24A5-4 lnc-MYEF2-6 lnc-FBN1-5 MYEF2
GH15J048266 Enhancer 0.5 FANTOM5 Ensembl 9.9 +89.0 88979 2.2 EZH2 CBFA2T3 ENSG00000259235 SLC12A1 SLC24A5 CTXN2 L13714-146 HSALNG0105747 LOC107984755 DUT MYEF2
GH15J048131 Enhancer 0.3 Ensembl 10.8 -46.5 -46521 0.8 SPI1 SLC12A1 CTXN2 lnc-MYEF2-6 SLC24A5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CTXN2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CTXN2

Top Transcription factor binding sites by QIAGEN in the CTXN2 gene promoter:
  • aMEF-2
  • ATF-2
  • FOXD3
  • MEF-2A
  • Nkx5-1
  • Olf-1
  • POU2F1
  • RSRFC4

Genomic Locations for CTXN2 Gene

Genomic Locations for CTXN2 Gene
chr15:48,178,122-48,203,758
(GRCh38/hg38)
Size:
25,637 bases
Orientation:
Plus strand
chr15:48,483,736-48,495,953
(GRCh37/hg19)
Size:
12,218 bases
Orientation:
Plus strand

Genomic View for CTXN2 Gene

Genes around CTXN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTXN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTXN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTXN2 Gene

Proteins for CTXN2 Gene

  • Protein details for CTXN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C2S0-CTXN2_HUMAN
    Recommended name:
    Cortexin-2
    Protein Accession:
    P0C2S0

    Protein attributes for CTXN2 Gene

    Size:
    81 amino acids
    Molecular mass:
    8980 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CTXN2 Gene

Post-translational modifications for CTXN2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CTXN2 Gene

Domains & Families for CTXN2 Gene

Gene Families for CTXN2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CTXN2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CTXN2 Gene

GenScript: Design optimal peptide antigens:
  • Cortexin-2 (CTXN2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0C2S0

UniProtKB/Swiss-Prot:

CTXN2_HUMAN :
  • Belongs to the cortexin family.
Family:
  • Belongs to the cortexin family.
genes like me logo Genes that share domains with CTXN2: view

Function for CTXN2 Gene

Phenotypes From GWAS Catalog for CTXN2 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTXN2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CTXN2 Gene

Localization for CTXN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTXN2 Gene

Membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTXN2 gene
Compartment Confidence
cytosol 2
extracellular 1
plasma membrane 0
nucleus 0

Gene Ontology (GO) - Cellular Components for CTXN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CTXN2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CTXN2 Gene

Pathways & Interactions for CTXN2 Gene

PathCards logo

SuperPathways for CTXN2 Gene

No Data Available

Interacting Proteins for CTXN2 Gene

Gene Ontology (GO) - Biological Process for CTXN2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CTXN2 Gene

Drugs & Compounds for CTXN2 Gene

No Compound Related Data Available

Transcripts for CTXN2 Gene

mRNA/cDNA for CTXN2 Gene

3 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTXN2

Alternative Splicing Database (ASD) splice patterns (SP) for CTXN2 Gene

No ASD Table

Relevant External Links for CTXN2 Gene

GeneLoc Exon Structure for
CTXN2

Expression for CTXN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CTXN2 Gene

mRNA differential expression in normal tissues according to GTEx for CTXN2 Gene

This gene is overexpressed in Brain - Hypothalamus (x6.1), Brain - Frontal Cortex (BA9) (x5.6), Brain - Cortex (x5.3), and Brain - Anterior cingulate cortex (BA24) (x4.7).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CTXN2

SOURCE GeneReport for Unigene cluster for CTXN2 Gene:

Hs.721408

Evidence on tissue expression from TISSUES for CTXN2 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with CTXN2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTXN2 Gene

Orthologs for CTXN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CTXN2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CTXN2 30 31
  • 100 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CTXN2 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia CTXN2 30 31
  • 96.71 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CTXN2 30 31
  • 96.3 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ctxn2 30 17 31
  • 86.83 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ctxn2 30
  • 83.54 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia CTXN2 31
  • 79 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LOC100859495 30
  • 83.95 (n)
Zebrafish
(Danio rerio)
Actinopterygii ctxn2 30
  • 65 (n)
Species where no ortholog for CTXN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CTXN2 Gene

ENSEMBL:
Gene Tree for CTXN2 (if available)
TreeFam:
Gene Tree for CTXN2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CTXN2: view image

Paralogs for CTXN2 Gene

Paralogs for CTXN2 Gene

(2) SIMAP similar genes for CTXN2 Gene using alignment to 1 proteins:

  • CTXN2_HUMAN
genes like me logo Genes that share paralogs with CTXN2: view

Variants for CTXN2 Gene

Additional dbSNP identifiers (rs#s) for CTXN2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CTXN2 Gene

Variant ID Type Subtype PubMed ID
esv3636411 CNV loss 21293372

Variation tolerance for CTXN2 Gene

Gene Damage Index Score: 1.33; 26.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CTXN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTXN2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CTXN2 Gene

Disorders for CTXN2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CTXN2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
simple partial epilepsy
  • epilepsy, simple partial
cardiomyopathy, dilated, 1e
  • cmd1e
- elite association - COSMIC cancer census association via MalaCards
Search CTXN2 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with CTXN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTXN2 Gene

Publications for CTXN2 Gene

  1. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 3 4
  2. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4

Products for CTXN2 Gene

Sources for CTXN2 Gene