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Aliases for CTU1 Gene

Aliases for CTU1 Gene

  • Cytosolic Thiouridylase Subunit 1 2 3 5
  • ATP-Binding Domain-Containing Protein 3 3 4
  • Cytoplasmic TRNA Adenylyltransferase 1 3 4
  • Cancer-Associated Gene Protein 3 4
  • ATP Binding Domain 3 2 3
  • ATPBD3 3 4
  • NCS6 3 4
  • Cytosolic Thiouridylase Subunit 1 Homolog (S. Pombe) 2
  • Cytosolic Thiouridylase Subunit 1 Homolog 3
  • Cytoplasmic TRNA 2-Thiolation Protein 1 3
  • Cancer-Associated Protein 3
  • EC 2.7.7.- 4
  • EC 2.7.7 56

External Ids for CTU1 Gene

Previous HGNC Symbols for CTU1 Gene

  • ATPBD3

Previous GeneCards Identifiers for CTU1 Gene

  • GC19M056295
  • GC19M051601
  • GC19M047934

Summaries for CTU1 Gene

GeneCards Summary for CTU1 Gene

CTU1 (Cytosolic Thiouridylase Subunit 1) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. Gene Ontology (GO) annotations related to this gene include tRNA binding and nucleotidyltransferase activity.

UniProtKB/Swiss-Prot for CTU1 Gene

  • Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.

Additional gene information for CTU1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTU1 Gene

Genomics for CTU1 Gene

GeneHancer (GH) Regulatory Elements for CTU1 Gene

Promoters and enhancers for CTU1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I051106 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 555.7 +0.3 286 2.4 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 IRF4 YY1 ZNF766 CTU1 SIGLEC9 SIGLEC14 PIR34748
GH19I050328 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.5 +776.8 776787 5.9 ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 KCNC3 NR1H2 LOC105372437 NUP62 PRR12 POLD1 ENSG00000268047 PTOV1-AS2 SNORD35A CTU1
GH19I050802 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 23.4 +304.1 304107 4.2 HDGF HNRNPUL1 PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 C19orf48 GC19M050829 GC19M050838 SNORD88C POLD1 PTOV1-AS2 NUP62 PNKP ZNF175 CTU1
GH19I051393 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE 25.8 -286.7 -286657 2.8 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A IRF4 YY1 POLR2B LOC105372446 ENSG00000268889 ZNF841 ZNF766 ZNF577 ZNF616 ZNF175 ZNF836 ZNF432 ZNF614
GH19I050496 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 23 +609.0 609043 6.1 GLI4 ZNF48 TCF12 GLIS2 GATA2 ZNF143 ZNF202 NCOA1 REST MEF2D PRR12 ENSG00000268047 NUP62 CTU1 POLD1 ADM5 PTOV1 PRMT1 AKT1S1 PTOV1-AS2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CTU1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CTU1 Gene

Genomic Locations for CTU1 Gene
chr19:51,097,606-51,108,390
(GRCh38/hg38)
Size:
10,785 bases
Orientation:
Minus strand
chr19:51,600,863-51,611,647
(GRCh37/hg19)

Genomic View for CTU1 Gene

Genes around CTU1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTU1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTU1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTU1 Gene

Proteins for CTU1 Gene

  • Protein details for CTU1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7A3-CTU1_HUMAN
    Recommended name:
    Cytoplasmic tRNA 2-thiolation protein 1
    Protein Accession:
    Q7Z7A3
    Secondary Accessions:
    • A8K558
    • Q96GZ7

    Protein attributes for CTU1 Gene

    Size:
    348 amino acids
    Molecular mass:
    36450 Da
    Quaternary structure:
    • Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3. May form a heterodimer with CTU2/NCS2.

neXtProt entry for CTU1 Gene

Selected DME Specific Peptides for CTU1 Gene

Q7Z7A3:
  • TGHNADD
  • AETVLMN
  • ASGGKDSTVLAH
  • GASGGKDSTVLA
  • SGQALCG
  • DLFGGWTMDAVARSTAGSGRSR
  • CFCAAFEAEVL
  • LEAARPSA

Post-translational modifications for CTU1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTU1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CTU1 Gene

Gene Families for CTU1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CTU1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z7A3

UniProtKB/Swiss-Prot:

CTU1_HUMAN :
  • Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
Family:
  • Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
genes like me logo Genes that share domains with CTU1: view

Function for CTU1 Gene

Molecular function for CTU1 Gene

UniProtKB/Swiss-Prot Function:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.

Enzyme Numbers (IUBMB) for CTU1 Gene

Phenotypes From GWAS Catalog for CTU1 Gene

Gene Ontology (GO) - Molecular Function for CTU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 19017811
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with CTU1: view
genes like me logo Genes that share phenotypes with CTU1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CTU1 Gene

Localization for CTU1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTU1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTU1 gene
Compartment Confidence
cytosol 5
mitochondrion 4
extracellular 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CTU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CTU1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CTU1 Gene

Pathways & Interactions for CTU1 Gene

genes like me logo Genes that share pathways with CTU1: view

Pathways by source for CTU1 Gene

1 KEGG pathway for CTU1 Gene

UniProtKB/Swiss-Prot Q7Z7A3-CTU1_HUMAN

  • Pathway: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.

Gene Ontology (GO) - Biological Process for CTU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002098 tRNA wobble uridine modification IEA,NAS 19017811
GO:0006400 tRNA modification TAS --
GO:0008033 tRNA processing IEA --
GO:0034227 tRNA thio-modification NAS 19017811
genes like me logo Genes that share ontologies with CTU1: view

No data available for SIGNOR curated interactions for CTU1 Gene

Drugs & Compounds for CTU1 Gene

No Compound Related Data Available

Transcripts for CTU1 Gene

mRNA/cDNA for CTU1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(41) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CTU1 Gene

Cytosolic thiouridylase subunit 1 homolog (S. pombe):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTU1 Gene

No ASD Table

Relevant External Links for CTU1 Gene

GeneLoc Exon Structure for
CTU1
ECgene alternative splicing isoforms for
CTU1

Expression for CTU1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTU1 Gene

Protein differential expression in normal tissues from HIPED for CTU1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (28.9), Heart (14.0), and Pancreas (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CTU1 Gene



Protein tissue co-expression partners for CTU1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CTU1 Gene:

CTU1

SOURCE GeneReport for Unigene cluster for CTU1 Gene:

Hs.148425

Evidence on tissue expression from TISSUES for CTU1 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with CTU1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTU1 Gene

Orthologs for CTU1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CTU1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTU1 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 94 (a)
OneToMany
LOC484342 33
  • 90.81 (n)
-- 34
  • 61 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 93 (a)
OneToMany
CTU1 34
  • 93 (a)
OneToMany
LOC100297056 33
  • 91.55 (n)
oppossum
(Monodelphis domestica)
Mammalia CTU1 34
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ctu1 33 16 34
  • 82.99 (n)
rat
(Rattus norvegicus)
Mammalia Ctu1 33
  • 81.85 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CTU1 34
  • 73 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ctu1 34
  • 51 (a)
OneToOne
zgc55395 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7038 33
fruit fly
(Drosophila melanogaster)
Insecta CG8078 34
  • 48 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tut-1 34
  • 40 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NCS6 34
  • 44 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
OneToOne
Species where no ortholog for CTU1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CTU1 Gene

ENSEMBL:
Gene Tree for CTU1 (if available)
TreeFam:
Gene Tree for CTU1 (if available)

Paralogs for CTU1 Gene

Pseudogenes.org Pseudogenes for CTU1 Gene

genes like me logo Genes that share paralogs with CTU1: view

No data available for Paralogs for CTU1 Gene

Variants for CTU1 Gene

Sequence variations from dbSNP and Humsavar for CTU1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000183396 -- 51,101,128(-) C/T intron_variant
rs1000235230 -- 51,105,106(-) G/A intron_variant
rs1000235681 -- 51,100,885(-) C/T intron_variant
rs1000473648 -- 51,107,328(-) G/A intron_variant
rs1000677953 -- 51,100,177(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CTU1 Gene

Variant ID Type Subtype PubMed ID
esv34104 CNV loss 18971310
nsv1140251 OTHER inversion 24896259
nsv953606 CNV deletion 24416366

Variation tolerance for CTU1 Gene

Gene Damage Index Score: 7.92; 83.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CTU1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTU1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTU1 Gene

Disorders for CTU1 Gene

Additional Disease Information for CTU1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CTU1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTU1 Gene

Publications for CTU1 Gene

  1. A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway. (PMID: 19017811) Schlieker CD … Ploegh HL (Proceedings of the National Academy of Sciences of the United States of America 2008) 2 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for CTU1 Gene

Sources for CTU1 Gene

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