Aliases for CTTNBP2NL Gene

Aliases for CTTNBP2NL Gene

  • CTTNBP2 N-Terminal Like 2 3 5
  • CTTNBP2 N-Terminal-Like Protein 3 4
  • DKFZp547A023 2
  • KIAA1433 4

External Ids for CTTNBP2NL Gene

Previous GeneCards Identifiers for CTTNBP2NL Gene

  • GC01P112651
  • GC01P112740
  • GC01P112938
  • GC01P110795

Summaries for CTTNBP2NL Gene

GeneCards Summary for CTTNBP2NL Gene

CTTNBP2NL (CTTNBP2 N-Terminal Like) is a Protein Coding gene. Diseases associated with CTTNBP2NL include Retinitis Pigmentosa 6 and Myeloproliferative Syndrome, Transient. Gene Ontology (GO) annotations related to this gene include protein phosphatase 2A binding. An important paralog of this gene is FILIP1.

UniProtKB/Swiss-Prot Summary for CTTNBP2NL Gene

Gene Wiki entry for CTTNBP2NL Gene

Additional gene information for CTTNBP2NL Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CTTNBP2NL Gene

Genomics for CTTNBP2NL Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CTTNBP2NL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CTTNBP2NL on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CTTNBP2NL

Top Transcription factor binding sites by QIAGEN in the CTTNBP2NL gene promoter:
  • AML1a
  • c-Myb
  • GCNF
  • GCNF-1
  • GCNF-2
  • HSF2
  • POU2F1a
  • SRF
  • SRF (504 AA)
  • STAT5A

Genomic Locations for CTTNBP2NL Gene

Genomic Locations for CTTNBP2NL Gene
72,372 bases
Plus strand
67,279 bases
Plus strand

Genomic View for CTTNBP2NL Gene

Genes around CTTNBP2NL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTTNBP2NL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTTNBP2NL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTTNBP2NL Gene

Proteins for CTTNBP2NL Gene

  • Protein details for CTTNBP2NL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CTTNBP2 N-terminal-like protein
    Protein Accession:
    Secondary Accessions:
    • B3KMS5
    • Q96B40

    Protein attributes for CTTNBP2NL Gene

    639 amino acids
    Molecular mass:
    70158 Da
    Quaternary structure:
    • Interacts with CTTN/cortactin; this interaction may redistribute CTTN to stress fibers (By similarity). May form homomers. May interact with MOB4, PPP2R1A, PPP2CB, STK24, STK25, STK26, STRN4, STRIP1 and STRIP2.
    • Sequence=BAA92671.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for CTTNBP2NL Gene

Post-translational modifications for CTTNBP2NL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTTNBP2NL Gene

No data available for DME Specific Peptides for CTTNBP2NL Gene

Domains & Families for CTTNBP2NL Gene

Gene Families for CTTNBP2NL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CTTNBP2NL Gene


Suggested Antigen Peptide Sequences for CTTNBP2NL Gene

GenScript: Design optimal peptide antigens:
  • CTTNBP2 N-terminal-like protein (CT2NL_HUMAN)
genes like me logo Genes that share domains with CTTNBP2NL: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CTTNBP2NL Gene

Function for CTTNBP2NL Gene

Molecular function for CTTNBP2NL Gene

UniProtKB/Swiss-Prot Function:
Regulates lamellipodial actin dynamics in a CTTN-dependent manner.

Phenotypes From GWAS Catalog for CTTNBP2NL Gene

Gene Ontology (GO) - Molecular Function for CTTNBP2NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18782753
GO:0051721 protein phosphatase 2A binding IDA 24218568
genes like me logo Genes that share ontologies with CTTNBP2NL: view
genes like me logo Genes that share phenotypes with CTTNBP2NL: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTTNBP2NL

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CTTNBP2NL Gene

Localization for CTTNBP2NL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTTNBP2NL Gene

Cell projection, lamellipodium. Cytoplasm, cytoskeleton, stress fiber.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTTNBP2NL gene
Compartment Confidence
cytoskeleton 4
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CTTNBP2NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with CTTNBP2NL: view

Pathways & Interactions for CTTNBP2NL Gene

PathCards logo

SuperPathways for CTTNBP2NL Gene

No Data Available

Gene Ontology (GO) - Biological Process for CTTNBP2NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA,IMP 24218568
GO:0032410 negative regulation of transporter activity IMP 24218568
GO:0034763 negative regulation of transmembrane transport IMP 24218568
genes like me logo Genes that share ontologies with CTTNBP2NL: view

No data available for Pathways by source and SIGNOR curated interactions for CTTNBP2NL Gene

Drugs & Compounds for CTTNBP2NL Gene

No Compound Related Data Available

Transcripts for CTTNBP2NL Gene


9 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTTNBP2NL

Alternative Splicing Database (ASD) splice patterns (SP) for CTTNBP2NL Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: - -
SP3: - - - -

Relevant External Links for CTTNBP2NL Gene

GeneLoc Exon Structure for

Expression for CTTNBP2NL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CTTNBP2NL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CTTNBP2NL Gene

This gene is overexpressed in Adrenal (34.1) and Cervix (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CTTNBP2NL Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CTTNBP2NL

SOURCE GeneReport for Unigene cluster for CTTNBP2NL Gene:


Evidence on tissue expression from TISSUES for CTTNBP2NL Gene

  • Nervous system(4.7)
  • Skin(4.3)
genes like me logo Genes that share expression patterns with CTTNBP2NL: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTTNBP2NL Gene

Orthologs for CTTNBP2NL Gene

This gene was present in the common ancestor of animals.

Orthologs for CTTNBP2NL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CTTNBP2NL 30 31
  • 99.48 (n)
(Bos Taurus)
Mammalia CTTNBP2NL 30 31
  • 89.25 (n)
(Canis familiaris)
Mammalia CTTNBP2NL 30 31
  • 87.79 (n)
(Mus musculus)
Mammalia Cttnbp2nl 30 17 31
  • 87.04 (n)
(Rattus norvegicus)
Mammalia Cttnbp2nl 30
  • 86.99 (n)
(Ornithorhynchus anatinus)
Mammalia CTTNBP2NL 31
  • 83 (a)
(Monodelphis domestica)
Mammalia CTTNBP2NL 31
  • 81 (a)
(Gallus gallus)
Aves CTTNBP2NL 30 31
  • 73.26 (n)
(Anolis carolinensis)
Reptilia CTTNBP2NL 31
  • 77 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cttnbp2nl 30
  • 66.67 (n)
(Danio rerio)
Actinopterygii cttnbp2nlb 30
  • 56.97 (n)
CTTNBP2NL (1 of 2) 31
  • 50 (a)
cttnbp2nl 31
  • 49 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta CG10915 31
  • 24 (a)
(Caenorhabditis elegans)
Secernentea C49H3.6 31
  • 21 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 28 (a)
Species where no ortholog for CTTNBP2NL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CTTNBP2NL Gene

Gene Tree for CTTNBP2NL (if available)
Gene Tree for CTTNBP2NL (if available)
Evolutionary constrained regions (ECRs) for CTTNBP2NL: view image

Paralogs for CTTNBP2NL Gene

Paralogs for CTTNBP2NL Gene

(3) SIMAP similar genes for CTTNBP2NL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CTTNBP2NL: view

Variants for CTTNBP2NL Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CTTNBP2NL Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
716275 Benign: not provided 112,449,053(+) G/A MISSENSE_VARIANT
782383 Benign: not provided 112,456,408(+) A/G MISSENSE_VARIANT
rs1175640 - p.Val296Met
rs12137578 - p.Ser409Gly

Additional dbSNP identifiers (rs#s) for CTTNBP2NL Gene

Structural Variations from Database of Genomic Variants (DGV) for CTTNBP2NL Gene

Variant ID Type Subtype PubMed ID
esv2660196 CNV deletion 23128226
esv27061 CNV gain+loss 19812545
esv3587211 CNV loss 21293372
nsv159278 CNV deletion 16902084
nsv159431 CNV insertion 16902084
nsv506955 OTHER sequence alteration 20534489
nsv831081 CNV loss 17160897

Variation tolerance for CTTNBP2NL Gene

Residual Variation Intolerance Score: 36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CTTNBP2NL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTTNBP2NL Gene

Disorders for CTTNBP2NL Gene

MalaCards: The human disease database

(2) MalaCards diseases for CTTNBP2NL Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with CTTNBP2NL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTTNBP2NL Gene

Publications for CTTNBP2NL Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4
  2. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M … Gingras AC (Molecular & cellular proteomics : MCP 2009) 3 4
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for CTTNBP2NL Gene

Sources for CTTNBP2NL Gene