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The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be inv... See more...
Aliases for CTSZ Gene
Aliases for CTSZ Gene
External Ids for CTSZ Gene
- HGNC: 2547
- Entrez Gene: 1522
- Ensembl: ENSG00000101160
- OMIM: 603169
- UniProtKB: Q9UBR2
Previous GeneCards Identifiers for CTSZ Gene
- GC20M057298
- GC20M058208
- GC20M058255
- GC20M057003
- GC20M057570
- GC20M054357
Summaries for CTSZ Gene
-
The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008]
GeneCards Summary for CTSZ Gene
CTSZ (Cathepsin Z) is a Protein Coding gene. Diseases associated with CTSZ include Dacryoadenitis. Among its related pathways are Vesicle-mediated transport and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include cysteine-type peptidase activity. An important paralog of this gene is CTSC.
UniProtKB/Swiss-Prot Summary for CTSZ Gene
-
Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (PubMed:10504234). Capable of producing kinin potentiating peptides (By similarity).
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CTSZ Gene
Genomics for CTSZ Gene
GeneHancer (GH) Regulatory Elements for CTSZ Gene
Promoters and enhancers for CTSZ Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CTSZ on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CTSZ gene promoter:
-
- ATF
- C/EBPalpha
- C/EBPbeta
- En-1
- Pax-6
- SRF
- SRF (504 AA)
- YY1
Genomic Locations for CTSZ Gene
Genomic Locations for CTSZ Gene
- chr20:58,995,185-59,007,254
- (GRCh38/hg38)
- Size:
- 12,070 bases
- Orientation:
- Minus strand
- chr20:57,570,240-57,582,309
- (GRCh37/hg19)
- Size:
- 12,070 bases
- Orientation:
- Minus strand
Genomic View for CTSZ Gene
Genes around CTSZ on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.32 by HGNC
- 20q13.32 by Entrez Gene
- 20q13.32 by Ensembl
CTSZ Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CTSZ Gene
Proteins for CTSZ Gene
-
Protein details for CTSZ Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UBR2-CATZ_HUMAN
- Recommended name:
- Cathepsin Z
- Protein Accession:
- Q9UBR2
- B2RC40
- O75331
- Q9UQV5
- Q9UQV6
Protein attributes for CTSZ Gene
- Size:
- 303 amino acids
- Molecular mass:
- 33868 Da
- Quaternary structure:
- No Data Available
Protein Expression for CTSZ Gene
Selected DME Specific Peptides for CTSZ Gene
- Q9UBR2:
-
- VGDYGSLSGREKMMAEIY
- RIVTSTYK
- EYWIVRNSWGEPWGE
- TRNQHIPQYCGSCWAH
- NGPISCGIMATE
Post-translational modifications for CTSZ Gene
Other Protein References for CTSZ Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Atlas Antibodies Anti-CTSZ Antibody (HPA049876) and Anti-CTSZ Antibody (HPA053504)
-
Creative Biolabs
- Mouse Anti-CTSZ Recombinant Antibody (05)
- Mouse Anti-CTSZ Recombinant Antibody (CBFYC-2464)
- Mouse Anti-CTSZ Recombinant Antibody (163702)
- Mouse Anti-CTSZ Recombinant Antibody (CBYY-C2328)
- Mouse Anti-CTSZ Recombinant Antibody (6G11)
- Mouse Anti-CTSZ Recombinant Antibody (CBXC-3015)
- Recombinant Mouse anti-Human CTSZ Monoclonal antibody (NN0245-8M27)
- Mouse Anti-CTSZ Recombinant Antibody (CBFYC-2465)
- Rabbit Anti-CTSZ Recombinant Antibody (CBYY-C2329)
- Mouse Anti-CTSZ Recombinant Antibody (15B19)
- Mouse Anti-CTSZ Recombinant Antibody (CBXC-0983)
- Mouse Anti-CTSZ Recombinant Antibody (7L16)
- Mouse Anti-CTSZ Recombinant Antibody (14L81)
- Mouse Anti-CTSZ (AA 62-303) Recombinant Antibody (CBFYC-2466)
-
Custom Antibody ServicesOriGene Antibodies for CTSZ
- Novus Biologicals Antibodies for CTSZ
-
Abcam antibodies for CTSZ
- Invitrogen Antibodies for CTSZ (AFLGC-CTSZ)
- antibodies-online: Show 18 available Cathepsin Z Antibodies ranked by validation data
- Compare Top Cathepsin Z Antibodies
-
Recommended
- 78 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 14 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 10 WB Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CTSZ
- Sino Biological Antibodies for CTSZ
Protein Products
- G Biosciences Human Cathepsin X/Z/P, Liquid
- Search Origene for MassSpec and Protein Over-expression Lysates for CTSZ
- Origene Custom Protein Services for CTSZ
- Sino Biological Recombinant Proteins for CTSZ
- Sino Biological Cell Lysates for CTSZ
- ProSpec Recombinant Proteins for CTSZ
-
ProSci Proteins for CTSZ
-
Abcam proteins for CTSZ
Assay Products
- RayBiotech Custom Human Cathepsin X/Cathepsin P ELISA
- Aviva Systems Biology CTSZ ELISA Kit (Human) (OKDD00216) and CTSZ ELISA Kit (Human) (OKCD00361)
Domains & Families for CTSZ Gene
Gene Families for CTSZ Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for CTSZ Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CTSZ Gene
- GenScript: Design optimal peptide antigens:
-
- Cathepsin X (CATZ_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9UBR2- Family:
-
- Belongs to the peptidase C1 family.
Function for CTSZ Gene
Molecular function for CTSZ Gene
- UniProtKB/Swiss-Prot Function:
- Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (PubMed:10504234). Capable of producing kinin potentiating peptides (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.; EC=3.4.18.1; Evidence=. ;.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- The disulfide bridge formed between Cys-33 in the propeptide and the active site residue Cys-92 may prevent activation of the zymogen through formation of a reversible covalent bond with the active site residue.
- GENATLAS Biochemistry:
- cathepsin Z,cysteine proteinase,papain superfamily member,ubiquitously expressed,involved normal intracellular degradation
Enzyme Numbers (IUBMB) for CTSZ Gene
Phenotypes From GWAS Catalog for CTSZ Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004180 | carboxypeptidase activity | IMP | 19433310 |
| GO:0004197 | cysteine-type endopeptidase activity | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 21516116 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008234 | cysteine-type peptidase activity | TAS | -- |
Phenotypes for CTSZ Gene
- MGI mutant phenotypes for CTSZ:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CTSZ:
-
- Decreased HIV-LTR-beta-galactosidase protein expression
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased interferon-beta reporter expression
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Decreased NF-kappaB reporter expression
- shRNA abundance <= 50%
Animal Models for CTSZ Gene
- MGI Knock Outs for CTSZ:
-
- Ctsz Ctsz<tm1Thre>
Animal Model Products
-
Taconic Biosciences Mouse Models for CTSZ
CRISPR Products
-
OriGene CRISPR knockouts for CTSZ
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CTSZ
- genomics-online: gRNA clones - Search for available Cathepsin Z gRNA products
- Overview of 130 available Cathepsin Z gene related products
- Applied Biological Materials (abm): CRISPR Clones for CTSZ - Select products 50% OFF >
- * CTSZ CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * CTSZ CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for CTSZ
miRNA for CTSZ Gene
- miRTarBase miRNAs that target CTSZ
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CTSZ
- Browse OriGene Inhibitory RNA Products For CTSZ
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTSZ
- genomics-online: shRNA clones - Search for available Cathepsin Z shRNA products
- Overview of 130 available Cathepsin Z gene related products
Clone Products
- Sino Biological Human cDNA Clone for CTSZ
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CTSZ
- Applied Biological Materials (abm): Clones for CTSZ - Select products 50% OFF >
- * CTSZ as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * CTSZ tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for CTSZ
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTSZ Gene
Localization for CTSZ Gene
Subcellular locations from UniProtKB/Swiss-Prot for CTSZ Gene
- Lysosome.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| lysosome | 5 |
| plasma membrane | 4 |
| endoplasmic reticulum | 4 |
| golgi apparatus | 2 |
| endosome | 1 |
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IDA,IEA | 19433310 |
| GO:0005764 | lysosome | IDA | 19433310 |
| GO:0005783 | endoplasmic reticulum | IDA | -- |
Pathways & Interactions for CTSZ Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transport to the Golgi and subsequent modification | ||
| 2 | Clathrin derived vesicle budding | ||
| 3 | Innate Immune System |
.61
|
|
| 4 | Vesicle-mediated transport | ||
| 5 | Peptide hormone metabolism | ||
Pathways by source for CTSZ Gene
17 Reactome pathways for CTSZ Gene
1 GeneTex pathway for CTSZ Gene
Interacting Proteins for CTSZ Gene
Selected Interacting proteins:
Q9UBR2-CATZ_HUMAN
ENSP00000217131
for CTSZ Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CTSZ
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002003 | angiotensin maturation | TAS | -- |
| GO:0006508 | proteolysis | IMP,TAS | 19433310 |
| GO:0006888 | ER to Golgi vesicle-mediated transport | TAS | -- |
| GO:0010757 | negative regulation of plasminogen activation | IMP | 19433310 |
| GO:0010977 | negative regulation of neuron projection development | IEA | -- |
No data available for SIGNOR curated interactions for CTSZ Gene
Drugs & Compounds for CTSZ Gene
(2) ApexBio Compounds for CTSZ Gene
| Compound | Action | Cas Number |
|---|---|---|
| E-64-c | Inhibitor of cysteine proteinases | 76684-89-4 |
| Odanacatib (MK-0822) | Cathepsin K,potent and selective | 603139-19-1 |
Transcripts for CTSZ Gene
mRNA/cDNA for CTSZ Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (231) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000217131 1502 bps (ENST00000217131.5)
- ENST00000503833 955 bps (ENST00000503833.6)
- ENST00000488395 647 bps (ENST00000488395.1)
- ENST00000472025 564 bps (ENST00000472025.1)
CRISPR Products
-
OriGene CRISPR knockouts for CTSZ
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CTSZ
- genomics-online: gRNA clones - Search for available Cathepsin Z gRNA products
- Overview of 130 available Cathepsin Z gene related products
- Applied Biological Materials (abm): CRISPR Clones for CTSZ - Select products 50% OFF >
- * CTSZ CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * CTSZ CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for CTSZ
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CTSZ
- Browse OriGene Inhibitory RNA Products For CTSZ
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTSZ
- genomics-online: shRNA clones - Search for available Cathepsin Z shRNA products
- Overview of 130 available Cathepsin Z gene related products
Clone Products
- Sino Biological Human cDNA Clone for CTSZ
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CTSZ
- Applied Biological Materials (abm): Clones for CTSZ - Select products 50% OFF >
- * CTSZ as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * CTSZ tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for CTSZ Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for CTSZ Gene
This gene is overexpressed in Whole Blood (x4.7).
This gene is overexpressed in Nasal epithelium (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CTSZ Gene
NURSA nuclear receptor signaling pathways regulating expression of CTSZ Gene:
CTSZSOURCE GeneReport for Unigene cluster for CTSZ Gene:
Hs.252549mRNA Expression by UniProt/SwissProt for CTSZ Gene:
Q9UBR2-CATZ_HUMAN
Tissue specificity:
Widely expressed.
Evidence on tissue expression from TISSUES for CTSZ Gene
- Intestine(4.6)
- Liver(4.5)
- Blood(4.3)
- Pancreas(4.3)
- Stomach(2.9)
- Spleen(2.8)
- Lung(2.7)
- Lymph node(2.7)
- Nervous system(2)
Primer Products
-
OriGene qPCR primer pairs for CTSZ
-
OriGene qPCR primer pairs and template standards for CTSZ
- genomics-online: primer clones - Search for available Cathepsin Z Primer products
- Overview of 130 available Cathepsin Z gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTSZ Gene
Orthologs for CTSZ Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CTSZ 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CTSZ 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CTSZ 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ctsz 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ctsz 32 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CTSZ 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CTSZ 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CTSZ 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
OneToMany | |
| -- 33 |
|
OneToMany | |||
| -- 33 |
|
OneToMany | |||
| -- 33 |
|
OneToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ctsz 32 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.8587 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ctsz 33 32 |
|
OneToOne | |
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1216 32 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | F32B5.8 34 |
|
|
|
| cpz-1 33 32 |
|
OneToOne | |||
| M04G12.2 34 |
|
|
- Species where no ortholog for CTSZ was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for CTSZ Gene
- ENSEMBL:
- Gene Tree for CTSZ (if available)
- TreeFam:
- Gene Tree for CTSZ (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CTSZ: view image
Paralogs for CTSZ Gene
Variants for CTSZ Gene
| SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000409839 | -- | 59,008,246(-) | G/A | upstream_transcript_variant | |
| rs1000441604 | -- | 58,997,479(-) | G/C | intron_variant | |
| rs1000506139 | -- | 59,001,329(-) | C/T | intron_variant | |
| rs1000510762 | -- | 58,997,326(-) | C/T | intron_variant | |
| rs1000664531 | -- | 59,006,499(-) | A/T | intron_variant |
Residual Variation Intolerance Score:
28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.33;
41.51% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CTSZ Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTSZ Gene
Disorders for CTSZ Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dacryoadenitis |
|
|
Search CTSZ in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CTSZ
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CTSZ Gene
Publications for CTSZ Gene
- Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location. (PMID: 9642240) Santamaría I … López-Otín C (The Journal of biological chemistry 1998) 2 3 4 23 56
- Mapping of a novel susceptibility locus suggests a role for MC3R and CTSZ in human tuberculosis. (PMID: 18420963) Cooke GS … Hill AV (American journal of respiratory and critical care medicine 2008) 3 23 43 56
- Murine and human cathepsin Z: cDNA-cloning, characterization of the genes and chromosomal localization. (PMID: 10760573) Deussing J … Peters C (Biochimica et biophysica acta 2000) 3 4 23 56
- Identification and molecular cloning of cathepsin P, a novel human putative cysteine protease of the papain family. (PMID: 10653162) Pungercar J … Ivanovski G (Pflugers Archiv : European journal of physiology 2000) 3 4 23 56
- Tissue expression and immunolocalization of a novel human cathepsin P. (PMID: 10653163) Pungercar J … Krizaj I (Pflugers Archiv : European journal of physiology 2000) 3 4 23 56
ExternalLinks
Products for CTSZ Gene
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- Custom Antibody ServicesOriGene Antibodies for CTSZ
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- Find your next knockout model in the Taconic Knockout Repository
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- Humanized Mice
- Invitrogen Antibodies for CTSZ (AFLGC-CTSZ)
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- antibodies-online: Show 18 available Cathepsin Z Antibodies ranked by validation data
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- 10 WB Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- antibodies-online: Show 13 available Cathepsin Z Elisa Kits ranked by validation data
- Compare Top Cathepsin Z Elisa Kits
- antibodies-online: Show 20 available Cathepsin Z Proteins ranked by validation data
- Compare Top Cathepsin Z Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CTSZ
- Search Santa Cruz Biotechnology (SCBT) for CTSZ siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CTSZ
- Search for CTSZ Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for CTSZ
- Horizon Cell Lines for CTSZ
- genomics-online: cdna clones - Search for available Cathepsin Z CDNA products
- Overview of 130 available Cathepsin Z gene related products
- orf clones - Search for available Cathepsin Z ORF products
- Overview of 130 available Cathepsin Z gene related products
- genomics-online: gRNA clones - Search for available Cathepsin Z gRNA products
- Overview of 130 available Cathepsin Z gene related products
- genomics-online: primer clones - Search for available Cathepsin Z Primer products
- Overview of 130 available Cathepsin Z gene related products
- genomics-online: shRNA clones - Search for available Cathepsin Z shRNA products
- Overview of 130 available Cathepsin Z gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CTSZ
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CTSZ
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CTSZ
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTSZ
Sources for CTSZ Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource