Aliases for CTSZ Gene
External Ids for CTSZ Gene
Previous GeneCards Identifiers for CTSZ Gene
The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008]
GeneCards Summary for CTSZ Gene
CTSZ (Cathepsin Z) is a Protein Coding gene. Diseases associated with CTSZ include Cercarial Dermatitis and Mitochondrial Complex V Deficiency, Nuclear Type 5. Among its related pathways are Lysosome and Peptide hormone metabolism. Gene Ontology (GO) annotations related to this gene include cysteine-type peptidase activity. An important paralog of this gene is CTSC.
UniProtKB/Swiss-Prot Summary for CTSZ Gene
Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (PubMed:10504234). Capable of producing kinin potentiating peptides (By similarity).