The protein encoded by this gene, a member of the peptidase C1 family, is a cysteine proteinase that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2.... See more...

Aliases for CTSW Gene

Aliases for CTSW Gene

  • Cathepsin W 2 3 4 5
  • Lymphopain 3 4
  • Cathepsin W (Lymphopain) 2
  • EC 3.4.22.- 4
  • LYPN 3
  • CTSW 5

External Ids for CTSW Gene

Previous GeneCards Identifiers for CTSW Gene

  • GC11P068181
  • GC11P067328
  • GC11P065897
  • GC11P065422
  • GC11P065405
  • GC11P065647
  • GC11P061973

Summaries for CTSW Gene

Entrez Gene Summary for CTSW Gene

  • The protein encoded by this gene, a member of the peptidase C1 family, is a cysteine proteinase that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2. [provided by RefSeq, Jul 2008]

GeneCards Summary for CTSW Gene

CTSW (Cathepsin W) is a Protein Coding gene. Diseases associated with CTSW include Autoimmune Atrophic Gastritis. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Lysosome. Gene Ontology (GO) annotations related to this gene include cysteine-type peptidase activity. An important paralog of this gene is CTSF.

UniProtKB/Swiss-Prot Summary for CTSW Gene

  • May have a specific function in the mechanism or regulation of T-cell cytolytic activity.
  • (Microbial infection) Plays a role during influenza virus infection in lungs cells ex vivo. Acts at the level of virus entering host cytoplasm from late endosome.

Gene Wiki entry for CTSW Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CTSW Gene

Genomics for CTSW Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CTSW Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J065878 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 301.2 +0.1 121 3.7 POLR2A MAX ZNF3 GABPB1 SREBF1 CTSW HSALNG0084962 SNX32 FIBP
GH11J065884 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 51.2 +14.6 14631 20.5 CHD2 TBP ZBTB10 SP1 MXD4 FEZF1 CEBPA SIX5 NR2C1 MNT FOSL1 FIBP DRAP1 HSALNG0084963 RBM14 KAT5 SNX32 RBM4 MUS81 ENSG00000254461
GH11J065868 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 29.3 -8.1 -8100 5.6 ZBTB10 SP1 MXD4 MNT IKZF1 SMAD5 ZFP64 POLR2A BHLHE40 ZEB1 EFEMP2 HSALNG0084960 lnc-CFL1-5 CTSW SNX32 RBM14 RBM4 ENSG00000260233 ENSG00000245156 RNASEH2C
GH11J065851 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 14.4 -22.3 -22324 12.2 ZBTB10 SP1 MXD4 FEZF1 ZNF217 SIX5 NR2C1 MNT IKZF1 SMAD5 MUS81 CFL1 HSALNG0084955 lnc-CFL1-2 piR-49993-002 RBM14 SNX32 POLA2 SART1 SF3B2
GH11J065816 Promoter/Enhancer 1.5 ENCODE CraniofacialAtlas dbSUPER 22 -62.0 -62034 2.3 TBP DEK IRF2 ZNF217 BRCA1 CTCF BHLHE40 NONO ZIC2 HOMEZ OVOL1-AS1 lnc-CFL1-1 CTSW CFL1 ENSG00000254855 ZDHHC24 RF00017-948 SNX32 OVOL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CTSW on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CTSW

Top Transcription factor binding sites by QIAGEN in the CTSW gene promoter:
  • ATF-2
  • c-Jun
  • COMP1
  • FAC1
  • IRF-1
  • Lmo2
  • p53
  • PPAR-alpha
  • Roaz

Genomic Locations for CTSW Gene

Latest Assembly
chr11:65,879,809-65,883,741
(GRCh38/hg38)
Size:
3,933 bases
Orientation:
Plus strand

Previous Assembly
chr11:65,647,308-65,651,212
(GRCh37/hg19 by Entrez Gene)
Size:
3,905 bases
Orientation:
Plus strand

chr11:65,647,280-65,651,212
(GRCh37/hg19 by Ensembl)
Size:
3,933 bases
Orientation:
Plus strand

Genomic View for CTSW Gene

Genes around CTSW on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTSW Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTSW Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSW Gene

Proteins for CTSW Gene

  • Protein details for CTSW Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56202-CATW_HUMAN
    Recommended name:
    Cathepsin W
    Protein Accession:
    P56202
    Secondary Accessions:
    • Q86VT4

    Protein attributes for CTSW Gene

    Size:
    376 amino acids
    Molecular mass:
    42120 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CTSW Gene

Post-translational modifications for CTSW Gene

  • Glycosylation at Asn50 and Asn205
  • Modification sites at PhosphoSitePlus

Other Protein References for CTSW Gene

No data available for DME Specific Peptides for CTSW Gene

Domains & Families for CTSW Gene

Gene Families for CTSW Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for CTSW Gene

InterPro:
Blocks:
  • Papain cysteine protease (C1) family signature
  • Proteinase inhibitor I29, cathepsin propeptide
ProtoNet:

Suggested Antigen Peptide Sequences for CTSW Gene

GenScript: Design optimal peptide antigens:
  • Lymphopain (CATW_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P56202

UniProtKB/Swiss-Prot:

CATW_HUMAN :
  • Belongs to the peptidase C1 family.
Family:
  • Belongs to the peptidase C1 family.
genes like me logo Genes that share domains with CTSW: view

Function for CTSW Gene

Molecular function for CTSW Gene

UniProtKB/Swiss-Prot Function:
May have a specific function in the mechanism or regulation of T-cell cytolytic activity.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Plays a role during influenza virus infection in lungs cells ex vivo. Acts at the level of virus entering host cytoplasm from late endosome.
GENATLAS Biochemistry:
cathepsin W,cysteine protease,papain superfamily,expressed in endoplasmic reticulum in CD8+ T-lymphocytes,subgroup F-like protease

Enzyme Numbers (IUBMB) for CTSW Gene

Phenotypes From GWAS Catalog for CTSW Gene

Gene Ontology (GO) - Molecular Function for CTSW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IBA 21873635
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA,TAS 9823953
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CTSW: view
genes like me logo Genes that share phenotypes with CTSW: view

Animal Models for CTSW Gene

MGI Knock Outs for CTSW:
  • Ctsw Ctsw<tm1Ctnp>

miRNA for CTSW Gene

miRTarBase miRNAs that target CTSW

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTSW

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTSW Gene

Localization for CTSW Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTSW Gene

Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTSW gene
Compartment Confidence
extracellular 5
lysosome 4
endoplasmic reticulum 3
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CTSW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
GO:0005764 lysosome IBA 21873635
GO:0005783 endoplasmic reticulum IEA --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with CTSW: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CTSW Gene

Pathways & Interactions for CTSW Gene

genes like me logo Genes that share pathways with CTSW: view

Pathways by source for CTSW Gene

1 GeneTex pathway for CTSW Gene

Gene Ontology (GO) - Biological Process for CTSW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0006508 proteolysis IEA --
GO:0006955 immune response TAS 9823953
GO:0051603 proteolysis involved in cellular protein catabolic process IBA 21873635
genes like me logo Genes that share ontologies with CTSW: view

No data available for SIGNOR curated interactions for CTSW Gene

Drugs & Compounds for CTSW Gene

(4) Drugs for CTSW Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Papain Inhibitor Pharma Inhibitor of peptidase activity of Papain 0

(1) ApexBio Compounds for CTSW Gene

Compound Action Cas Number
Papain Inhibitor Inhibitor of peptidase activity of Papain 70195-20-9
genes like me logo Genes that share compounds with CTSW: view

Drug products for research

Transcripts for CTSW Gene

mRNA/cDNA for CTSW Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTSW

Alternative Splicing Database (ASD) splice patterns (SP) for CTSW Gene

No ASD Table

Relevant External Links for CTSW Gene

GeneLoc Exon Structure for
CTSW

Expression for CTSW Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CTSW Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTSW Gene

This gene is overexpressed in Whole Blood (x39.9).

Protein differential expression in normal tissues from HIPED for CTSW Gene

This gene is overexpressed in NK cells (37.5), Peripheral blood mononuclear cells (20.6), and CD8 Tcells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CTSW Gene



Protein tissue co-expression partners for CTSW Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CTSW

SOURCE GeneReport for Unigene cluster for CTSW Gene:

Hs.416848

mRNA Expression by UniProt/SwissProt for CTSW Gene:

P56202-CATW_HUMAN
Tissue specificity: Expressed predominantly in natural killer cells, and in cytotoxic T cells.

Evidence on tissue expression from TISSUES for CTSW Gene

  • Pancreas(4.1)
  • Blood(2.4)
  • Spleen(2.2)
  • Bone marrow(2.1)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with CTSW: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CTSW Gene

Orthologs for CTSW Gene

This gene was present in the common ancestor of animals.

Orthologs for CTSW Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CTSW 30 31
  • 99.47 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CTSW 30 31
  • 81.19 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ctsw 30
  • 75.56 (n)
Mouse
(Mus musculus)
Mammalia Ctsw 30 17 31
  • 75.56 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CTSW 31
  • 71 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CTSW 31
  • 50 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 48 (a)
OneToMany
-- 31
  • 48 (a)
OneToMany
-- 31
  • 39 (a)
OneToMany
-- 31
  • 37 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 21 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 17 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ctsw 30
  • 54.4 (n)
Zebrafish
(Danio rerio)
Actinopterygii zgc:110239 31
  • 17 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG12163 31
  • 18 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea R09F10.1 32
  • 33 (a)
R07E3.1 32
  • 29 (a)
tag-196 31
  • 23 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2594 31
  • 39 (a)
OneToMany
Species where no ortholog for CTSW was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CTSW Gene

ENSEMBL:
Gene Tree for CTSW (if available)
TreeFam:
Gene Tree for CTSW (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CTSW: view image

Paralogs for CTSW Gene

Paralogs for CTSW Gene

(8) SIMAP similar genes for CTSW Gene using alignment to 3 proteins:

  • CATW_HUMAN
  • E9PI30_HUMAN
  • H0YDT2_HUMAN
genes like me logo Genes that share paralogs with CTSW: view

Variants for CTSW Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CTSW Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs604630 - p.Ser139Gly
rs606830 - p.Gln218Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CTSW Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CTSW Gene

Variant ID Type Subtype PubMed ID
esv2759834 CNV gain 17122850
nsv1159905 CNV duplication 26073780
nsv555215 CNV loss 21841781
nsv832191 CNV loss 17160897
nsv951019 CNV deletion 24416366

Variation tolerance for CTSW Gene

Residual Variation Intolerance Score: 78.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CTSW Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTSW

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTSW Gene

Disorders for CTSW Gene

MalaCards: The human disease database

(1) MalaCards diseases for CTSW Gene - From: GCD

Disorder Aliases PubMed IDs
autoimmune atrophic gastritis
- elite association - COSMIC cancer census association via MalaCards
Search CTSW in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CTSW

genes like me logo Genes that share disorders with CTSW: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTSW Gene

Publications for CTSW Gene

  1. Genomic structure, chromosomal localization, and expression of human cathepsin W. (PMID: 9675123) Wex T … Bromme D (Biochemical and biophysical research communications 1998) 2 3 4 23
  2. Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes. (PMID: 9108299) Linnevers C … Brömme D (FEBS letters 1997) 2 3 4 23
  3. Human cathepsin W, a cysteine protease predominantly expressed in NK cells, is mainly localized in the endoplasmic reticulum. (PMID: 11490002) Wex T … Brömme D (Journal of immunology (Baltimore, Md. : 1950) 2001) 3 4 23
  4. Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase. (PMID: 9823953) Brown J … Enver T (Leukemia 1998) 3 4 23
  5. Cathepsin W Is Required for Escape of Influenza A Virus from Late Endosomes. (PMID: 26060270) Edinger TO … Stertz S (mBio 2015) 3 4

Products for CTSW Gene

Sources for CTSW Gene