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Aliases for CTSW Gene

Aliases for CTSW Gene

  • Cathepsin W 2 3 3 5
  • Lymphopain 3 4
  • Cathepsin W (Lymphopain) 2
  • EC 3.4.22.- 4
  • LYPN 3

External Ids for CTSW Gene

Previous GeneCards Identifiers for CTSW Gene

  • GC11P068181
  • GC11P067328
  • GC11P065897
  • GC11P065422
  • GC11P065405
  • GC11P065647
  • GC11P061973

Summaries for CTSW Gene

Entrez Gene Summary for CTSW Gene

  • The protein encoded by this gene, a member of the peptidase C1 family, is a cysteine proteinase that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2. [provided by RefSeq, Jul 2008]

GeneCards Summary for CTSW Gene

CTSW (Cathepsin W) is a Protein Coding gene. Diseases associated with CTSW include Autoimmune Atrophic Gastritis. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Lysosome. Gene Ontology (GO) annotations related to this gene include cysteine-type peptidase activity. An important paralog of this gene is CTSF.

UniProtKB/Swiss-Prot for CTSW Gene

  • May have a specific function in the mechanism or regulation of T-cell cytolytic activity.

Gene Wiki entry for CTSW Gene

Additional gene information for CTSW Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSW Gene

Genomics for CTSW Gene

GeneHancer (GH) Regulatory Elements for CTSW Gene

Promoters and enhancers for CTSW Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J065878 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 701.2 +0.1 121 3.7 SREBF1 ZNF3 POLR2A GABPB1 MAX ZFP36 CTSW SNX32 FIBP
GH11J065886 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 51.2 +15.6 15649 18.4 CLOCK ZFP64 FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 ZNF263 SP3 FOSL1 FIBP DRAP1 RBM14 ENSG00000258297 KAT5 MUS81 SART1 SF3B2 RBM4
GH11J065868 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 29.2 -8.1 -8100 5.6 HDGF SMAD1 MLX ZFP64 ARID4B SIN3A POLR2B ZNF207 ZNF143 KLF13 EFEMP2 ENSG00000258297 CTSW RBM14 MUS81 RBM4 KAT5 SNX32 ZFPL1 SSSCA1-AS1
GH11J065884 Enhancer 1 ENCODE 51.2 +5.2 5226 1.6 HDGF CLOCK ARID4B SIN3A ZNF2 IRF4 ZNF48 GLIS2 E2F8 ARID2 CTSW FIBP
GH11J065851 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14.4 -22.3 -22325 12.2 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MUS81 CFL1 EIF1AD ENSG00000258297 POLA2 RBM14 SART1 PCNX3 RBM4 ZFPL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CTSW on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CTSW gene promoter:
  • c-Jun
  • ATF-2
  • p53
  • Lmo2
  • PPAR-alpha
  • IRF-1
  • Roaz
  • FAC1
  • COMP1

Genomic Locations for CTSW Gene

Genomic Locations for CTSW Gene
3,933 bases
Plus strand
3,933 bases
Plus strand

Genomic View for CTSW Gene

Genes around CTSW on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTSW Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTSW Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSW Gene

Proteins for CTSW Gene

  • Protein details for CTSW Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cathepsin W
    Protein Accession:
    Secondary Accessions:
    • Q86VT4

    Protein attributes for CTSW Gene

    376 amino acids
    Molecular mass:
    42120 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CTSW Gene

Post-translational modifications for CTSW Gene

  • Glycosylation at posLast=205205 and posLast=5050
  • Modification sites at PhosphoSitePlus

Other Protein References for CTSW Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for CTSW

No data available for DME Specific Peptides for CTSW Gene

Domains & Families for CTSW Gene

Gene Families for CTSW Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CTSW Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C1 family.
  • Belongs to the peptidase C1 family.
genes like me logo Genes that share domains with CTSW: view

Function for CTSW Gene

Molecular function for CTSW Gene

UniProtKB/Swiss-Prot Function:
May have a specific function in the mechanism or regulation of T-cell cytolytic activity.
GENATLAS Biochemistry:
cathepsin W,cysteine protease,papain superfamily,expressed in endoplasmic reticulum in CD8+ T-lymphocytes,subgroup F-like protease

Enzyme Numbers (IUBMB) for CTSW Gene

Phenotypes From GWAS Catalog for CTSW Gene

Gene Ontology (GO) - Molecular Function for CTSW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IBA --
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity TAS,IEA 9823953
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CTSW: view
genes like me logo Genes that share phenotypes with CTSW: view

Animal Models for CTSW Gene

MGI Knock Outs for CTSW:
  • Ctsw Ctsw<tm1Ctnp>

Animal Model Products

miRNA for CTSW Gene

miRTarBase miRNAs that target CTSW

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTSW Gene

Localization for CTSW Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTSW gene
Compartment Confidence
extracellular 5
lysosome 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CTSW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0005764 lysosome IBA --
GO:0016020 membrane HDA 19946888
GO:0031089 platelet dense granule lumen TAS --
genes like me logo Genes that share ontologies with CTSW: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CTSW Gene

Pathways & Interactions for CTSW Gene

genes like me logo Genes that share pathways with CTSW: view

Pathways by source for CTSW Gene

2 KEGG pathways for CTSW Gene

Gene Ontology (GO) - Biological Process for CTSW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0006508 proteolysis IEA --
GO:0006955 immune response TAS 9823953
GO:0051603 proteolysis involved in cellular protein catabolic process IBA --
genes like me logo Genes that share ontologies with CTSW: view

No data available for SIGNOR curated interactions for CTSW Gene

Drugs & Compounds for CTSW Gene

(3) Drugs for CTSW Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Papain Inhibitor Pharma Inhibitor of peptidase activity of Papain 0

(1) Additional Compounds for CTSW Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CTSW: view

Transcripts for CTSW Gene

mRNA/cDNA for CTSW Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(87) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CTSW Gene

Cathepsin W:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTSW Gene

No ASD Table

Relevant External Links for CTSW Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTSW Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTSW Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTSW Gene

This gene is overexpressed in Whole Blood (x39.9).

Protein differential expression in normal tissues from HIPED for CTSW Gene

This gene is overexpressed in NK cells (37.5), Peripheral blood mononuclear cells (20.6), and CD8 Tcells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CTSW Gene

Protein tissue co-expression partners for CTSW Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CTSW Gene:


SOURCE GeneReport for Unigene cluster for CTSW Gene:


mRNA Expression by UniProt/SwissProt for CTSW Gene:

Tissue specificity: Expressed in natural killer and cytotoxic T cells.

Evidence on tissue expression from TISSUES for CTSW Gene

  • Pancreas(4.1)
  • Blood(2)
genes like me logo Genes that share expression patterns with CTSW: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CTSW Gene

Orthologs for CTSW Gene

This gene was present in the common ancestor of animals.

Orthologs for CTSW Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CTSW 34 33
  • 99.47 (n)
(Canis familiaris)
Mammalia CTSW 34 33
  • 81.19 (n)
(Mus musculus)
Mammalia Ctsw 16 34 33
  • 75.56 (n)
(Rattus norvegicus)
Mammalia Ctsw 33
  • 75.56 (n)
(Bos Taurus)
Mammalia CTSW 34
  • 71 (a)
(Monodelphis domestica)
Mammalia CTSW 34
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 48 (a)
-- 34
  • 48 (a)
-- 34
  • 39 (a)
-- 34
  • 37 (a)
(Gallus gallus)
Aves -- 34
  • 21 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 17 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ctsw 33
  • 54.4 (n)
(Danio rerio)
Actinopterygii zgc:110239 34
  • 17 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12163 34
  • 18 (a)
(Caenorhabditis elegans)
Secernentea R09F10.1 35
  • 33 (a)
R07E3.1 35
  • 29 (a)
tag-196 34
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2594 34
  • 39 (a)
Species where no ortholog for CTSW was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTSW Gene

Gene Tree for CTSW (if available)
Gene Tree for CTSW (if available)
Evolutionary constrained regions (ECRs) for CTSW: view image

Paralogs for CTSW Gene

Paralogs for CTSW Gene

(8) SIMAP similar genes for CTSW Gene using alignment to 3 proteins:

  • E9PI30_HUMAN
genes like me logo Genes that share paralogs with CTSW: view

Variants for CTSW Gene

Sequence variations from dbSNP and Humsavar for CTSW Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000433510 -- 65,883,003(+) G/C intron_variant
rs1000583119 -- 65,880,911(+) C/G intron_variant
rs1000765021 -- 65,884,006(+) G/A downstream_transcript_variant
rs1001059607 -- 65,879,009(+) A/G upstream_transcript_variant
rs1001830491 -- 65,877,952(+) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CTSW Gene

Variant ID Type Subtype PubMed ID
esv2759834 CNV gain 17122850
nsv1159905 CNV duplication 26073780
nsv555215 CNV loss 21841781
nsv832191 CNV loss 17160897
nsv951019 CNV deletion 24416366

Variation tolerance for CTSW Gene

Residual Variation Intolerance Score: 78.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CTSW Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTSW Gene

Disorders for CTSW Gene

MalaCards: The human disease database

(1) MalaCards diseases for CTSW Gene - From: GeneCards

Disorder Aliases PubMed IDs
autoimmune atrophic gastritis
- elite association - COSMIC cancer census association via MalaCards
Search CTSW in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CTSW

genes like me logo Genes that share disorders with CTSW: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTSW Gene

Publications for CTSW Gene

  1. Genomic structure, chromosomal localization, and expression of human cathepsin W. (PMID: 9675123) Wex T … Bromme D (Biochemical and biophysical research communications 1998) 2 3 4 22 58
  2. Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes. (PMID: 9108299) Linnevers C … Brömme D (FEBS letters 1997) 2 3 4 22 58
  3. Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase. (PMID: 9823953) Brown J … Enver T (Leukemia 1998) 3 4 22 58
  4. Cathepsin W expressed exclusively in CD8+ T cells and NK cells, is secreted during target cell killing but is not essential for cytotoxicity in human CTLs. (PMID: 19100676) Stoeckle C … Tolosa E (Experimental hematology 2009) 3 22 58
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 58

Products for CTSW Gene

Sources for CTSW Gene

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