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CTSS Gene(Protein Coding)

Cathepsin S

GCID:
GC01M150702
GIFtS:
55
Genes Participants
UDN Logo

Aliases for CTSS Gene

Aliases for CTSS Gene

  • Cathepsin S 2 3 5
  • EC 3.4.22.27 4 56
  • EC 3.4.22 56

External Ids for CTSS Gene

Previous GeneCards Identifiers for CTSS Gene

  • GC01M148546
  • GC01M146449
  • GC01M147477
  • GC01M147919
  • GC01M147515
  • GC01M148969
  • GC01M122080

Summaries for CTSS Gene

Entrez Gene Summary for CTSS Gene

  • The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for CTSS Gene

CTSS (Cathepsin S) is a Protein Coding gene. Diseases associated with CTSS include Cercarial Dermatitis and Mandibular Cancer. Among its related pathways are Bacterial infections in CF airways and Innate Immune System. Gene Ontology (GO) annotations related to this gene include peptidase activity and cysteine-type peptidase activity. An important paralog of this gene is CTSK.

UniProtKB/Swiss-Prot for CTSS Gene

  • Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.

Gene Wiki entry for CTSS Gene

Additional gene information for CTSS Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSS Gene

Genomics for CTSS Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for CTSS Gene

Promoters and enhancers for CTSS Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01I150763 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 569.9 +1.0 971 3 HDAC1 PKNOX1 IRF4 GTF3C2 POLR3A ATF7 ETV6 FOS BCLAF1 IKZF2 CTSS HORMAD1 ARNT MCL1 RPRD2 POGZ LYSMD1 CDC42SE1 TNFAIP8L2 RPS27AP6
GH01I150609 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 20.8 +153.2 153215 7.5 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A IRF4 YY1 SLC30A9 ZNF766 HORMAD1 MCL1 PRPF3 ARNT GOLPH3L CTSS GABPB2 PI4KB PIP5K1A UBE2D3P3
GH01I150557 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE dbSUPER 11.3 +196.7 196653 23.1 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC RN7SL600P MCL1 GOLPH3L SETDB1 HORMAD1 PRPF3 PIP5K1A PI4KB SF3B4 ARNT
GH01I150548 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.7 +214.3 214345 6.4 HDGF PKNOX1 CLOCK ZFP64 ARID4B SIN3A DMAP1 ZBTB7B POLR2B E2F8 ADAMTSL4 MIR4257 HORMAD1 CTSS MRPS21 C1orf56 LOC100289061
GH01I150969 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.9 -209.0 -209000 10.6 CLOCK MLX ZFP64 DMAP1 YY1 E2F8 ZNF143 SP3 SSRP1 GLIS1 CERS2 ENSG00000231073 PRPF3 SETDB1 ZNF687 HORMAD1 PIP5K1A ARNT GOLPH3L PI4KB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CTSS on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CTSS gene promoter:

Genomic Locations for CTSS Gene

Genomic Locations for CTSS Gene
chr1:150,730,196-150,765,957
(GRCh38/hg38)
Size:
35,762 bases
Orientation:
Minus strand
chr1:150,702,672-150,738,433
(GRCh37/hg19)

Genomic View for CTSS Gene

Genes around CTSS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTSS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTSS Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CTSS Gene

Proteins for CTSS Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CTSS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25774-CATS_HUMAN
    Recommended name:
    Cathepsin S
    Protein Accession:
    P25774
    Secondary Accessions:
    • B4DWC9
    • D3DV05
    • Q5T5I0
    • Q6FHS5
    • Q9BUG3

    Protein attributes for CTSS Gene

    Size:
    331 amino acids
    Molecular mass:
    37496 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CTSS Gene

    Alternative splice isoforms for CTSS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CTSS Gene

Protein Expression for CTSS Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for CTSS Gene

P25774:
  • QNLVDCS
  • RRLIWEKNLK
  • VDWREKG
  • VLVVGYG
  • CWAFSAVGALE
  • QLKLKTGKL
  • PTLDHHW
  • LHNLEHSMGMHSY
  • DWREKGCVTEVKYQG
  • GDMTSEE
  • MNHLGDMT
  • GYIRMAR
  • YWLVKNS
  • KTGKLVSLS

Post-translational modifications for CTSS Gene

Other Protein References for CTSS Gene

ENSEMBL proteins:
REFSEQ proteins:

Protein Products

Domains & Families for CTSS Gene

Gene Families for CTSS Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for CTSS Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CTSS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25774

UniProtKB/Swiss-Prot:

CATS_HUMAN :
  • Belongs to the peptidase C1 family.
Family:
  • Belongs to the peptidase C1 family.
genes like me logo Genes that share domains with CTSS: view

Function for CTSS Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CTSS Gene

GENATLAS Biochemistry:
cathepsin S,lysosomal cysteine proteinase,expressed in spleen,heart and lung,papain superfamily,specifically involved in MHCII-associated chain processing and peptide loading
UniProtKB/Swiss-Prot CatalyticActivity:
Similar to cathepsin L, but with much less activity on Z-Phe-Arg- -NHMec, and more activity on the Z-Val-Val-Arg- -Xaa compound.
UniProtKB/Swiss-Prot Function:
Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.

Enzyme Numbers (IUBMB) for CTSS Gene

Phenotypes From GWAS Catalog for CTSS Gene

Gene Ontology (GO) - Molecular Function for CTSS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding IPI 22952693
GO:0004197 cysteine-type endopeptidase activity TAS,IDA --
GO:0004252 serine-type endopeptidase activity TAS --
GO:0005518 collagen binding IDA 22952693
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with CTSS: view
genes like me logo Genes that share phenotypes with CTSS: view

Animal Models for CTSS Gene

MGI Knock Outs for CTSS:

Animal Model Products

Clone Products

  • Addgene plasmids for CTSS

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTSS Gene

Localization for CTSS Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTSS Gene

Lysosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTSS gene
Compartment Confidence
extracellular 5
lysosome 5
endosome 5
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CTSS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 22952693
GO:0005764 lysosome IDA,IEA 15196205
GO:0036021 endolysosome lumen TAS --
GO:0043202 lysosomal lumen TAS --
genes like me logo Genes that share ontologies with CTSS: view

Pathways & Interactions for CTSS Gene

genes like me logo Genes that share pathways with CTSS: view

Gene Ontology (GO) - Biological Process for CTSS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002250 adaptive immune response IEP 15196205
GO:0006508 proteolysis IEA,IDA 12788072
GO:0006955 immune response TAS 8157683
GO:0010447 response to acidic pH IDA 22864553
genes like me logo Genes that share ontologies with CTSS: view

No data available for SIGNOR curated interactions for CTSS Gene

Drugs & Compounds for CTSS Gene

Products:

  1. Drug

(16) Drugs for CTSS Gene - From: DrugBank, ApexBio, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(1R)-2-[(CYANOMETHYL)AMINO]-1-({[2-(DIFLUOROMETHOXY)BENZYL]SULFONYL}METHYL)-2-OXOETHYL MORPHOLINE-4-CARBOXYLATE Experimental Pharma Target 0
2-[(2',3',4'-TRIFLUOROBIPHENYL-2-YL)OXY]ETHANOL Experimental Pharma Target 0
Morpholine-4-Carboxylic Acid (1-(3-Benzenesulfonyl-1-Phenethylallylcarbamoyl)-3-Methylbutyl)-Amide Experimental Pharma Target 0
Morpholine-4-Carboxylic Acid [1-(2-Benzylsulfanyl-1-Formyl-Ethylcarbamoyl)-2-Phenyl-Ethyl]-Amide Experimental Pharma Target 0
Morpholine-4-Carboxylic Acid [1s-(2-Benzyloxy-1r-Cyano-Ethylcarbamoyl)-3-Methyl-Butyl]Amide Experimental Pharma Target 0

(3) ApexBio Compounds for CTSS Gene

Compound Action Cas Number
Cathepsin Inhibitor 1 Cathepsin inhibitor 225120-65-0
Cathepsin S inhibitor Blocks MHCII antigen presentation 1373215-15-6
E-64 Cysteine protease inhibitor,irriversible 66701-25-5
genes like me logo Genes that share compounds with CTSS: view

Drug Products

Transcripts for CTSS Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CTSS Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(328) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CTSS Gene

Cathepsin S:
Representative Sequences:

Clone Products

  • Addgene plasmids for CTSS

Alternative Splicing Database (ASD) splice patterns (SP) for CTSS Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10
SP1: - -
SP2: -
SP3:
SP4: - - -
SP5: -

Relevant External Links for CTSS Gene

GeneLoc Exon Structure for
CTSS
ECgene alternative splicing isoforms for
CTSS

Expression for CTSS Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTSS Gene

mRNA expression in normal human tissues for CTSS Gene
mRNA expression by BioGPS for CTSS GenemRNA expression by GTEx for CTSS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTSS Gene

This gene is overexpressed in Whole Blood (x25.9) and Spleen (x4.3).

Protein differential expression in normal tissues from HIPED for CTSS Gene

This gene is overexpressed in Monocytes (12.2), Peripheral blood mononuclear cells (9.0), Spleen (6.3), and Nasal epithelium (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CTSS Gene



NURSA nuclear receptor signaling pathways regulating expression of CTSS Gene:

CTSS

SOURCE GeneReport for Unigene cluster for CTSS Gene:

Hs.181301

Evidence on tissue expression from TISSUES for CTSS Gene

  • Liver(4.6)
  • Blood(4.5)
  • Pancreas(4.5)
  • Intestine(4.3)
  • Lung(3.6)
  • Nervous system(3.6)
  • Spleen(3.5)
  • Lymph node(3.3)
  • Bone marrow(2.8)
  • Muscle(2.8)
  • Stomach(2.7)
  • Heart(2.6)
  • Kidney(2.6)
  • Skin(2.3)
  • Thyroid gland(2.2)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with CTSS: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTSS Gene

Orthologs for CTSS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CTSS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CTSS 33 34
  • 99.5 (n)
dog
(Canis familiaris)
 Mammalia CTSS 33 34
  • 88.82 (n)
cow
(Bos Taurus)
 Mammalia CTSS 33 34
  • 87.11 (n)
rat
(Rattus norvegicus)
 Mammalia Ctss 33
  • 81.45 (n)
mouse
(Mus musculus)
 Mammalia Ctss 33 16 34
  • 80.97 (n)
oppossum
(Monodelphis domestica)
 Mammalia CTSS 34
  • 78 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia CTSS 34
  • 73 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CTSS 33 34
  • 66.67 (n)
lizard
(Anolis carolinensis)
 Reptilia CTSS 34
  • 64 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia ctss 33
  • 67.98 (n)
African clawed frog
(Xenopus laevis)
 Amphibia ctss-prov 33
zebrafish
(Danio rerio)
 Actinopterygii ctssb.1 33 34
  • 62.26 (n)
ctssb.2 34
  • 58 (a)
 OneToMany
-- 33
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.8503 33
fruit fly
(Drosophila melanogaster)
 Insecta Cp1 35
  • 50 (a)
CG4847 35
  • 38 (a)
CG11459 35
  • 37 (a)
26-29kD-proteinase 35
  • 35 (a)
worm
(Caenorhabditis elegans)
 Secernentea cpl-1 35
  • 47 (a)
R09F10.1 35
  • 32 (a)
thale cress
(Arabidopsis thaliana)
 eudicotyledons AT4G11320 33
  • 51.52 (n)
Species where no ortholog for CTSS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTSS Gene

ENSEMBL:
Gene Tree for CTSS (if available)
TreeFam:
Gene Tree for CTSS (if available)

Paralogs for CTSS Gene

Variants for CTSS Gene

Sequence variations from dbSNP and Humsavar for CTSS Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000052625 -- 150,738,377(-) G/A intron_variant
rs1000106333 -- 150,730,782(-) A/T 3_prime_UTR_variant
rs1000137095 -- 150,755,195(-) A/G intron_variant
rs1000281354 -- 150,736,083(-) G/A intron_variant
rs1000420635 -- 150,744,911(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CTSS Gene

Variant ID Type Subtype PubMed ID
nsv952803 CNV deletion 24416366
nsv437169 CNV loss 16327808
nsv1144404 CNV deletion 24896259
nsv1076858 CNV deletion 25765185
nsv1008381 CNV gain 25217958
nsv1006838 CNV gain 25217958
esv3587511 CNV loss 21293372
esv2717818 CNV deletion 23290073
esv1542672 CNV deletion 17803354
esv1299298 CNV deletion 17803354

Variation tolerance for CTSS Gene

Residual Variation Intolerance Score: 33.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.13; 93.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CTSS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTSS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTSS Gene

Disorders for CTSS Gene

MalaCards: The human disease database

(8) MalaCards diseases for CTSS Gene - From: DISEASES

Disorder Aliases PubMed IDs
cercarial dermatitis
  • cutaneous schistosomiasis
mandibular cancer
  • malignant neoplasm of inferior maxilla
non-suppurative otitis media
  • nonsuppurative otitis media
jaw cancer
  • jaw neoplasm
corneal dystrophy, subepithelial mucinous
  • smcd
- elite association - COSMIC cancer census association via MalaCards
Search CTSS in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CTSS

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CTSS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTSS Gene

Publications for CTSS Gene

  1. CTSS promoter -25G/A: not a risk factor for CHD in Chinese. (PMID: 19593952) Sun A … Ge J (Acta cardiologica 2009) 3 22 44 58
  2. Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease. (PMID: 1373132) Shi GP … Chapman HA (The Journal of biological chemistry 1992) 2 3 4 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk. (PMID: 19336475) Drenos F … Hingorani AD (Human molecular genetics 2009) 3 44 58
  5. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PMID: 18977241) Starr JM … Deary IJ (Mechanisms of ageing and development 2008) 3 44 58

Products for CTSS Gene

  • Addgene plasmids for CTSS

Sources for CTSS Gene