Aliases for CTSS Gene
External Ids for CTSS Gene
- HGNC: 2545
- Entrez Gene: 1520
- Ensembl: ENSG00000163131
- OMIM: 116845
- UniProtKB: P25774
Previous GeneCards Identifiers for CTSS Gene
- GC01M148546
- GC01M146449
- GC01M147477
- GC01M147919
- GC01M147515
- GC01M148969
- GC01M122080
Summaries for CTSS Gene
-
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
GeneCards Summary for CTSS Gene
CTSS (Cathepsin S) is a Protein Coding gene. Diseases associated with CTSS include Cercarial Dermatitis and Mandibular Cancer. Among its related pathways are Collagen chain trimerization and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include peptidase activity and cysteine-type peptidase activity. An important paralog of this gene is CTSK.
UniProtKB/Swiss-Prot for CTSS Gene
-
Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.
Additional gene information for CTSS Gene
- Monarch Initiative
- Search for CTSS at DataMed
- Search for CTSS at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSS Gene
Genomics for CTSS Gene
GeneHancer (GH) Regulatory Elements for CTSS Gene
Promoters and enhancers for CTSS Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CTSS on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for CTSS Gene
Genomic Locations for CTSS Gene
- chr1:150,730,196-150,765,957
- (GRCh38/hg38)
- Size:
- 35,762 bases
- Orientation:
- Minus strand
- chr1:150,702,672-150,738,433
- (GRCh37/hg19)
Genomic View for CTSS Gene
Genes around CTSS on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.3 by Entrez Gene
- 1q21.3 by HGNC
- 1q21.3 by Ensembl
CTSS Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CTSS Gene
Proteins for CTSS Gene
-
Protein details for CTSS Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P25774-CATS_HUMAN
- Recommended name:
- Cathepsin S
- Protein Accession:
- P25774
- B4DWC9
- D3DV05
- Q5T5I0
- Q6FHS5
- Q9BUG3
Protein attributes for CTSS Gene
- Size:
- 331 amino acids
- Molecular mass:
- 37496 Da
- Quaternary structure:
-
- Monomer.
Three dimensional structures from OCA and Proteopedia for CTSS Gene
Protein Expression for CTSS Gene
Post-translational modifications for CTSS Gene
Other Protein References for CTSS Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CTSS (Cathepsin S)
-
Custom Antibody ServicesOriGene Antibodies for CTSS
- Novus Biologicals Antibodies for CTSS
- Invitrogen Antibodies for CTSS
- antibodies-online: Search results for 162 available Cathepsin S Antibodies ranked by validation data
- Compare Top Cathepsin S Antibodies
-
Recommended
- 99 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 7 IHC Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 29 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 14 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- GeneTex CTSS Antibody for CTSS
-
Santa Cruz Biotechnology (SCBT) Antibodies for CTSS
- Sino Biological Antibodies for CTSS
Protein Products
- R&D Systems Proteins and Enzymes for CTSS (Cathepsin S)
-
OriGene Purified Proteins for CTSS
- Search Origene for MassSpec and Protein Over-expression Lysates for CTSS
- Origene Custom Protein Services for CTSS
- Sino Biological Cell Lysates for CTSS
- Sino Biological Recombinant Proteins for CTSS
- ProSpec Recombinant Proteins for CTSS
- Search GeneTex for Proteins for CTSS
-
ProSci Proteins for CTSS
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for CTSS
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for CTSS (Cathepsin S)
- Novus Biologicals ELISA Kits for CTSS
- antibodies-online: Search results for 60 available Cathepsin S Elisa Kits ranked by validation data
- Compare Top Cathepsin S Elisa Kits
-
Recommended
- 1 Chicken ELISA Kit
- 2 Cow (Bovine) ELISA Kits
- 2 Dog (Canine) ELISA Kits
- 1 Goat ELISA Kit
- 1 Guinea Pig ELISA Kit
- 20 Human ELISA Kits
- 1 Monkey ELISA Kit
- 11 Mouse (Murine) ELISA Kits
- 1 Pig (Porcine) ELISA Kit
- 1 Rabbit ELISA Kit
- 12 Rat (Rattus) ELISA Kits
- 1 Rhesus Monkey ELISA Kit
- 1 Sheep (Ovine) ELISA Kit
- ABIN1882448
- ABIN411885
-
Boster Bio ELISA Kits for CTSS
No data available for DME Specific Peptides for CTSS Gene
Domains & Families for CTSS Gene
Gene Families for CTSS Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for CTSS Gene
Suggested Antigen Peptide Sequences for CTSS Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P25774- Family:
-
- Belongs to the peptidase C1 family.
Function for CTSS Gene
Molecular function for CTSS Gene
- UniProtKB/Swiss-Prot Function:
- Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Similar to cathepsin L, but with much less activity on Z-Phe-Arg- -NHMec, and more activity on the Z-Val-Val-Arg- -Xaa compound.
- GENATLAS Biochemistry:
- cathepsin S,lysosomal cysteine proteinase,expressed in spleen,heart and lung,papain superfamily,specifically involved in MHCII-associated chain processing and peptide loading
Enzyme Numbers (IUBMB) for CTSS Gene
Phenotypes From GWAS Catalog for CTSS Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001968 | fibronectin binding | IPI | 22952693 |
| GO:0004197 | cysteine-type endopeptidase activity | IDA,TAS | -- |
| GO:0004252 | serine-type endopeptidase activity | TAS | -- |
| GO:0005518 | collagen binding | IDA | 22952693 |
| GO:0008233 | peptidase activity | IEA | -- |
Phenotypes for CTSS Gene
- MGI mutant phenotypes for CTSS:
-
inferred from 2 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- behavior/neurological phenotype
- endocrine/exocrine gland phenotype
- cellular phenotype
- muscle phenotype
- skeleton phenotype
- hematopoietic system phenotype
- immune system phenotype
- GenomeRNAi human phenotypes for CTSS:
-
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased shRNA abundance
- shRNA abundance <= 50%
- Mitotic spindle defects
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CTSS
-
CRISPR Products
-
OriGene CRISPR knockouts for CTSS
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CTSS
- genomics-online: gRNA clones - Search results for 144 available Cathepsin S gene related products
- Overview of 144 available Cathepsin S gene related products
- Applied Biological Materials CRISPR for CTSS
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CTSS
- GenScript: Design CRISPR guide RNA sequences for CTSS
miRNA for CTSS Gene
- miRTarBase miRNAs that target CTSS
-
- hsa-mir-20a-5p (MIRT440857)
- hsa-mir-106b-5p (MIRT440859)
- hsa-mir-6864-3p (MIRT704384)
- hsa-mir-3672 (MIRT704385)
- hsa-mir-769-5p (MIRT704386)
- hsa-mir-4786-5p (MIRT704387)
- hsa-mir-664a-5p (MIRT704388)
- hsa-mir-4794 (MIRT704389)
- hsa-mir-7162-3p (MIRT704390)
- hsa-mir-544b (MIRT704391)
- hsa-mir-6849-3p (MIRT704392)
- hsa-mir-4433a-3p (MIRT704393)
- hsa-mir-4459 (MIRT704394)
- hsa-mir-4768-3p (MIRT704395)
- hsa-mir-6765-3p (MIRT704396)
- hsa-mir-3622b-3p (MIRT704397)
- hsa-mir-3622a-3p (MIRT704398)
- hsa-mir-8066 (MIRT704399)
- hsa-mir-519d-3p (MIRT727918)
- hsa-mir-93-5p (MIRT727919)
- hsa-mir-20b-5p (MIRT727920)
- hsa-mir-17-5p (MIRT727921)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CTSS
- Browse OriGene Inhibitory RNA Products For CTSS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTSS
- genomics-online: shRNA clones - Search results for 144 available Cathepsin S gene related products
- Overview of 144 available Cathepsin S gene related products
Clone Products
- Sino Biological Human cDNA Clone for CTSS
- VectorBuilder custom plasmid, inducible vectors for CTSS
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CTSS
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CTSS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CTSS
- Applied Biological Materials Clones for CTSS
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CTSS
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTSS Gene
Localization for CTSS Gene
Subcellular locations from UniProtKB/Swiss-Prot for CTSS Gene
- Lysosome.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| lysosome | 5 |
| endosome | 5 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| golgi apparatus | 2 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IDA | 22952693 |
| GO:0005764 | lysosome | IDA,IEA | 15196205 |
| GO:0036021 | endolysosome lumen | TAS | -- |
| GO:0043202 | lysosomal lumen | TAS | -- |
Pathways & Interactions for CTSS Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Class I MHC mediated antigen processing and presentation | ||
| 3 | Antigen processing-Cross presentation | ||
| 4 | Collagen chain trimerization | ||
| 5 | Degradation of the extracellular matrix | ||
Pathways by source for CTSS Gene
1 GeneTex pathway for CTSS Gene
5 KEGG pathways for CTSS Gene
2 GeneGo (Thomson Reuters) pathways for CTSS Gene
Interacting Proteins for CTSS Gene
GPS-Prot Interaction Network for CTSS
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002224 | toll-like receptor signaling pathway | TAS | -- |
| GO:0002250 | adaptive immune response | IEP | 15196205 |
| GO:0006508 | proteolysis | IDA,IEA | 12788072 |
| GO:0006955 | immune response | TAS | 8157683 |
| GO:0010447 | response to acidic pH | IDA | 22864553 |
No data available for SIGNOR curated interactions for CTSS Gene
Drugs & Compounds for CTSS Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
| (1R)-2-[(CYANOMETHYL)AMINO]-1-({[2-(DIFLUOROMETHOXY)BENZYL]SULFONYL}METHYL)-2-OXOETHYL MORPHOLINE-4-CARBOXYLATE | Experimental | Pharma | Target | 0 | ||
| 2-[(2',3',4'-TRIFLUOROBIPHENYL-2-YL)OXY]ETHANOL | Experimental | Pharma | Target | 0 | ||
| Morpholine-4-Carboxylic Acid (1-(3-Benzenesulfonyl-1-Phenethylallylcarbamoyl)-3-Methylbutyl)-Amide | Experimental | Pharma | Target | 0 | ||
| Morpholine-4-Carboxylic Acid [1-(2-Benzylsulfanyl-1-Formyl-Ethylcarbamoyl)-2-Phenyl-Ethyl]-Amide | Experimental | Pharma | Target | 0 |
(3) ApexBio Compounds for CTSS Gene
| Compound | Action | Cas Number |
|---|---|---|
| Cathepsin Inhibitor 1 | Cathepsin inhibitor | 225120-65-0 |
| Cathepsin S inhibitor | Blocks MHCII antigen presentation | 1373215-15-6 |
| E-64 | Cysteine protease inhibitor,irriversible | 66701-25-5 |
Transcripts for CTSS Gene
mRNA/cDNA for CTSS Gene
- (328) Selected AceView cDNA sequences:
- (9) Additional mRNA sequences :
- (2) REFSEQ mRNAs :
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000368985 4107 bps (uc001evn.3)
- ENST00000448301 1421 bps (uc010pcj.3)
- ENST00000472977 673 bps (uc057kpu.1)
- ENST00000480760 650 bps (uc057kpx.1)
- ENST00000483930 752 bps (uc057kpw.1)
CRISPR Products
-
OriGene CRISPR knockouts for CTSS
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CTSS
- genomics-online: gRNA clones - Search results for 144 available Cathepsin S gene related products
- Overview of 144 available Cathepsin S gene related products
- Applied Biological Materials CRISPR for CTSS
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CTSS
- GenScript: Design CRISPR guide RNA sequences for CTSS
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CTSS
- Browse OriGene Inhibitory RNA Products For CTSS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTSS
- genomics-online: shRNA clones - Search results for 144 available Cathepsin S gene related products
- Overview of 144 available Cathepsin S gene related products
Clone Products
- Sino Biological Human cDNA Clone for CTSS
- VectorBuilder custom plasmid, inducible vectors for CTSS
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CTSS
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CTSS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CTSS
- Applied Biological Materials Clones for CTSS
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||
| SP5: | - |
Expression for CTSS Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
- Plasmacytoid Dendritic cells Peripheral Blood
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Hematopoietic Bone Marrow
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Hyoid Arch Muscles
- Mononuclear Myocytes Mandibular Arch Muscles
- Myoblasts Mandibular Arch Muscles
- Myoblasts Hyoid Arch Muscles
-
Eye (Sensory Organs)
- nGnG Amacrine Cells Inner Nuclear Layer
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
-
Neurons
- nGnG Amacrine Cells Inner Nuclear Layer
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Epithelial Cells
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
-
Peripheral Nervous System (Nervous System)
- Schwann Precursor Cells Peripheral Nerve Domain
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
- Ovary (Reproductive System)
- Endothelium (Cardiovascular System)
-
Colon (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Stomach (Gastrointestinal Tract)
-
Lung (Respiratory System)
-
Gall Bladder (Hepatobiliary System)
-
Spleen (Hematopoietic System)
-
Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for CTSS Gene
This gene is overexpressed in Whole Blood (x25.9) and Spleen (x4.3).
This gene is overexpressed in Monocytes (12.2), Peripheral blood mononuclear cells (9.0), Spleen (6.3), and Nasal epithelium (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CTSS Gene
NURSA nuclear receptor signaling pathways regulating expression of CTSS Gene:
CTSSSOURCE GeneReport for Unigene cluster for CTSS Gene:
Hs.181301Evidence on tissue expression from TISSUES for CTSS Gene
- Liver(4.6)
- Blood(4.5)
- Pancreas(4.5)
- Intestine(4.3)
- Lung(3.6)
- Nervous system(3.6)
- Spleen(3.5)
- Lymph node(3.3)
- Bone marrow(2.8)
- Muscle(2.8)
- Stomach(2.7)
- Heart(2.6)
- Kidney(2.6)
- Skin(2.3)
- Thyroid gland(2.2)
- Gall bladder(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for CTSS
-
OriGene qPCR primer pairs for CTSS
- genomics-online: primer clones - Search results for 144 available Cathepsin S gene related products
- Overview of 144 available Cathepsin S gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTSS Gene
Orthologs for CTSS Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CTSS 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CTSS 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CTSS 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Ctss 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Ctss 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CTSS 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CTSS 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CTSS 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CTSS 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ctss 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | ctss-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ctssb.1 34 33 |
|
OneToMany | |
| ctssb.2 34 |
|
OneToMany | |||
| -- 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8503 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Cp1 35 |
|
|
|
| CG4847 35 |
|
|
|||
| CG11459 35 |
|
|
|||
| 26-29kD-proteinase 35 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | cpl-1 35 |
|
|
|
| R09F10.1 35 |
|
|
|||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT4G11320 33 |
|
- Species where no ortholog for CTSS was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for CTSS Gene
- ENSEMBL:
- Gene Tree for CTSS (if available)
- TreeFam:
- Gene Tree for CTSS (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CTSS: view image
Paralogs for CTSS Gene
(83) SIMAP similar genes for CTSS Gene using alignment to 3 proteins:
- CATS_HUMAN
- U3KPS4_HUMAN
- U3KQE7_HUMAN
- COL24A1
- UBIAD1
- MEFV
- ARMC4
- ZNF737
- ZNF564
- TNFRSF17
- FAM210A
- HKR1
- NF2
- LINC00596
- ZNF738
- TSEN2
- TMEM44
- RBMS2
- NPLOC4
- CHID1
- ASB11
- FAM175A
- ZNF585B
- ZNF461
- ZNF100
- KLHL2
- CFLAR
- APOD
- TMEM14B
- SHANK2
- KNSTRN
- ZNF763
- SH3PXD2A
- LEPROTL1
- ZNF283
- TMEM135
- RBBP4
- PLA2G6
- NEK4
- HECW1
- BECN1
- RUFY1
- LAMB4
- ZNF547
- CLUL1
- AEBP2
- SPATS2L
- SEPT2
- FAT3
- USP10
- RPE
- RARS2
- GCDH
- RNF217
- CTSK
- UTY
- GLT8D2
- ZNF83
- EDRF1
- AURA2
- ZNF28
- CTSL
- CTSV
- NSRP1
- CTSL1
- DKFZp686B24257
- TMSB15B
- FOPNL
- CTSB
- B3GALNT1
- PKN1
- DAPL1
- EIF3L
- DNAPTP3
- DCTN5
- MPP4
- ERBB2
- C16orf89
- BTBD2
- KDM5B
- CTSH
- CCDC132
- CTSO
- CTSF
- ZNF20
- CTSW
Variants for CTSS Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000052625 | -- | 150,738,377(-) | G/A | intron_variant | |
| rs1000106333 | -- | 150,730,782(-) | A/T | 3_prime_UTR_variant | |
| rs1000137095 | -- | 150,755,195(-) | A/G | intron_variant | |
| rs1000281354 | -- | 150,736,083(-) | G/A | intron_variant | |
| rs1000420635 | -- | 150,744,911(-) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1299298 | CNV | deletion | 17803354 |
| esv1542672 | CNV | deletion | 17803354 |
| esv2717818 | CNV | deletion | 23290073 |
| esv3587511 | CNV | loss | 21293372 |
| nsv1006838 | CNV | gain | 25217958 |
| nsv1008381 | CNV | gain | 25217958 |
| nsv1076858 | CNV | deletion | 25765185 |
| nsv1144404 | CNV | deletion | 24896259 |
| nsv437169 | CNV | loss | 16327808 |
| nsv952803 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
33.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
12.13;
93.87% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CTSS Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CTSS
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTSS Gene
Disorders for CTSS Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cercarial dermatitis |
|
|
| mandibular cancer |
|
|
| non-suppurative otitis media |
|
|
| jaw cancer |
|
|
| corneal dystrophy, subepithelial mucinous |
|
|
Search CTSS in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CTSS
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CTSS Gene
Publications for CTSS Gene
- CTSS promoter -25G/A: not a risk factor for CHD in Chinese. (PMID: 19593952) Sun A … Ge J (Acta cardiologica 2009) 3 22 44 58
- Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease. (PMID: 1373132) Shi GP … Chapman HA (The Journal of biological chemistry 1992) 2 3 4 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk. (PMID: 19336475) Drenos F … Hingorani AD (Human molecular genetics 2009) 3 44 58
- Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PMID: 18977241) Starr JM … Deary IJ (Mechanisms of ageing and development 2008) 3 44 58
Products for CTSS Gene
- R&D Systems Antibodies for CTSS (Cathepsin S)
- R&D Systems Proteins and Enzymes for CTSS (Cathepsin S)
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for CTSS (Cathepsin S)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
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- Browse Immunoprecipitation Assays
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CTSS
- Custom Assay ServicesOriGene ELISA Kits for CTSS
- OriGene Purified Proteins for CTSS
- Search Origene for MassSpec and Protein Over-expression Lysates for CTSS
- Origene Custom Protein Services for CTSS
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CTSS
- Browse OriGene Inhibitory RNA Products For CTSS
- OriGene qPCR primer pairs and template standards for CTSS
- OriGene qPCR primer pairs for CTSS
- OriGene CRISPR knockouts for CTSS
- OriGene ORF clones in human for CTSS
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CTSS
- GenScript: Next-day shipping of latest version cDNA ORF clones for CTSS in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CTSS
- GenScript Activity-based Kinase Assay for Compound Screening for CTSS
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- GenScript Custom overexpressing Cell Line Services for CTSS
- GenScript: Design CRISPR guide RNA sequences for CTSS
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CTSS
- Sino Biological Human cDNA Clone for CTSS
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- Browse Sino Biological Assays
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- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for CTSS
- Novus Biologicals lysates and proteins for CTSS
- Novus Biologicals ELISA Kits for CTSS
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- ProSpec Recombinant Proteins for CTSS
- Invitrogen Antibodies for CTSS
- ApexBio compounds for CTSS
- Cyagen custom Knockout/knockin (KOKI) mouse models for CTSS
- VectorBuilder custom plasmid, inducible vectors for CTSS
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CTSS
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CTSS
- antibodies-online: Search results for 162 available Cathepsin S Antibodies ranked by validation data
- Compare Top Cathepsin S Antibodies
- Recommended
- 99 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 7 IHC Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 29 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 14 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Search results for 60 available Cathepsin S Elisa Kits ranked by validation data
- Compare Top Cathepsin S Elisa Kits
- Recommended
- 1 Chicken ELISA Kit
- 2 Cow (Bovine) ELISA Kits
- 2 Dog (Canine) ELISA Kits
- 1 Goat ELISA Kit
- 1 Guinea Pig ELISA Kit
- 20 Human ELISA Kits
- 1 Monkey ELISA Kit
- 11 Mouse (Murine) ELISA Kits
- 1 Pig (Porcine) ELISA Kit
- 1 Rabbit ELISA Kit
- 12 Rat (Rattus) ELISA Kits
- 1 Rhesus Monkey ELISA Kit
- 1 Sheep (Ovine) ELISA Kit
- ABIN1882448
- ABIN411885
- antibodies-online: Search results for 27 available Cathepsin S Proteins ranked by validation data
- Compare Top Cathepsin S Proteins
- GeneTex CTSS Antibody for CTSS
- Search GeneTex for Proteins for CTSS
- Santa Cruz Biotechnology (SCBT) Antibodies for CTSS
- Search Santa Cruz Biotechnology (SCBT) for CTSS siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CTSS
- Search for CTSS Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for CTSS
- Horizon Cell Lines for CTSS
- genomics-online: cdna clones - Search results for 144 available Cathepsin S gene related products
- Overview of 144 available Cathepsin S gene related products
- orf clones - Search results for 144 available Cathepsin S gene related products
- Overview of 144 available Cathepsin S gene related products
- genomics-online: gRNA clones - Search results for 144 available Cathepsin S gene related products
- Overview of 144 available Cathepsin S gene related products
- genomics-online: primer clones - Search results for 144 available Cathepsin S gene related products
- Overview of 144 available Cathepsin S gene related products
- genomics-online: shRNA clones - Search results for 144 available Cathepsin S gene related products
- Overview of 144 available Cathepsin S gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CTSS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CTSS
- GeneCopoeia miRNA 3'UTR Target clone products for CTSS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTSS
Sources for CTSS Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106)