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The preproprotein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that participates in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The mature protein cleaves the invariant chain of MHC class II molecules in endolysosomal compartments and enables the formation of antigen-MHC class II ... See more...
Aliases for CTSS Gene
External Ids for CTSS Gene
- HGNC: 2545
- NCBI Entrez Gene: 1520
- Ensembl: ENSG00000163131
- OMIM®: 116845
- UniProtKB/Swiss-Prot: P25774
Previous GeneCards Identifiers for CTSS Gene
- GC01M148546
- GC01M146449
- GC01M147477
- GC01M147919
- GC01M147515
- GC01M148969
- GC01M150702
- GC01M122080
Summaries for CTSS Gene
-
The preproprotein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that participates in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The mature protein cleaves the invariant chain of MHC class II molecules in endolysosomal compartments and enables the formation of antigen-MHC class II complexes and the proper display of extracellular antigenic peptides by MHC-II. The mature protein also functions as an elastase over a broad pH range. When secreted from cells, this protein can remodel components of the extracellular matrix such as elastin, collagen, and fibronectin. This gene is implicated in the pathology of many inflammatory and autoimmune diseases and, given its elastase activity, plays a significant role in some pulmonary diseases. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2020]
GeneCards Summary for CTSS Gene
CTSS (Cathepsin S) is a Protein Coding gene. Diseases associated with CTSS include Dacryoadenitis and Cerebellopontine Angle Tumor. Among its related pathways are Bacterial infections in CF airways and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include peptidase activity and cysteine-type peptidase activity. An important paralog of this gene is CTSK.
UniProtKB/Swiss-Prot Summary for CTSS Gene
-
Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation (PubMed:30612035). The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.
Additional gene information for CTSS Gene
- HGNC (2545)
- NCBI Entrez Gene (1520)
- Ensembl (ENSG00000163131)
- OMIM® (116845)
- UniProtKB/Swiss-Prot (P25774)
- Open Targets Platform(ENSG00000163131)
- Monarch Initiative
- Search for CTSS at DataMed
- Search for CTSS at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CTSS Gene
Genomics for CTSS Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CTSS Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CTSS on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CTSS
- Top Transcription factor binding sites by QIAGEN in the CTSS gene promoter:
-
- AREB6
- En-1
- Evi-1
- Ik-1
- Ik-2
- IRF-1
- STAT5A
- STAT5B
- TBP
Genomic Locations for CTSS Gene
Latest Assembly
- chr1:150,730,079-150,765,957
- (GRCh38/hg38)
- Size:
- 35,879 bases
- Orientation:
- Minus strand
Previous Assembly
- chr1:150,702,664-150,738,254
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 35,591 bases
- Orientation:
- Minus strand
- chr1:150,702,672-150,738,433
- (GRCh37/hg19 by Ensembl)
- Size:
- 35,762 bases
- Orientation:
- Minus strand
Genomic View for CTSS Gene
Genes around CTSS on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.3 by HGNC
- 1q21.3 by Entrez Gene
- 1q21.3 by Ensembl
CTSS Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CTSS Gene
Proteins for CTSS Gene
-
Protein details for CTSS Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P25774-CATS_HUMAN
- Recommended name:
- Cathepsin S
- Protein Accession:
- P25774
- B4DWC9
- D3DV05
- Q5T5I0
- Q6FHS5
- Q9BUG3
Protein attributes for CTSS Gene
- Size:
- 331 amino acids
- Molecular mass:
- 37496 Da
- Quaternary structure:
-
- Monomer.
Three dimensional structures from OCA and Proteopedia for CTSS Gene
Protein Expression for CTSS Gene
Selected DME Specific Peptides for CTSS Gene
- P25774:
-
- QNLVDCS
- RRLIWEKNLK
- VDWREKG
- VLVVGYG
- CWAFSAVGALE
- QLKLKTGKL
- PTLDHHW
- LHNLEHSMGMHSY
- DWREKGCVTEVKYQG
- GDMTSEE
- MNHLGDMT
- GYIRMAR
- YWLVKNS
- KTGKLVSLS
Post-translational modifications for CTSS Gene
Other Protein References for CTSS Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences CTSS / Cathepsin S Monoclonal Antibody
- G Biosciences Immunotag™ CTSS Antibody
-
Custom Antibody ServicesOriGene Antibodies for CTSS
- Novus Biologicals Antibodies for CTSS
-
Abcam antibodies for CTSS
- Invitrogen Antibodies for CTSS (AFLGC-CTSS)
-
Custom Antibody ServicesProSci Antibodies for CTSS
-
Santa Cruz Biotechnology (SCBT) Antibodies for CTSS
- Sino Biological Antibodies for CTSS
Protein products for research
- G Biosciences Human Cathepsin S/CTSS, Liquid
-
OriGene Purified Proteins for CTSS
- Search Origene for MassSpec and Protein Over-expression Lysates for CTSS
- Origene Custom Protein Services for CTSS
- Sino Biological Recombinant Proteins for CTSS
- Sino Biological Cell Lysates for CTSS
- ProSpec Recombinant Proteins for CTSS
-
ProSci Proteins for CTSS
-
Abcam proteins for CTSS
Assay products for research
- G Biosciences Immunotag™ Human CTSS (Cathepsin S) ELISA and Immunotag™ Cathepsin S ELISA Kit
- RayBiotech Human Cathepsin S ELISA
-
Custom Assay ServicesOriGene ELISA Kits for CTSS
- Novus Biologicals ELISA Kits for CTSS
- antibodies-online: Show 72 available Cathepsin S Elisa Kits ranked by validation data
- Compare Top Cathepsin S Elisa Kits
-
Quality Products:
- ABIN415099
- ABIN577937
- ABIN625273
- ABIN1672865
- ABIN4993017
- ABIN1569260
- ABIN1888486
- ABIN5520257
- ABIN4993396
- ABIN2708089
- ABIN415776
- ABIN829565
- ABIN1569261
- ABIN5520258
- ABIN5591877
- ABIN772994
- ABIN5652717
- ABIN4967852
- ABIN2542601
- ABIN6203084
- ABIN829566
- ABIN432421
- ABIN1569262
- ABIN5520259
- ABIN771676
- ABIN5591878
- ABIN5652718
- ABIN4967851
- ABIN2542602
- ABIN6203086
-
Boster Bio ELISA Kits for CTSS
-
Abcam assays for CTSS
Domains & Families for CTSS Gene
Gene Families for CTSS Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for CTSS Gene
- InterPro:
- Blocks:
-
- Papain cysteine protease (C1) family signature
- Proteinase inhibitor I29, cathepsin propeptide
- ProtoNet:
Suggested Antigen Peptide Sequences for CTSS Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ50259, highly similar to Cathepsin S (EC 3.4.22.27) (B4DWC9_HUMAN)
- Cathepsin S (CATS_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P25774- Family:
-
- Belongs to the peptidase C1 family.
Function for CTSS Gene
Molecular function for CTSS Gene
- UniProtKB/Swiss-Prot Function:
- Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation (PubMed:30612035). The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.; EC=3.4.22.27;.
- GENATLAS Biochemistry:
- cathepsin S,lysosomal cysteine proteinase,expressed in spleen,heart and lung,papain superfamily,specifically involved in MHCII-associated chain processing and peptide loading
Enzyme Numbers (IUBMB) for CTSS Gene
Phenotypes From GWAS Catalog for CTSS Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001968 | fibronectin binding | IPI | 22952693 |
| GO:0004197 | cysteine-type endopeptidase activity | IDA,TAS | -- |
| GO:0005518 | collagen binding | IDA | 22952693 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008234 | cysteine-type peptidase activity | IEA | -- |
Phenotypes for CTSS Gene
- MGI mutant phenotypes for CTSS:
-
inferred from 3 alleles
- muscle phenotype
- homeostasis/metabolism phenotype
- cellular phenotype
- cardiovascular system phenotype
- behavior/neurological phenotype
- immune system phenotype
- respiratory system phenotype
- hematopoietic system phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- skeleton phenotype
- GenomeRNAi human phenotypes for CTSS:
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CTSS - Starting at $85 >
- * CTSS CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CTSS
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CTSS
-
Santa Cruz Biotechnology (SCBT) CRISPR for CTSS
miRNA for CTSS Gene
- miRTarBase miRNAs that target CTSS
-
- mmu-miR-758-3p (MIRT007697)
- hsa-miR-20a-5p (MIRT440857)
- hsa-miR-106b-5p (MIRT440859)
- hsa-miR-6864-3p (MIRT704384)
- hsa-miR-3672 (MIRT704385)
- hsa-miR-769-5p (MIRT704386)
- hsa-miR-4786-5p (MIRT704387)
- hsa-miR-664a-5p (MIRT704388)
- hsa-miR-4794 (MIRT704389)
- hsa-miR-7162-3p (MIRT704390)
- hsa-miR-544b (MIRT704391)
- hsa-miR-6849-3p (MIRT704392)
- hsa-miR-4433a-3p (MIRT704393)
- hsa-miR-4459 (MIRT704394)
- hsa-miR-4768-3p (MIRT704395)
- hsa-miR-6765-3p (MIRT704396)
- hsa-miR-3622b-3p (MIRT704397)
- hsa-miR-3622a-3p (MIRT704398)
- hsa-miR-8066 (MIRT704399)
- hsa-miR-519d-3p (MIRT727918)
- hsa-miR-93-5p (MIRT727919)
- hsa-miR-20b-5p (MIRT727920)
- hsa-miR-17-5p (MIRT727921)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CTSS
- Browse OriGene Inhibitory RNA Products For CTSS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTSS
Clone products for research
- Applied Biological Materials (abm): Clones for CTSS - Starting at $45 >
- * CTSS as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CTSS
- Addgene plasmids for CTSS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CTSS
Cell Lines for research
-
Horizon Cell Lines for CTSS
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTSS Gene
Localization for CTSS Gene
Subcellular locations from UniProtKB/Swiss-Prot for CTSS Gene
- Lysosome. Secreted. Cytoplasmic vesicle, phagosome.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| lysosome | 5 |
| endosome | 4 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IBA,IDA | 9524075 |
| GO:0005764 | lysosome | IBA,IDA | 15196205 |
| GO:0005770 | late endosome | IDA | 22365146 |
| GO:0031410 | cytoplasmic vesicle | IEA | -- |
Pathways & Interactions for CTSS Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Class I MHC mediated antigen processing and presentation | ||
| 3 | Antigen processing-Cross presentation | ||
| 4 | Collagen chain trimerization | ||
| 5 | Degradation of the extracellular matrix | ||
Pathways by source for CTSS Gene
14 Reactome pathways for CTSS Gene
5 KEGG pathways for CTSS Gene
2 GeneGo (Thomson Reuters) pathways for CTSS Gene
- Bacterial infections in CF airways
- Immune response Antigen presentation by MHC class II
1 GeneTex pathway for CTSS Gene
Interacting Proteins for CTSS Gene
GPS-Prot Interaction Network for CTSS
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002224 | toll-like receptor signaling pathway | TAS | -- |
| GO:0002250 | adaptive immune response | IEP | 15196205 |
| GO:0006508 | proteolysis | IEA,IDA | 12788072 |
| GO:0006955 | immune response | TAS,IBA | 21873635 |
| GO:0010447 | response to acidic pH | IDA | 22864553 |
Drugs & Compounds for CTSS Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
| (1R)-2-[(CYANOMETHYL)AMINO]-1-({[2-(DIFLUOROMETHOXY)BENZYL]SULFONYL}METHYL)-2-OXOETHYL MORPHOLINE-4-CARBOXYLATE | Experimental | Pharma | Target | 0 | ||
| 2-[(2',3',4'-TRIFLUOROBIPHENYL-2-YL)OXY]ETHANOL | Experimental | Pharma | Target | 0 | ||
| Morpholine-4-Carboxylic Acid (1-(3-Benzenesulfonyl-1-Phenethylallylcarbamoyl)-3-Methylbutyl)-Amide | Experimental | Pharma | Target | 0 | ||
| Morpholine-4-Carboxylic Acid [1-(2-Benzylsulfanyl-1-Formyl-Ethylcarbamoyl)-2-Phenyl-Ethyl]-Amide | Experimental | Pharma | Target | 0 |
(3) ApexBio Compounds for CTSS Gene
| Compound | Action | Cas Number |
|---|---|---|
| Cathepsin Inhibitor 1 | Cathepsin inhibitor | 225120-65-0 |
| Cathepsin S inhibitor | Blocks MHCII antigen presentation | 1373215-15-6 |
| E-64 | Cysteine protease inhibitor,irriversible | 66701-25-5 |
Transcripts for CTSS Gene
mRNA/cDNA for CTSS Gene
- 2 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000368985 3936 nts (view in UCSC)
- ENST00000448301 1233 nts (view in UCSC)
- ENST00000472977 2152 nts (view in UCSC)
- ENST00000480760 626 nts (view in UCSC)
- ENST00000483930 1864 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CTSS - Starting at $85 >
- * CTSS CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CTSS
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CTSS
-
Santa Cruz Biotechnology (SCBT) CRISPR for CTSS
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CTSS
- Browse OriGene Inhibitory RNA Products For CTSS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTSS
Clone products for research
- Applied Biological Materials (abm): Clones for CTSS - Starting at $45 >
- * CTSS as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CTSS
- Addgene plasmids for CTSS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CTSS
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||
| SP5: | - |
Relevant External Links for CTSS Gene
- GeneLoc Exon Structure for
- CTSS
Expression for CTSS Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
- Plasmacytoid Dendritic cells Peripheral Blood
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Hematopoietic Bone Marrow
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Hyoid Arch Muscles
- Mononuclear Myocytes Mandibular Arch Muscles
- Myoblasts Mandibular Arch Muscles
- Myoblasts Hyoid Arch Muscles
-
Eye (Sensory Organs)
- nGnG Amacrine Cells Inner Nuclear Layer
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
-
Neurons
- nGnG Amacrine Cells Inner Nuclear Layer
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Epithelial Cells
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
-
Peripheral Nervous System (Nervous System)
- Schwann Precursor Cells Peripheral Nerve Domain
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
- Ovary (Reproductive System)
- Endothelium (Cardiovascular System)
-
Colon (Gastrointestinal Tract)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for CTSS Gene
This gene is overexpressed in Whole Blood (x25.9) and Spleen (x4.3).
This gene is overexpressed in Monocytes (12.2), Peripheral blood mononuclear cells (9.0), Spleen (6.3), and Nasal epithelium (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CTSS Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CTSS
SOURCE GeneReport for Unigene cluster for CTSS Gene:
Hs.181301Evidence on tissue expression from TISSUES for CTSS Gene
- Liver(4.5)
- Pancreas(4.5)
- Blood(4.4)
- Intestine(4.2)
- Nervous system(3.4)
- Lung(3.2)
- Spleen(3.2)
- Lymph node(3.1)
- Bone marrow(2.9)
- Heart(2.4)
- Stomach(2.4)
- Muscle(2.2)
- Skin(2.2)
- Kidney(2.1)
- Thyroid gland(2)
Primer products for research
-
OriGene qPCR primer pairs for CTSS
-
OriGene qPCR primer pairs and template standards for CTSS
Gene Expression Assays for research
No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTSS Gene
Orthologs for CTSS Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CTSS 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CTSS 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CTSS 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ctss 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Ctss 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CTSS 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CTSS 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CTSS 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CTSS 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ctss 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | ctss-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ctssb.1 30 31 |
|
OneToMany | |
| ctssb.2 31 |
|
OneToMany | |||
| -- 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8503 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Cp1 32 |
|
|
|
| CG4847 32 |
|
|
|||
| CG11459 32 |
|
|
|||
| 26-29kD-proteinase 32 |
|
|
|||
| Worm (Caenorhabditis elegans) |
Secernentea | cpl-1 32 |
|
|
|
| R09F10.1 32 |
|
|
|||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT4G11320 30 |
|
- Species where no ortholog for CTSS was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for CTSS Gene
- ENSEMBL:
- Gene Tree for CTSS (if available)
- TreeFam:
- Gene Tree for CTSS (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CTSS: view image
Paralogs for CTSS Gene
Paralogs for CTSS Gene
(83) SIMAP similar genes for CTSS Gene using alignment to 3 proteins:
- CATS_HUMAN
- U3KPS4_HUMAN
- U3KQE7_HUMAN
- COL24A1
- UBIAD1
- MEFV
- ARMC4
- ZNF737
- ZNF564
- TNFRSF17
- FAM210A
- HKR1
- NF2
- LINC00596
- ZNF738
- TSEN2
- TMEM44
- RBMS2
- NPLOC4
- CHID1
- ASB11
- FAM175A
- ZNF585B
- ZNF461
- ZNF100
- KLHL2
- CFLAR
- APOD
- TMEM14B
- SHANK2
- KNSTRN
- ZNF763
- SH3PXD2A
- LEPROTL1
- ZNF283
- TMEM135
- RBBP4
- PLA2G6
- NEK4
- HECW1
- BECN1
- RUFY1
- LAMB4
- ZNF547
- CLUL1
- AEBP2
- SPATS2L
- SEPT2
- FAT3
- USP10
- RPE
- RARS2
- GCDH
- RNF217
- CTSK
- UTY
- GLT8D2
- ZNF83
- EDRF1
- AURA2
- ZNF28
- CTSL
- CTSV
- NSRP1
- CTSL1
- DKFZp686B24257
- TMSB15B
- FOPNL
- CTSB
- B3GALNT1
- PKN1
- DAPL1
- EIF3L
- DNAPTP3
- DCTN5
- MPP4
- ERBB2
- C16orf89
- BTBD2
- KDM5B
- CTSH
- CCDC132
- CTSO
- CTSF
- ZNF20
- CTSW
Variants for CTSS Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CTSS Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs140408537 | Benign: not provided | 150,747,785(-) |
C/A NM_004079.5(CTSS):c.888G>T (p.Val296=) |
SYNONYMOUS | |
| rs16840587 | Benign: not provided | 150,751,772(-) |
A/T NM_004079.5(CTSS):c.627+9T>A |
INTRON | |
| rs1059604 | - |
p.Ser161Thr |
|||
| rs2230061 | - |
p.Arg113Trp |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1299298 | CNV | deletion | 17803354 |
| esv1542672 | CNV | deletion | 17803354 |
| esv2717818 | CNV | deletion | 23290073 |
| esv3587511 | CNV | loss | 21293372 |
| nsv1006838 | CNV | gain | 25217958 |
| nsv1008381 | CNV | gain | 25217958 |
| nsv1076858 | CNV | deletion | 25765185 |
| nsv1144404 | CNV | deletion | 24896259 |
| nsv437169 | CNV | loss | 16327808 |
| nsv952803 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
33.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
12.13;
93.87% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CTSS Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CTSS
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTSS Gene
Disorders for CTSS Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dacryoadenitis |
|
|
| cerebellopontine angle tumor |
|
|
Search CTSS in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CTSS
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CTSS Gene
Publications for CTSS Gene
- CTSS promoter -25G/A: not a risk factor for CHD in Chinese. (PMID: 19593952) Sun A … Ge J (Acta cardiologica 2009) 3 23 41
- Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease. (PMID: 1373132) Shi GP … Chapman HA (The Journal of biological chemistry 1992) 2 3 4
- The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation. (PMID: 30612035) Baranov MV … van den Bogaart G (iScience 2019) 3 4
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
- Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk. (PMID: 19336475) Drenos F … Hingorani AD (Human molecular genetics 2009) 3 41
ExternalLinks
Products for CTSS Gene
- View all 11 R&D Systems CTSS (Cathepsin S) Products
- View all R&D Systems CTSS (Cathepsin S) Proteins and Enzymes
- View all 3 R&D Systems CTSS (Cathepsin S) Primary Antibodies
- View all 2 R&D Systems CTSS (Cathepsin S) ELISAs
- View all R&D Systems CTSS (Cathepsin S) Luminex Assays
- View all 4 R&D Systems CTSS (Cathepsin S) Proteome Profiler Antibody Arrays
- Learn more about R&D Systems custom CTSS antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for CTSS
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- Search Origene for MassSpec and Protein Over-expression Lysates for CTSS
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- Browse OriGene Inhibitory RNA Products For CTSS
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- OriGene qPCR primer pairs and template standards for CTSS
- OriGene CRISPR knockouts for CTSS
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CTSS
- Sino Biological Human cDNA Clone for CTSS
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- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CTSS
- Novus Biologicals proteins and lysates for CTSS
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- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CTSS
- Abcam proteins for CTSS
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- Find your target
- Browse Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ApexBio compounds for CTSS
- VectorBuilder Custom and pre-made DNA vectors for CTSS (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CTSS (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CTSS (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CTSS CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CTSS
- Addgene plasmids for CTSS
- antibodies-online: Show 232 available Cathepsin S Antibodies ranked by validation data
- Compare Top Cathepsin S Antibodies
- antibodies-online: Show 72 available Cathepsin S Elisa Kits ranked by validation data
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- antibodies-online: Show 31 available Cathepsin S Proteins ranked by validation data
- Compare Top Cathepsin S Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CTSS
- Search Santa Cruz Biotechnology (SCBT) for CTSS siRNA/shRNA