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Aliases for CTSO Gene

Aliases for CTSO Gene

  • Cathepsin O 2 3 5
  • CTSO1 3 4
  • EC 4

External Ids for CTSO Gene

Previous HGNC Symbols for CTSO Gene

  • CTSO1

Previous GeneCards Identifiers for CTSO Gene

  • GC04M157734
  • GC04M157274
  • GC04M157422
  • GC04M157202
  • GC04M157064
  • GC04M156845
  • GC04M152584

Summaries for CTSO Gene

Entrez Gene Summary for CTSO Gene

  • The protein encoded by the gene is a cysteine proteinase and a member of the papain superfamily. This proteolytic enzyme is involved in cellular protein degradation and turnover. The recombinant form of this enzyme was shown to degrade synthetic peptides typically used as substrates for cysteine proteinases and its proteolytic activity was abolished by an inhibitor of cyteine proteinase. [provided by RefSeq, Jul 2008]

GeneCards Summary for CTSO Gene

CTSO (Cathepsin O) is a Protein Coding gene. Among its related pathways are Innate Immune System and MHC class II antigen presentation. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and cysteine-type peptidase activity. An important paralog of this gene is CTSC.

UniProtKB/Swiss-Prot for CTSO Gene

  • Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.

Gene Wiki entry for CTSO Gene

Additional gene information for CTSO Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSO Gene

Genomics for CTSO Gene

GeneHancer (GH) Regulatory Elements for CTSO Gene

Promoters and enhancers for CTSO Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I155952 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 567.4 0.0 -34 3.4 FOXA2 SIN3A DMAP1 ZNF48 ETS1 YY1 ZNF213 ZNF143 ZNF207 ATF7 CTSO FTH1P21
GH04I156109 Enhancer 0.6 Ensembl ENCODE 15 -157.0 -156999 2.7 CTCF HLF CTSO GC04P156132 PIR40160
GH04I155973 Enhancer 0.9 ENCODE dbSUPER 7 -20.3 -20259 1.4 PKNOX1 BATF RELA BCLAF1 IKZF2 RUNX3 SMARCA5 DPF2 ELF1 ATF2 CTSO FTH1P21
GH04I155940 Enhancer 0.6 ENCODE 7.6 +11.0 11020 3.8 FOXA2 JUND ATF3 MAX ZBTB33 HNF4A REST RAD21 FOXA1 TDO2 CTSO ASIC5
GH04I155959 Enhancer 0.4 ENCODE dbSUPER 11.2 -6.7 -6669 2.2 CTSO FTH1P21
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CTSO on UCSC Golden Path with GeneCards custom track

Genomic Locations for CTSO Gene

Genomic Locations for CTSO Gene
29,800 bases
Minus strand

Genomic View for CTSO Gene

Genes around CTSO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTSO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTSO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSO Gene

Proteins for CTSO Gene

  • Protein details for CTSO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cathepsin O
    Protein Accession:

    Protein attributes for CTSO Gene

    321 amino acids
    Molecular mass:
    35958 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CTSO Gene

Post-translational modifications for CTSO Gene

  • Glycosylation at Asn62 and Asn105
  • Modification sites at PhosphoSitePlus

Other Protein References for CTSO Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CTSO Gene

Domains & Families for CTSO Gene

Gene Families for CTSO Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CTSO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C1 family.
  • Belongs to the peptidase C1 family.
genes like me logo Genes that share domains with CTSO: view

Function for CTSO Gene

Molecular function for CTSO Gene

GENATLAS Biochemistry:
cathepsin O,lysosomal cysteine proteinase,papain superfamily,ubiquitously expressed
UniProtKB/Swiss-Prot CatalyticActivity:
The recombinant human enzyme hydrolyzes synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec.
UniProtKB/Swiss-Prot Function:
Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.

Enzyme Numbers (IUBMB) for CTSO Gene

Phenotypes From GWAS Catalog for CTSO Gene

Gene Ontology (GO) - Molecular Function for CTSO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity TAS 7929457
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CTSO: view
genes like me logo Genes that share phenotypes with CTSO: view

Animal Models for CTSO Gene

MGI Knock Outs for CTSO:
  • Ctso tm2b(KOMP)Wtsi

Animal Model Products

  • Taconic Biosciences Mouse Models for CTSO

CRISPR Products

miRNA for CTSO Gene

miRTarBase miRNAs that target CTSO

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTSO Gene

Localization for CTSO Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTSO Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTSO gene
Compartment Confidence
lysosome 5
extracellular 3

Gene Ontology (GO) - Cellular Components for CTSO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005764 lysosome IBA --
genes like me logo Genes that share ontologies with CTSO: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CTSO Gene

Pathways & Interactions for CTSO Gene

genes like me logo Genes that share pathways with CTSO: view

Pathways by source for CTSO Gene

2 KEGG pathways for CTSO Gene

Gene Ontology (GO) - Biological Process for CTSO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis TAS 7929457
GO:0051603 proteolysis involved in cellular protein catabolic process IBA --
genes like me logo Genes that share ontologies with CTSO: view

No data available for SIGNOR curated interactions for CTSO Gene

Drugs & Compounds for CTSO Gene

(1) Drugs for CTSO Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Papain Inhibitor Pharma Inhibitor of peptidase activity of Papain 0

(1) ApexBio Compounds for CTSO Gene

Compound Action Cas Number
Papain Inhibitor Inhibitor of peptidase activity of Papain 70195-20-9
genes like me logo Genes that share compounds with CTSO: view

Drug Products

Transcripts for CTSO Gene

mRNA/cDNA for CTSO Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(138) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CTSO Gene

Cathepsin O:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTSO Gene

No ASD Table

Relevant External Links for CTSO Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTSO Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTSO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CTSO Gene

This gene is overexpressed in NK cells (19.8), Islet of Langerhans (14.6), Prostate (12.3), and CD8 Tcells (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CTSO Gene

NURSA nuclear receptor signaling pathways regulating expression of CTSO Gene:


SOURCE GeneReport for Unigene cluster for CTSO Gene:


mRNA Expression by UniProt/SwissProt for CTSO Gene:

Tissue specificity: Expressed in all tissues examined. High levels seen in the ovary, kidney and placenta while low levels seen in thymus and skeletal muscle.

Evidence on tissue expression from TISSUES for CTSO Gene

  • Intestine(4)
genes like me logo Genes that share expression patterns with CTSO: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTSO Gene

Orthologs for CTSO Gene

This gene was present in the common ancestor of animals.

Orthologs for CTSO Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CTSO 33 34
  • 99.37 (n)
(Canis familiaris)
Mammalia CTSO 33 34
  • 88.04 (n)
(Bos Taurus)
Mammalia CTSO 33 34
  • 82.76 (n)
(Mus musculus)
Mammalia Ctso 33 16 34
  • 80.16 (n)
(Monodelphis domestica)
Mammalia CTSO 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 26 (a)
(Gallus gallus)
Aves CTSO 33 34
  • 74.18 (n)
(Anolis carolinensis)
Reptilia CTSO 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ctso 33
  • 66.79 (n)
(Danio rerio)
Actinopterygii ctso 33 34
  • 61.82 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6991 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002720 33
  • 46.3 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6347 34
  • 21 (a)
(Caenorhabditis elegans)
Secernentea R07E3.1 35 34
  • 33 (a)
Y40H7A.10 34
  • 24 (a)
R09F10.1 34
  • 22 (a)
tag-329 34
  • 22 (a)
Y113G7B.15 34
  • 22 (a)
Y51A2D.8 34
  • 20 (a)
Y51A2D.1 34
  • 19 (a)
Species where no ortholog for CTSO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTSO Gene

Gene Tree for CTSO (if available)
Gene Tree for CTSO (if available)

Paralogs for CTSO Gene

Paralogs for CTSO Gene

(8) SIMAP similar genes for CTSO Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CTSO: view

Variants for CTSO Gene

Sequence variations from dbSNP and Humsavar for CTSO Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs10000523 -- 155,939,953(-) C/G/T intron_variant
rs1000091125 -- 155,934,438(-) G/A intron_variant
rs1000174042 -- 155,949,685(-) G/C intron_variant
rs10002427 -- 155,951,679(-) C/T intron_variant
rs1000247612 -- 155,949,430(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CTSO Gene

Variant ID Type Subtype PubMed ID
esv274871 CNV loss 21479260
esv3569758 CNV loss 25503493
esv3575777 CNV gain 25503493
esv999516 CNV insertion 20482838
nsv1026581 CNV gain 25217958
nsv1029122 CNV gain 25217958
nsv262 CNV insertion 15895083
nsv437447 CNV loss 16327808
nsv4564 CNV insertion 18451855
nsv480081 CNV novel sequence insertion 20440878
nsv830121 CNV gain 17160897

Variation tolerance for CTSO Gene

Residual Variation Intolerance Score: 43.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 36.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CTSO Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTSO Gene

Disorders for CTSO Gene

Additional Disease Information for CTSO

No disorders were found for CTSO Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTSO Gene

Publications for CTSO Gene

  1. Genomic structure and chromosomal localization of the human cathepsin O gene (CTSO). (PMID: 9790772) Santamaría I … López-Otín C (Genomics 1998) 2 3 22 58
  2. First genome-wide association scan on neurophysiological endophenotypes points to trans-regulation effects on SLC2A3 in dyslexic children. (PMID: 19786962) Roeske D … Schulte-Körne G (Molecular psychiatry 2011) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues. (PMID: 7929457) Velasco G … López-Otín C (The Journal of biological chemistry 1994) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for CTSO Gene

Sources for CTSO Gene

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