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The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein may be necessary for entry of SARS-CoV-2 (COVID-19 virus) into the cell. [provided by RefSeq, May 2020]
CTSL (Cathepsin L) is a Protein Coding gene. Diseases associated with CTSL include Covid-19 and Vulva Basal Cell Carcinoma. Among its related pathways are Lysosome and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include histone binding and cysteine-type peptidase activity. An important paralog of this gene is CTSV.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001968 | fibronectin binding | IPI | 22952693 |
GO:0004197 | cysteine-type endopeptidase activity | IMP | 28743268 |
GO:0005515 | protein binding | IPI | 12504904 |
GO:0005518 | collagen binding | IDA | 22952693 |
GO:0008233 | peptidase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IBA,IDA | 22952693 |
GO:0005634 | nucleus | TAS | 21326229 |
GO:0005764 | lysosome | IBA,IDA | 1837142 |
GO:0005771 | multivesicular body | IDA | 22365146 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Degradation of the extracellular matrix | ||
2 | Class I MHC mediated antigen processing and presentation | ||
3 | Antigen processing-Cross presentation | ||
4 | Collagen chain trimerization | ||
5 | Innate Immune System |
.61
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002224 | toll-like receptor signaling pathway | TAS | -- |
GO:0002250 | adaptive immune response | IEP | 15196205 |
GO:0006508 | proteolysis | IEA,IDA | 8811434 |
GO:0006955 | immune response | IBA | 21873635 |
GO:0019882 | antigen processing and presentation | TAS | 15196205 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
Trastuzumab deruxtecan | Approved, Investigational | Pharma | Enzyme, substrate | 0 | ||
Cysteic acid | Experimental | Pharma | Target | 0 | ||
Felbinac | Experimental | Pharma | Target | 0 | ||
E 64d | Pharma | Cysteine protease inhibitor, Cathepsin inhibitor; interferes with autolysosomal digestion | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
N-Acetyl-L-leucyl-L-leucyl-L-methional |
|
136632-32-1 |
|
|
Compound | Action | Cas Number |
---|---|---|
E 64d | Cathepsin inhibitor; interferes with autolysosomal digestion | 88321-09-9 |
L 006235 | Potent cathepsin K inhibitor | 294623-49-7 |
N-Acetyl-L-leucyl-L-leucyl-L-methional | Cathepsin inhibitor | 136632-32-1 |
SID 26681509 | Cathepsin L inhibitor | 958772-66-2 |
Compound | Action | Cas Number |
---|---|---|
Calpain Inhibitor I, ALLN | Calpain I/II/ B/L inhibitor | 110044-82-1 |
Calpain Inhibitor II, ALLM | Calpain inhibitor | 136632-32-1 |
Cathepsin Inhibitor 1 | Cathepsin inhibitor | 225120-65-0 |
E 64d | Cysteine protease inhibitor | 88321-09-9 |
E-64 | Cysteine protease inhibitor,irriversible | 66701-25-5 |
E-64-c | Inhibitor of cysteine proteinases | 76684-89-4 |
Odanacatib (MK-0822) | Cathepsin K,potent and selective | 603139-19-1 |
Papain Inhibitor | Inhibitor of peptidase activity of Papain | 70195-20-9 |
SID 26681509 | Human cathepsin L inhibitor,potent and reversible | 958772-66-2 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP13: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP14: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP15: | - |
ExUns: | 9b | ^ | 10 |
---|---|---|---|
SP1: | |||
SP2: | |||
SP3: | |||
SP4: | |||
SP5: | |||
SP6: | |||
SP7: | |||
SP8: | |||
SP9: | |||
SP10: | |||
SP11: | |||
SP12: | |||
SP13: | |||
SP14: | |||
SP15: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CTSL1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CTSL1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CTSL 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ctsll3 31 |
|
OneToMany | |
BC051665 31 |
|
OneToMany | |||
4930486L24Rik 31 |
|
OneToMany | |||
Ctsm 31 |
|
OneToMany | |||
Cts8 31 |
|
OneToMany | |||
Ctsr 31 |
|
OneToMany | |||
Cts3 31 |
|
OneToMany | |||
Cts6 31 |
|
OneToMany | |||
Ctsj 31 |
|
OneToMany | |||
Ctsq 31 |
|
OneToMany | |||
Cts7 31 |
|
OneToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | CTSL2 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | ctsla 31 |
|
ManyToMany | |
ctsll 31 |
|
ManyToMany | |||
si:dkey-269i1.4 31 31 |
|
ManyToMany | |||
si:dkey-26g8.5 31 |
|
ManyToMany | |||
ctslb 31 31 31 |
|
ManyToMany | |||
si:dkey-26g8.4 31 |
|
ManyToMany | |||
zgc:174153 31 |
|
ManyToMany | |||
si:dkey-269i1.3 31 |
|
ManyToMany | |||
zgc:174855 31 |
|
ManyToMany | |||
si:dkey-239j18.2 31 |
|
ManyToMany | |||
si:dkey-239j18.3 31 |
|
ManyToMany | |||
ctsl.1 31 |
|
ManyToMany | |||
Dr.26555 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | Cp1 31 32 |
|
OneToMany | |
CG4847 32 |
|
|
|||
26-29kD-proteinase 32 |
|
|
|||
CG11459 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | cpl-1 31 32 |
|
OneToMany | |
R09F10.1 32 |
|
|
|||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT5G50260 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os08g0556900 30 |
|
||
Barley (Hordeum vulgare) |
Liliopsida | Hv.12411 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
CSA.11034 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759703 | CNV | loss | 17122850 |
nsv968717 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
covid-19 |
|
|
vulva basal cell carcinoma |
|
|
gingival overgrowth |
|
|
benign meningioma |
|
|
middle east respiratory syndrome |
|
|