Aliases for CTSH Gene
External Ids for CTSH Gene
Previous HGNC Symbols for CTSH Gene
Previous GeneCards Identifiers for CTSH Gene
The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
GeneCards Summary for CTSH Gene
CTSH (Cathepsin H) is a Protein Coding gene. Diseases associated with CTSH include Narcolepsy 1 and Retinitis Pigmentosa 46. Among its related pathways are Lysosome and Innate Immune System. Gene Ontology (GO) annotations related to this gene include peptidase activity. An important paralog of this gene is CTSV.
UniProtKB/Swiss-Prot Summary for CTSH Gene
Important for the overall degradation of proteins in lysosomes.