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Aliases for CTSG Gene

Aliases for CTSG Gene

  • Cathepsin G 2 3 3 5
  • CG 3 4
  • EC 4
  • CATG 3

External Ids for CTSG Gene

Previous GeneCards Identifiers for CTSG Gene

  • GC14M022415
  • GC14M018830
  • GC14M023032
  • GC14M024112
  • GC14M025042
  • GC14M005157

Summaries for CTSG Gene

Entrez Gene Summary for CTSG Gene

  • The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. In addition, the encoded protein is antimicrobial, with bacteriocidal activity against S. aureus and N. gonorrhoeae. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Sep 2014]

GeneCards Summary for CTSG Gene

CTSG (Cathepsin G) is a Protein Coding gene. Diseases associated with CTSG include Vasculitis and Cutaneous Mastocytosis. Among its related pathways are Defensins and ACE Inhibitor Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and peptidase activity. An important paralog of this gene is GZMH.

UniProtKB/Swiss-Prot for CTSG Gene

  • Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.

Gene Wiki entry for CTSG Gene

Additional gene information for CTSG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSG Gene

Genomics for CTSG Gene

GeneHancer (GH) Regulatory Elements for CTSG Gene

Promoters and enhancers for CTSG Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J024576 Promoter 0.6 EPDnew 650.7 0.0 -10 0.1 POLR2A CTSG ENSG00000258657
GH14J024212 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.3 +361.6 361572 4.9 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 MDP1 CHMP4A ENSG00000254692 ENSG00000260669 RNA5SP383 TSSK4 RNF31 KHNYN IPO4 NGDN
GH14J024607 Promoter/Enhancer 1.2 EPDnew ENCODE dbSUPER 11.2 -33.3 -33328 3.7 ATF4 NR2C1 CEBPG NR2F6 TRIM24 NR2C2 GZMH GZMB CTSG CMA1 ENSG00000258744 KHNYN PIR56771 ENSG00000258657
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CTSG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CTSG gene promoter:
  • C/EBPalpha
  • FOXO1a
  • FOXO1
  • NF-kappaB1
  • NF-kappaB
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3

Genomic Locations for CTSG Gene

Genomic Locations for CTSG Gene
2,743 bases
Minus strand
2,743 bases
Minus strand

Genomic View for CTSG Gene

Genes around CTSG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTSG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTSG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSG Gene

Proteins for CTSG Gene

  • Protein details for CTSG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cathepsin G
    Protein Accession:
    Secondary Accessions:
    • Q6IBJ6
    • Q9UCA5
    • Q9UCU6

    Protein attributes for CTSG Gene

    255 amino acids
    Molecular mass:
    28837 Da
    Quaternary structure:
    • (Microbial infection) Interacts with M.tuberculosis protein Rv3364c.

    Three dimensional structures from OCA and Proteopedia for CTSG Gene

neXtProt entry for CTSG Gene

Post-translational modifications for CTSG Gene

  • Glycosylation at Asn71
  • Modification sites at PhosphoSitePlus

Other Protein References for CTSG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CTSG Gene

Domains & Families for CTSG Gene

Gene Families for CTSG Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CTSG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with CTSG: view

Function for CTSG Gene

Molecular function for CTSG Gene

UniProtKB/Swiss-Prot Function:
Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.
UniProtKB/Swiss-Prot CatalyticActivity:
Specificity similar to chymotrypsin C.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by soybean trypsin inhibitor, benzamidine, the synthetic peptide R13K, Z-Gly-Leu-Phe-CH2Cl, phenylmethylsulfonyl fluoride, 3,4-dichloroisocoumarin, DFP, SBTI and alpha-1-antitrypsin. Inhibited by LPS from P.aeruginosa but not by LPS from S.minnesota. Not inhibited by elastinal, CMK, TLCK and ETDA.
UniProtKB/Swiss-Prot EnzymeRegulation:
(Microbial infection) Serine protease activity is inhibited by the M.tuberculosis protein Rv3364c, which leads to the suppression of downstream caspase-1-dependent apoptosis in macrophages.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.15 mM for Z-Lys-SBzl {ECO:0000269 PubMed:8194606}; KM=0.26 mM for Suc-Ala-Ala-Pro-Phe-SBzl {ECO:0000269 PubMed:8194606};
GENATLAS Biochemistry:
cathepsin G,granule serine protease,25kDa,expressed in promyelocyte/promonocyte,oxygen independent phagocytosis of Gram- bacteria

Enzyme Numbers (IUBMB) for CTSG Gene

Phenotypes From GWAS Catalog for CTSG Gene

Gene Ontology (GO) - Molecular Function for CTSG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IDA,TAS --
GO:0005515 protein binding IPI 25416956
GO:0008201 heparin binding IDA 11907569
GO:0008233 peptidase activity IDA 11907569
GO:0008236 serine-type peptidase activity IMP 1937776
genes like me logo Genes that share ontologies with CTSG: view
genes like me logo Genes that share phenotypes with CTSG: view

Animal Models for CTSG Gene

MGI Knock Outs for CTSG:
  • Ctsg Ctsg<tm1Ley>
  • Ctsg Ctsg<tm1.1Roes>

Animal Model Products

  • Taconic Biosciences Mouse Models for CTSG

Clone Products

  • Addgene plasmids for CTSG

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CTSG Gene

Localization for CTSG Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTSG Gene

Cell surface.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTSG gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
lysosome 5
cytosol 1

Gene Ontology (GO) - Cellular Components for CTSG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IDA --
GO:0005615 extracellular space IDA,HDA 20551380
GO:0005634 nucleus HDA 21630459
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with CTSG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CTSG Gene

Pathways & Interactions for CTSG Gene

genes like me logo Genes that share pathways with CTSG: view

Gene Ontology (GO) - Biological Process for CTSG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002003 angiotensin maturation TAS --
GO:0006468 protein phosphorylation IDA 8573071
GO:0006508 proteolysis IDA 1861080
GO:0006955 immune response TAS 2569462
GO:0016485 protein processing IBA --
genes like me logo Genes that share ontologies with CTSG: view

No data available for SIGNOR curated interactions for CTSG Gene

Drugs & Compounds for CTSG Gene

(44) Drugs for CTSG Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid Experimental Pharma Target 0
Bis-Napthyl Beta-Ketophosphonic Acid Experimental Pharma Target 0
Cathepsin G Inhibitor I Pharma Cathepsin G inhibitor 0
Dermolastin Pharma inhibitor 0

(51) Additional Compounds for CTSG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CTSG: view

Transcripts for CTSG Gene

mRNA/cDNA for CTSG Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(55) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CTSG Gene

Cathepsin G:
Representative Sequences:

Clone Products

  • Addgene plasmids for CTSG

Alternative Splicing Database (ASD) splice patterns (SP) for CTSG Gene

No ASD Table

Relevant External Links for CTSG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTSG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTSG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTSG Gene

This gene is overexpressed in Whole Blood (x23.0) and Skin - Sun Exposed (Lower leg) (x4.1).

Protein differential expression in normal tissues from HIPED for CTSG Gene

This gene is overexpressed in Neutrophil (44.5) and Nasal epithelium (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CTSG Gene

Protein tissue co-expression partners for CTSG Gene

NURSA nuclear receptor signaling pathways regulating expression of CTSG Gene:


SOURCE GeneReport for Unigene cluster for CTSG Gene:


Evidence on tissue expression from TISSUES for CTSG Gene

  • Blood(4.7)
  • Skin(4.4)
  • Bone marrow(3.7)
  • Spleen(3)
  • Lung(2.6)
  • Lymph node(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with CTSG: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTSG Gene

Orthologs for CTSG Gene

This gene was present in the common ancestor of mammals.

Orthologs for CTSG Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CTSG 34 33
  • 98.04 (n)
(Bos Taurus)
Mammalia CTSG 33
  • 76.19 (n)
-- 34
  • 66 (a)
-- 34
  • 62 (a)
(Mus musculus)
Mammalia Ctsg 16 34 33
  • 75.51 (n)
(Rattus norvegicus)
Mammalia Ctsg 33
  • 74.89 (n)
(Canis familiaris)
Mammalia CTSG 34
  • 67 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 45 (a)
Species where no ortholog for CTSG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CTSG Gene

Gene Tree for CTSG (if available)
Gene Tree for CTSG (if available)
Evolutionary constrained regions (ECRs) for CTSG: view image

Paralogs for CTSG Gene

Variants for CTSG Gene

Sequence variations from dbSNP and Humsavar for CTSG Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs45567233 benign, not specified 24,574,465(-) T/C coding_sequence_variant, missense_variant
rs1000333362 -- 24,575,228(-) T/C intron_variant
rs1001851042 -- 24,573,244(-) C/A downstream_transcript_variant
rs1002706454 -- 24,576,915(-) C/T upstream_transcript_variant
rs1003238583 -- 24,577,830(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CTSG Gene

Variant ID Type Subtype PubMed ID
nsv510631 CNV deletion 20534489

Variation tolerance for CTSG Gene

Residual Variation Intolerance Score: 59.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.67; 45.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CTSG Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTSG Gene

Disorders for CTSG Gene

MalaCards: The human disease database

(20) MalaCards diseases for CTSG Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • angiitis
cutaneous mastocytosis
  • cm
wegener granulomatosis
  • wg
crescentic glomerulonephritis
  • idiopathic crescentic glomerulonephritis
  • acute gingivitis
- elite association - COSMIC cancer census association via MalaCards
Search CTSG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CTSG

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CTSG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTSG Gene

Publications for CTSG Gene

  1. The 1.8 A crystal structure of human cathepsin G in complex with Suc-Val-Pro-PheP-(OPh)2: a Janus-faced proteinase with two opposite specificities. (PMID: 8896442) Hof P … Bode W (The EMBO journal 1996) 3 4 22 58
  2. Comparison of granule proteins from human polymorphonuclear leukocytes which are bactericidal toward Pseudomonas aeruginosa. (PMID: 1937776) Wasiluk KR … Gray BH (Infection and immunity 1991) 3 4 22 58
  3. Genomic organization and chromosomal localization of the human cathepsin G gene. (PMID: 2569462) Hohn PA … Ley TJ (The Journal of biological chemistry 1989) 2 3 4 58
  4. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L … Crovella S (Vaccine 2010) 3 44 58
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58

Products for CTSG Gene

  • Addgene plasmids for CTSG

Sources for CTSG Gene

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