The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. In addition, the... See more...

Aliases for CTSG Gene

Aliases for CTSG Gene

  • Cathepsin G 2 3 4 5
  • CG 2 3 4
  • EC 3.4.21.20 4
  • EC 3.4.21 50
  • CATG 3
  • CTSG 5

External Ids for CTSG Gene

Previous GeneCards Identifiers for CTSG Gene

  • GC14M022415
  • GC14M018830
  • GC14M023032
  • GC14M024112
  • GC14M025042
  • GC14M005157

Summaries for CTSG Gene

Entrez Gene Summary for CTSG Gene

  • The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. In addition, the encoded protein is antimicrobial, with bacteriocidal activity against S. aureus and N. gonorrhoeae. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Sep 2014]

GeneCards Summary for CTSG Gene

CTSG (Cathepsin G) is a Protein Coding gene. Diseases associated with CTSG include Vasculitis and Crescentic Glomerulonephritis. Among its related pathways are Lysosome and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and peptidase activity. An important paralog of this gene is GZMB.

UniProtKB/Swiss-Prot Summary for CTSG Gene

  • Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.

Gene Wiki entry for CTSG Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CTSG Gene

Genomics for CTSG Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CTSG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J024576 Promoter/Enhancer 0.8 EPDnew Ensembl 250.7 +0.2 249 4 SPI1 MAX POLR2A ATF2 ATF7 MNT CTSG GZMB ENSG00000258744 CMA1 SDR39U1 HSALNG0100150
GH14J024212 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 11.3 +361.7 361672 5.2 BCLAF1 SP1 ZNF207 ZNF654 NCOR1 MYC ZNF600 SSRP1 ZMYM3 KLF9 MDP1 CHMP4A ENSG00000260669 ENSG00000254692 RNF31 RNA5SP383 NGDN KHNYN AP1G2-AS1 ENSG00000259321
GH14J024672 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 18.4 -97.9 -97900 2.9 BCLAF1 SP1 POLR2A BCL11A IRF4 EBF1 ASH2L SPI1 BATF ELF1 GZMB GZMH CTSG STXBP6 CMA1 CIDEB LTB4R RIPK3 TINF2 KHNYN
GH14J024535 Enhancer 0.7 FANTOM5 Ensembl 21.9 +41.0 41049 2 SPI1 MAX RAD51 RUNX3 MNT CTSG GZMB ENSG00000258744 CMA1 SDR39U1 RIPK3 TINF2 piR-47211-170 piR-48209-189
GH14J024607 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE dbSUPER 11.2 -33.3 -33338 3.7 JUND EP400 ATF4 NR2F6 NR2C1 TRIM24 NR2F1 GZMH GZMB CTSG CMA1 ENSG00000258744 KHNYN piR-61772 ENSG00000258657
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CTSG on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CTSG

Top Transcription factor binding sites by QIAGEN in the CTSG gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • C/EBPalpha
  • FOXO1
  • FOXO1a
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for CTSG Gene

Latest Assembly
chr14:24,573,518-24,576,250
(GRCh38/hg38)
Size:
2,733 bases
Orientation:
Minus strand

Previous Assembly
chr14:25,042,724-25,045,456
(GRCh37/hg19 by Entrez Gene)
Size:
2,733 bases
Orientation:
Minus strand

chr14:25,042,728-25,045,466
(GRCh37/hg19 by Ensembl)
Size:
2,739 bases
Orientation:
Minus strand

Genomic View for CTSG Gene

Genes around CTSG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTSG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTSG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSG Gene

Proteins for CTSG Gene

  • Protein details for CTSG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08311-CATG_HUMAN
    Recommended name:
    Cathepsin G
    Protein Accession:
    P08311
    Secondary Accessions:
    • Q6IBJ6
    • Q9UCA5
    • Q9UCU6

    Protein attributes for CTSG Gene

    Size:
    255 amino acids
    Molecular mass:
    28837 Da
    Quaternary structure:
    • (Microbial infection) Interacts with M.tuberculosis protein Rv3364c.

    Three dimensional structures from OCA and Proteopedia for CTSG Gene

neXtProt entry for CTSG Gene

Selected DME Specific Peptides for CTSG Gene

P08311:
  • NDIMLLQL
  • VLTAAHC
  • GDSGGPL
  • VTLGAHN
  • PHSRPYMA

Post-translational modifications for CTSG Gene

  • Glycosylation at Asn71
  • Modification sites at PhosphoSitePlus

Other Protein References for CTSG Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CTSG Gene

Gene Families for CTSG Gene

Protein Domains for CTSG Gene

InterPro:
Blocks:
  • Serine protease, trypsin family
  • Chymotrypsin serine protease family (S1) signature

Suggested Antigen Peptide Sequences for CTSG Gene

GenScript: Design optimal peptide antigens:
  • Cathepsin G (CATG_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P08311

UniProtKB/Swiss-Prot:

CATG_HUMAN :
  • Belongs to the peptidase S1 family.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with CTSG: view

Function for CTSG Gene

Molecular function for CTSG Gene

UniProtKB/Swiss-Prot Function:
Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Specificity similar to chymotrypsin C.; EC=3.4.21.20;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.15 mM for Z-Lys-SBzl {ECO:0000269|PubMed:8194606}; KM=0.26 mM for Suc-Ala-Ala-Pro-Phe-SBzl {ECO:0000269|PubMed:8194606};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by soybean trypsin inhibitor, benzamidine, the synthetic peptide R13K, Z-Gly-Leu-Phe-CH2Cl, phenylmethylsulfonyl fluoride, 3,4-dichloroisocoumarin, DFP, SBTI and alpha-1-antitrypsin. Inhibited by LPS from P.aeruginosa but not by LPS from S.minnesota. Not inhibited by elastinal, CMK, TLCK and ETDA.
GENATLAS Biochemistry:
cathepsin G,granule serine protease,25kDa,expressed in promyelocyte/promonocyte,oxygen independent phagocytosis of Gram- bacteria

Enzyme Numbers (IUBMB) for CTSG Gene

Phenotypes From GWAS Catalog for CTSG Gene

Gene Ontology (GO) - Molecular Function for CTSG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0008201 heparin binding IDA 11907569
GO:0008233 peptidase activity IDA 11907569
GO:0008236 serine-type peptidase activity IMP 1937776
genes like me logo Genes that share ontologies with CTSG: view
genes like me logo Genes that share phenotypes with CTSG: view

Animal Models for CTSG Gene

MGI Knock Outs for CTSG:
  • Ctsg Ctsg<tm1Ley>
  • Ctsg Ctsg<tm1.1Roes>

Animal Models for research

  • Taconic Biosciences Mouse Models for CTSG

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTSG

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CTSG Gene

Localization for CTSG Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTSG Gene

Cell surface.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTSG gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 5
nucleus 4
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
cytosol 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CTSG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region HDA,TAS --
GO:0005615 extracellular space HDA 20551380
GO:0005634 nucleus HDA 21630459
GO:0005737 cytoplasm IBA 21873635
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with CTSG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CTSG Gene

Pathways & Interactions for CTSG Gene

genes like me logo Genes that share pathways with CTSG: view

SIGNOR curated interactions for CTSG Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for CTSG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002003 angiotensin maturation TAS --
GO:0006468 protein phosphorylation IDA 8573071
GO:0006508 proteolysis IDA 1861080
GO:0006955 immune response TAS 2569462
GO:0019730 antimicrobial humoral response TAS --
genes like me logo Genes that share ontologies with CTSG: view

Drugs & Compounds for CTSG Gene

(45) Drugs for CTSG Gene - From: DrugBank, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid Experimental Pharma Target 0
Bis-Napthyl Beta-Ketophosphonic Acid Experimental Pharma Target 0
Cathepsin G Inhibitor I Pharma Cathepsin G inhibitor 0
1,3-BIS(PHENYLMETHYL)-1,3-DIAZETIDINE-2,4-DIONE Pharma 0
Dermolastin Pharma inhibitor 0

(50) Additional Compounds for CTSG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for CTSG Gene

Compound Action Cas Number
Cathepsin G Inhibitor I Cathepsin G inhibitor 429676-93-7
genes like me logo Genes that share compounds with CTSG: view

Drug products for research

Transcripts for CTSG Gene

mRNA/cDNA for CTSG Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTSG

Alternative Splicing Database (ASD) splice patterns (SP) for CTSG Gene

No ASD Table

Relevant External Links for CTSG Gene

GeneLoc Exon Structure for
CTSG

Expression for CTSG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CTSG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTSG Gene

This gene is overexpressed in Whole Blood (x23.0) and Skin - Sun Exposed (Lower leg) (x4.1).

Protein differential expression in normal tissues from HIPED for CTSG Gene

This gene is overexpressed in Neutrophil (44.5) and Nasal epithelium (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CTSG Gene



Protein tissue co-expression partners for CTSG Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CTSG

SOURCE GeneReport for Unigene cluster for CTSG Gene:

Hs.421724

Evidence on tissue expression from TISSUES for CTSG Gene

  • Blood(4.7)
  • Skin(4.5)
  • Bone marrow(3.9)
  • Spleen(3.4)
  • Lymph node(2.9)
  • Heart(2.7)
  • Lung(2.5)
  • Liver(2.4)
  • Intestine(2.4)
  • Kidney(2.2)
  • Nervous system(2.1)
  • Pancreas(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with CTSG: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTSG Gene

Orthologs for CTSG Gene

This gene was present in the common ancestor of mammals.

Orthologs for CTSG Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CTSG 29 30
  • 98.04 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CTSG 29
  • 76.19 (n)
-- 30
  • 66 (a)
OneToMany
-- 30
  • 62 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Ctsg 29 16 30
  • 75.51 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ctsg 29
  • 74.89 (n)
Dog
(Canis familiaris)
Mammalia CTSG 30
  • 67 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 52 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 45 (a)
OneToMany
Species where no ortholog for CTSG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CTSG Gene

ENSEMBL:
Gene Tree for CTSG (if available)
TreeFam:
Gene Tree for CTSG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CTSG: view image
Alliance of Genome Resources:
Additional Orthologs for CTSG

Paralogs for CTSG Gene

Variants for CTSG Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CTSG Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs145092554 Benign: not provided 24,574,311(-) G/A
NM_001911.3(CTSG):c.528C>T (p.Phe176=)
SYNONYMOUS
rs45567233 Benign: not specified 24,574,465(-) T/Cp.Asn125Ser
NM_001911.3(CTSG):c.374A>G (p.Asn125Ser)
MISSENSE
rs61737120 Benign: not provided 24,574,745(-) G/A
NM_001911.3(CTSG):c.269C>T (p.Thr90Ile)
MISSENSE
rs61737123 Benign: not provided 24,576,180(-) C/G
NM_001911.3(CTSG):c.44G>C (p.Gly15Ala)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CTSG Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CTSG Gene

Variant ID Type Subtype PubMed ID
nsv510631 CNV deletion 20534489

Variation tolerance for CTSG Gene

Residual Variation Intolerance Score: 59.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.67; 45.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CTSG Gene

Human Gene Mutation Database (HGMD)
CTSG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTSG
Leiden Open Variation Database (LOVD)
CTSG

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTSG Gene

Disorders for CTSG Gene

MalaCards: The human disease database

(29) MalaCards diseases for CTSG Gene - From: COP and GCD

Disorder Aliases PubMed IDs
vasculitis
  • angiitis
crescentic glomerulonephritis
  • idiopathic crescentic glomerulonephritis
gingivitis
  • acute gingivitis
granulomatosis with polyangiitis
  • gpa
bronchiectasis
  • polynesian bronchiectasis
- elite association - COSMIC cancer census association via MalaCards
Search CTSG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CTSG

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CTSG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTSG Gene

Publications for CTSG Gene

  1. The 1.8 A crystal structure of human cathepsin G in complex with Suc-Val-Pro-PheP-(OPh)2: a Janus-faced proteinase with two opposite specificities. (PMID: 8896442) Hof P … Bode W (The EMBO journal 1996) 3 4 22
  2. Comparison of granule proteins from human polymorphonuclear leukocytes which are bactericidal toward Pseudomonas aeruginosa. (PMID: 1937776) Wasiluk KR … Gray BH (Infection and immunity 1991) 3 4 22
  3. Genomic organization and chromosomal localization of the human cathepsin G gene. (PMID: 2569462) Hohn PA … Ley TJ (The Journal of biological chemistry 1989) 2 3 4
  4. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L … Crovella S (Vaccine 2010) 3 40
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 40

Products for CTSG Gene

Sources for CTSG Gene