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This gene encodes a member of the A1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme, an aspartic endopeptidase, may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. [provided by RefSeq, Nov 2015]
CTSE (Cathepsin E) is a Protein Coding gene. Diseases associated with CTSE include Gastric Adenocarcinoma and Rosai-Dorfman Disease. Among its related pathways are Class I MHC mediated antigen processing and presentation and Lysosome. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and aspartic-type endopeptidase activity. An important paralog of this gene is PGA3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004190 | aspartic-type endopeptidase activity | IDA | 7789521 |
GO:0008233 | peptidase activity | IDA | 16997486 |
GO:0016787 | hydrolase activity | IEA | -- |
GO:0042803 | protein homodimerization activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005768 | endosome | IDA,IBA | 7983070 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Lysosome |
-
|
|
2 | Class I MHC mediated antigen processing and presentation | ||
3 | Innate Immune System |
.61
|
|
4 | MHC class II antigen presentation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006508 | proteolysis | IDA | 16997486 |
GO:0016540 | protein autoprocessing | IEA | -- |
GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II | IDA | 8765029 |
GO:0030163 | protein catabolic process | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
(2S)-N-[(2S,3R)-1-CYCLOHEXYL-4,4-DIFLUORO-3-HYDROXY-4-{[(2S)-2-METHYLBUTYL]CARBAMOYL}BUTAN-2-YL]-2-[(2S)-2-[(MORPHOLINE-4-SULFONYL)AMINO]-3-PHENYLPROPANAMIDO]PENT-4-ENAMIDE | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||
SP4: | - | - |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | CTSE 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | CTSE 33 32 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | Ctse 32 |
|
||
mouse (Mus musculus) |
Mammalia | Ctse 17 33 32 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | CTSE 33 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 33 |
|
OneToMany | |
-- 33 |
|
OneToMany | |||
chicken (Gallus gallus) |
Aves | CTSE 33 32 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | CTSE 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | ctse 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | nots 33 |
|
OneToOne | |
fruit fly (Drosophila melanogaster) |
Insecta | CG13095 34 |
|
|
|
Bace 33 |
|
ManyToMany | |||
CG17134 33 34 |
|
ManyToMany | |||
CG5863 33 34 |
|
ManyToMany | |||
pcl 33 34 |
|
ManyToMany | |||
CG10104 34 |
|
|
|||
CG33128 33 |
|
ManyToMany | |||
CG6508 33 34 |
|
ManyToMany | |||
CG5860 33 34 |
|
ManyToMany | |||
CG31661 33 |
|
ManyToMany | |||
CG31926 33 |
|
ManyToMany | |||
CG17283 33 34 |
|
ManyToMany | |||
CG31928 33 |
|
ManyToMany | |||
worm (Caenorhabditis elegans) |
Secernentea | asp-4 34 |
|
|
|
asp-3 34 |
|
|
|||
Y39B6A.21 34 |
|
|
|||
C11D2.2 34 |
|
|
|||
asp-1 33 |
|
ManyToMany | |||
asp-9 33 |
|
ManyToMany | |||
Y39B6A.23 34 |
|
|
|||
asp-12 33 |
|
ManyToMany | |||
asp-17 33 |
|
ManyToMany | |||
F59D6.3 34 |
|
|
|||
F21F8.4 34 |
|
|
|||
C15C8.3 34 |
|
|
|||
asp-18 33 |
|
ManyToMany | |||
asp-5 33 34 |
|
ManyToMany | |||
asp-16 33 |
|
ManyToMany | |||
asp-6 33 34 |
|
ManyToMany | |||
Y39B6A.24 34 |
|
|
|||
asp-10 33 |
|
ManyToMany | |||
F28A12.4 34 |
|
|
|||
F59D6.2 34 |
|
|
|||
Y39B6A.22 34 |
|
|
|||
asp-15 33 |
|
ManyToMany | |||
asp-7 33 |
|
ManyToMany | |||
asp-19 33 |
|
ManyToMany | |||
asp-13 33 |
|
ManyToMany | |||
asp-8 33 |
|
ManyToMany | |||
asp-2 33 34 |
|
ManyToMany | |||
asp-14 33 |
|
ManyToMany | |||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PEP4 33 |
|
OneToMany | |
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10126 33 |
|
ManyToMany |
SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs193920960 | uncertain-significance, Malignant tumor of prostate | 206,022,174(-) | C/T | coding_sequence_variant, missense_variant | |
rs1000034488 | -- | 206,025,202(-) | C/A | upstream_transcript_variant | |
rs1000120987 | -- | 206,024,091(-) | C/A | upstream_transcript_variant | |
rs1000134354 | -- | 206,020,195(-) | A/G | intron_variant | |
rs1000407214 | -- | 206,024,930(-) | G/A | upstream_transcript_variant |
Disorder | Aliases | PubMed IDs |
---|---|---|
gastric adenocarcinoma |
|
|
rosai-dorfman disease |
|
|