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This gene encodes a member of the A1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme, an aspartic endopeptidase, may be involved in antigen processing and the maturation of secretory proteins. Elevat... See more...
Aliases for CTSE Gene
Aliases for CTSE Gene
External Ids for CTSE Gene
- HGNC: 2530
- Entrez Gene: 1510
- Ensembl: ENSG00000196188
- OMIM: 116890
- UniProtKB: P14091
Previous GeneCards Identifiers for CTSE Gene
- GC01U990032
- GC01P202860
- GC01P204484
- GC01P206319
- GC01P177247
Summaries for CTSE Gene
-
This gene encodes a member of the A1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme, an aspartic endopeptidase, may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. [provided by RefSeq, Nov 2015]
GeneCards Summary for CTSE Gene
CTSE (Cathepsin E) is a Protein Coding gene. Diseases associated with CTSE include Gastric Adenocarcinoma and Rosai-Dorfman Disease. Among its related pathways are Class I MHC mediated antigen processing and presentation and Lysosome. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and aspartic-type endopeptidase activity. An important paralog of this gene is PGA3.
UniProtKB/Swiss-Prot Summary for CTSE Gene
-
May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CTSE Gene
Genomics for CTSE Gene
GeneHancer (GH) Regulatory Elements for CTSE Gene
Promoters and enhancers for CTSE Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CTSE on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CTSE gene promoter:
-
- Cdc5
- Evi-1
- Ik-2
- NF-E2
- NF-E2 p45
- NF-kappaB
- NF-kappaB1
- RelA
- Zic3
Genomic Locations for CTSE Gene
Genomic Locations for CTSE Gene
- chr1:206,009,264-206,023,909
- (GRCh38/hg38)
- Size:
- 14,646 bases
- Orientation:
- Minus strand
- chr1:206,317,459-206,332,104
- (GRCh37/hg19)
- Size:
- 14,646 bases
- Orientation:
- Plus strand
Genomic View for CTSE Gene
Genes around CTSE on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q32.1 by HGNC
- 1q32.1 by Entrez Gene
- 1q32.1 by Ensembl
CTSE Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CTSE Gene
Proteins for CTSE Gene
-
Protein details for CTSE Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P14091-CATE_HUMAN
- Recommended name:
- Cathepsin E
- Protein Accession:
- P14091
- Q5TZ01
- Q5TZ02
- Q9NY58
- Q9UCE3
- Q9UCE4
Protein attributes for CTSE Gene
- Size:
- 396 amino acids
- Molecular mass:
- 42794 Da
- Quaternary structure:
-
- Homodimer; disulfide-linked.
Protein Expression for CTSE Gene
Selected DME Specific Peptides for CTSE Gene
- P14091:
-
- GGVTPVFD
- GTSLITGP
- DTGSSNLW
- FTVIFDT
- WILGDVF
- GGVTPVFDNMMAQNLV
- GIIGADQVS
- LPMFSVY
- GSLNWVPV
- AIVDTGTSL
- LWVPSVYC
Post-translational modifications for CTSE Gene
- Glycosylated. The nature of the carbohydrate chain varies between cell types. In fibroblasts, the proenzyme contains a high mannose-type oligosaccharide, while the mature enzyme contains a complex-type oligosaccharide. In erythrocyte membranes, both the proenzyme and mature enzyme contain a complex-type oligosaccharide.
- Two forms are produced by autocatalytic cleavage, form I begins at Ile-54, form II begins at Thr-57.
-
Glycosylation at Asn90
- NX_P14091 (NX_P14091-1)
- Modification sites at PhosphoSitePlus
Other Protein References for CTSE Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ Cathepsin E Antibody and Immunotag™ CTSE Antibody
- NSJ Bioreagents Cathepsin E Antibody / CTSE
- Atlas Antibodies Anti-CTSE Antibody
- Creative Diagnostics Anti-CTSE (aa 132-151) polyclonal antibody and Anti-CTSE (aa 414-513) polyclonal antibody
-
Creative Biolabs
- Recombinant Anti-Human CTSE Antibody Fab Fragment
- Recombinant Anti-Human CTSE Antibody
- Mouse Anti-CTSE Recombinant Antibody (CBYY-C2315)
- Mouse Anti-CTSE Recombinant Antibody (14L295)
- Mouse Anti-CTSE Recombinant Antibody (212211)
- Mouse Anti-CTSE Recombinant Antibody (2D5)
- Mouse Anti-CTSE Recombinant Antibody (CBXC-1013)
- Mouse Anti-CTSF Recombinant Antibody (237208)
- Rat Anti-CTSE Recombinant Antibody (CBYY-C2316)
- Mouse Anti-CTSF Recombinant Antibody (3A41)
- Mouse Anti-CTSE Recombinant Antibody (4F50)
- Mouse Anti-CTSE Recombinant Antibody (CBFYC-2442)
- Mouse Anti-CTSE Recombinant Antibody (CBFYC-2445)
- Recombinant Mouse anti-Human CTSE Monoclonal antibody (NN0239-5G60)
-
Custom Antibody ServicesOriGene Antibodies for CTSE
- Novus Biologicals Antibodies for CTSE
-
Abcam antibodies for CTSE
- Invitrogen Antibodies for CTSE (AFLGC-CTSE)
-
Boster Bio Antibodies for CTSE
-
Santa Cruz Biotechnology (SCBT) Antibodies for CTSE
- Sino Biological Antibodies for CTSE
Protein Products
- G Biosciences Human Cathepsin E/CTSE, Lyophilized
- Atlas Antibodies PrEST Antigen CTSE
- Search Origene for MassSpec and Protein Over-expression Lysates for CTSE
- Origene Custom Protein Services for CTSE
- Sino Biological Cell Lysates for CTSE
- Sino Biological Recombinant Proteins for CTSE
- ProSpec Recombinant Proteins for CTSE
-
ProSci Proteins for CTSE
-
Abcam proteins for CTSE
Assay Products
- RayBiotech Custom Human Cathepsin E ELISA
- Aviva Systems Biology CTSE ELISA Kit (Human) (OKCD08115)
-
Custom Assay ServicesOriGene ELISA Kits for CTSE
- antibodies-online: Show 21 available Cathepsin E Elisa Kits ranked by validation data
- Compare Top Cathepsin E Elisa Kits
-
Quality Products:
-
Boster Bio ELISA Kits for CTSE
-
Abcam assays for CTSE
Domains & Families for CTSE Gene
Gene Families for CTSE Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted secreted proteins
Protein Domains for CTSE Gene
Suggested Antigen Peptide Sequences for CTSE Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ60742, highly similar to Homo sapiens cathepsin E (CTSE), transcript variant 2, mRNA (B4DNU8_HUMAN)
- Cathepsin E (CATE_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P14091- Family:
-
- Belongs to the peptidase A1 family.
Function for CTSE Gene
Molecular function for CTSE Gene
- UniProtKB/Swiss-Prot Function:
- May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=Similar to cathepsin D, but slightly broader specificity.; EC=3.4.23.34; Evidence={ECO:0000269 PubMed:7789521, ECO:0000269 PubMed:8765029};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=0.06 mM for hemoglobin {ECO:0000269 PubMed:8346912}; KM=0.13 mM for Pro-Pro-Thr-Ile-Phe-Phe(4-NO2)-Arg-Leu {ECO:0000269 PubMed:8346912}; KM=0.04 mM for Lys-Pro-Ile-Glu-Phe-Phe(4-NO2)-Arg-Leu {ECO:0000269 PubMed:8346912};
- GENATLAS Biochemistry:
- cathepsin E,aspartic proteinase
Enzyme Numbers (IUBMB) for CTSE Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004190 | aspartic-type endopeptidase activity | IDA | 7789521 |
| GO:0008233 | peptidase activity | IDA | 16997486 |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0042803 | protein homodimerization activity | IEA | -- |
Phenotypes for CTSE Gene
- MGI mutant phenotypes for CTSE:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for CTSE:
-
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased POU5F1-GFP protein expression
- Dynamic nuclei (hole, folded or small irregular)
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased infection with West Nile virus (WNV)
- Decreased West Nile virus (WNV) infection
- Decreased IL-8 secretion
- Increased viability
Animal Model Products
-
Taconic Biosciences Mouse Models for CTSE
CRISPR Products
-
OriGene CRISPR knockouts for CTSE
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CTSE
- genomics-online: gRNA clones - Search for available Cathepsin E gRNA products
- Overview of 164 available Cathepsin E gene related products
- Applied Biological Materials (abm): CRISPR Clones for CTSE - Select products 50% OFF >
- * CTSE CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * CTSE CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for CTSE
miRNA for CTSE Gene
- miRTarBase miRNAs that target CTSE
-
- hsa-mir-25-3p (MIRT050230)
- hsa-mir-574-5p (MIRT550938)
- hsa-mir-3611 (MIRT550939)
- hsa-mir-573 (MIRT550940)
- hsa-mir-6867-5p (MIRT550941)
- hsa-mir-3616-5p (MIRT550942)
- hsa-mir-4795-5p (MIRT550943)
- hsa-mir-223-5p (MIRT550944)
- hsa-mir-511-3p (MIRT550945)
- hsa-mir-595 (MIRT550946)
- hsa-mir-6818-5p (MIRT569476)
- hsa-mir-297 (MIRT569477)
- hsa-mir-567 (MIRT569478)
- hsa-mir-3650 (MIRT569479)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CTSE
- Browse OriGene Inhibitory RNA Products For CTSE
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTSE
- genomics-online: shRNA clones - Search for available Cathepsin E shRNA products
- Overview of 164 available Cathepsin E gene related products
Clone Products
-
- MG206223
- MR206223
- MR206223L1
- MR206223L1V
- MR206223L2
- MR206223L2V
- MR206223L3
- MR206223L3V
- MR206223L4
- MR206223L4V
- RC206604
- RC206604L3
- RC206604L3V
- RC206604L4
- RC206604L4V
- RC220117
- RC220117L3
- RC220117L3V
- RC220117L4
- RC220117L4V
- RG206604
- RG220117
- RR209222
- RR209222L1
- RR209222L1V
- RR209222L2
- RR209222L2V
- RR209222L3
- RR209222L3V
- RR209222L4
- RR209222L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CTSE
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CTSE
- Applied Biological Materials (abm): Clones for CTSE - Select products 50% OFF >
- * CTSE as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * CTSE tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for CTSE
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTSE Gene
Localization for CTSE Gene
Subcellular locations from UniProtKB/Swiss-Prot for CTSE Gene
- Endosome. Note=The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome.
| Compartment | Confidence |
|---|---|
| endosome | 5 |
| lysosome | 3 |
| extracellular | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005768 | endosome | IDA,IBA | 7983070 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CTSE Gene
Pathways & Interactions for CTSE Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Lysosome |
-
|
|
| 2 | Class I MHC mediated antigen processing and presentation | ||
| 3 | Innate Immune System |
.61
|
|
| 4 | MHC class II antigen presentation | ||
Pathways by source for CTSE Gene
3 Reactome pathways for CTSE Gene
1 KEGG pathway for CTSE Gene
1 GeneTex pathway for CTSE Gene
Interacting Proteins for CTSE Gene
GPS-Prot Interaction Network for CTSE
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006508 | proteolysis | IDA | 16997486 |
| GO:0016540 | protein autoprocessing | IEA | -- |
| GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II | IDA | 8765029 |
| GO:0030163 | protein catabolic process | IBA | 21873635 |
No data available for SIGNOR curated interactions for CTSE Gene
Drugs & Compounds for CTSE Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| (2S)-N-[(2S,3R)-1-CYCLOHEXYL-4,4-DIFLUORO-3-HYDROXY-4-{[(2S)-2-METHYLBUTYL]CARBAMOYL}BUTAN-2-YL]-2-[(2S)-2-[(MORPHOLINE-4-SULFONYL)AMINO]-3-PHENYLPROPANAMIDO]PENT-4-ENAMIDE | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for CTSE Gene
mRNA/cDNA for CTSE Gene
- (3) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (84) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000358184 2214 bps (ENST00000358184.6)
- ENST00000360218 2071 bps (ENST00000360218.2)
- ENST00000468617 647 bps (ENST00000468617.1)
- ENST00000486757 435 bps (ENST00000486757.1)
CRISPR Products
-
OriGene CRISPR knockouts for CTSE
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CTSE
- genomics-online: gRNA clones - Search for available Cathepsin E gRNA products
- Overview of 164 available Cathepsin E gene related products
- Applied Biological Materials (abm): CRISPR Clones for CTSE - Select products 50% OFF >
- * CTSE CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * CTSE CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for CTSE
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CTSE
- Browse OriGene Inhibitory RNA Products For CTSE
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTSE
- genomics-online: shRNA clones - Search for available Cathepsin E shRNA products
- Overview of 164 available Cathepsin E gene related products
Clone Products
-
- MG206223
- MR206223
- MR206223L1
- MR206223L1V
- MR206223L2
- MR206223L2V
- MR206223L3
- MR206223L3V
- MR206223L4
- MR206223L4V
- RC206604
- RC206604L3
- RC206604L3V
- RC206604L4
- RC206604L4V
- RC220117
- RC220117L3
- RC220117L3V
- RC220117L4
- RC220117L4V
- RG206604
- RG220117
- RR209222
- RR209222L1
- RR209222L1V
- RR209222L2
- RR209222L2V
- RR209222L3
- RR209222L3V
- RR209222L4
- RR209222L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CTSE
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CTSE
- Applied Biological Materials (abm): Clones for CTSE - Select products 50% OFF >
- * CTSE as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * CTSE tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||
| SP4: | - | - |
Expression for CTSE Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Kidney (Urinary System)
- Inner Cell Mass (Early Embryonic Tissues)
-
Yolk Sac (Extraembryonic Tissues)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
-
Blood (Cardiovascular System)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
-
Epidermis (Integumentary System)
- Corneocytes Stratified Epidermis
-
Epithelial Cells
- Corneocytes Stratified Epidermis
- NULL (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for CTSE Gene
This gene is overexpressed in Stomach (x41.1) and Lung (x6.0).
This gene is overexpressed in Stomach (42.8), Cardia (17.1), and Lung (6.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CTSE Gene
NURSA nuclear receptor signaling pathways regulating expression of CTSE Gene:
CTSESOURCE GeneReport for Unigene cluster for CTSE Gene:
Hs.644082mRNA Expression by UniProt/SwissProt for CTSE Gene:
P14091-CATE_HUMAN
Tissue specificity:
Expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. Not expressed in resting B-lymphocytes.
Evidence on tissue expression from TISSUES for CTSE Gene
- Stomach(4.8)
- Blood(4.5)
- Intestine(4.4)
- Nervous system(4.2)
- Lung(2.2)
Primer Products
-
OriGene qPCR primer pairs for CTSE
-
OriGene qPCR primer pairs and template standards for CTSE
- genomics-online: primer clones - Search for available Cathepsin E Primer products
- Overview of 164 available Cathepsin E gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTSE Gene
Orthologs for CTSE Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CTSE 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CTSE 33 32 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Ctse 32 |
|
||
| mouse (Mus musculus) |
Mammalia | Ctse 17 33 32 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CTSE 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 33 |
|
OneToMany | |
| -- 33 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | CTSE 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CTSE 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ctse 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | nots 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG13095 34 |
|
|
|
| Bace 33 |
|
ManyToMany | |||
| CG17134 33 34 |
|
ManyToMany | |||
| CG5863 33 34 |
|
ManyToMany | |||
| pcl 33 34 |
|
ManyToMany | |||
| CG10104 34 |
|
|
|||
| CG33128 33 |
|
ManyToMany | |||
| CG6508 33 34 |
|
ManyToMany | |||
| CG5860 33 34 |
|
ManyToMany | |||
| CG31661 33 |
|
ManyToMany | |||
| CG31926 33 |
|
ManyToMany | |||
| CG17283 33 34 |
|
ManyToMany | |||
| CG31928 33 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | asp-4 34 |
|
|
|
| asp-3 34 |
|
|
|||
| Y39B6A.21 34 |
|
|
|||
| C11D2.2 34 |
|
|
|||
| asp-1 33 |
|
ManyToMany | |||
| asp-9 33 |
|
ManyToMany | |||
| Y39B6A.23 34 |
|
|
|||
| asp-12 33 |
|
ManyToMany | |||
| asp-17 33 |
|
ManyToMany | |||
| F59D6.3 34 |
|
|
|||
| F21F8.4 34 |
|
|
|||
| C15C8.3 34 |
|
|
|||
| asp-18 33 |
|
ManyToMany | |||
| asp-5 33 34 |
|
ManyToMany | |||
| asp-16 33 |
|
ManyToMany | |||
| asp-6 33 34 |
|
ManyToMany | |||
| Y39B6A.24 34 |
|
|
|||
| asp-10 33 |
|
ManyToMany | |||
| F28A12.4 34 |
|
|
|||
| F59D6.2 34 |
|
|
|||
| Y39B6A.22 34 |
|
|
|||
| asp-15 33 |
|
ManyToMany | |||
| asp-7 33 |
|
ManyToMany | |||
| asp-19 33 |
|
ManyToMany | |||
| asp-13 33 |
|
ManyToMany | |||
| asp-8 33 |
|
ManyToMany | |||
| asp-2 33 34 |
|
ManyToMany | |||
| asp-14 33 |
|
ManyToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PEP4 33 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10126 33 |
|
ManyToMany |
- Species where no ortholog for CTSE was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for CTSE Gene
- ENSEMBL:
- Gene Tree for CTSE (if available)
- TreeFam:
- Gene Tree for CTSE (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CTSE: view image
Paralogs for CTSE Gene
Paralogs for CTSE Gene
(8) SIMAP similar genes for CTSE Gene using alignment to 3 proteins:
- CATE_HUMAN
- B4DNU8_HUMAN
- J3KP48_HUMAN
Variants for CTSE Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs193920960 | uncertain-significance, Malignant tumor of prostate | 206,022,174(-) | C/T | coding_sequence_variant, missense_variant | |
| rs1000034488 | -- | 206,025,202(-) | C/A | upstream_transcript_variant | |
| rs1000120987 | -- | 206,024,091(-) | C/A | upstream_transcript_variant | |
| rs1000134354 | -- | 206,020,195(-) | A/G | intron_variant | |
| rs1000407214 | -- | 206,024,930(-) | G/A | upstream_transcript_variant |
Residual Variation Intolerance Score:
80.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.38;
63.55% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CTSE Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CTSE
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTSE Gene
Disorders for CTSE Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gastric adenocarcinoma |
|
|
| rosai-dorfman disease |
|
|
Search CTSE in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CTSE
No data available for UniProtKB/Swiss-Prot and Genatlas for CTSE Gene
Publications for CTSE Gene
- An alternatively spliced variant of cathepsin E in human gastric adenocarcinoma cells. (PMID: 12531480) Tatnell PJ … Kay J (Biochimica et biophysica acta 2003) 3 4 23 56
- Regulation of human and mouse procathepsin E gene expression. (PMID: 11322887) Cook M … Tatnell PJ (European journal of biochemistry 2001) 3 4 23 56
- Regulation of cathepsin E expression during human B cell differentiation in vitro. (PMID: 8765029) Sealy L … Chain B (European journal of immunology 1996) 3 4 23 56
- Monomeric human cathepsin E. (PMID: 7789521) Fowler SD … Tatnell PJ (FEBS letters 1995) 3 4 23 56
- Human gastric cathepsin E gene. Multiple transcripts result from alternative polyadenylation of the primary transcripts of a single gene locus at 1q31-q32. (PMID: 1370478) Azuma T … Taggart RT (The Journal of biological chemistry 1992) 3 4 23 56
ExternalLinks
Products for CTSE Gene
- View all 9 R&D Systems CTSE (Cathepsin E) Products
- View all R&D Systems CTSE (Cathepsin E) Proteins and Enzymes
- View all 6 R&D Systems CTSE (Cathepsin E) Primary Antibodies
- View all 2 R&D Systems CTSE (Cathepsin E) Proteome Profiler Antibody Arrays
- Learn more about R&D Systems custom CTSE antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for CTSE
- Custom Assay ServicesOriGene ELISA Kits for CTSE
- Search Origene for MassSpec and Protein Over-expression Lysates for CTSE
- Origene Custom Protein Services for CTSE
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CTSE
- Browse OriGene Inhibitory RNA Products For CTSE
- OriGene qPCR primer pairs for CTSE
- OriGene qPCR primer pairs and template standards for CTSE
- OriGene CRISPR knockouts for CTSE
- MG206223
- MR206223
- MR206223L1
- MR206223L1V
- MR206223L2
- MR206223L2V
- MR206223L3
- MR206223L3V
- MR206223L4
- MR206223L4V
- RC206604
- RC206604L3
- RC206604L3V
- RC206604L4
- RC206604L4V
- RC220117
- RC220117L3
- RC220117L3V
- RC220117L4
- RC220117L4V
- RG206604
- RG220117
- RR209222
- RR209222L1
- RR209222L1V
- RR209222L2
- RR209222L2V
- RR209222L3
- RR209222L3V
- RR209222L4
- RR209222L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CTSE
- Sino Biological Human cDNA Clone for CTSE
- Sino Biological Cell Lysates for CTSE
- Sino Biological Recombinant Proteins for CTSE
- Sino Biological Antibodies for CTSE
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CTSE
- Novus Biologicals proteins and lysates for CTSE
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CTSE
- Abcam proteins for CTSE
- Abcam assays for CTSE
- Find your target
- Browse Primary Antibodies
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- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
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- ProSpec Recombinant Proteins for CTSE
- Taconic Biosciences Mouse Models for CTSE
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CTSE (AFLGC-CTSE)
- antibodies-online: Show 16 available Cathepsin E Antibodies ranked by validation data
- Compare Top Cathepsin E Antibodies
- antibodies-online: Show 21 available Cathepsin E Elisa Kits ranked by validation data
- Compare Top Cathepsin E Elisa Kits
- Quality Products:
- antibodies-online: Show 25 available Cathepsin E Proteins ranked by validation data
- Compare Top Cathepsin E Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CTSE
- Search Santa Cruz Biotechnology (SCBT) for CTSE siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CTSE
- Horizon Cell Lines for CTSE
- genomics-online: cdna clones - Search for available Cathepsin E CDNA products
- Overview of 164 available Cathepsin E gene related products
- orf clones - Search for available Cathepsin E ORF products
- Overview of 164 available Cathepsin E gene related products
- genomics-online: gRNA clones - Search for available Cathepsin E gRNA products
- Overview of 164 available Cathepsin E gene related products
- genomics-online: primer clones - Search for available Cathepsin E Primer products
- Overview of 164 available Cathepsin E gene related products
- genomics-online: shRNA clones - Search for available Cathepsin E shRNA products
- Overview of 164 available Cathepsin E gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CTSE
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CTSE
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CTSE
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTSE
Sources for CTSE Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource