Aliases for CTSE Gene
External Ids for CTSE Gene
Previous GeneCards Identifiers for CTSE Gene
This gene encodes a member of the A1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme, an aspartic endopeptidase, may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. [provided by RefSeq, Nov 2015]
GeneCards Summary for CTSE Gene
CTSE (Cathepsin E) is a Protein Coding gene. Diseases associated with CTSE include Gastric Papillary Adenocarcinoma and Rosai-Dorfman Disease. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and aspartic-type endopeptidase activity. An important paralog of this gene is PGA5.
UniProtKB/Swiss-Prot Summary for CTSE Gene
May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.