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Aliases for CTSE Gene

Aliases for CTSE Gene

  • Cathepsin E 2 3 5
  • EC 4 56
  • Erythrocyte Membrane Aspartic Proteinase 3
  • Slow-Moving Proteinase 3
  • EC 3.4.23 56
  • CATE 3

External Ids for CTSE Gene

Previous GeneCards Identifiers for CTSE Gene

  • GC01U990032
  • GC01P202860
  • GC01P204484
  • GC01P206319
  • GC01P177247

Summaries for CTSE Gene

Entrez Gene Summary for CTSE Gene

  • This gene encodes a member of the A1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme, an aspartic endopeptidase, may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. [provided by RefSeq, Nov 2015]

GeneCards Summary for CTSE Gene

CTSE (Cathepsin E) is a Protein Coding gene. Diseases associated with CTSE include Gastric Adenocarcinoma and Rosai-Dorfman Disease. Among its related pathways are Innate Immune System and MHC class II antigen presentation. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and aspartic-type endopeptidase activity. An important paralog of this gene is PGA3.

UniProtKB/Swiss-Prot for CTSE Gene

  • May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.

Gene Wiki entry for CTSE Gene

Additional gene information for CTSE Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSE Gene

Genomics for CTSE Gene

GeneHancer (GH) Regulatory Elements for CTSE Gene

Promoters and enhancers for CTSE Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I206020 Promoter/Enhancer 1.1 EPDnew ENCODE 550.8 +1.5 1462 4.1 RXRA JUN TEAD4 TAL1 CBFA2T3 ZNF395 TCF12 HNF4G NR2C1 CBFA2T2 CTSE PM20D1 RAB7B
GH01I206046 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.6 -26.5 -26478 7.8 HDGF PKNOX1 FOXA2 ARID4B DMAP1 IRF4 ZNF48 ETS1 ZNF207 ZNF143 RHEX ELK4 EIF2D ENSG00000252692 RPL7AP20 CTSE ENSG00000226780 AVPR1B SLC26A9 TMCC2
GH01I206106 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.9 -82.7 -82707 0.4 HDAC1 CTCF RB1 ZNF449 ARNT ARID4B KLF17 IRF4 RAD21 RELA ENSG00000252692 CTSE NUCKS1 IKBKE RAB29 AVPR1B
GH01I206093 Promoter/Enhancer 1.2 EPDnew ENCODE dbSUPER 11 -70.3 -70307 1.3 MITF POLR2A BHLHE40 USF2 RHEX AVPR1B ENSG00000226780 CTSE ENSG00000252692
GH01I206113 Enhancer 0.9 ENCODE dbSUPER 11.2 -89.5 -89480 0.7 ELF3 SOX13 GATAD2A PKNOX1 ZNF687 SAP130 HLF ARID4B CEBPG ELF1 CTSE AVPR1B ENSG00000252692
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CTSE on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CTSE gene promoter:

Genomic Locations for CTSE Gene

Genomic Locations for CTSE Gene
14,646 bases
Minus strand

Genomic View for CTSE Gene

Genes around CTSE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTSE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTSE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSE Gene

Proteins for CTSE Gene

  • Protein details for CTSE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cathepsin E
    Protein Accession:
    Secondary Accessions:
    • Q5TZ01
    • Q5TZ02
    • Q9NY58
    • Q9UCE3
    • Q9UCE4

    Protein attributes for CTSE Gene

    401 amino acids
    Molecular mass:
    43312 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for CTSE Gene

    Alternative splice isoforms for CTSE Gene


neXtProt entry for CTSE Gene

Selected DME Specific Peptides for CTSE Gene


Post-translational modifications for CTSE Gene

  • Glycosylated. The nature of the carbohydrate chain varies between cell types. In fibroblasts, the proenzyme contains a high mannose-type oligosaccharide, while the mature enzyme contains a complex-type oligosaccharide. In erythrocyte membranes, both the proenzyme and mature enzyme contain a complex-type oligosaccharide.
  • Two forms are produced by autocatalytic cleavage, form I begins at Ile-54, form II begins at Thr-57.
  • Glycosylation at posLast=9090
  • Modification sites at PhosphoSitePlus

Other Protein References for CTSE Gene

Domains & Families for CTSE Gene

Gene Families for CTSE Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CTSE Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase A1 family.
  • Belongs to the peptidase A1 family.
genes like me logo Genes that share domains with CTSE: view

Function for CTSE Gene

Molecular function for CTSE Gene

GENATLAS Biochemistry:
cathepsin E,aspartic proteinase
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.06 mM for hemoglobin {ECO:0000269 PubMed:8346912}; KM=0.13 mM for Pro-Pro-Thr-Ile-Phe-Phe(4-NO2)-Arg-Leu {ECO:0000269 PubMed:8346912}; KM=0.04 mM for Lys-Pro-Ile-Glu-Phe-Phe(4-NO2)-Arg-Leu {ECO:0000269 PubMed:8346912};
UniProtKB/Swiss-Prot CatalyticActivity:
Similar to cathepsin D, but slightly broader specificity.
UniProtKB/Swiss-Prot Function:
May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.

Enzyme Numbers (IUBMB) for CTSE Gene

Gene Ontology (GO) - Molecular Function for CTSE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004190 aspartic-type endopeptidase activity IDA 7789521
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with CTSE: view
genes like me logo Genes that share phenotypes with CTSE: view

Animal Models for CTSE Gene

MGI Knock Outs for CTSE:

Animal Model Products

  • Taconic Biosciences Mouse Models for CTSE

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTSE Gene

Localization for CTSE Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTSE Gene

Endosome. Note=The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTSE gene
Compartment Confidence
extracellular 5
endosome 5
lysosome 4
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CTSE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IDA,IEA 7983070
GO:0070062 extracellular exosome IDA,HDA 23376485
genes like me logo Genes that share ontologies with CTSE: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CTSE Gene

Pathways & Interactions for CTSE Gene

genes like me logo Genes that share pathways with CTSE: view

Pathways by source for CTSE Gene

1 GeneTex pathway for CTSE Gene
1 KEGG pathway for CTSE Gene

Gene Ontology (GO) - Biological Process for CTSE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007586 digestion TAS 2674141
GO:0016540 protein autoprocessing IEA --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II IDA 8765029
GO:0030163 protein catabolic process IBA --
genes like me logo Genes that share ontologies with CTSE: view

No data available for SIGNOR curated interactions for CTSE Gene

Drugs & Compounds for CTSE Gene

(5) Drugs for CTSE Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for CTSE Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CTSE: view

Transcripts for CTSE Gene

Unigene Clusters for CTSE Gene

Cathepsin E:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTSE Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: -
SP2: - -
SP4: - -

Relevant External Links for CTSE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTSE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTSE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTSE Gene

This gene is overexpressed in Stomach (x41.1) and Lung (x6.0).

Protein differential expression in normal tissues from HIPED for CTSE Gene

This gene is overexpressed in Stomach (42.8), Cardia (17.1), and Lung (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CTSE Gene

NURSA nuclear receptor signaling pathways regulating expression of CTSE Gene:


SOURCE GeneReport for Unigene cluster for CTSE Gene:


mRNA Expression by UniProt/SwissProt for CTSE Gene:

Tissue specificity: Expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. Not expressed in resting B-lymphocytes.

Evidence on tissue expression from TISSUES for CTSE Gene

  • Stomach(4.8)
  • Blood(4.5)
  • Intestine(4.4)
  • Nervous system(4.2)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with CTSE: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTSE Gene

Orthologs for CTSE Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CTSE Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CTSE 33 34
  • 99.58 (n)
(Canis familiaris)
Mammalia CTSE 33 34
  • 87.12 (n)
(Rattus norvegicus)
Mammalia Ctse 33
  • 84.39 (n)
(Mus musculus)
Mammalia Ctse 33 16 34
  • 83.33 (n)
(Monodelphis domestica)
Mammalia CTSE 34
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 42 (a)
-- 34
  • 35 (a)
(Gallus gallus)
Aves CTSE 33 34
  • 69.94 (n)
(Anolis carolinensis)
Reptilia CTSE 34
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ctse 33
  • 67.2 (n)
(Danio rerio)
Actinopterygii nots 34
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13095 35
  • 45 (a)
Bace 34
  • 44 (a)
pcl 35 34
  • 43 (a)
CG17134 35 34
  • 42 (a)
CG5863 35 34
  • 42 (a)
CG17283 35 34
  • 40 (a)
CG6508 35 34
  • 40 (a)
CG10104 35
  • 39 (a)
CG33128 34
  • 38 (a)
CG5860 35 34
  • 36 (a)
CG31661 34
  • 32 (a)
CG31926 34
  • 32 (a)
CG31928 34
  • 31 (a)
(Caenorhabditis elegans)
Secernentea asp-4 35
  • 45 (a)
asp-3 35
  • 42 (a)
Y39B6A.21 35
  • 35 (a)
asp-2 35 34
  • 34 (a)
asp-6 35 34
  • 34 (a)
C11D2.2 35
  • 34 (a)
asp-5 35 34
  • 33 (a)
Y39B6A.23 35
  • 33 (a)
asp-1 34
  • 33 (a)
asp-9 34
  • 33 (a)
C15C8.3 35
  • 32 (a)
F21F8.4 35
  • 32 (a)
F59D6.3 35
  • 32 (a)
asp-12 34
  • 32 (a)
asp-17 34
  • 32 (a)
Y39B6A.24 35
  • 31 (a)
asp-16 34
  • 31 (a)
asp-18 34
  • 31 (a)
F28A12.4 35
  • 30 (a)
asp-10 34
  • 30 (a)
F59D6.2 35
  • 29 (a)
Y39B6A.22 35
  • 29 (a)
asp-15 34
  • 28 (a)
asp-7 34
  • 28 (a)
asp-19 34
  • 27 (a)
asp-13 34
  • 26 (a)
asp-8 34
  • 23 (a)
asp-14 34
  • 19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PEP4 34
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10126 34
  • 43 (a)
Species where no ortholog for CTSE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTSE Gene

Gene Tree for CTSE (if available)
Gene Tree for CTSE (if available)

Paralogs for CTSE Gene

Paralogs for CTSE Gene

(8) SIMAP similar genes for CTSE Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CTSE: view

Variants for CTSE Gene

Sequence variations from dbSNP and Humsavar for CTSE Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs193920960 uncertain-significance, Malignant tumor of prostate 206,022,174(-) C/T coding_sequence_variant, missense_variant
rs1000034488 -- 206,025,202(-) C/A upstream_transcript_variant
rs1000120987 -- 206,024,091(-) C/A upstream_transcript_variant
rs1000134354 -- 206,020,195(-) A/G intron_variant
rs1000407214 -- 206,024,930(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CTSE Gene

Variant ID Type Subtype PubMed ID
dgv786n54 CNV loss 21841781
dgv787n54 CNV loss 21841781
dgv788n54 CNV loss 21841781
dgv789n54 CNV loss 21841781
esv3578387 CNV loss 25503493
esv3588649 CNV loss 21293372
esv3588654 CNV loss 21293372
nsv549060 CNV loss 21841781

Variation tolerance for CTSE Gene

Residual Variation Intolerance Score: 80.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.38; 63.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CTSE Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTSE Gene

Disorders for CTSE Gene

MalaCards: The human disease database

(4) MalaCards diseases for CTSE Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gastric adenocarcinoma
  • adenocarcinoma of stomach
rosai-dorfman disease
  • histiocytosis with joint contractures and sensorineural deafness
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
pancreas adenocarcinoma
  • pancreatic adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards
Search CTSE in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CTSE

genes like me logo Genes that share disorders with CTSE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTSE Gene

Publications for CTSE Gene

  1. An alternatively spliced variant of cathepsin E in human gastric adenocarcinoma cells. (PMID: 12531480) Tatnell PJ … Kay J (Biochimica et biophysica acta 2003) 3 4 22 58
  2. Regulation of human and mouse procathepsin E gene expression. (PMID: 11322887) Cook M … Tatnell PJ (European journal of biochemistry 2001) 3 4 22 58
  3. Regulation of cathepsin E expression during human B cell differentiation in vitro. (PMID: 8765029) Sealy L … Chain B (European journal of immunology 1996) 3 4 22 58
  4. Monomeric human cathepsin E. (PMID: 7789521) Fowler SD … Tatnell PJ (FEBS letters 1995) 3 4 22 58
  5. Human gastric cathepsin E gene. Multiple transcripts result from alternative polyadenylation of the primary transcripts of a single gene locus at 1q31-q32. (PMID: 1370478) Azuma T … Taggart RT (The Journal of biological chemistry 1992) 3 4 22 58

Products for CTSE Gene

Sources for CTSE Gene

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