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Aliases for CTRC Gene

Aliases for CTRC Gene

  • Chymotrypsin C 2 3 5
  • Caldecrin 2 3 4
  • Elastase 4 2 3
  • CLCR 3 4
  • Serum Calcium Decreasing Factor 3
  • Chymotrypsin C (Caldecrin) 2
  • Chymotrypsin-C 3
  • Elastase IV 3
  • EC 4
  • EC 3.4.21 56
  • ELA4 3

External Ids for CTRC Gene

Previous GeneCards Identifiers for CTRC Gene

  • GC01P015162
  • GC01P014943
  • GC01P015033
  • GC01P015127
  • GC01P015510
  • GC01P015637
  • GC01P015764
  • GC01P014284

Summaries for CTRC Gene

Entrez Gene Summary for CTRC Gene

  • This gene encodes a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for CTRC Gene

CTRC (Chymotrypsin C) is a Protein Coding gene. Diseases associated with CTRC include Pancreatitis, Hereditary and Tropical Calcific Pancreatitis. Among its related pathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and peptidase activity. An important paralog of this gene is CELA2A.

UniProtKB/Swiss-Prot for CTRC Gene

  • Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity.

Gene Wiki entry for CTRC Gene

Additional gene information for CTRC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTRC Gene

Genomics for CTRC Gene

GeneHancer (GH) Regulatory Elements for CTRC Gene

Promoters and enhancers for CTRC Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I015438 Promoter 0.5 EPDnew 550.8 0.0 -15 0.1 CTRC GC01M015414
GH01I015406 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.3 -24.8 -24795 13.8 HDGF PKNOX1 SIN3A IRF4 ZNF143 FOS SP3 JUNB ZNF592 RFX3 EFHD2 LOC101927441 SPEN CTRC LOC101927417 FHAD1 CASP9 PLEKHM2 ENSG00000224621 DDI2
GH01I015322 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.8 -114.1 -114078 2.7 HDAC1 PKNOX1 RB1 ARNT ZBTB40 RAD21 RFX5 TCF12 ZNF766 ARID2 FHAD1 CTRC CASP9 EFHD2 PLEKHM2 ENSG00000236045 PIR39012
GH01I015454 Promoter/Enhancer 1.5 EPDnew FANTOM5 ENCODE 6.5 +18.0 18002 3 HDAC1 TCF12 CREM NFYA ZBTB2 NFYC CEBPB MTA1 SMARCA4 IKZF1 CELA2A CTRC CASP9
GH01I015128 Enhancer 0.9 ENCODE dbSUPER 10.8 -309.7 -309739 0.2 DRAP1 CTCF ZNF792 SAP130 RB1 ARID4B SIN3A ZNF2 RAD21 SMC3 FHAD1 CTRC LOC101927417 TMEM51-AS1 GC01M015029
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CTRC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CTRC gene promoter:

Genomic Locations for CTRC Gene

Genomic Locations for CTRC Gene
10,809 bases
Plus strand

Genomic View for CTRC Gene

Genes around CTRC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTRC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTRC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTRC Gene

Proteins for CTRC Gene

  • Protein details for CTRC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K082
    • O00765
    • Q9NUH5

    Protein attributes for CTRC Gene

    268 amino acids
    Molecular mass:
    29484 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CTRC Gene

neXtProt entry for CTRC Gene

Selected DME Specific Peptides for CTRC Gene


Post-translational modifications for CTRC Gene

  • Glycosylation at posLast=2525, posLast=5252, and Asn226

Other Protein References for CTRC Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CTRC (Chymotrypsin C/CTRC)

Protein Products

Domains & Families for CTRC Gene

Gene Families for CTRC Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CTRC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family. Elastase subfamily.
  • Belongs to the peptidase S1 family. Elastase subfamily.
genes like me logo Genes that share domains with CTRC: view

Function for CTRC Gene

Molecular function for CTRC Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: Leu- -Xaa, Tyr- -Xaa, Phe- -Xaa, Met- -Xaa, Trp- -Xaa, Gln- -Xaa, Asn- -Xaa.
UniProtKB/Swiss-Prot Function:
Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity.

Enzyme Numbers (IUBMB) for CTRC Gene

Phenotypes From GWAS Catalog for CTRC Gene

Gene Ontology (GO) - Molecular Function for CTRC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008233 peptidase activity TAS --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CTRC: view
genes like me logo Genes that share phenotypes with CTRC: view

Human Phenotype Ontology for CTRC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for CTRC

Inhibitory RNA Products

Clone Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CTRC Gene

Localization for CTRC Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTRC gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CTRC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with CTRC: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CTRC Gene

Pathways & Interactions for CTRC Gene

genes like me logo Genes that share pathways with CTRC: view

Gene Ontology (GO) - Biological Process for CTRC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,TAS --
GO:0009235 cobalamin metabolic process TAS --
genes like me logo Genes that share ontologies with CTRC: view

No data available for SIGNOR curated interactions for CTRC Gene

Drugs & Compounds for CTRC Gene

(2) Drugs for CTRC Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CTRC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CTRC: view

Transcripts for CTRC Gene

Unigene Clusters for CTRC Gene

Chymotrypsin C (caldecrin):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTRC Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1: -
SP2: - - -
SP3: - -

Relevant External Links for CTRC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTRC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTRC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTRC Gene

This gene is overexpressed in Pancreas (x52.8).

Protein differential expression in normal tissues from HIPED for CTRC Gene

This gene is overexpressed in Pancreatic juice (66.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CTRC Gene

Protein tissue co-expression partners for CTRC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CTRC Gene:


SOURCE GeneReport for Unigene cluster for CTRC Gene:


mRNA Expression by UniProt/SwissProt for CTRC Gene:

Tissue specificity: Pancreas.

Evidence on tissue expression from TISSUES for CTRC Gene

  • Pancreas(4.9)
  • Urine(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CTRC Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • nervous
  • respiratory
  • urinary
Head and neck:
  • brain
  • ear
  • eye
  • head
  • diaphragm
  • esophagus
  • heart
  • lung
  • intestine
  • kidney
  • large intestine
  • pancreas
  • small intestine
  • stomach
  • blood
  • blood vessel
  • coagulation system
  • peripheral nerve
  • peripheral nervous system
  • red blood cell
  • white blood cell
genes like me logo Genes that share expression patterns with CTRC: view

Orthologs for CTRC Gene

This gene was present in the common ancestor of animals.

Orthologs for CTRC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CTRC 33 34
  • 98.38 (n)
(Canis familiaris)
Mammalia CTRC 33 34
  • 84.52 (n)
(Bos Taurus)
Mammalia CTRC 33 34
  • 83.46 (n)
(Mus musculus)
Mammalia Ctrc 33 16 34
  • 79.1 (n)
(Rattus norvegicus)
Mammalia Ctrc 33
  • 78.11 (n)
(Ornithorhynchus anatinus)
Mammalia CTRC 34
  • 75 (a)
(Monodelphis domestica)
Mammalia CTRC 34
  • 68 (a)
(Gallus gallus)
Aves CTRC 33 34
  • 71.21 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ctrc 33
  • 66.41 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23779 33
(Danio rerio)
Actinopterygii ela2 34
  • 59 (a)
ela2l 34
  • 58 (a)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta CG10472 35
  • 37 (a)
CG7542 35
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 23 (a)
Species where no ortholog for CTRC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTRC Gene

Gene Tree for CTRC (if available)
Gene Tree for CTRC (if available)

Paralogs for CTRC Gene

Variants for CTRC Gene

Sequence variations from dbSNP and Humsavar for CTRC Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1060504817 likely-benign, Hereditary pancreatitis 15,438,479(+) T/C coding_sequence_variant, synonymous_variant
rs111790169 benign, Hereditary pancreatitis 15,444,600(+) C/T intron_variant
rs113087202 benign, Hereditary pancreatitis 15,444,667(+) G/A coding_sequence_variant, intron_variant, synonymous_variant
rs121909293 risk-factor, conflicting-interpretations-of-pathogenicity, likely-pathogenic, Pancreatitis, chronic, susceptibility to, Hereditary pancreatitis, not specified, Pancreatitis, hereditary (PCTT) [MIM:167800] 15,445,717(+) C/T coding_sequence_variant, missense_variant
rs121909294 risk-factor, pathogenic, Pancreatitis, chronic, susceptibility to, Hereditary pancreatitis 15,440,524(+) G/A/T coding_sequence_variant, missense_variant, stop_gained

Structural Variations from Database of Genomic Variants (DGV) for CTRC Gene

Variant ID Type Subtype PubMed ID
esv2117572 CNV deletion 18987734
nsv833536 CNV loss 17160897

Variation tolerance for CTRC Gene

Residual Variation Intolerance Score: 84.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.63; 45.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CTRC Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTRC Gene

Disorders for CTRC Gene

MalaCards: The human disease database

(6) MalaCards diseases for CTRC Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CTRC in MalaCards View complete list of genes associated with diseases


  • Pancreatitis, hereditary (PCTT) [MIM:167800]: A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks. {ECO:0000269 PubMed:18059268, ECO:0000269 PubMed:18172691, ECO:0000269 PubMed:22580415, ECO:0000269 PubMed:22942235}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Loss-of-function CTRC variants predispose to pancreatitis by diminishing its protective trypsin-degrading activity (PubMed:18059268). They cause loss of function by one or more of three mechanisms: reduced secretion, catalytic defect and increased degradation by trypsin (PubMed:22942235). {ECO:0000269 PubMed:18059268, ECO:0000269 PubMed:22942235}.

Additional Disease Information for CTRC

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CTRC: view

No data available for Genatlas for CTRC Gene

Publications for CTRC Gene

  1. Association of novel chymotrypsin C gene variations and haplotypes in patients with chronic pancreatitis in Chinese in Taiwan. (PMID: 19407484) Chang MC … Wong JM (Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2009) 3 4 22 44 58
  2. Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis. (PMID: 18059268) Rosendahl J … Sahin-Tóth M (Nature genetics 2008) 3 4 22 44 58
  3. Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis. (PMID: 18172691) Masson E … Férec C (Human genetics 2008) 3 4 22 44 58
  4. Molecular cloning and expression of human caldecrin. (PMID: 8635596) Tomomura A … Saheki T (FEBS letters 1996) 2 3 4 22 58
  5. Caldecrin is a novel-type serine protease expressed in pancreas, but its homologue, elastase IV, is an artifact during cloning derived from caldecrin gene. (PMID: 9538241) Yoshino-Yasuda I … Saheki T (Journal of biochemistry 1998) 3 4 22 58

Products for CTRC Gene

Sources for CTRC Gene

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