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Aliases for CTRB2 Gene

Aliases for CTRB2 Gene

  • Chymotrypsinogen B2 2 3 3 5
  • Chymotrypsin B2 3
  • EC 4

External Ids for CTRB2 Gene

Previous GeneCards Identifiers for CTRB2 Gene

  • GC00U990074
  • GC16M073796
  • GC16M075237
  • GC16M060989

Summaries for CTRB2 Gene

GeneCards Summary for CTRB2 Gene

CTRB2 (Chymotrypsinogen B2) is a Protein Coding gene. Among its related pathways are Metabolism and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is CTRB1.

Additional gene information for CTRB2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTRB2 Gene

Genomics for CTRB2 Gene

GeneHancer (GH) Regulatory Elements for CTRB2 Gene

Promoters and enhancers for CTRB2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J075206 Promoter/Enhancer 1.1 EPDnew ENCODE dbSUPER 663.6 -0.3 -260 1 ZFHX2 EGR2 CTRB2 BCAR1 ENSG00000261783 CTRB1
GH16J075207 Enhancer 0.2 ENCODE 663.3 -1.5 -1544 1.5 CTRB2 ENSG00000261783 BCAR1 ADAT1 CTRB1
GH16J075233 Enhancer 1.2 ENCODE dbSUPER 22.7 -27.1 -27098 1.7 HDGF CLOCK ATF1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 BCAR1 CTRB2 RFWD3 ENSG00000261783 LOC100506281 ENSG00000280152
GH16J075215 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 13.2 -11.0 -10965 5.1 MYRF IRF2 AHR TFAP4 FOXA2 EBF1 BATF IRF4 THRB TEAD3 CTRB1 CTRB2 BCAR1 ENSG00000261783 CFDP1
GH16J075260 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 8.1 -57.5 -57548 7.9 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 BCAR1 ENSG00000259972 CTRB2 ENSG00000261783 TMEM170A TERF2IP LOC105371344
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CTRB2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CTRB2 gene promoter:
  • Tal-1beta
  • ITF-2
  • PPAR-gamma2
  • PPAR-gamma1
  • NF-1
  • GATA-1
  • GATA-2
  • GATA-3
  • SREBP-1a
  • SREBP-1b

Genomic Locations for CTRB2 Gene

Genomic Locations for CTRB2 Gene
3,090 bases
Minus strand
3,090 bases
Minus strand

Genomic View for CTRB2 Gene

Genes around CTRB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTRB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTRB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTRB2 Gene

Proteins for CTRB2 Gene

  • Protein details for CTRB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Chymotrypsinogen B2
    Protein Accession:
    Secondary Accessions:
    • A8K707

    Protein attributes for CTRB2 Gene

    263 amino acids
    Molecular mass:
    27923 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CTRB2 Gene

Post-translational modifications for CTRB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTRB2 Gene

No data available for DME Specific Peptides for CTRB2 Gene

Domains & Families for CTRB2 Gene

Gene Families for CTRB2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CTRB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with CTRB2: view

Function for CTRB2 Gene

Molecular function for CTRB2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: Tyr- -Xaa, Trp- -Xaa, Phe- -Xaa, Leu- -Xaa.

Enzyme Numbers (IUBMB) for CTRB2 Gene

Phenotypes From GWAS Catalog for CTRB2 Gene

Gene Ontology (GO) - Molecular Function for CTRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity TAS --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity TAS --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CTRB2: view

Animal Model Products

CRISPR Products

miRNA for CTRB2 Gene

miRTarBase miRNAs that target CTRB2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTRB2

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CTRB2 Gene

Localization for CTRB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTRB2 Gene

Secreted, extracellular space.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTRB2 gene
Compartment Confidence
extracellular 5
lysosome 1

Gene Ontology (GO) - Cellular Components for CTRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CTRB2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CTRB2 Gene

Pathways & Interactions for CTRB2 Gene

genes like me logo Genes that share pathways with CTRB2: view

Gene Ontology (GO) - Biological Process for CTRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007586 digestion IEA --
GO:0009235 cobalamin metabolic process TAS --
GO:0022617 extracellular matrix disassembly TAS --
genes like me logo Genes that share ontologies with CTRB2: view

No data available for SIGNOR curated interactions for CTRB2 Gene

Drugs & Compounds for CTRB2 Gene

No Compound Related Data Available

Transcripts for CTRB2 Gene

mRNA/cDNA for CTRB2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(375) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CTRB2 Gene

Chymotrypsinogen B2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTRB2

Alternative Splicing Database (ASD) splice patterns (SP) for CTRB2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7
SP3: - -

Relevant External Links for CTRB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTRB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTRB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTRB2 Gene

This gene is overexpressed in Pancreas (x52.9).

Protein differential expression in normal tissues from HIPED for CTRB2 Gene

This gene is overexpressed in Pancreatic juice (59.1) and Pancreas (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CTRB2 Gene

Protein tissue co-expression partners for CTRB2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CTRB2 Gene:


SOURCE GeneReport for Unigene cluster for CTRB2 Gene:


Evidence on tissue expression from TISSUES for CTRB2 Gene

  • Pancreas(5)
genes like me logo Genes that share expression patterns with CTRB2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTRB2 Gene

Orthologs for CTRB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CTRB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CTRB2 34
  • 96 (a)
(Canis familiaris)
Mammalia LOC479649 33
  • 87.33 (n)
CTRB1 34
  • 87 (a)
-- 34
  • 85 (a)
-- 34
  • 72 (a)
(Mus musculus)
Mammalia Ctrb1 16 34 33
  • 83.9 (n)
(Rattus norvegicus)
Mammalia Ctrb1 33
  • 83.78 (n)
(Bos Taurus)
Mammalia LOC100848132 33
  • 83.4 (n)
-- 34
  • 68 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 73 (a)
-- 34
  • 54 (a)
-- 34
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 69 (a)
(Gallus gallus)
Aves LOC431235 33
  • 71.74 (n)
-- 34
  • 69 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ctrl 33
  • 64.89 (n)
(Danio rerio)
Actinopterygii zgc:136461 34 33
  • 70.09 (n)
zgc:112160 34
  • 64 (a)
ctrb1 34
  • 38 (a)
fruit fly
(Drosophila melanogaster)
Insecta Jon99Ciii 34
  • 32 (a)
Jon99Cii 34
  • 32 (a)
Jon99Fii 34
  • 31 (a)
Jon66Cii 34
  • 31 (a)
Jon99Fi 34
  • 31 (a)
Jon44E 34
  • 31 (a)
CG10469 34
  • 30 (a)
Jon25Bi 34
  • 30 (a)
yip7 34
  • 30 (a)
Jon25Biii 34
  • 30 (a)
CG8952 34
  • 30 (a)
Jon66Ci 34
  • 30 (a)
CG7542 34
  • 29 (a)
Jon99Ci 34
  • 29 (a)
Jon65Aii 34
  • 29 (a)
CG18179 34
  • 28 (a)
Jon65Aiii 34
  • 28 (a)
CG10477 34
  • 28 (a)
CG10472 34
  • 28 (a)
Jon65Aiv 34
  • 27 (a)
Jon65Ai 34
  • 27 (a)
Jon25Bii 34
  • 27 (a)
CG18180 34
  • 27 (a)
CG8329 34
  • 27 (a)
CG11529 34
  • 27 (a)
CG3088 34
  • 26 (a)
CG6462 34
  • 25 (a)
sphinx2 34
  • 22 (a)
sphinx1 34
  • 21 (a)
Jon74E 34
  • 18 (a)
CG6592 34
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
Species where no ortholog for CTRB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTRB2 Gene

Gene Tree for CTRB2 (if available)
Gene Tree for CTRB2 (if available)
Evolutionary constrained regions (ECRs) for CTRB2: view image

Paralogs for CTRB2 Gene

Paralogs for CTRB2 Gene Pseudogenes for CTRB2 Gene

genes like me logo Genes that share paralogs with CTRB2: view

Variants for CTRB2 Gene

Sequence variations from dbSNP and Humsavar for CTRB2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000012029 -- 75,206,239(-) C/G intron_variant
rs1000043253 -- 75,205,999(-) G/A intron_variant
rs1000649772 -- 75,203,954(-) T/C downstream_transcript_variant
rs1000715297 -- 75,209,061(-) C/G upstream_transcript_variant
rs1001457207 -- 75,206,662(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CTRB2 Gene

Variant ID Type Subtype PubMed ID
dgv1638e59 OTHER inversion 20981092
dgv20n50 OTHER inversion 21212237
dgv25n47 OTHER inversion 21111241
dgv51n16 OTHER inversion 17901297
esv1000574 OTHER inversion 20482838
esv1356452 OTHER inversion 17803354
esv2504659 OTHER inversion 19546169
esv3582318 CNV loss 25503493
esv3582319 CNV loss 25503493
esv3582320 CNV loss 25503493
nsv482197 CNV gain 20164927
nsv516504 CNV gain+loss 19592680
nsv523405 CNV loss 19592680
nsv7286 OTHER inversion 18451855
nsv833282 CNV gain+loss 17160897

Variation tolerance for CTRB2 Gene

Gene Damage Index Score: 0.78; 16.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CTRB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTRB2 Gene

Disorders for CTRB2 Gene

Additional Disease Information for CTRB2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CTRB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTRB2 Gene

Publications for CTRB2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Genomic cloning and partial characterization of human chymotrypsinogen gene. (PMID: 8186414) Hou DX … Soeda E (The Japanese journal of human genetics 1993) 2 3 58
  3. Molecular cloning and nucleotide sequence of human pancreatic prechymotrypsinogen cDNA. (PMID: 2917002) Tomita N … Matsubara K (Biochemical and biophysical research communications 1989) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. (PMID: 25086665) Wolpin BM … Amundadottir LT (Nature genetics 2014) 3 58

Products for CTRB2 Gene

Sources for CTRB2 Gene

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