The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] See more...

Aliases for CTNNBIP1 Gene

Aliases for CTNNBIP1 Gene

  • Catenin Beta Interacting Protein 1 2 3 5
  • Inhibitor Of Beta-Catenin And Tcf-4 2 3 4
  • Beta-Catenin-Interacting Protein ICAT 2 3
  • Beta-Catenin-Interacting Protein 1 3 4
  • ICAT 3 4
  • Catenin, Beta-Interacting Protein 1 2
  • Catenin, Beta Interacting Protein 1 2

External Ids for CTNNBIP1 Gene

Previous GeneCards Identifiers for CTNNBIP1 Gene

  • GC01M009869
  • GC01M009752
  • GC01M009517
  • GC01M009617
  • GC01M009842
  • GC01M009064
  • GC01M009908

Summaries for CTNNBIP1 Gene

Entrez Gene Summary for CTNNBIP1 Gene

  • The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CTNNBIP1 Gene

CTNNBIP1 (Catenin Beta Interacting Protein 1) is a Protein Coding gene. Diseases associated with CTNNBIP1 include Keratocystic Odontogenic Tumor. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. Gene Ontology (GO) annotations related to this gene include beta-catenin binding and armadillo repeat domain binding. An important paralog of this gene is LZIC.

UniProtKB/Swiss-Prot Summary for CTNNBIP1 Gene

  • Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway.

Gene Wiki entry for CTNNBIP1 Gene

Additional gene information for CTNNBIP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CTNNBIP1 Gene

Genomics for CTNNBIP1 Gene

GeneHancer (GH) Regulatory Elements for CTNNBIP1 Gene

Promoters and enhancers for CTNNBIP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J009908 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 763.9 -0.5 -502 4.2 ZNF785 ZBTB40 SP1 ZBTB6 MLX POLR2A CREB1 MIXL1 MYC CC2D1A CTNNBIP1 DFFA CENPS RBP7 lnc-CTNNBIP1-1
GH01J009909 Promoter/Enhancer 0.5 Ensembl dbSUPER 763.9 +1.8 1835 0.2 CTNNBIP1 lnc-NMNAT1-2
GH01J009877 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 22.2 +32.5 32535 2 ZNF217 MNT SMARCC1 CTBP1 ZSCAN4 POLR2A RFX5 SIN3A ELF1 FOS CLSTN1 CTNNBIP1 ENSG00000223989 ENSG00000228150 LZIC NMNAT1 RN7SKP269 piR-42072 piR-56341-001
GH01J009651 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 10.4 +256.6 256595 5.9 POLR2A CC2D1A ETV6 RELA L3MBTL2 MAX NKRF MLLT1 ZNF687 PRDM1 PIK3CD-AS1 PIK3CD RERE CTNNBIP1 RF00017-046 piR-33270-001
GH01J009792 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.5 +107.8 107835 21 CTCF CTBP1 ZNF362 ZNF701 ZNF121 TEAD4 CBFA2T2 MLLT1 SP7 ZSCAN21 CLSTN1 NMNAT1 ENSG00000223989 PIK3CD-AS2 CTNNBIP1 ENSG00000228150 LZIC RN7SKP269 MIR34AHG UBE4B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CTNNBIP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CTNNBIP1 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • MyoD
  • p300
  • Sp1

Genomic Locations for CTNNBIP1 Gene

Genomic Locations for CTNNBIP1 Gene
chr1:9,848,276-9,910,336
(GRCh38/hg38)
Size:
62,061 bases
Orientation:
Minus strand
chr1:9,908,334-9,970,394
(GRCh37/hg19)
Size:
62,061 bases
Orientation:
Minus strand

Genomic View for CTNNBIP1 Gene

Genes around CTNNBIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTNNBIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTNNBIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTNNBIP1 Gene

Proteins for CTNNBIP1 Gene

  • Protein details for CTNNBIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSA3-CNBP1_HUMAN
    Recommended name:
    Beta-catenin-interacting protein 1
    Protein Accession:
    Q9NSA3
    Secondary Accessions:
    • Q5T4V2

    Protein attributes for CTNNBIP1 Gene

    Size:
    81 amino acids
    Molecular mass:
    9170 Da
    Quaternary structure:
    • Binds CTNNB1.

    Three dimensional structures from OCA and Proteopedia for CTNNBIP1 Gene

neXtProt entry for CTNNBIP1 Gene

Post-translational modifications for CTNNBIP1 Gene

  • Ubiquitination at Lys19
  • Modification sites at PhosphoSitePlus

Other Protein References for CTNNBIP1 Gene

No data available for DME Specific Peptides for CTNNBIP1 Gene

Domains & Families for CTNNBIP1 Gene

Gene Families for CTNNBIP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CTNNBIP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CTNNBIP1 Gene

GenScript: Design optimal peptide antigens:
  • Inhibitor of beta-catenin and Tcf-4 (CNBP1_HUMAN)
  • Catenin, beta interacting protein 1, isoform CRA_a (Q5T4V2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NSA3

UniProtKB/Swiss-Prot:

CNBP1_HUMAN :
  • Belongs to the CTNNBIP1 family.
Family:
  • Belongs to the CTNNBIP1 family.
genes like me logo Genes that share domains with CTNNBIP1: view

Function for CTNNBIP1 Gene

Molecular function for CTNNBIP1 Gene

UniProtKB/Swiss-Prot Function:
Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway.

Phenotypes From GWAS Catalog for CTNNBIP1 Gene

Gene Ontology (GO) - Molecular Function for CTNNBIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12408824
GO:0008013 beta-catenin binding IPI 12408825
GO:0070016 armadillo repeat domain binding IPI 12408825
genes like me logo Genes that share ontologies with CTNNBIP1: view
genes like me logo Genes that share phenotypes with CTNNBIP1: view

Animal Models for CTNNBIP1 Gene

MGI Knock Outs for CTNNBIP1:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTNNBIP1 Gene

Localization for CTNNBIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTNNBIP1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTNNBIP1 gene
Compartment Confidence
nucleus 4
cytosol 4
mitochondrion 2
plasma membrane 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Mitochondria (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CTNNBIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IBA 18287330
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 19569129
GO:0005829 cytosol IDA 18287330
GO:0030877 beta-catenin destruction complex IDA 16188939
genes like me logo Genes that share ontologies with CTNNBIP1: view

Pathways & Interactions for CTNNBIP1 Gene

genes like me logo Genes that share pathways with CTNNBIP1: view

Pathways by source for CTNNBIP1 Gene

SIGNOR curated interactions for CTNNBIP1 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for CTNNBIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001658 branching involved in ureteric bud morphogenesis IEA --
GO:0002528 regulation of vascular permeability involved in acute inflammatory response IMP 18287330
GO:0009952 anterior/posterior pattern specification IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0030178 negative regulation of Wnt signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with CTNNBIP1: view

Drugs & Compounds for CTNNBIP1 Gene

No Compound Related Data Available

Transcripts for CTNNBIP1 Gene

mRNA/cDNA for CTNNBIP1 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTNNBIP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2: - - -
SP3:
SP4: - - - - -

Relevant External Links for CTNNBIP1 Gene

GeneLoc Exon Structure for
CTNNBIP1
ECgene alternative splicing isoforms for
CTNNBIP1

Expression for CTNNBIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTNNBIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTNNBIP1 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x9.4) and Skin - Not Sun Exposed (Suprapubic) (x6.7).

Protein differential expression in normal tissues from HIPED for CTNNBIP1 Gene

This gene is overexpressed in Cervix (47.9) and Skin (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CTNNBIP1 Gene



NURSA nuclear receptor signaling pathways regulating expression of CTNNBIP1 Gene:

CTNNBIP1

SOURCE GeneReport for Unigene cluster for CTNNBIP1 Gene:

Hs.463759

Evidence on tissue expression from TISSUES for CTNNBIP1 Gene

  • Lung(4.6)
  • Nervous system(4.6)
  • Stomach(2)
genes like me logo Genes that share expression patterns with CTNNBIP1: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTNNBIP1 Gene

Orthologs for CTNNBIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CTNNBIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTNNBIP1 33 32
  • 100 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CTNNBIP1 33
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CTNNBIP1 33
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ctnnbip1 32
  • 95.06 (n)
mouse
(Mus musculus)
Mammalia Ctnnbip1 17 33 32
  • 93.83 (n)
cow
(Bos Taurus)
Mammalia CTNNBIP1 33 32
  • 93.83 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CTNNBIP1 33 32
  • 92.59 (n)
OneToOne
chicken
(Gallus gallus)
Aves CTNNBIP1 33 32
  • 84.77 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CTNNBIP1 33
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ctnnbip1 32
  • 81.07 (n)
zebrafish
(Danio rerio)
Actinopterygii ctnnbip1 33 32
  • 80.66 (n)
OneToOne
-- 32
Species where no ortholog for CTNNBIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTNNBIP1 Gene

ENSEMBL:
Gene Tree for CTNNBIP1 (if available)
TreeFam:
Gene Tree for CTNNBIP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CTNNBIP1: view image

Paralogs for CTNNBIP1 Gene

Paralogs for CTNNBIP1 Gene

(1) SIMAP similar genes for CTNNBIP1 Gene using alignment to 1 proteins:

  • CNBP1_HUMAN
genes like me logo Genes that share paralogs with CTNNBIP1: view

Variants for CTNNBIP1 Gene

Sequence variations from dbSNP and Humsavar for CTNNBIP1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000090783 -- 9,883,118(-) G/A intron_variant
rs1000121087 -- 9,866,372(-) A/G intron_variant
rs1000138706 -- 9,864,389(-) C/T intron_variant
rs1000195035 -- 9,866,755(-) G/C intron_variant
rs1000198497 -- 9,898,999(-) G/A/C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CTNNBIP1 Gene

Variant ID Type Subtype PubMed ID
nsv1112518 CNV deletion 24896259
nsv545380 CNV loss 21841781

Variation tolerance for CTNNBIP1 Gene

Residual Variation Intolerance Score: 57.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CTNNBIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTNNBIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTNNBIP1 Gene

Disorders for CTNNBIP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CTNNBIP1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
keratocystic odontogenic tumor
  • ktoc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CTNNBIP1

genes like me logo Genes that share disorders with CTNNBIP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTNNBIP1 Gene

Publications for CTNNBIP1 Gene

  1. Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein. (PMID: 10898789) Tago K … Akiyama T (Genes & development 2000) 2 3 4 23 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT. (PMID: 12408824) Graham TA … Xu W (Molecular cell 2002) 3 4 56
  4. ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules. (PMID: 12408825) Daniels DL … Weis WI (Molecular cell 2002) 3 4 56
  5. Mutation and expression of the beta-catenin-interacting protein ICAT in human colorectal tumors. (PMID: 12417602) Koyama T … Akiyama T (Japanese journal of clinical oncology 2002) 3 23 56

Products for CTNNBIP1 Gene

  • Biorbyt antibodies for CTNNBIP1

Sources for CTNNBIP1 Gene