CTNNB1 Gene (Protein Coding)

Catenin Beta 1

GC03P041236
GIFtS:
53
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cel... See more...

Aliases for CTNNB1 Gene

Aliases for CTNNB1 Gene

  • Catenin Beta 1 2 3 5
  • Catenin (Cadherin-Associated Protein), Beta 1, 88kDa 2 3
  • Catenin Beta-1 3 4
  • Beta-Catenin 2 4
  • Armadillo 2 3
  • CTNNB 3 4
  • Catenin (Cadherin-Associated Protein), Beta 1 (88kD) 2
  • Catenin (Cadherin-Associated Protein), Beta 1 2
  • NEDSDV 3
  • CTNNB1 5
  • MRD19 3
  • EVR7 3

External Ids for CTNNB1 Gene

Previous HGNC Symbols for CTNNB1 Gene

  • CTNNB

Previous GeneCards Identifiers for CTNNB1 Gene

  • GC03P040551
  • GC03P041054
  • GC03P041201
  • GC03P041216

Summaries for CTNNB1 Gene

Entrez Gene Summary for CTNNB1 Gene

  • The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

CIViC Summary for CTNNB1 Gene

GeneCards Summary for CTNNB1 Gene

CTNNB1 (Catenin Beta 1) is a Protein Coding gene. Diseases associated with CTNNB1 include Pilomatrixoma and Neurodevelopmental Disorder With Spastic Diplegia And Visual Defects. Among its related pathways are Association Between Physico-Chemical Features and Toxicity Associated Pathways and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and binding. An important paralog of this gene is JUP.

UniProtKB/Swiss-Prot Summary for CTNNB1 Gene

  • Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity).

Tocris Summary for CTNNB1 Gene

  • beta-catenin protein is an integral part of the canonical Wnt signaling pathway. Wnt binding to Frizzled (Fz) receptors and LRP co-receptors activates Dishevelled (Dsh) proteins; these in turn inhibit the destruction complex responsible for degrading beta-catenin, which includes GSK-3.

Gene Wiki entry for CTNNB1 Gene

Additional gene information for CTNNB1 Gene

No data available for PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CTNNB1 Gene

Genomics for CTNNB1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for CTNNB1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH03J041198 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 633.8 +6.8 6760 6.6 RNF2 SP1 GATAD2A CTCF HNRNPL TEAD4 REST ZNF629 TFE3 IKZF1 CTNNB1 ZNF619 ZNF620 RPL14 ENSG00000234287 ULK4 TRAK1 lnc-ULK4-1
GH03J041194 Enhancer 0.6 UCNEbase 606.9 +0.3 336 0.3 RNF2 BMI1 SMARCA4 CTNNB1 HSALNG0025379 lnc-ULK4-1 ULK4
GH03J042011 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 22 +819.7 819665 5 HNRNPL GATAD2A PRDM10 ZNF629 NFKBIZ ZNF692 POLR2A ZNF7 BACH1 JUND TRAK1 LOC107986077 lnc-TRAK1-1 lnc-ULK4-14 lnc-VIPR1-6 NKTR ULK4 CTNNB1 ZNF662 CCK
GH03J041158 Enhancer 1 Ensembl ENCODE 31.8 -35.3 -35340 2.8 ZNF629 ZNF692 ZNF501 ZNF140 ZBTB20 ZNF639 KLF7 ZXDB ESR1 TSHZ1 ZNF619 CTNNB1 ZNF620 ENSG00000233919 ZNF621 piR-55985-127
GH03J040456 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.4 -737.7 -737668 4.5 SP1 HNRNPL CREB1 TFE3 SIX5 POLR2A BACH1 ZHX2 JUND FOXA1 ENTPD3-AS1 RPL14 NONHSAG034829.2 ZNF619 CTNNB1 ENTPD3 lnc-RPL14-5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CTNNB1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CTNNB1

Top Transcription factor binding sites by QIAGEN in the CTNNB1 gene promoter:
  • ATF-2
  • CUTL1
  • E47
  • Evi-1
  • GATA-1
  • GATA-2
  • HOXA5
  • p300
  • p53

Genomic Locations for CTNNB1 Gene

Genomic Locations for CTNNB1 Gene
chr3:41,194,741-41,260,096
(GRCh38/hg38)
Size:
65,356 bases
Orientation:
Plus strand
chr3:41,236,328-41,301,587
(GRCh37/hg19)
Size:
65,260 bases
Orientation:
Plus strand

Genomic View for CTNNB1 Gene

Genes around CTNNB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTNNB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTNNB1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CTNNB1 Gene

Proteins for CTNNB1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CTNNB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35222-CTNB1_HUMAN
    Recommended name:
    Catenin beta-1
    Protein Accession:
    P35222
    Secondary Accessions:
    • A8K1L7
    • Q8NEW9
    • Q8NI94
    • Q9H391

    Protein attributes for CTNNB1 Gene

    Size:
    781 amino acids
    Molecular mass:
    85497 Da
    Quaternary structure:
    • Two separate complex-associated pools are found in the cytoplasm. The majority is present as component of an E-cadherin:catenin adhesion complex composed of at least E-cadherin/CDH1 and beta-catenin/CTNNB1, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Alternatively, the CTNNA1-containing complex may be linked to F-actin by other proteins such as LIMA1. Another cytoplasmic pool is part of a large complex containing AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. Wnt-dependent activation of DVL antagonizes the action of GSK3B. When GSK3B activity is inhibited the complex dissociates, CTNNB1 is dephosphorylated and is no longer targeted for destruction. The stabilized protein translocates to the nucleus, where it binds TCF/LEF-1 family members, TBP, BCL9, BCL9L and possibly also RUVBL1 and CHD8. Binds CTNNBIP and EP300. CTNNB1 forms a ternary complex with LEF1 and EP300 that is disrupted by CTNNBIP1 binding. Interacts with TAX1BP3 (via the PDZ domain); this interaction inhibits the transcriptional activity of CTNNB1. Interacts with AJAP1, BAIAP1, CARM1, CTNNA3, CXADR and PCDH11Y. Binds SLC9A3R1. Interacts with GLIS2 and MUC1. Interacts with SLC30A9. Interacts with XIRP1. Interacts directly with AXIN1; the interaction is regulated by CDK2 phosphorylation of AXIN1. Interacts with SCRIB. Interacts with RAPGEF2. Interacts with PTPRU (via the cytoplasmic juxtamembrane domain). Interacts with EMD. Interacts with TNIK and TCF7L2. Interacts with SESTD1 and TRPC4. Interacts with CAV1. Interacts with TRPV4. The TRPV4 and CTNNB1 complex can interact with CDH1. Interacts with VCL. Interacts with PTPRJ. Interacts with PKT7 and CDK2. Interacts with FAT1 (via the cytoplasmic domain). Interacts with NANOS1 and NDRG2. Interacts with isoform 1 of NEK2. Interacts with both isoform 1 and isoform 2 of CDK5. Interacts with PTK6. Interacts with SOX7; this interaction may lead to proteasomal degradation of active CTNNB1 and thus inhibition of Wnt/beta-catenin-stimulated transcription. Identified in a complex with HINT1 and MITF. Interacts with FHIT. The CTNNB1 and TCF7L2/TCF4 complex interacts with PML (isoform PML-4). Interacts with FERMT2. Identified in a complex with TCF7L2/TCF4 and FERMT2 (PubMed:29739711, PubMed:22699938). Interacts with RORA. May interact with P-cadherin/CDH3. Interacts with RNF220 (PubMed:25266658). Interacts with CTNND2 (PubMed:25807484). Interacts (via the C-terminal region) with CBY1 (PubMed:12712206, PubMed:16424001). The complex composed, at least, of APC, CTNNB1 and GSK3B interacts with JPT1; the interaction requires the inactive form of GSK3B (phosphorylated at 'Ser-9') (PubMed:25169422). Interacts with DLG5 (By similarity). Interacts with FAM53B; promoting translocation to the nucleus (PubMed:25183871). Interacts with TMEM170B (PubMed:29367600). Interacts with AHI1 (PubMed:21623382). Interacts with GID8 (PubMed:28829046). Component of an cadherin:catenin adhesion complex composed of at least of CDH26, beta-catenin/CTNNB1, alpha-catenin/CTNNA1 and p120 catenin/CTNND1 (PubMed:28051089). Forms a complex comprising APPL1, RUVBL2, APPL2, HDAC1 and HDAC2 (PubMed:19433865). Interacts with IRF2BPL; mediates the ubiquitination and degradation of CTNNB1 (PubMed:29374064). Interacts with AMFR (By similarity). Interacts with LMBR1L (PubMed:31073040). Interacts with SOX30; prevents interaction of CTNNB1 with TCF7L2/TCF4 and leads to inhibition of Wnt signaling (PubMed:29739711). Interacts with SOX9; inhibiting CTNNB1 activity by competing with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity).
    • (Microbial infection) Interacts with herpes virus 8 protein vPK; this interaction inhibits the Wnt signaling pathway.
    SequenceCaution:
    • Sequence=AAG35511.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAB93475.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CTNNB1 Gene

neXtProt entry for CTNNB1 Gene

Protein Expression for CTNNB1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CTNNB1 Gene

  • Phosphorylation at Ser-552 by AMPK promotes stabilizion of the protein, enhancing TCF/LEF-mediated transcription (By similarity). Phosphorylation by GSK3B requires prior phosphorylation of Ser-45 by another kinase. Phosphorylation proceeds then from Thr-41 to Ser-37 and Ser-33. Phosphorylated by NEK2. EGF stimulates tyrosine phosphorylation. Phosphorylation on Tyr-654 decreases CDH1 binding and enhances TBP binding. Phosphorylated on Ser-33 and Ser-37 by HIPK2 and GSK3B, this phosphorylation triggers proteasomal degradation (PubMed:25169422). Phosphorylation on Ser-191 and Ser-246 by CDK5. Phosphorylation by CDK2 regulates insulin internalization. Phosphorylation by PTK6 at Tyr-64, Tyr-142, Tyr-331 and/or Tyr-333 with the predominant site at Tyr-64 is not essential for inhibition of transcriptional activity.
  • Ubiquitinated by the SCF(BTRC) E3 ligase complex when phosphorylated by GSK3B, leading to its degradation (PubMed:12077367). Ubiquitinated by a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X, leading to its subsequent proteasomal degradation (PubMed:11389839, PubMed:11389840, PubMed:20307497). Ubiquitinated and degraded following interaction with SOX9 (By similarity).
  • S-nitrosylation at Cys-619 within adherens junctions promotes VEGF-induced, NO-dependent endothelial cell permeability by disrupting interaction with E-cadherin, thus mediating disassembly adherens junctions.
  • O-glycosylation at Ser-23 decreases nuclear localization and transcriptional activity, and increases localization to the plasma membrane and interaction with E-cadherin CDH1.
  • Deacetylated at Lys-49 by SIRT1.
  • Glycosylation at Ser23
  • Ubiquitination at Lys19, Lys133, Lys158, Lys170, Lys233, Lys335, Lys345, Lys354, Lys435, and Lys508
  • Modification sites at PhosphoSitePlus

Other Protein References for CTNNB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CTNNB1 Gene

Domains & Families for CTNNB1 Gene

Gene Families for CTNNB1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CTNNB1 Gene

InterPro:
Blocks:
  • HEAT repeat
  • Armadillo repeat
ProtoNet:

Suggested Antigen Peptide Sequences for CTNNB1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57878, highly similar to Beta-catenin (B4DGU4_HUMAN)
  • Catenin beta-1 (B5BU28_HUMAN)
  • Beta-catenin (CTNB1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P35222

UniProtKB/Swiss-Prot:

CTNB1_HUMAN :
  • Belongs to the beta-catenin family.
Family:
  • Belongs to the beta-catenin family.
genes like me logo Genes that share domains with CTNNB1: view

Function for CTNNB1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CTNNB1 Gene

UniProtKB/Swiss-Prot Function:
Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity).
GENATLAS Biochemistry:
catenin beta 188 kDa,desmosomal plaque component,localized to the nucleus,regulating cell adhesion (component of the E cadherin multiprotein complex,homologous to plakoglobin (CTNNG1) and Drosophila Armadillo segment polarity gene),negatively regulated by APC,transducing wingless signals,interacting with LEF1and TCF4 components,a targetting AP-1 transcription complex,urokinase and presinilin 1 (PSEN1),involved in hair development with aberrant beta catenin in murine hair tumors,mutated in melanoma cell lines in anaplastic thyroid carcinoma in Wilms tumors,some colon,non polyposis colorectal,gastric or endometrioid ovarian carcinomas early onset type,in desmoid tumors without familial adenomatous polyposis,prostate cancer pilomatricomas and in hepatoblastomas and in Wilms tumor (see TSG3C),mutated or dysregulated in sporadic agressive fibromatosis(desmoid tumor) without familial adenomatous polyposis

Phenotypes From GWAS Catalog for CTNNB1 Gene

Gene Ontology (GO) - Molecular Function for CTNNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001085 RNA polymerase II transcription factor binding IDA,IPI 18936100
GO:0001102 RNA polymerase II activating transcription factor binding IPI 19443654
GO:0003682 chromatin binding ISS --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0003713 transcription coactivator activity IBA,IMP 12949260
genes like me logo Genes that share ontologies with CTNNB1: view
genes like me logo Genes that share phenotypes with CTNNB1: view

Human Phenotype Ontology for CTNNB1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CTNNB1 Gene

MGI Knock Outs for CTNNB1:

Animal Model Products

CRISPR Products

miRNA for CTNNB1 Gene

miRTarBase miRNAs that target CTNNB1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTNNB1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CTNNB1 Gene

Localization for CTNNB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTNNB1 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cell junction, synapse. Cytoplasm, cytoskeleton, cilium basal body. Note=Colocalized with RAPGEF2 and TJP1 at cell-cell contacts (By similarity). Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 and MUC1 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization. The majority of beta-catenin is localized to the cell membrane. In interphase, colocalizes with CROCC between CEP250 puncta at the proximal end of centrioles, and this localization is dependent on CROCC and CEP250. In mitosis, when NEK2 activity increases, it localizes to centrosomes at spindle poles independent of CROCC. Colocalizes with CDK5 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Interaction with FAM53B promotes translocation to the nucleus (PubMed:25183871). {ECO:0000250 UniProtKB:B6V8E6, ECO:0000269 PubMed:25183871}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTNNB1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 5
mitochondrion 3
endoplasmic reticulum 3
lysosome 3
peroxisome 2
endosome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CTNNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005623 cell IEA --
GO:0005634 nucleus IEA,IDA 9707618
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IDA 11751639
genes like me logo Genes that share ontologies with CTNNB1: view

Pathways & Interactions for CTNNB1 Gene

PathCards logo

SuperPathways for CTNNB1 Gene

SuperPathway Contained pathways
1 S45 mutants of beta-catenin arent phosphorylated
S45 mutants of beta-catenin arent phosphorylated
.93
Disassembly of the destruction complex and recruitment of AXIN to the membrane
.47
Signaling by WNT in cancer
.43
Canonical Wnt signaling pathway
.31
Beta-catenin phosphorylation cascade
.01
Misspliced GSK3beta mutants stabilize beta-catenin
.01
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
.01
S33 mutants of beta-catenin arent phosphorylated
.01
S37 mutants of beta-catenin arent phosphorylated
.01
T41 mutants of beta-catenin arent phosphorylated
.01
2 Endometrial cancer
Colorectal cancer
.50
Endometrial cancer
.50
Signal transduction PTEN pathway
.44
Thyroid cancer
.36
Prostate cancer
.32
Binding of TCF/LEF-CTNNB1 to target gene promoters
.01
3 Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling
Blood-Brain Barrier and Immune Cell Transmigration: ICAM-1/CD54 Signaling
.80
Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling
.80
Blood-Brain Barrier and Immune Cell Transmigration: CCL2/MCP-1 Signaling
.52
Blood-Brain Barrier and Immune Cell Transmigration: VEGF Signaling
.51
Leukocyte transendothelial migration
.45
4 Apoptotic execution phase
Apoptotic cleavage of cellular proteins
.74
Apoptotic execution phase
.74
Apoptosis
.31
Programmed Cell Death
.30
Apoptotic cleavage of cell adhesion proteins
.01
5 Regulation of activated PAK-2p34 by proteasome mediated degradation
Beta-catenin independent WNT signaling
.64
Degradation of beta-catenin by the destruction complex
.63
Ca2+ pathway
.41
Canonical Wnt Pathway
.31
genes like me logo Genes that share pathways with CTNNB1: view

Pathways by source for CTNNB1 Gene

3 Sino Biological pathways for CTNNB1 Gene
1 PharmGKB pathway for CTNNB1 Gene
14 GeneGo (Thomson Reuters) pathways for CTNNB1 Gene
  • Cell adhesion_Cadherin-mediated cell adhesion
  • Cell adhesion_Endothelial cell contacts by junctional mechanisms
  • Cell adhesion_Endothelial cell contacts by non-junctional mechanisms
  • Cytoskeleton remodeling Integrin outside-in signaling
  • Cytoskeleton remodeling Reverse signaling by ephrin B
2 Tocris pathways for CTNNB1 Gene
25 Qiagen pathways for CTNNB1 Gene
  • CDK5 Pathway
  • Colorectal Cancer Metastasis
  • EGF Pathway
  • EphB-EphrinB Signaling
  • Ephrin-Eph Signaling
2 Cell Signaling Technology pathways for CTNNB1 Gene
2 GeneTex pathways for CTNNB1 Gene

SIGNOR curated interactions for CTNNB1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for CTNNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0000209 protein polyubiquitination IDA 29374064
GO:0000578 embryonic axis specification IEA --
GO:0000904 cell morphogenesis involved in differentiation IEA --
GO:0001501 skeletal system development IEA --
genes like me logo Genes that share ontologies with CTNNB1: view

Drugs & Compounds for CTNNB1 Gene

Products:

  1. Drug

(119) Drugs for CTNNB1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Urea Approved, Investigational Pharma Target 0
Dexamethasone Approved, Investigational, Vet_approved Pharma Agonist Anti-inflammatory glucocorticoid 2886
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 3670
Lenalidomide Approved Pharma Anti-angiogenic. 911
Thalidomide Approved, Investigational, Withdrawn Pharma Immunomodulatory agent,sedative drug,angiogenesis inhibitor, TNF-alpha synthesis inhibitor, Immunomodulatory agents 429

(60) Additional Compounds for CTNNB1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
endo-IWR 1
1127442-82-3

(5) Tocris Compounds for CTNNB1 Gene

Compound Action Cas Number
endo-IWR 1 Wnt/beta-catenin signaling inhibitor; axin stabilizer 1127442-82-3
exo-IWR 1 Negative control for endo-IWR 1 (Cat. No. 3532) 1127442-87-8
FH 535 Inhibitor of Wnt/beta-catenin signaling 108409-83-2
iCRT 14 Inhibits beta-catenin-responsive transcription (CRT) 677331-12-3
PNU 74654 beta-catenin binder; inhibits Wnt signaling 113906-27-7

(28) ApexBio Compounds for CTNNB1 Gene

Compound Action Cas Number
Cardiogenol C hydrochloride 1049741-55-0
Cardionogen 1 577696-37-8
CCT 031374 hydrobromide Inhibits TCF-dependent transcription 1219184-91-4
CCT251545 Orally bioavailable and potent WNT signaling inhibitor 1661839-45-7
exo-IWR 1 1127442-87-8
FH535 Wnt/B-catenin inhibitor 108409-83-2
ICG 001 Wnt/β-catenin pathway inhibitor 847591-62-2
iCRT 14 CRT inhibitor 677331-12-3
IDE 1 1160927-48-9
IDE 2 1136466-93-7
IQ 1 331001-62-8
ISX 9 832115-62-5
IWP 4 686772-17-8
IWR-1-endo Potent Wnt signaling inhibitor 1127442-82-3
JW 67 442644-28-2
Kartogenin 4727-31-5
KHS 101 hydrochloride
KY 02111 WNT signaling inhibitor 1118807-13-8
LGK-974 PORCN inhibitor,potent and specific 1243244-14-5
Neurodazine 937807-66-4
PNU 74654 113906-27-7
QS 11 Wnt synergistic agonist 944328-88-5
Salinomycin Polyether ionophore antibiotic;anti-cancer 53003-10-4
Shz 1 326886-05-9
TCS 2210 1201916-31-5
WAY-262611 1123231-07-1
Windorphen Wnt inhibitor 19881-70-0
Wnt-C59 PORCN inhibitor,highly potent and selective 1243243-89-1
genes like me logo Genes that share compounds with CTNNB1: view

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Transcripts for CTNNB1 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CTNNB1 Gene

4 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
56 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTNNB1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTNNB1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ·
SP1: - - - -
SP2: - - - -
SP3:
SP4: - - -
SP5: - - - - - - - - -
SP6: - -
SP7: - - - - -
SP8: - - - - - -
SP9: - - -
SP10:
SP11:
SP12:
SP13:
SP14:

ExUns: 15c · 15d ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c · 18d ^ 19 ^ 20 ^ 21a · 21b
SP1: - - -
SP2: - - -
SP3: - - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12: - -
SP13: -
SP14:

Relevant External Links for CTNNB1 Gene

GeneLoc Exon Structure for
CTNNB1

Expression for CTNNB1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CTNNB1 Gene

mRNA expression in normal human tissues for CTNNB1 Gene
mRNA expression by GTEx for CTNNB1 GenemRNA expression by BioGPS for CTNNB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CTNNB1 Gene

This gene is overexpressed in Fetal Brain (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CTNNB1 Gene



Protein tissue co-expression partners for CTNNB1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CTNNB1

SOURCE GeneReport for Unigene cluster for CTNNB1 Gene:

Hs.476018

mRNA Expression by UniProt/SwissProt for CTNNB1 Gene:

P35222-CTNB1_HUMAN
Tissue specificity: Expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Expressed in colon. Present in cortical neurons (at protein level). Expressed in breast cancer tissues (at protein level) (PubMed:29367600).

Evidence on tissue expression from TISSUES for CTNNB1 Gene

  • Nervous system(5)
  • Liver(4.8)
  • Skin(4.8)
  • Intestine(4.5)
  • Heart(4)
  • Kidney(3.8)
  • Muscle(3.8)
  • Lung(3.8)
  • Pancreas(3.7)
  • Blood(3.7)
  • Bone marrow(3.7)
  • Lymph node(3.7)
  • Eye(3.6)
  • Thyroid gland(3.6)
  • Stomach(3.6)
  • Spleen(3.5)
  • Adrenal gland(3.4)
  • Bone(3.3)
  • Gall bladder(3.1)
  • Urine(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CTNNB1 Gene