Aliases for CTNNB1 Gene
Aliases for CTNNB1 Gene
External Ids for CTNNB1 Gene
- HGNC: 2514
- Entrez Gene: 1499
- Ensembl: ENSG00000168036
- OMIM: 116806
- UniProtKB: P35222
Previous HGNC Symbols for CTNNB1 Gene
- CTNNB
Previous GeneCards Identifiers for CTNNB1 Gene
- GC03P040551
- GC03P041054
- GC03P041201
- GC03P041216
Summaries for CTNNB1 Gene
-
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
GeneCards Summary for CTNNB1 Gene
CTNNB1 (Catenin Beta 1) is a Protein Coding gene. Diseases associated with CTNNB1 include Mental Retardation, Autosomal Dominant 19 and Pilomatrixoma. Among its related pathways are ERK Signaling and Focal Adhesion. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and binding. An important paralog of this gene is JUP.
UniProtKB/Swiss-Prot for CTNNB1 Gene
-
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity).
-
beta-catenin protein is an integral part of the canonical Wnt signaling pathway. Wnt binding to Frizzled (Fz) receptors and LRP co-receptors activates Dishevelled (Dsh) proteins; these in turn inhibit the destruction complex responsible for degrading beta-catenin, which includes GSK-3.
Additional gene information for CTNNB1 Gene
- Monarch Initiative
- Search for CTNNB1 at DataMed
- Search for CTNNB1 at HumanCyc
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTNNB1 Gene
Genomics for CTNNB1 Gene
GeneHancer (GH) Regulatory Elements for CTNNB1 Gene
Promoters and enhancers for CTNNB1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CTNNB1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CTNNB1 gene promoter:
-
- p53
- p300
- ATF-2
- HOXA5
- GATA-1
- E47
- Evi-1
- CUTL1
- GATA-2
Regulatory Element Products
Genomic Locations for CTNNB1 Gene
Genomic Locations for CTNNB1 Gene
- chr3:41,194,741-41,260,096
- (GRCh38/hg38)
- Size:
- 65,356 bases
- Orientation:
- Plus strand
- chr3:41,236,328-41,301,587
- (GRCh37/hg19)
- Size:
- 65,260 bases
- Orientation:
- Plus strand
Genomic View for CTNNB1 Gene
Genes around CTNNB1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3p22.1 by Entrez Gene
- 3p22.1 by HGNC
- 3p22.1 by Ensembl
CTNNB1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CTNNB1 Gene
Proteins for CTNNB1 Gene
-
Protein details for CTNNB1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35222-CTNB1_HUMAN
- Recommended name:
- Catenin beta-1
- Protein Accession:
- P35222
- A8K1L7
- Q8NEW9
- Q8NI94
- Q9H391
Protein attributes for CTNNB1 Gene
- Size:
- 781 amino acids
- Molecular mass:
- 85497 Da
- Quaternary structure:
-
- Two separate complex-associated pools are found in the cytoplasm. The majority is present as component of an E-cadherin:catenin adhesion complex composed of at least E-cadherin/CDH1 and beta-catenin/CTNNB1, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Alternatively, the CTNNA1-containing complex may be linked to F-actin by other proteins such as LIMA1. Another cytoplasmic pool is part of a large complex containing AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. Wnt-dependent activation of DVL antagonizes the action of GSK3B. When GSK3B activity is inhibited the complex dissociates, CTNNB1 is dephosphorylated and is no longer targeted for destruction. The stabilized protein translocates to the nucleus, where it binds TCF/LEF-1 family members, TBP, BCL9, BCL9L and possibly also RUVBL1 and CHD8. Binds CTNNBIP and EP300. CTNNB1 forms a ternary complex with LEF1 and EP300 that is disrupted by CTNNBIP1 binding. Interacts with TAX1BP3 (via the PDZ domain); this interaction inhibits the transcriptional activity of CTNNB1. Interacts with AJAP1, BAIAP1, CARM1, CTNNA3, CXADR and PCDH11Y. Binds SLC9A3R1. Interacts with GLIS2 and MUC1. Interacts with SLC30A9. Interacts with XIRP1. Interacts directly with AXIN1; the interaction is regulated by CDK2 phosphorylation of AXIN1. Interacts with SCRIB. Interacts with RAPGEF2. Interacts with PTPRU (via the cytoplasmic juxtamembrane domain). Interacts with EMD. Interacts with TNIK and TCF7L2. Interacts with SESTD1 and TRPC4. Interacts with CAV1. Interacts with TRPV4. The TRPV4 and CTNNB1 complex can interact with CDH1. Interacts with VCL. Interacts with PTPRJ. Interacts with PKT7 and CDK2. Interacts with FAT1 (via the cytoplasmic domain). Interacts with NANOS1 and NDRG2. Interacts with isoform 1 of NEK2. Interacts with both isoform 1 and isoform 2 of CDK5. Interacts with PTK6. Interacts with SOX7; this interaction may lead to proteasomal degradation of active CTNNB1 and thus inhibition of Wnt/beta-catenin-stimulated transcription. Identified in a complex with HINT1 and MITF. Interacts with FHIT. The CTNNB1 and TCF7L2/TCF4 complex interacts with PML (isoform PML-4). Interacts with FERMT2. Identified in a complex with TCF7L2/TCF4 and FERMT2. Interacts with RORA. May interact with P-cadherin/CDH3. Interacts with RNF220 (PubMed:25266658). Interacts with CTNND2 (PubMed:25807484). Interacts (via the C-terminal region) with CBY1 (PubMed:12712206, PubMed:16424001). The complex composed, at least, of APC, CTNNB1 and GSK3B interacts with JPT1; the interaction requires the inactive form of GSK3B (phosphorylated at Ser-9) (PubMed:25169422). Interacts with DLG5 (By similarity). Interacts with FAM53B; promoting translocation to the nucleus (PubMed:25183871). Interacts with TMEM170B (PubMed:29367600). Interacts with AHI1 (PubMed:21623382).
- SequenceCaution:
-
- Sequence=AAG35511.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAB93475.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for CTNNB1 Gene
Post-translational modifications for CTNNB1 Gene
- Phosphorylation at Ser-552 by AMPK promotes stabilizion of the protein, enhancing TCF/LEF-mediated transcription (By similarity). Phosphorylation by GSK3B requires prior phosphorylation of Ser-45 by another kinase. Phosphorylation proceeds then from Thr-41 to Ser-37 and Ser-33. Phosphorylated by NEK2. EGF stimulates tyrosine phosphorylation. Phosphorylation on Tyr-654 decreases CDH1 binding and enhances TBP binding. Phosphorylated on Ser-33 and Ser-37 by HIPK2 and GSK3B, this phosphorylation triggers proteasomal degradation (PubMed:25169422). Phosphorylation on Ser-191 and Ser-246 by CDK5. Phosphorylation by CDK2 regulates insulin internalization. Phosphorylation by PTK6 at Tyr-64, Tyr-142, Tyr-331 and/or Tyr-333 with the predominant site at Tyr-64 is not essential for inhibition of transcriptional activity.
- Ubiquitinated by the SCF(BTRC) E3 ligase complex when phosphorylated by GSK3B, leading to its degradation. Ubiquitinated by a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X, leading to its subsequent proteasomal degradation (By similarity).
- S-nitrosylation at Cys-619 within adherens junctions promotes VEGF-induced, NO-dependent endothelial cell permeability by disrupting interaction with E-cadherin, thus mediating disassembly adherens junctions.
- O-glycosylation at Ser-23 decreases nuclear localization and transcriptional activity, and increases localization to the plasma membrane and interaction with E-cadherin CDH1.
- Deacetylated at Lys-49 by SIRT1.
- Glycosylation at posLast=2323
- Ubiquitination at posLast=508508, posLast=435435, Lys354, Lys345, Lys335, Lys233, Lys170, Lys158, Lys133, and Lys19
- Modification sites at PhosphoSitePlus
Other Protein References for CTNNB1 Gene
- ENSEMBL proteins:
-
- ENSP00000412219
- ENSP00000495076
- ENSP00000494053
- ENSP00000494654
- ENSP00000385604
- ENSP00000495426
- ENSP00000409302
- ENSP00000496295
- ENSP00000494422
- ENSP00000495992
- ENSP00000495794
- ENSP00000496020
- ENSP00000496021
- ENSP00000496385
- ENSP00000496180
- ENSP00000496584
- ENSP00000495244
- ENSP00000494845
- ENSP00000494849
- ENSP00000494914
- ENSP00000494411
- ENSP00000379486
- ENSP00000379488
- ENSP00000493610
- ENSP00000495552
- ENSP00000495450
- ENSP00000411226
- ENSP00000401599
- ENSP00000496649
- ENSP00000496511
- ENSP00000493583
- ENSP00000495719
- ENSP00000494677
- ENSP00000493533
- ENSP00000387455
- ENSP00000344456
- ENSP00000495360
- ENSP00000495161
- ENSP00000400508
- ENSP00000494263
- ENSP00000494467
- ENSP00000496067
- ENSP00000495286
- ENSP00000495287
- ENSP00000494780
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CTNNB1 (beta-Catenin)
-
Custom Antibody ServicesOriGene Antibodies for CTNNB1
- AM00015BT-N
- AM00015PU-N
- AM00016BT-N
- AM00016PU-N
- AM00017PU-N
- AM00018PU-N
- AM00019PU-N
- AM00020BT-N
- AM00020PU-N
- AM00021PU-N
- AM00022PU-N
- AM00023PU-N
- AM06389SU-N
- AM20692PU-N
- AM26027PU-N
- AM26372PU-N
- AM33102PU-N
- AP00134PU-N
- AP01543PU-N
- AP02406PU-N
- AP02406PU-S
- AP02477PU-N
- AP02477PU-S
- AP02478PU-N
- AP02478PU-S
- AP02636PU-N
- AP02636PU-S
- AP02721PU-N
- AP02721PU-S
- AP02722PU-N
- AP02722PU-S
- AP06038PU-N
- AP06611PU-N
- AP06683PU-N
- AP08092PU-N
- AP08092PU-S
- AP20705PU-N
- AP20706PU-N
- AP20826PU-N
- AP20827PU-N
- AP20926PU-N
- AP20927PU-N
- AP21016PU-N
- AP21100PU-N
- AP23420PU-N
- AP26073PU-N
- AP26073PU-S
- AP32836PU-N
- AP32836PU-S
- AP32836PU-T
- AP51124PU-N
- TA313134
- TA313136
- TA313138
- TA313140
- TA313142
- TA319264
- TA325394
- TA325395
- TA325396
- TA325397
- TA325398
- TA330025
- TA330026
- TA336809
- TA348952
- TA353639
- TA500048
- CF500048
- TA500049
- CF500049
- TA500239
- CF500239
- TA500240
- CF500240
- TA502299
- CF502299
- TA502300
- CF502300
- TA502301
- CF502301
- TA502302
- CF502302
- TA502303
- CF502303
- TA502304
- CF502304
- TA502305
- CF502305
- TA502306
- CF502306
- TA502337
- CF502337
- TA502338
- CF502338
- TA502339
- CF502339
- TA502340
- CF502340
- TA502341
- CF502341
- TA502407
- CF502407
- TA502408
- CF502408
- TA502409
- CF502409
- TA502412
- CF502412
- TA600034
- TA600035
- TA600047
- TA600141
- TA700034
- TA700035
- TA700047
- TA700141
- TA807908
- CF807908
- UM570014
- UM570015
- TA502409S
- Novus Biologicals Antibodies for CTNNB1
- Invitrogen Antibodies for CTNNB1
- antibodies-online: Search results for 497 available beta Catenin Antibodies ranked by validation data
- Compare Top beta Catenin Antibodies
-
Recommended
- 189 WB Antibodies (anti-mouse)
- 8 IHC (p) Antibodies (anti-mouse)
- 7 FACS Antibodies (anti-mouse)
- 4 IP Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 165 WB Antibodies (anti-rat)
- 8 IHC (p) Antibodies (anti-rat)
- 7 FACS Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 419 WB Antibodies (anti-human)
- 12 FACS Antibodies (anti-human)
- 11 IHC (p) Antibodies (anti-human)
- 7 LMNX Antibodies (anti-human)
- 5 IP Antibodies (anti-human)
- 2 IF/ICC Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- 189 WB Antibodies (anti-mouse)
- 8 IHC (p) Antibodies (anti-mouse)
- 7 FACS Antibodies (anti-mouse)
- 4 IP Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 165 WB Antibodies (anti-rat)
- 8 IHC (p) Antibodies (anti-rat)
- 7 FACS Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 419 WB Antibodies (anti-human)
- 12 FACS Antibodies (anti-human)
- 11 IHC (p) Antibodies (anti-human)
- 7 LMNX Antibodies (anti-human)
- 5 IP Antibodies (anti-human)
- 2 IF/ICC Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- GeneTex CTNNB1 Antibody for CTNNB1
-
Santa Cruz Biotechnology (SCBT) Antibodies for CTNNB1
- -catenin (E-5)
- -catenin (15B8)
- -catenin (6F9)
- p--catenin (1B11)
- p--catenin (24E1)
- p--catenin (BC-22)
- -catenin (12F7)
- -catenin (BDI870)
- -catenin (BDI920)
- -catenin (10H8)
- -catenin (C-1F12)
- -catenin (E-11)
- -catenin (D-10)
- -catenin (H-1)
- -catenin (H-2)
- -catenin (B-9)
- -catenin (G-10)
- -catenin (A-5)
- -catenin (E-2)
- -catenin (A-12)
- Sino Biological Antibodies for CTNNB1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CTNNB1
- Origene Custom Protein Services for CTNNB1
- Sino Biological Recombinant Proteins for CTNNB1
- Sino Biological Cell Lysates for CTNNB1
- Search GeneTex for Proteins for CTNNB1
-
ProSci Proteins for CTNNB1
Assay Products
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for CTNNB1 (beta-Catenin)
- antibodies-online: Search results for 36 available beta Catenin Elisa Kits ranked by validation data
- Compare Top beta Catenin Elisa Kits
-
Recommended
- 1 Chicken ELISA Kit
- 1 Cow (Bovine) ELISA Kit
- 1 Dog (Canine) ELISA Kit
- 1 Guinea Pig ELISA Kit
- 10 Human ELISA Kits
- 1 Monkey ELISA Kit
- 10 Mouse (Murine) ELISA Kits
- 1 Pig (Porcine) ELISA Kit
- 1 Rabbit ELISA Kit
- 11 Rat (Rattus) ELISA Kits
- 1 Chicken ELISA Kit
- 1 Cow (Bovine) ELISA Kit
- 1 Dog (Canine) ELISA Kit
- 1 Guinea Pig ELISA Kit
- 10 Human ELISA Kits
- 1 Monkey ELISA Kit
- 10 Mouse (Murine) ELISA Kits
- 1 Pig (Porcine) ELISA Kit
- 1 Rabbit ELISA Kit
- 11 Rat (Rattus) ELISA Kits
No data available for DME Specific Peptides for CTNNB1 Gene
Domains & Families for CTNNB1 Gene
Gene Families for CTNNB1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for CTNNB1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CTNNB1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P35222- Family:
-
- Belongs to the beta-catenin family.
Function for CTNNB1 Gene
Molecular function for CTNNB1 Gene
- UniProtKB/Swiss-Prot Function:
- Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity).
- GENATLAS Biochemistry:
- catenin beta 188 kDa,desmosomal plaque component,localized to the nucleus,regulating cell adhesion (component of the E cadherin multiprotein complex,homologous to plakoglobin (CTNNG1) and Drosophila Armadillo segment polarity gene),negatively regulated by APC,transducing wingless signals,interacting with LEF1and TCF4 components,a targetting AP-1 transcription complex,urokinase and presinilin 1 (PSEN1),involved in hair development with aberrant beta catenin in murine hair tumors,mutated in melanoma cell lines in anaplastic thyroid carcinoma in Wilms tumors,some colon,non polyposis colorectal,gastric or endometrioid ovarian carcinomas early onset type,in desmoid tumors without familial adenomatous polyposis,prostate cancer pilomatricomas and in hepatoblastomas and in Wilms tumor (see TSG3C),mutated or dysregulated in sporadic agressive fibromatosis(desmoid tumor) without familial adenomatous polyposis
Phenotypes From GWAS Catalog for CTNNB1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001085 | RNA polymerase II transcription factor binding | IPI,IDA | 18936100 |
| GO:0001102 | RNA polymerase II activating transcription factor binding | IPI | 19443654 |
| GO:0003682 | chromatin binding | ISS | -- |
| GO:0003700 | DNA binding transcription factor activity | IEA | -- |
| GO:0003713 | transcription coactivator activity | IMP | 12949260 |
Phenotypes for CTNNB1 Gene
- MGI mutant phenotypes for CTNNB1:
-
inferred from 22 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- limbs/digits/tail phenotype
- pigmentation phenotype
- vision/eye phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- no phenotypic analysis
- neoplasm
- integument phenotype
- taste/olfaction phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- craniofacial phenotype
- liver/biliary system phenotype
- reproductive system phenotype
- skeleton phenotype
- embryo phenotype
- normal phenotype
- hearing/vestibular/ear phenotype
- renal/urinary system phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for CTNNB1:
-
- Wnt reporter downregulated
- Decreased shRNA abundance (Z-score < -2)
- Dynamic nuclei (hole, folded or small irregular)
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Increased shRNA abundance (Z-score > 2)
- Increased cell death HMECs cells
- Decreased viability in esophageal squamous lineage
- Downregulation of Wnt pathway after Wnt3A stimulation
- Increased cell migration
- Decreased cell migration
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased influenza A/WSN/33 replication
- Increased viability
Animal Models for CTNNB1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CTNNB1
-
CRISPR Products
-
OriGene CRISPR knockouts for CTNNB1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CTNNB1
- genomics-online: gRNA clones - Search results for 9 available beta Catenin gene related products
- Overview of 9 available beta Catenin gene related products
- Applied Biological Materials CRISPR for CTNNB1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CTNNB1
- GenScript: Design CRISPR guide RNA sequences for CTNNB1
miRNA for CTNNB1 Gene
- miRTarBase miRNAs that target CTNNB1
-
- hsa-mir-200a-3p (MIRT001175)
- hsa-mir-155-5p (MIRT001557)
- hsa-mir-1826 (MIRT006602)
- hsa-mir-214-3p (MIRT007031)
- hsa-mir-124-3p (MIRT022723)
- hsa-mir-221-3p (MIRT024185)
- hsa-mir-34a-5p (MIRT025403)
- hsa-mir-30a-5p (MIRT028521)
- hsa-mir-1226-3p (MIRT036496)
- hsa-mir-744-5p (MIRT037700)
- hsa-mir-532-3p (MIRT037926)
- hsa-mir-331-3p (MIRT043472)
- hsa-mir-512-5p (MIRT053427)
- hsa-mir-624-3p (MIRT053731)
- hsa-mir-34a-3p (MIRT054050)
- hsa-mir-34b-5p (MIRT054051)
- hsa-mir-34c-3p (MIRT054052)
- gga-mir-217-5p (MIRT054670)
- gga-mir-1467-5p (MIRT054671)
- gga-mir-1623 (MIRT054673)
- gga-mir-1697 (MIRT054675)
- hsa-mir-183-3p (MIRT091926)
- hsa-mir-3591-5p (MIRT091931)
- hsa-mir-4765 (MIRT091932)
- hsa-mir-5586-3p (MIRT091934)
- hsa-mir-8062 (MIRT091935)
- hsa-mir-4255 (MIRT209910)
- hsa-mir-548l (MIRT307297)
- hsa-mir-7849-3p (MIRT307327)
- hsa-mir-142-3p (MIRT524299)
- hsa-mir-5010-3p (MIRT704436)
- hsa-mir-2113 (MIRT704437)
- hsa-mir-607 (MIRT704438)
- hsa-mir-4474-3p (MIRT704439)
- hsa-mir-7108-5p (MIRT704440)
- hsa-mir-3144-3p (MIRT704441)
- hsa-mir-891a-3p (MIRT704442)
- hsa-mir-3688-5p (MIRT704443)
- hsa-mir-520h (MIRT704444)
- hsa-mir-520g-3p (MIRT704445)
- hsa-mir-3973 (MIRT704446)
- hsa-mir-875-5p (MIRT704447)
- hsa-mir-370-3p (MIRT731452)
- hsa-mir-375 (MIRT732085)
- hsa-mir-3162-3p (MIRT732180)
- hsa-mir-150-3p (MIRT732969)
- hsa-mir-181a-5p (MIRT733915)
- hsa-mir-320a (MIRT733956)
- hsa-mir-200a-5p (MIRT734086)
- hsa-mir-506-5p (MIRT734316)
- hsa-mir-101-3p (MIRT734412)
- hsa-mir-885-5p (MIRT734670)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CTNNB1
- Browse OriGene Inhibitory RNA Products For CTNNB1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTNNB1
- genomics-online: shRNA clones - Search results for 9 available beta Catenin gene related products
- Overview of 9 available beta Catenin gene related products
Clone Products
-
OriGene ORF clones in human for CTNNB1
- RC212056L1V
- RC212056L2V
- RC214557L1V
- RC214557L2V
- RC208947L1V
- RC208947L2V
- RC212056
- RC212056L1
- RC212056L2
- RG212056
- RC214557
- RC214557L1
- RC214557L2
- RG214557
- RC208947
- RC208947L1
- RC208947L2
- RC400198
- RC400199
- RC400200
- RC400201
- RC400202
- RC400203
- RC400204
- RC400205
- RC400206
- RC400207
- RC400208
- RC400209
- RC400210
- RC400211
- RC400212
- RC400213
- RC400214
- RC400215
- RC400216
- RC400217
- RC400218
- RC400219
- RC400220
- RC400221
- RC400222
- RC400223
- RC400224
- RC400225
- RC400226
- RC400227
- RC400228
- RC400229
- RC400230
- RC400231
- RC400232
- RC400233
- RC400234
- RC400235
- RC400236
- RC400237
- RC400238
- RC400239
- RC400240
- RC400241
- RC400242
- RC402574
- RG208947
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CTNNB1
- VectorBuilder custom plasmid, inducible vectors for CTNNB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CTNNB1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CTNNB1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CTNNB1
- Applied Biological Materials Clones for CTNNB1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CTNNB1 (beta-Catenin)
Cell Line Products
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CTNNB1 Gene
Localization for CTNNB1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CTNNB1 Gene
- Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cell junction, synapse. Cytoplasm, cytoskeleton, cilium basal body. Note=Colocalized with RAPGEF2 and TJP1 at cell-cell contacts (By similarity). Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 and MUC1 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization. The majority of beta-catenin is localized to the cell membrane. In interphase, colocalizes with CROCC between CEP250 puncta at the proximal end of centrioles, and this localization is dependent on CROCC and CEP250. In mitosis, when NEK2 activity increases, it localizes to centrosomes at spindle poles independent of CROCC. Colocalizes with CDK5 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Interaction with FAM53B promotes translocation to the nucleus (PubMed:25183871). {ECO:0000250 UniProtKB:B6V8E6, ECO:0000269 PubMed:25183871}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 1 |
| golgi apparatus | 1 |
| endosome | 1 |
- Plasma membrane (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000922 | spindle pole | IEA | -- |
| GO:0005622 | intracellular | IDA | 12651860 |
| GO:0005634 | nucleus | IDA,IEA | 9707618 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005667 | transcription factor complex | IDA | 11751639 |
Pathways & Interactions for CTNNB1 Gene
Pathways by source for CTNNB1 Gene
3 Sino Biological pathways for CTNNB1 Gene
2 GeneTex pathways for CTNNB1 Gene
44 BioSystems pathways for CTNNB1 Gene
49 Reactome pathways for CTNNB1 Gene
1 PharmGKB pathway for CTNNB1 Gene
27 KEGG pathways for CTNNB1 Gene
14 GeneGo (Thomson Reuters) pathways for CTNNB1 Gene
9 R&D Systems pathways for CTNNB1 Gene
- Blood-Brain Barrier and Immune Cell Transmigration: CCL2/MCP-1 Signaling Pathways
- Blood-Brain Barrier and Immune Cell Transmigration: ICAM-1/CD54 Signaling Pathways
- Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview
- Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways
- Blood-Brain Barrier and Immune Cell Transmigration: VEGF Signaling Pathways
2 Tocris pathways for CTNNB1 Gene
25 Qiagen pathways for CTNNB1 Gene
2 Cell Signaling Technology pathways for CTNNB1 Gene
Interacting Proteins for CTNNB1 Gene
Selected Interacting proteins:
P35222-CTNB1_HUMAN
ENSP00000344456
for CTNNB1 Gene via
MINT
IID
UniProtKB
STRING
GPS-Prot Interaction Network for CTNNB1
SIGNOR curated interactions for CTNNB1 Gene
- Activates:
- Inactivates:
- Is activated by:
- Is inactivated by:
- Other effect:
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0000578 | embryonic axis specification | IEA | -- |
| GO:0000904 | cell morphogenesis involved in differentiation | IEA | -- |
| GO:0001501 | skeletal system development | IEA | -- |
| GO:0001569 | branching involved in blood vessel morphogenesis | IC | 20123964 |
Drugs & Compounds for CTNNB1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Urea | Approved, Investigational | Pharma | Target | 0 | ||
| Dexamethasone | Approved, Investigational, Vet_approved | Pharma | Agonist | Anti-inflammatory glucocorticoid | 2314 | |
| Lithium | Approved | Pharma | 0 | |||
| Cyclophosphamide | Approved, Investigational | Pharma | Nitrogen mustard alkylating agent and prodrug. | 3113 | ||
| Lenalidomide | Approved | Pharma | Anti-angiogenic. | 769 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| endo-IWR 1 |
|
1127442-82-3 |
|
|
(5) Tocris Compounds for CTNNB1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| endo-IWR 1 | Wnt/beta-catenin signaling inhibitor; axin stabilizer | 1127442-82-3 |
| exo-IWR 1 | Negative control for endo-IWR 1 (Cat. No. 3532) | 1127442-87-8 |
| FH 535 | Inhibitor of Wnt/beta-catenin signaling | 108409-83-2 |
| iCRT 14 | Inhibits beta-catenin-responsive transcription (CRT) | 677331-12-3 |
| PNU 74654 | beta-catenin binder; inhibits Wnt signaling | 113906-27-7 |
(28) ApexBio Compounds for CTNNB1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Cardiogenol C hydrochloride | 1049741-55-0 | |
| Cardionogen 1 | 577696-37-8 | |
| CCT 031374 hydrobromide | Inhibits TCF-dependent transcription | 1219184-91-4 |
| CCT251545 | Orally bioavailable and potent WNT signaling inhibitor | 1661839-45-7 |
| exo-IWR 1 | 1127442-87-8 | |
| FH535 | Wnt/B-catenin inhibitor | 108409-83-2 |
| ICG 001 | Wnt/β-catenin pathway inhibitor | 847591-62-2 |
| iCRT 14 | CRT inhibitor | 677331-12-3 |
| IDE 1 | 1160927-48-9 | |
| IDE 2 | 1136466-93-7 | |
| IQ 1 | 331001-62-8 | |
| ISX 9 | 832115-62-5 | |
| IWP 4 | 686772-17-8 | |
| IWR-1-endo | Potent Wnt signaling inhibitor | 1127442-82-3 |
| JW 67 | 442644-28-2 | |
| Kartogenin | 4727-31-5 | |
| KHS 101 hydrochloride | ||
| KY 02111 | WNT signaling inhibitor | 1118807-13-8 |
| LGK-974 | PORCN inhibitor,potent and specific | 1243244-14-5 |
| Neurodazine | 937807-66-4 | |
| PNU 74654 | 113906-27-7 | |
| QS 11 | Wnt synergistic agonist | 944328-88-5 |
| Salinomycin | Polyether ionophore antibiotic;anti-cancer | 53003-10-4 |
| Shz 1 | 326886-05-9 | |
| TCS 2210 | 1201916-31-5 | |
| WAY-262611 | 1123231-07-1 | |
| Windorphen | Wnt inhibitor | 19881-70-0 |
| Wnt-C59 | PORCN inhibitor,highly potent and selective | 1243243-89-1 |
Transcripts for CTNNB1 Gene
mRNA/cDNA for CTNNB1 Gene
- (12) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (390) Selected AceView cDNA sequences:
- (56) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000396183 3268 bps (uc003ckp.3)
- ENST00000441708 3906 bps (uc062imm.1)
- ENST00000450969 2764 bps (uc062iml.1)
- ENST00000453024 3052 bps (uc011azf.2)
- ENST00000465552 883 bps (uc062imo.1)
Unigene Clusters for CTNNB1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CTNNB1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CTNNB1
- genomics-online: gRNA clones - Search results for 9 available beta Catenin gene related products
- Overview of 9 available beta Catenin gene related products
- Applied Biological Materials CRISPR for CTNNB1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CTNNB1
- GenScript: Design CRISPR guide RNA sequences for CTNNB1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CTNNB1
- Browse OriGene Inhibitory RNA Products For CTNNB1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTNNB1
- genomics-online: shRNA clones - Search results for 9 available beta Catenin gene related products
- Overview of 9 available beta Catenin gene related products
Clone Products
-
OriGene ORF clones in human for CTNNB1
- RC212056L1V
- RC212056L2V
- RC214557L1V
- RC214557L2V
- RC208947L1V
- RC208947L2V
- RC212056
- RC212056L1
- RC212056L2
- RG212056
- RC214557
- RC214557L1
- RC214557L2
- RG214557
- RC208947
- RC208947L1
- RC208947L2
- RC400198
- RC400199
- RC400200
- RC400201
- RC400202
- RC400203
- RC400204
- RC400205
- RC400206
- RC400207
- RC400208
- RC400209
- RC400210
- RC400211
- RC400212
- RC400213
- RC400214
- RC400215
- RC400216
- RC400217
- RC400218
- RC400219
- RC400220
- RC400221
- RC400222
- RC400223
- RC400224
- RC400225
- RC400226
- RC400227
- RC400228
- RC400229
- RC400230
- RC400231
- RC400232
- RC400233
- RC400234
- RC400235
- RC400236
- RC400237
- RC400238
- RC400239
- RC400240
- RC400241
- RC400242
- RC402574
- RG208947
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CTNNB1
- VectorBuilder custom plasmid, inducible vectors for CTNNB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CTNNB1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CTNNB1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CTNNB1
- Applied Biological Materials Clones for CTNNB1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CTNNB1 (beta-Catenin)
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: |
| ExUns: | 15c | · | 15d | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18a | · | 18b | · | 18c | · | 18d | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||
| SP10: | - | ||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||
| SP12: | - | - | |||||||||||||||||||||||||
| SP13: | - | ||||||||||||||||||||||||||
| SP14: |
Expression for CTNNB1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Limb (Muscoskeletal System)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Ectoderm (Gastrulation Derivatives)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Ovary (Reproductive System)
- Ovarian Somatic Cells Ovigerous Cord
This gene is overexpressed in Fetal Brain (7.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CTNNB1 Gene
NURSA nuclear receptor signaling pathways regulating expression of CTNNB1 Gene:
CTNNB1SOURCE GeneReport for Unigene cluster for CTNNB1 Gene:
Hs.476018mRNA Expression by UniProt/SwissProt for CTNNB1 Gene:
P35222-CTNB1_HUMAN
Tissue specificity:
Expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Expressed in colon. Present in cortical neurons (at protein level). Expressed in breast cancer tissues (at protein level) (PubMed:29367600).
Evidence on tissue expression from TISSUES for CTNNB1 Gene
- Nervous system(5)
- Liver(4.7)
- Skin(4.7)
- Intestine(4.4)
- Lung(3.6)
- Heart(3.5)
- Muscle(3.4)
- Kidney(3.3)
- Lymph node(3.3)
- Pancreas(3.3)
- Bone marrow(3.2)
- Eye(3.2)
- Blood(3.1)
- Thyroid gland(3.1)
- Stomach(3)
- Adrenal gland(2.9)
- Bone(2.9)
- Spleen(2.6)
- Gall bladder(2.5)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CTNNB1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- nervous
- reproductive
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- face
- head
- lip
- mouth
- salivary gland
- skull
Thorax:
- breast
- esophagus
Abdomen:
- abdominal wall
- intestine
- kidney
- large intestine
- liver
- small intestine
- spleen
- stomach
Pelvis:
- anus
- ovary
- rectum
- testicle
- ureter
- urethra
- urinary bladder
- uterus
Limb:
- digit
- finger
- foot
- hand
- lower limb
- nail
- toe
- upper limb
General:
- blood vessel
- coagulation system
- hair
- skin
Primer Products
-
OriGene qPCR primer pairs and template standards for CTNNB1
-
OriGene qPCR primer pairs for CTNNB1
- genomics-online: primer clones - Search results for 9 available beta Catenin gene related products
- Overview of 9 available beta Catenin gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues for CTNNB1 Gene
Orthologs for CTNNB1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| oppossum (Monodelphis domestica) |
Mammalia | CTNNB1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CTNNB1 34 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | CTNNB1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CTNNB1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CTNNB1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ctnnb1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ctnnb1 33 |
|
||
| chicken (Gallus gallus) |
Aves | CTNNB1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CTNNB1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ctnnb1 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | ctnnb1-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ctnnb1 34 33 |
|
OneToOne | |
| -- 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8312 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | arm 34 35 33 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | ARM_ANOGA 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | hmp-2 35 33 |
|
||
| bar-1 35 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.7922 34 |
|
OneToOne |
- Species where no ortholog for CTNNB1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for CTNNB1 Gene
- ENSEMBL:
- Gene Tree for CTNNB1 (if available)
- TreeFam:
- Gene Tree for CTNNB1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CTNNB1: view image