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Aliases for CTNNAL1 Gene

Aliases for CTNNAL1 Gene

  • Catenin Alpha Like 1 2 3 5
  • Catenin (Cadherin-Associated Protein), Alpha-Like 1 2 3
  • Alpha-Catenin-Related Protein 3 4
  • Catenin Alpha-Like Protein 1 3 4
  • Alpha2-Catulin 2 3
  • Alpha-Catulin 2 3
  • ACRP 3 4
  • Catenin Alpha-Like 1 2
  • Alpha-CATU 3
  • CLLP 3

External Ids for CTNNAL1 Gene

Previous GeneCards Identifiers for CTNNAL1 Gene

  • GC09M102503
  • GC09M103437
  • GC09M105162
  • GC09M107084
  • GC09M108784
  • GC09M110744
  • GC09M111704
  • GC09M081304

Summaries for CTNNAL1 Gene

GeneCards Summary for CTNNAL1 Gene

CTNNAL1 (Catenin Alpha Like 1) is a Protein Coding gene. Among its related pathways are Toll-like Receptor Signaling Pathway. Gene Ontology (GO) annotations related to this gene include structural molecule activity and cadherin binding. An important paralog of this gene is CTNNA2.

UniProtKB/Swiss-Prot for CTNNAL1 Gene

  • May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).

Gene Wiki entry for CTNNAL1 Gene

Additional gene information for CTNNAL1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTNNAL1 Gene

Genomics for CTNNAL1 Gene

GeneHancer (GH) Regulatory Elements for CTNNAL1 Gene

Promoters and enhancers for CTNNAL1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J109010 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 675.7 +6.0 5994 5.4 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 CTNNAL1 GC09M109014 PIR44811 FRRS1L ELP1 TMEM245 ENSG00000199331 MIR32
GH09J109113 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 25 -98.7 -98704 9 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 IRF4 YY1 TMEM245 FRRS1L ELP1 CTNNAL1 MIR32 ENSG00000199331 FAM206A GC09M109081
GH09J109106 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 29.2 -90.8 -90811 5.6 PKNOX1 ATF1 ARNT FEZF1 ZNF48 NCOA2 TCF12 GATA2 FOS ATF7 CTNNAL1 FRRS1L ELP1 MIR32 ENSG00000199331 TMEM245 GC09M109081
GH09J109096 Enhancer 1.3 Ensembl ENCODE dbSUPER 34.9 -81.1 -81096 6.5 HDGF PKNOX1 FOXA2 ARNT ARID4B FEZF1 IRF4 YY1 ATF7 FOS ELP1 CTNNAL1 FRRS1L TMEM245 FAM206A MIR32 ENSG00000199331 GC09M109081
GH09J109128 Enhancer 1.1 ENCODE dbSUPER 32.4 -113.0 -113037 6 ATF1 PKNOX1 ARNT NCOA2 TCF12 ZNF766 GATA2 ATF7 RXRA NCOA1 CTNNAL1 FRRS1L TMEM245 MIR32 ENSG00000199331 RNU6-984P EPB41L4B GC09M109131
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CTNNAL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CTNNAL1 gene promoter:
  • POU3F2 (N-Oct-5b)
  • POU3F2 (N-Oct-5a)
  • POU3F2
  • HNF-3beta
  • C/EBPalpha
  • SREBP-1c
  • SREBP-1a
  • SREBP-1b
  • AP-1
  • c-Fos

Genomic Locations for CTNNAL1 Gene

Genomic Locations for CTNNAL1 Gene
76,234 bases
Minus strand
70,959 bases
Minus strand

Genomic View for CTNNAL1 Gene

Genes around CTNNAL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTNNAL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTNNAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTNNAL1 Gene

Proteins for CTNNAL1 Gene

  • Protein details for CTNNAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B5BU47
    • O76084
    • Q53FQ2
    • Q5JTQ7
    • Q5JTQ8
    • Q9Y401

    Protein attributes for CTNNAL1 Gene

    734 amino acids
    Molecular mass:
    81896 Da
    Quaternary structure:
    • Interacts with ARHGEF1.

    Alternative splice isoforms for CTNNAL1 Gene


neXtProt entry for CTNNAL1 Gene

Post-translational modifications for CTNNAL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTNNAL1 Gene

No data available for DME Specific Peptides for CTNNAL1 Gene

Domains & Families for CTNNAL1 Gene

Gene Families for CTNNAL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CTNNAL1 Gene

Suggested Antigen Peptide Sequences for CTNNAL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the vinculin/alpha-catenin family.
  • Belongs to the vinculin/alpha-catenin family.
genes like me logo Genes that share domains with CTNNAL1: view

Function for CTNNAL1 Gene

Molecular function for CTNNAL1 Gene

UniProtKB/Swiss-Prot Function:
May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).
UniProtKB/Swiss-Prot Induction:
Down-regulated in cancer pancreatic cells undergoing differentiation and apoptosis.
GENATLAS Biochemistry:
catenin alpha-catulin-like 1,cadherin-associated protein,widely expressed,including pancreas,heart and skeletal muscle,neural tissues,homolog to alpha-catenin and vinculin

Phenotypes From GWAS Catalog for CTNNAL1 Gene

Gene Ontology (GO) - Molecular Function for CTNNAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0045296 cadherin binding IEA --
GO:0051015 actin filament binding IEA --
genes like me logo Genes that share ontologies with CTNNAL1: view
genes like me logo Genes that share phenotypes with CTNNAL1: view

Animal Model Products

miRNA for CTNNAL1 Gene

miRTarBase miRNAs that target CTNNAL1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CTNNAL1 Gene

Localization for CTNNAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTNNAL1 Gene

Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTNNAL1 gene
Compartment Confidence
cytosol 5
plasma membrane 4
cytoskeleton 4
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CTNNAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA 12270917
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with CTNNAL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CTNNAL1 Gene

Pathways & Interactions for CTNNAL1 Gene

genes like me logo Genes that share pathways with CTNNAL1: view

Pathways by source for CTNNAL1 Gene

1 BioSystems pathway for CTNNAL1 Gene

Gene Ontology (GO) - Biological Process for CTNNAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007266 Rho protein signal transduction IDA,IEA 12270917
genes like me logo Genes that share ontologies with CTNNAL1: view

No data available for SIGNOR curated interactions for CTNNAL1 Gene

Drugs & Compounds for CTNNAL1 Gene

(3) Drugs for CTNNAL1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with CTNNAL1: view

Transcripts for CTNNAL1 Gene

Unigene Clusters for CTNNAL1 Gene

Catenin (cadherin-associated protein), alpha-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTNNAL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b
SP1: - -
SP2: -

Relevant External Links for CTNNAL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTNNAL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTNNAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTNNAL1 Gene

This gene is overexpressed in Adrenal Gland (x9.3).

Protein differential expression in normal tissues from HIPED for CTNNAL1 Gene

This gene is overexpressed in Bone (29.8) and Cerebrospinal fluid (25.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CTNNAL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CTNNAL1 Gene:


SOURCE GeneReport for Unigene cluster for CTNNAL1 Gene:


mRNA Expression by UniProt/SwissProt for CTNNAL1 Gene:

Tissue specificity: Widely expressed. Expressed at lower level in neural tissues and at the highest level in the adrenal gland.

Evidence on tissue expression from TISSUES for CTNNAL1 Gene

  • Nervous system(4.5)
  • Stomach(4.2)
  • Lung(2.2)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with CTNNAL1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTNNAL1 Gene

Orthologs for CTNNAL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CTNNAL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CTNNAL1 34 33
  • 99.23 (n)
(Canis familiaris)
Mammalia CTNNAL1 34 33
  • 92.56 (n)
(Bos Taurus)
Mammalia CTNNAL1 34 33
  • 92.26 (n)
(Mus musculus)
Mammalia Ctnnal1 16 34 33
  • 85.08 (n)
(Rattus norvegicus)
Mammalia Ctnnal1 33
  • 85.01 (n)
(Monodelphis domestica)
Mammalia CTNNAL1 34
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia CTNNAL1 34
  • 66 (a)
(Gallus gallus)
Aves CTNNAL1 34 33
  • 76.1 (n)
(Anolis carolinensis)
Reptilia CTNNAL1 34
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ctnnal1 33
  • 70.62 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11519 33
(Danio rerio)
Actinopterygii ctnnal1 34 33
  • 62.93 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011097 33
  • 48.81 (n)
fruit fly
(Drosophila melanogaster)
Insecta alpha-catenin-related 34 35 33
  • 44.15 (n)
(Caenorhabditis elegans)
Secernentea ctn-1 34 35 33
  • 50.82 (n)
Species where no ortholog for CTNNAL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTNNAL1 Gene

Gene Tree for CTNNAL1 (if available)
Gene Tree for CTNNAL1 (if available)
Evolutionary constrained regions (ECRs) for CTNNAL1: view image

Paralogs for CTNNAL1 Gene

Paralogs for CTNNAL1 Gene

genes like me logo Genes that share paralogs with CTNNAL1: view

Variants for CTNNAL1 Gene

Sequence variations from dbSNP and Humsavar for CTNNAL1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000006986 -- 108,985,084(-) T/C intron_variant
rs1000012990 -- 108,975,330(-) C/T intron_variant
rs1000154177 -- 108,946,347(-) T/A intron_variant
rs1000204190 -- 108,944,264(-) A/G intron_variant
rs1000208301 -- 108,985,386(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CTNNAL1 Gene

Variant ID Type Subtype PubMed ID
esv2676852 CNV deletion 23128226
esv3621426 CNV loss 21293372
nsv1141020 CNV deletion 24896259
nsv475684 CNV novel sequence insertion 20440878
nsv6660 CNV deletion 18451855

Variation tolerance for CTNNAL1 Gene

Residual Variation Intolerance Score: 63.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.59; 89.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CTNNAL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTNNAL1 Gene

Disorders for CTNNAL1 Gene

Additional Disease Information for CTNNAL1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CTNNAL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTNNAL1 Gene

Publications for CTNNAL1 Gene

  1. Identification and chromosomal localization of CTNNAL1, a novel protein homologous to alpha-catenin. (PMID: 9806841) Zhang JS … Smith DI (Genomics 1998) 2 3 4 22 58
  2. Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation. (PMID: 12270917) Park B … Toksoz D (The Journal of biological chemistry 2002) 3 4 22 58
  3. Human alpha-catulin, a novel alpha-catenin-like molecule with conserved genomic structure, but deviating alternative splicing. (PMID: 10542337) Janssens B … van Roy F (Biochimica et biophysica acta 1999) 3 4 22 58
  4. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 44 58
  5. Alpha-catulin, a Rho signalling component, can regulate NF-kappaB through binding to IKK-beta, and confers resistance to apoptosis. (PMID: 17952117) Wiesner C … de Martin R (Oncogene 2008) 3 22 58

Products for CTNNAL1 Gene

Sources for CTNNAL1 Gene

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