Aliases for CTNNA3 Gene
External Ids for CTNNA3 Gene
Previous GeneCards Identifiers for CTNNA3 Gene
This gene encodes a protein that belongs to the vinculin/alpha-catenin family. The encoded protein plays a role in cell-cell adhesion in muscle cells. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia, familial 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
GeneCards Summary for CTNNA3 Gene
CTNNA3 (Catenin Alpha 3) is a Protein Coding gene. Diseases associated with CTNNA3 include Arrhythmogenic Right Ventricular Dysplasia, Familial, 13 and Arrhythmogenic Right Ventricular Cardiomyopathy. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Sertoli-Sertoli Cell Junction Dynamics. Gene Ontology (GO) annotations related to this gene include structural molecule activity and beta-catenin binding. An important paralog of this gene is CTNNA2.
UniProtKB/Swiss-Prot for CTNNA3 Gene
May be involved in formation of stretch-resistant cell-cell adhesion complexes.