Aliases for CTNNA3 Gene
Aliases for CTNNA3 Gene
External Ids for CTNNA3 Gene
- HGNC: 2511
- Entrez Gene: 29119
- Ensembl: ENSG00000183230
- OMIM: 607667
- UniProtKB: Q9UI47
Previous GeneCards Identifiers for CTNNA3 Gene
- GC00U990693
- GC10M067024
- GC10M067349
- GC10M067679
- GC10M061677
Summaries for CTNNA3 Gene
-
This gene encodes a protein that belongs to the vinculin/alpha-catenin family. The encoded protein plays a role in cell-cell adhesion in muscle cells. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia, familial 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
GeneCards Summary for CTNNA3 Gene
CTNNA3 (Catenin Alpha 3) is a Protein Coding gene. Diseases associated with CTNNA3 include Arrhythmogenic Right Ventricular Dysplasia, Familial, 13 and Arrhythmogenic Right Ventricular Cardiomyopathy. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Sertoli-Sertoli Cell Junction Dynamics. Gene Ontology (GO) annotations related to this gene include structural molecule activity and beta-catenin binding. An important paralog of this gene is CTNNA2.
UniProtKB/Swiss-Prot for CTNNA3 Gene
-
May be involved in formation of stretch-resistant cell-cell adhesion complexes.
Additional gene information for CTNNA3 Gene
- Monarch Initiative
- Search for CTNNA3 at DataMed
- Search for CTNNA3 at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTNNA3 Gene
Genomics for CTNNA3 Gene
GeneHancer (GH) Regulatory Elements for CTNNA3 Gene
Promoters and enhancers for CTNNA3 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH10J067763 | Enhancer | 1.3 | Ensembl ENCODE | 658.7 | -0.7 | -745 | 2.6 | HDGF ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 E2F8 ZNF207 | CTNNA3 TRS-TGA1-1 CCAR1 HNRNPH3 HERC4 SIRT1 RUFY2 RPL26P27 TET1 RPL12P8 | |
| GH10J067667 | Promoter | 0.8 | EPDnew | 650.2 | +98.0 | 98020 | 0.1 | ZNF148 ZNF335 PKNOX1 POLR2A DPF2 | CTNNA3 AKR1B10P1 PIR34883 | |
| GH10J067696 | Promoter | 0.6 | EPDnew | 650.2 | +67.4 | 67438 | 0.1 | ATF7 | CTNNA3 AKR1B10P1 PIR34883 | |
| GH10J067761 | Enhancer | 0.4 | Ensembl | 650.7 | +1.7 | 1655 | 0.4 | ZNF316 ZBTB33 | CTNNA3 AKR1B10P1 | |
| GH10J067762 | Enhancer | 0.2 | Ensembl | 650.7 | +0.7 | 709 | 0.2 | CTNNA3 TRS-TGA1-1 AKR1B10P1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CTNNA3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CTNNA3 gene promoter:
-
- Zic1
- deltaCREB
- CREB
- Evi-1
- C/EBPalpha
- CHOP-10
- FAC1
- p53
- TFIID
- TBP
Regulatory Element Products
Genomic Locations for CTNNA3 Gene
Genomic Locations for CTNNA3 Gene
- chr10:65,912,518-67,763,610
- (GRCh38/hg38)
- Size:
- 1,851,093 bases
- Orientation:
- Minus strand
- chr10:67,672,276-69,455,949
- (GRCh37/hg19)
- Size:
- 1,783,674 bases
- Orientation:
- Minus strand
Genomic View for CTNNA3 Gene
Genes around CTNNA3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q21.3 by Entrez Gene
- 10q21.3 by HGNC
- 10q21.3 by Ensembl
CTNNA3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CTNNA3 Gene
Proteins for CTNNA3 Gene
-
Protein details for CTNNA3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UI47-CTNA3_HUMAN
- Recommended name:
- Catenin alpha-3
- Protein Accession:
- Q9UI47
- Q5VSR2
- Q6P056
Protein attributes for CTNNA3 Gene
- Size:
- 895 amino acids
- Molecular mass:
- 99809 Da
- Quaternary structure:
-
- Interacts with CTNNB1.
Protein Expression for CTNNA3 Gene
Post-translational modifications for CTNNA3 Gene
Other Protein References for CTNNA3 Gene
Antibody Products
- Novus Biologicals Antibodies for CTNNA3
- Invitrogen Antibodies for CTNNA3
- GeneTex CTNNA3 Antibody for CTNNA3
-
Boster Bio Antibodies for CTNNA3
-
Santa Cruz Biotechnology (SCBT) Antibodies for CTNNA3
- Sino Biological Antibodies for CTNNA3
Protein Products
-
OriGene Purified Proteins for CTNNA3
- Search Origene for MassSpec and Protein Over-expression Lysates for CTNNA3
- Origene Custom Protein Services for CTNNA3
- antibodies-online: Search results for 4 available CTNNA3 Proteins ranked by validation data
- Compare Top CTNNA3 Proteins
-
Quality Products:
- Search GeneTex for Proteins for CTNNA3
Assay Products
No data available for DME Specific Peptides for CTNNA3 Gene
Domains & Families for CTNNA3 Gene
Gene Families for CTNNA3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
Protein Domains for CTNNA3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CTNNA3 Gene
Graphical View of Domain Structure for InterPro Entry
Q9UI47- Family:
-
- Belongs to the vinculin/alpha-catenin family.
Function for CTNNA3 Gene
Molecular function for CTNNA3 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in formation of stretch-resistant cell-cell adhesion complexes.
Phenotypes From GWAS Catalog for CTNNA3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 11590244 |
| GO:0008013 | beta-catenin binding | IPI | 23136403 |
| GO:0045296 | cadherin binding | IEA,TAS | 11590244 |
| GO:0051015 | actin filament binding | IEA | -- |
Phenotypes for CTNNA3 Gene
- MGI mutant phenotypes for CTNNA3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CTNNA3:
Animal Models for CTNNA3 Gene
- MGI Knock Outs for CTNNA3:
-
- Ctnna3 Ctnna3<tm1.1Fvr>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CTNNA3
-
CRISPR Products
-
OriGene CRISPR knockouts for CTNNA3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CTNNA3
- genomics-online: gRNA clones - Search results for 86 available CTNNA3 gene related products
- Overview of 86 available CTNNA3 gene related products
- Applied Biological Materials CRISPR for CTNNA3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CTNNA3
- GenScript: Design CRISPR guide RNA sequences for CTNNA3
miRNA for CTNNA3 Gene
- miRTarBase miRNAs that target CTNNA3
-
- hsa-mir-182-5p (MIRT442967)
- hsa-mir-5704 (MIRT442968)
- hsa-mir-4470 (MIRT442969)
- hsa-mir-3065-5p (MIRT442970)
- hsa-mir-3613-3p (MIRT442971)
- hsa-mir-1295b-3p (MIRT442972)
- hsa-mir-15a-3p (MIRT442973)
- hsa-mir-4717-5p (MIRT442974)
- hsa-mir-6826-3p (MIRT643565)
- hsa-mir-6891-3p (MIRT643566)
- hsa-mir-6072 (MIRT643567)
- hsa-mir-6795-3p (MIRT643568)
- hsa-mir-6887-3p (MIRT643569)
- hsa-mir-548ay-3p (MIRT643570)
- hsa-mir-548at-3p (MIRT643571)
- hsa-mir-548as-3p (MIRT643572)
- hsa-mir-548t-3p (MIRT643573)
- hsa-mir-548ap-3p (MIRT643574)
- hsa-mir-548aa (MIRT643575)
- hsa-mir-548x-3p (MIRT643576)
- hsa-mir-548j-3p (MIRT643577)
- hsa-mir-548aq-3p (MIRT643578)
- hsa-mir-548am-3p (MIRT643579)
- hsa-mir-548aj-3p (MIRT643580)
- hsa-mir-548ah-3p (MIRT643581)
- hsa-mir-548ae-3p (MIRT643582)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CTNNA3
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- genomics-online: shRNA clones - Search results for 86 available CTNNA3 gene related products
- Overview of 86 available CTNNA3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CTNNA3
- VectorBuilder custom plasmid, inducible vectors for CTNNA3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CTNNA3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CTNNA3
- Applied Biological Materials Clones for CTNNA3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CTNNA3
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CTNNA3 Gene
Localization for CTNNA3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CTNNA3 Gene
- Cytoplasm, cytoskeleton. Note=Localizes to intercalated disks of cardiomyocytes and in peritubular myoid cells of testis, and colocalizes with CTNNA1 and CTNNA2. {ECO:0000269 PubMed:11590244}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 4 |
| plasma membrane | 2 |
| nucleus | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005912 | adherens junction | IEA | -- |
| GO:0005916 | fascia adherens | IEA,IDA | 11590244 |
| GO:0030027 | lamellipodium | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CTNNA3 Gene
Pathways & Interactions for CTNNA3 Gene
Pathways by source for CTNNA3 Gene
1 BioSystems pathway for CTNNA3 Gene
8 KEGG pathways for CTNNA3 Gene
3 GeneGo (Thomson Reuters) pathways for CTNNA3 Gene
4 R&D Systems pathways for CTNNA3 Gene
- Blood-Brain Barrier and Immune Cell Transmigration: CCL2/MCP-1 Signaling Pathways
- Blood-Brain Barrier and Immune Cell Transmigration: ICAM-1/CD54 Signaling Pathways
- Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways
- Blood-Brain Barrier and Immune Cell Transmigration: VEGF Signaling Pathways
Interacting Proteins for CTNNA3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007155 | cell adhesion | IEA | -- |
| GO:0086073 | bundle of His cell-Purkinje myocyte adhesion involved in cell communication | IMP | 23136403 |
| GO:0086091 | regulation of heart rate by cardiac conduction | IMP | 23136403 |
| GO:0098609 | cell-cell adhesion | IPI,IEA | 11590244 |
| GO:0098911 | regulation of ventricular cardiac muscle cell action potential | IMP | 23136403 |
No data available for SIGNOR curated interactions for CTNNA3 Gene
Drugs & Compounds for CTNNA3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| antidepressants | Pharma | 0 |
Transcripts for CTNNA3 Gene
mRNA/cDNA for CTNNA3 Gene
- (11) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (18) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000330298 696 bps (uc057tpe.1)
- ENST00000373735 1083 bps (uc057tow.1)
- ENST00000433211 10675 bps (uc001jmw.3)
- ENST00000494580 470 bps (uc057toz.1)
- ENST00000545309 555 bps (uc057tpd.1)
Unigene Clusters for CTNNA3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CTNNA3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CTNNA3
- genomics-online: gRNA clones - Search results for 86 available CTNNA3 gene related products
- Overview of 86 available CTNNA3 gene related products
- Applied Biological Materials CRISPR for CTNNA3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CTNNA3
- GenScript: Design CRISPR guide RNA sequences for CTNNA3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CTNNA3
- Browse OriGene Inhibitory RNA Products For CTNNA3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTNNA3
- genomics-online: shRNA clones - Search results for 86 available CTNNA3 gene related products
- Overview of 86 available CTNNA3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CTNNA3
- VectorBuilder custom plasmid, inducible vectors for CTNNA3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CTNNA3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CTNNA3
- Applied Biological Materials Clones for CTNNA3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for CTNNA3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Myelinating Oligodendrocyte Cells Forebrain White Matter
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
mRNA differential expression in normal tissues according to GTEx for CTNNA3 Gene
This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.9) and Heart - Left Ventricle (x6.5).
This gene is overexpressed in Heart (25.7), Spinal cord (22.4), and Fetal heart (18.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CTNNA3 Gene
NURSA nuclear receptor signaling pathways regulating expression of CTNNA3 Gene:
CTNNA3SOURCE GeneReport for Unigene cluster for CTNNA3 Gene:
Hs.660362mRNA Expression by UniProt/SwissProt for CTNNA3 Gene:
Q9UI47-CTNA3_HUMAN
Tissue specificity:
Predominantly expressed in heart and testis. Expressed at lower levels in brain, kidney, liver and skeletal muscle.
Evidence on tissue expression from TISSUES for CTNNA3 Gene
- Nervous system(4.3)
- Liver(4.1)
- Heart(3.4)
- Lung(2.5)
- Pancreas(2.5)
- Eye(2.3)
- Muscle(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CTNNA3 Gene
Germ Layers:
- mesoderm
Systems:
- cardiovascular
Regions:
Head and neck:
- ear
Thorax:
- heart
- heart valve
General:
- blood
- blood vessel
Primer Products
-
OriGene qPCR primer pairs for CTNNA3
- genomics-online: primer clones - Search results for 86 available CTNNA3 gene related products
- Overview of 86 available CTNNA3 gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners for CTNNA3 Gene
Orthologs for CTNNA3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CTNNA3 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CTNNA3 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CTNNA3 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| mouse (Mus musculus) |
Mammalia | Ctnna3 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ctnna3 33 |
|
||
| chicken (Gallus gallus) |
Aves | CTNNA3 34 33 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany |
- Species where no ortholog for CTNNA3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for CTNNA3 Gene
- ENSEMBL:
- Gene Tree for CTNNA3 (if available)
- TreeFam:
- Gene Tree for CTNNA3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CTNNA3: view image
Paralogs for CTNNA3 Gene
Variants for CTNNA3 Gene
| SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1060502222 | uncertain-significance, Arrhythmogenic right ventricular dysplasia, familial, 13 | 66,103,240(-) | C/T | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant | |
| rs1060502223 | uncertain-significance, Arrhythmogenic right ventricular dysplasia, familial, 13 | 66,103,185(-) | C/T | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant | |
| rs1060504519 | likely-benign, Arrhythmogenic right ventricular dysplasia, familial, 13 | 66,379,348(-) | G/A | coding_sequence_variant, genic_downstream_transcript_variant, synonymous_variant | |
| rs10997034 | benign, Arrhythmogenic right ventricular dysplasia, familial, 13 | 66,280,482(-) | G/T | coding_sequence_variant, genic_downstream_transcript_variant, synonymous_variant | |
| rs111880127 | benign, Arrhythmogenic right ventricular dysplasia, familial, 13 | 67,539,533(-) | A/G | coding_sequence_variant, genic_upstream_transcript_variant, synonymous_variant |
Residual Variation Intolerance Score:
39.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.26;
90.57% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CTNNA3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTNNA3 Gene
Disorders for CTNNA3 Gene
(10) MalaCards diseases for CTNNA3 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| arrhythmogenic right ventricular dysplasia, familial, 13 |
|
|
| arrhythmogenic right ventricular cardiomyopathy |
|
|
| familial isolated arrhythmogenic ventricular dysplasia, right dominant form |
|
|
| familial isolated arrhythmogenic ventricular dysplasia, biventricular form |
|
|
| familial isolated arrhythmogenic ventricular dysplasia, left dominant form |
|
|
Search CTNNA3 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
CTNA3_HUMAN- Arrhythmogenic right ventricular dysplasia, familial, 13 (ARVD13) [MIM:615616]: A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias. {ECO:0000269 PubMed:23136403}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for CTNNA3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for CTNNA3 Gene
Publications for CTNNA3 Gene
- Assessment of the CTNNA3 gene encoding human alpha T-catenin regarding its involvement in dilated cardiomyopathy. (PMID: 12596047) Janssens B … Towbin JA (Human genetics 2003) 2 3 4 22 58
- Alpha-T-catenin (CTNNA3) gene was identified as a risk variant for toluene diisocyanate-induced asthma by genome-wide association analysis. (PMID: 19187332) Kim SH … Park HS (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2009) 3 22 44 58
- An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3. (PMID: 19105203) Edwards TL … Ritchie MD (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 22 44 58
- Is alpha-T catenin (VR22) an Alzheimer's disease risk gene? (PMID: 17209133) Bertram L … Tanzi RE (Journal of medical genetics 2007) 3 22 44 58
- Interaction between the alpha-T catenin gene (VR22) and APOE in Alzheimer's disease. (PMID: 16199552) Martin ER … Pericak-Vance MA (Journal of medical genetics 2005) 3 22 44 58
Products for CTNNA3 Gene
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- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CTNNA3
- Sino Biological Human cDNA Clone for CTNNA3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for CTNNA3
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CTNNA3
- Novus Biologicals lysates and proteins for CTNNA3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- VectorBuilder custom plasmid, inducible vectors for CTNNA3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CTNNA3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 67 available CTNNA3 Antibodies ranked by validation data
- Compare Top CTNNA3 Antibodies
- antibodies-online: Search results for available CTNNA3 related products ranked by validation data
- antibodies-online: Search results for 4 available CTNNA3 Proteins ranked by validation data
- Compare Top CTNNA3 Proteins
- Quality Products:
- GeneTex CTNNA3 Antibody for CTNNA3
- Search GeneTex for Proteins for CTNNA3
- Santa Cruz Biotechnology (SCBT) Antibodies for CTNNA3
- Search Santa Cruz Biotechnology (SCBT) for CTNNA3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CTNNA3
- Horizon Cell Lines for CTNNA3
- genomics-online: cdna clones - Search results for 86 available CTNNA3 gene related products
- Overview of 86 available CTNNA3 gene related products
- orf clones - Search results for 86 available CTNNA3 gene related products
- Overview of 86 available CTNNA3 gene related products
- genomics-online: gRNA clones - Search results for 86 available CTNNA3 gene related products
- Overview of 86 available CTNNA3 gene related products
- genomics-online: primer clones - Search results for 86 available CTNNA3 gene related products
- Overview of 86 available CTNNA3 gene related products
- genomics-online: shRNA clones - Search results for 86 available CTNNA3 gene related products
- Overview of 86 available CTNNA3 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CTNNA3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CTNNA3
- GeneCopoeia miRNA 3'UTR Target clone products for CTNNA3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTNNA3
- Boster Bio Antibodies for CTNNA3
- Browse Boster Bio ELISA Kits
Sources for CTNNA3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt