Aliases for CTNNA2 Gene
External Ids for CTNNA2 Gene
Previous GeneCards Identifiers for CTNNA2 Gene
GeneCards Summary for CTNNA2 Gene
CTNNA2 (Catenin Alpha 2) is a Protein Coding gene. Diseases associated with CTNNA2 include Cortical Dysplasia, Complex, With Other Brain Malformations 9 and Arrhythmogenic Right Ventricular Cardiomyopathy. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling and Gastric cancer. Gene Ontology (GO) annotations related to this gene include structural molecule activity and structural constituent of cytoskeleton. An important paralog of this gene is CTNNA1.
UniProtKB/Swiss-Prot Summary for CTNNA2 Gene
May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity).