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Aliases for CTNNA2 Gene

Aliases for CTNNA2 Gene

  • Catenin Alpha 2 2 3 5
  • Catenin (Cadherin-Associated Protein), Alpha 2 2 3
  • Cadherin-Associated Protein, Related 2 3
  • Alpha-Catenin-Related Protein 3 4
  • Cancer/Testis Antigen 114 2 3
  • Alpha-N-Catenin 2 3
  • CAPR 3 4
  • Catenin Alpha-2 3
  • Alpha N-Catenin 4
  • CAP-R 3
  • CT114 3
  • CTNR 3

External Ids for CTNNA2 Gene

Previous GeneCards Identifiers for CTNNA2 Gene

  • GC02P080016
  • GC02P079697
  • GC02P079853
  • GC02P079790
  • GC02P079593
  • GC02P079412

Summaries for CTNNA2 Gene

GeneCards Summary for CTNNA2 Gene

CTNNA2 (Catenin Alpha 2) is a Protein Coding gene. Diseases associated with CTNNA2 include Mixed Germ Cell Cancer. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Sertoli-Sertoli Cell Junction Dynamics. Gene Ontology (GO) annotations related to this gene include structural molecule activity and structural constituent of cytoskeleton. An important paralog of this gene is CTNNA1.

UniProtKB/Swiss-Prot for CTNNA2 Gene

  • May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation.

Additional gene information for CTNNA2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTNNA2 Gene

Genomics for CTNNA2 Gene

GeneHancer (GH) Regulatory Elements for CTNNA2 Gene

Promoters and enhancers for CTNNA2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J079512 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 659.7 +327.8 327776 1.2 CTCF MXI1 USF1 MAX ZNF140 SIN3A POLR2A PATZ1 VEZF1 SCRT2 CTNNA2 RNU6-561P LOC101927987 ENSG00000277171
GH02J079579 Promoter 0.5 EPDnew 650.1 +394.7 394675 0.1 CTNNA2 LOC100422337 RNU6-561P
GH02J079511 Enhancer 0.9 ENCODE 9.7 +326.3 326269 0.1 MLX ARID4B SIN3A SLC30A9 ZNF143 NFKBIZ NFYC MXD4 MIER2 REST RNU6-561P CTNNA2 LOC101927987 ENSG00000277171
GH02J079670 Enhancer 0.5 ENCODE 11 +485.2 485179 0.2 CTCF XRCC5 ZNF143 RAD21 RNU6-561P CTNNA2 MIR4264 GC02M079749
GH02J079722 Enhancer 0.5 ENCODE 10 +538.3 538327 2.9 SP1 JUND FOSL2 FOS RNU6-561P CTNNA2 GC02M079749 MIR4264
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CTNNA2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CTNNA2 gene promoter:
  • SRY
  • HSF2
  • AML1a
  • Arnt
  • Gfi-1
  • Sp1
  • Sox5
  • POU2F1
  • POU2F1a
  • deltaCREB

Genomic Locations for CTNNA2 Gene

Genomic Locations for CTNNA2 Gene
1,463,638 bases
Plus strand
1,463,637 bases
Plus strand

Genomic View for CTNNA2 Gene

Genes around CTNNA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTNNA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTNNA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTNNA2 Gene

Proteins for CTNNA2 Gene

  • Protein details for CTNNA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Catenin alpha-2
    Protein Accession:
    Secondary Accessions:
    • B3KXE5
    • B7Z2W7
    • B7Z352
    • B7Z898
    • Q4ZFW1
    • Q53R26
    • Q53R33
    • Q53T67
    • Q53T71
    • Q53TM8
    • Q7Z3L1
    • Q7Z3Y0

    Protein attributes for CTNNA2 Gene

    953 amino acids
    Molecular mass:
    105313 Da
    Quaternary structure:
    • Interacts with CDH1 and CDH2 (By similarity). Interacts with ZNF639; recruits CTNNA2 to the nucleus (PubMed:16182284).

    Alternative splice isoforms for CTNNA2 Gene

neXtProt entry for CTNNA2 Gene

Post-translational modifications for CTNNA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CTNNA2 Gene

Domains & Families for CTNNA2 Gene

Gene Families for CTNNA2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CTNNA2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the vinculin/alpha-catenin family.
  • Belongs to the vinculin/alpha-catenin family.
genes like me logo Genes that share domains with CTNNA2: view

Function for CTNNA2 Gene

Molecular function for CTNNA2 Gene

UniProtKB/Swiss-Prot Function:
May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation.
GENATLAS Biochemistry:
catenin alpha 2,102 kDa,desmosomal plaque component,regulating cell adhesion (component of the E cadherin multiprotein complex,homologous to vinculin)

Phenotypes From GWAS Catalog for CTNNA2 Gene

Gene Ontology (GO) - Molecular Function for CTNNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton NAS 8432524
GO:0005515 protein binding IPI 16182284
GO:0008013 beta-catenin binding IEA --
GO:0042802 identical protein binding IEA --
GO:0045296 cadherin binding IDA,IEA 25468996
genes like me logo Genes that share ontologies with CTNNA2: view
genes like me logo Genes that share phenotypes with CTNNA2: view

Animal Models for CTNNA2 Gene

MGI Knock Outs for CTNNA2:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CTNNA2 Gene

Localization for CTNNA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTNNA2 Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell projection, axon. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTNNA2 gene
Compartment Confidence
cytosol 5
plasma membrane 3
nucleus 3
cytoskeleton 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for CTNNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA,IDA 16182284
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with CTNNA2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CTNNA2 Gene

Pathways & Interactions for CTNNA2 Gene

genes like me logo Genes that share pathways with CTNNA2: view

SIGNOR curated interactions for CTNNA2 Gene


Gene Ontology (GO) - Biological Process for CTNNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IEA --
GO:0007015 actin filament organization IEA --
GO:0007155 cell adhesion IEA --
GO:0007275 multicellular organism development IEA --
GO:0007409 axonogenesis ISS --
genes like me logo Genes that share ontologies with CTNNA2: view

Drugs & Compounds for CTNNA2 Gene

(1) Drugs for CTNNA2 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0
genes like me logo Genes that share compounds with CTNNA2: view

Transcripts for CTNNA2 Gene

Unigene Clusters for CTNNA2 Gene

Catenin (cadherin-associated protein), alpha 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTNNA2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: - -
SP2: - - -
SP3: - - - - - -
SP4: - -
SP5: -

Relevant External Links for CTNNA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTNNA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTNNA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTNNA2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x7.0), Brain - Amygdala (x6.8), Brain - Cortex (x6.5), Brain - Anterior cingulate cortex (BA24) (x6.3), Brain - Hippocampus (x4.9), and Brain - Caudate (basal ganglia) (x4.4).

Protein differential expression in normal tissues from HIPED for CTNNA2 Gene

This gene is overexpressed in Fetal Brain (13.9), Brain (13.8), Retina (9.4), and Frontal cortex (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CTNNA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CTNNA2 Gene:


SOURCE GeneReport for Unigene cluster for CTNNA2 Gene:


Evidence on tissue expression from TISSUES for CTNNA2 Gene

  • Nervous system(4.9)
  • Eye(2.5)
genes like me logo Genes that share expression patterns with CTNNA2: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTNNA2 Gene

Orthologs for CTNNA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CTNNA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CTNNA2 34
  • 100 (a)
-- 34
  • 99 (a)
(Pan troglodytes)
Mammalia CTNNA2 33
  • 99.23 (n)
(Ornithorhynchus anatinus)
Mammalia CTNNA2 34
  • 98 (a)
(Canis familiaris)
Mammalia CTNNA2 34 33
  • 94.26 (n)
(Monodelphis domestica)
Mammalia CTNNA2 34
  • 94 (a)
(Rattus norvegicus)
Mammalia Ctnna2 33
  • 90.98 (n)
(Mus musculus)
Mammalia Ctnna2 16 34 33
  • 90.77 (n)
(Gallus gallus)
Aves -- 34
  • 97 (a)
CTNNA2 34 33
  • 83.06 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 100 (a)
-- 34
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ctnna2 33
  • 81.6 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6961 33
(Danio rerio)
Actinopterygii ctnna2 34 33
  • 80.12 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003424 33
  • 63.2 (n)
fruit fly
(Drosophila melanogaster)
Insecta alpha-Cat 34 35 33
  • 62.23 (n)
(Caenorhabditis elegans)
Secernentea hmp-1 34 35 33
  • 48.42 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 15 (a)
Cin.3973 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3973 33
Species where no ortholog for CTNNA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTNNA2 Gene

Gene Tree for CTNNA2 (if available)
Gene Tree for CTNNA2 (if available)
Evolutionary constrained regions (ECRs) for CTNNA2: view image

Paralogs for CTNNA2 Gene

Paralogs for CTNNA2 Gene

(2) SIMAP similar genes for CTNNA2 Gene using alignment to 7 proteins:

  • B9A010_HUMAN
  • C9IZ88_HUMAN
  • C9J144_HUMAN
  • Q49AD3_HUMAN
genes like me logo Genes that share paralogs with CTNNA2: view

Variants for CTNNA2 Gene

Sequence variations from dbSNP and Humsavar for CTNNA2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000003009 -- 79,643,318(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000005779 -- 80,158,648(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000006209 -- 80,274,913(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000008715 -- 79,854,727(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000009224 -- 79,877,228(+) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CTNNA2 Gene

Variant ID Type Subtype PubMed ID
dgv1136e212 CNV loss 25503493
dgv466n27 CNV loss 19166990
dgv6942n54 CNV loss 21841781
esv22845 CNV loss 19812545
esv2658492 CNV deletion 23128226
esv2663198 CNV deletion 23128226
esv2672919 CNV deletion 23128226
esv2675267 CNV deletion 23128226
esv2720256 CNV deletion 23290073
esv2720257 CNV deletion 23290073
esv2720258 CNV deletion 23290073
esv2720259 CNV deletion 23290073
esv27488 CNV loss 19812545
esv2759069 CNV loss 17122850
esv2762266 CNV loss 21179565
esv2762701 CNV loss 21179565
esv3305536 CNV mobile element insertion 20981092
esv3306695 CNV mobile element insertion 20981092
esv3324614 CNV insertion 20981092
esv3325738 CNV insertion 20981092
esv3328298 CNV insertion 20981092
esv3348116 CNV insertion 20981092
esv3359648 CNV insertion 20981092
esv3375612 CNV insertion 20981092
esv34179 CNV loss 18971310
esv3447691 CNV insertion 20981092
esv3559177 CNV deletion 23714750
esv3583891 CNV loss 25503493
esv3583892 CNV loss 25503493
esv3583894 CNV loss 25503493
esv3583897 CNV loss 25503493
esv3591408 CNV loss 21293372
esv3591409 CNV loss 21293372
esv3591410 CNV loss 21293372
esv3591411 CNV loss 21293372
esv3591413 CNV gain 21293372
esv3591416 CNV gain 21293372
esv3591417 CNV loss 21293372
esv3591418 CNV loss 21293372
esv3591419 CNV loss 21293372
esv3591421 CNV loss 21293372
esv3591422 CNV loss 21293372
esv3591423 CNV loss 21293372
esv3591424 CNV loss 21293372
esv6333 CNV gain 19470904
nsv1000784 CNV loss 25217958
nsv10054 CNV loss 18304495
nsv10055 CNV gain 18304495
nsv10056 CNV loss 18304495
nsv1008702 CNV loss 25217958
nsv1012034 CNV gain 25217958
nsv1071599 CNV deletion 25765185
nsv1109264 CNV deletion 24896259
nsv1124793 CNV duplication 24896259
nsv1134875 CNV deletion 24896259
nsv1142948 CNV deletion 24896259
nsv2800 CNV insertion 18451855
nsv2801 CNV insertion 18451855
nsv433201 CNV loss 18776910
nsv437287 CNV loss 16327808
nsv458407 CNV loss 19166990
nsv458418 CNV loss 19166990
nsv475682 CNV novel sequence insertion 20440878
nsv478336 CNV novel sequence insertion 20440878
nsv516404 CNV gain 19592680
nsv516819 CNV loss 19592680
nsv518912 CNV loss 19592680
nsv522260 CNV gain 19592680
nsv524592 CNV gain 19592680
nsv527416 CNV gain 19592680
nsv528317 CNV loss 19592680
nsv528619 CNV loss 19592680
nsv528724 CNV loss 19592680
nsv582336 CNV loss 21841781
nsv582337 CNV loss 21841781
nsv582338 CNV loss 21841781
nsv582339 CNV loss 21841781
nsv582340 CNV loss 21841781
nsv818061 CNV gain 17921354
nsv829480 CNV gain 20364138
nsv829482 CNV loss 20364138
nsv963626 CNV duplication 23825009
nsv963627 CNV duplication 23825009

Variation tolerance for CTNNA2 Gene

Residual Variation Intolerance Score: 2.85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.73; 46.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CTNNA2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTNNA2 Gene

Disorders for CTNNA2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CTNNA2 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
mixed germ cell cancer
  • mixed germ cell neoplasm
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CTNNA2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CTNNA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTNNA2 Gene

Publications for CTNNA2 Gene

  1. Characterization and chromosomal assignment of a human cDNA encoding a protein related to the murine 102-kDa cadherin-associated protein (alpha-catenin). (PMID: 8432524) Claverie JM … Petit C (Genomics 1993) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58
  5. Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. (PMID: 19416921) Scott LJ … Boehnke M (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 44 58

Products for CTNNA2 Gene

Sources for CTNNA2 Gene

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