Aliases for CTHRC1 Gene
External Ids for CTHRC1 Gene
Previous GeneCards Identifiers for CTHRC1 Gene
This locus encodes a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]
GeneCards Summary for CTHRC1 Gene
CTHRC1 (Collagen Triple Helix Repeat Containing 1) is a Protein Coding gene. Diseases associated with CTHRC1 include Barrett Esophagus and Adenocarcinoma. Among its related pathways are Wnt signaling network and Noncanonical Wnt signaling pathway. Gene Ontology (GO) annotations related to this gene include frizzled binding and Wnt-protein binding. An important paralog of this gene is METTL24.
UniProtKB/Swiss-Prot Summary for CTHRC1 Gene
May act as a negative regulator of collagen matrix deposition.