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Aliases for CTGF Gene

Aliases for CTGF Gene

  • Connective Tissue Growth Factor 2 3 5
  • Hypertrophic Chondrocyte-Specific Protein 24 3 4
  • Insulin-Like Growth Factor-Binding Protein 8 3 4
  • IGF-Binding Protein 8 3 4
  • CCN Family Member 2 3 4
  • IGFBP-8 3 4
  • IGFBP8 3 4
  • HCS24 3 4
  • IBP-8 3 4
  • CCN2 3 4
  • NOV2 3

External Ids for CTGF Gene

Previous GeneCards Identifiers for CTGF Gene

  • GC06M132116
  • GC06M132249
  • GC06M132311
  • GC06M129844
  • GC06M132269

Summaries for CTGF Gene

Entrez Gene Summary for CTGF Gene

  • The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]

GeneCards Summary for CTGF Gene

CTGF (Connective Tissue Growth Factor) is a Protein Coding gene. Diseases associated with CTGF include Systemic Scleroderma and Renal Fibrosis. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PAK Pathway. Gene Ontology (GO) annotations related to this gene include growth factor activity and integrin binding. An important paralog of this gene is NOV.

UniProtKB/Swiss-Prot for CTGF Gene

  • Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.

Gene Wiki entry for CTGF Gene

Additional gene information for CTGF Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTGF Gene

Genomics for CTGF Gene

GeneHancer (GH) Regulatory Elements for CTGF Gene

Promoters and enhancers for CTGF Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I131946 Promoter/Enhancer 2.5 VISTA EPDnew Ensembl ENCODE dbSUPER 550.8 -0.1 -59 10.2 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 CTGF ENSG00000227220 LINC01013 GC06M131950 GC06P132061
GH06I131976 Enhancer 0.9 ENCODE 12 -25.6 -25557 0.7 FOXA2 MLX ZFP64 ARID4B DMAP1 ETS1 YY1 RXRA MXD4 MIER2 ENSG00000227220 CTGF LINC01013 GC06P132061
GH06I132146 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 3.8 -196.4 -196410 1.9 ATF7 ATF2 CTGF TAAR2 LINC01013 EEF1A1P36 GC06M132077
GH06I132059 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 1.7 -111.1 -111065 5.6 SOX5 SOX13 JUN HMG20A SP1 JUND POLR2A SMAD4 FOS FOSL2 GC06P132061 AKAP7 CTGF ENSG00000236166 ENSG00000227220
GH06I131979 Enhancer 1.2 Ensembl ENCODE 0.3 -30.3 -30305 4.4 FOXA2 MLX ARID4B DMAP1 ETS1 YY1 SLC30A9 ZNF121 ATF7 FOS LINC01013 CTGF ENSG00000227220 GC06P132061
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CTGF on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CTGF gene promoter:

Genomic Locations for CTGF Gene

Genomic Locations for CTGF Gene
3,203 bases
Minus strand

Genomic View for CTGF Gene

Genes around CTGF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTGF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTGF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTGF Gene

Proteins for CTGF Gene

  • Protein details for CTGF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Connective tissue growth factor
    Protein Accession:
    Secondary Accessions:
    • E1P578
    • Q6LCY0
    • Q96A79
    • Q96QX2
    • Q9UDL6

    Protein attributes for CTGF Gene

    349 amino acids
    Molecular mass:
    38091 Da
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for CTGF Gene


neXtProt entry for CTGF Gene

Post-translational modifications for CTGF Gene

  • Glycosylation at Asn28, posLast=193193, and posLast=225225
  • Modification sites at PhosphoSitePlus

Other Protein References for CTGF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CTGF Gene

Domains & Families for CTGF Gene

Gene Families for CTGF Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CCN family.
  • Belongs to the CCN family.
genes like me logo Genes that share domains with CTGF: view

Function for CTGF Gene

Molecular function for CTGF Gene

GENATLAS Biochemistry:
connective tissue growth factor,homologous to NOV,immediate early response gene
UniProtKB/Swiss-Prot Function:
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.

Phenotypes From GWAS Catalog for CTGF Gene

Gene Ontology (GO) - Molecular Function for CTGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding IEA --
GO:0005178 integrin binding IEA,IBA --
GO:0005515 protein binding IPI 16457822
GO:0005520 insulin-like growth factor binding TAS,IEA --
GO:0008022 protein C-terminus binding IPI 9927660
genes like me logo Genes that share ontologies with CTGF: view
genes like me logo Genes that share phenotypes with CTGF: view

Human Phenotype Ontology for CTGF Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CTGF Gene

MGI Knock Outs for CTGF:

Clone Products

  • Addgene plasmids for CTGF

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CTGF Gene

Localization for CTGF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTGF Gene

Secreted, extracellular space, extracellular matrix. Secreted.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTGF gene
Compartment Confidence
plasma membrane 5
extracellular 5
golgi apparatus 5
cytosol 3
cytoskeleton 2
nucleus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CTGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IBA,TAS --
GO:0005615 extracellular space IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005801 cis-Golgi network IEA --
genes like me logo Genes that share ontologies with CTGF: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CTGF Gene

Pathways & Interactions for CTGF Gene

genes like me logo Genes that share pathways with CTGF: view

SIGNOR curated interactions for CTGF Gene


Gene Ontology (GO) - Biological Process for CTGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001502 cartilage condensation IEA --
GO:0001503 ossification IEA --
GO:0001525 angiogenesis IEA --
GO:0001558 regulation of cell growth IEA --
GO:0001894 tissue homeostasis IEA --
genes like me logo Genes that share ontologies with CTGF: view

Drugs & Compounds for CTGF Gene

(42) Drugs for CTGF Gene - From: ClinicalTrials, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aldosterone Experimental, Investigational Pharma Agonist 0
Mitogens Pharma 1732
FG-3019 Pharma inhibitor 0

(33) Additional Compounds for CTGF Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CTGF: view

Transcripts for CTGF Gene

mRNA/cDNA for CTGF Gene

(1) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(962) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CTGF Gene

Connective tissue growth factor:
Representative Sequences:

Clone Products

  • Addgene plasmids for CTGF

Alternative Splicing Database (ASD) splice patterns (SP) for CTGF Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - -
SP3: -

Relevant External Links for CTGF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTGF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTGF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTGF Gene

This gene is overexpressed in Artery - Aorta (x9.0) and Artery - Coronary (x4.3).

Protein differential expression in normal tissues from HIPED for CTGF Gene

This gene is overexpressed in Amniocyte (64.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CTGF Gene

NURSA nuclear receptor signaling pathways regulating expression of CTGF Gene:


SOURCE GeneReport for Unigene cluster for CTGF Gene:


mRNA Expression by UniProt/SwissProt for CTGF Gene:

Tissue specificity: Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.

Evidence on tissue expression from TISSUES for CTGF Gene

  • Heart(4.7)
  • Kidney(4.7)
  • Liver(4.6)
  • Bone(4.5)
  • Nervous system(4.5)
  • Skin(4.4)
  • Lung(4.2)
  • Eye(4)
  • Pancreas(3.8)
  • Intestine(3.7)
  • Muscle(3.6)
  • Stomach(3.5)
  • Blood(2.6)
  • Spleen(2.6)
  • Gall bladder(2.4)
  • Thyroid gland(2.2)
  • Lymph node(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CTGF Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Head and neck:
  • brain
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • salivary gland
  • skull
  • tongue
  • tooth
  • chest wall
  • clavicle
  • esophagus
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
  • intestine
  • large intestine
  • small intestine
  • stomach
  • pelvis
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
  • blood
  • blood vessel
  • skin
  • spinal column
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with CTGF: view

No data available for Protein tissue co-expression partners for CTGF Gene

Orthologs for CTGF Gene

This gene was present in the common ancestor of chordates.

Orthologs for CTGF Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CTGF 33 34
  • 99.33 (n)
(Canis familiaris)
Mammalia CTGF 34
  • 93 (a)
LOC476202 33
  • 91.4 (n)
(Bos Taurus)
Mammalia CTGF 33 34
  • 89.37 (n)
(Rattus norvegicus)
Mammalia Ctgf 33
  • 88.86 (n)
(Mus musculus)
Mammalia Ctgf 33 16 34
  • 88.6 (n)
(Monodelphis domestica)
Mammalia CTGF 34
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia CTGF 34
  • 85 (a)
(Gallus gallus)
Aves CTGF 33 34
  • 83.82 (n)
(Anolis carolinensis)
Reptilia CTGF 34
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ctgf 33
  • 75.02 (n)
Str.15550 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398003 33
(Danio rerio)
Actinopterygii ctgfa 33 34
  • 73.29 (n)
hmzeh1559 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13898 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
-- 34
  • 44 (a)
Species where no ortholog for CTGF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTGF Gene

Gene Tree for CTGF (if available)
Gene Tree for CTGF (if available)

Paralogs for CTGF Gene

Paralogs for CTGF Gene

(7) SIMAP similar genes for CTGF Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CTGF: view

Variants for CTGF Gene

Sequence variations from dbSNP and Humsavar for CTGF Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000198671 -- 131,951,420(-) C/T upstream_transcript_variant
rs1000248948 -- 131,950,303(-) G/A coding_sequence_variant, missense_variant
rs1000250802 -- 131,951,821(-) C/A/G upstream_transcript_variant
rs1000584692 -- 131,951,347(-) C/T 5_prime_UTR_variant
rs1000734182 -- 131,950,891(-) G/A coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for CTGF Gene

Variant ID Type Subtype PubMed ID
nsv7968 CNV loss 18304495

Variation tolerance for CTGF Gene

Residual Variation Intolerance Score: 45.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CTGF Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTGF Gene

Disorders for CTGF Gene

MalaCards: The human disease database

(43) MalaCards diseases for CTGF Gene - From: HGMD, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
systemic scleroderma
  • scleroderma, familial progressive
renal fibrosis
scleroderma, familial progressive
  • systemic sclerosis
gingival overgrowth
  • gingival enlargement
urethral stricture
- elite association - COSMIC cancer census association via MalaCards
Search CTGF in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CTGF

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CTGF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTGF Gene

Publications for CTGF Gene

  1. Validation of connective tissue growth factor (CTGF/CCN2) and its gene polymorphisms as noninvasive biomarkers for the assessment of liver fibrosis. (PMID: 19243500) Kovalenko E … Weiskirchen R (Journal of viral hepatitis 2009) 3 22 44 58
  2. Aldosterone induces CTGF in mesangial cells by activation of the glucocorticoid receptor. (PMID: 17602195) Gauer S … Goppelt-Struebe M (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2007) 3 22 25 58
  3. The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion. (PMID: 12553878) Ball DK … Brigstock DR (The Journal of endocrinology 2003) 3 4 22 58
  4. Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. (PMID: 1654338) Bradham DM … Grotendorst GR (The Journal of cell biology 1991) 2 3 4 58
  5. Rac1-induced connective tissue growth factor regulates connexin 43 and N-cadherin expression in atrial fibrillation. (PMID: 20117462) Adam O … Laufs U (Journal of the American College of Cardiology 2010) 3 22 58

Products for CTGF Gene

  • Addgene plasmids for CTGF

Sources for CTGF Gene

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